» Introduction to and spread of COVID-19 in care homes in Norfolk, UK
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
BACKGROUND: Residential care homes for the elderly have been important settings for transmission of the SARS-CoV-2 virus that causes COVID-19 disease. METHODS: We undertook a secondary analysis of a dataset about 248 care homes in the co...

» Mathematical Modeling of Coronavirus Reproduction Rate with Policy and Behavioral Effects
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In this paper a modified mathematical model based on the SIR model used which can predict the spreading of the corona virus disease (COVID-19) and its effects on people in the days ahead. This model takes into account all the death, infe...

» The effectiveness of interventions to reduce COVID-19 transmission in a large urban jail
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: To estimate the impact of various mitigation strategies on COVID-19 transmission in a U.S. jail beyond those offered in national guidelines. Methods: We developed a stochastic dynamic transmission model of COVID-19 in one lar...

» GLUCOCOVID: A controlled trial of methylprednisolone in adults hospitalized with COVID-19 pneumonia
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background. We aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk of developing Acute Respiratory Distress Syndrome (ARDS). Methods. Multicentri...

» The first proof of the capability of wastewater surveillance for COVID-19 in India through the detection of the genetic material of SARS-CoV-2
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
we made the first-ever successful effort from India to detect the genetic material of SARS-CoV-2 viruses to understand the capability and application of WBE surveillance in India. Sampling was carried out on 8 and 27 May 2020 from Old Pi...

» Knowledge, Attitudes, and Fear of COVID-19 during the Rapid Rise Period in Bangladesh
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: To determine the level of Knowledge, Attitude, and Practice (KAP) related to COVID-19 preventive health habits and perception of Fear towards COVID-19 in subjects living in Bangladesh. Design: Prospective, cross-sectional sur...

» Exosomal microRNAs Drive Thrombosis in COVID-19
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Thrombotic and thromboembolic complications have been shown to play a critical role in the clinical outcome of COVID-19. Emerging evidence has shown that exosomal miRNAs are functionally involved in a number of physiologic and pathologic...

» Associations of Global Country Profiles and Modifiable Risk Factors with COVID-19 Cases and Deaths
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Modifiable risk factors affect SARS-CoV-2 infection and mortality raising the possibility that lifestyle modification could play a role. This has not been studied at a global level. We analysed publicly available data from countries repo...

» Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The impact of COVID-19 on mental health is unclear. Evidence from longitudinal studies with pre pandemic data are needed to address (1) how mental health has changed from pre-pandemic levels to during the COVID-19 pandemic an...

» Limited Role for Antibiotics in COVID-19: Scarce Evidence of Bacterial Coinfection
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: There is currently a paucity of data describing bacterial coinfections, related antibiotic prescribing patterns, and the potential role of antimicrobial stewardship in the care of patients infected with SARS-CoV-2. Methods: T...

» Combined point of care nucleic acid and antibody testing for SARS-CoV-2: a prospective cohort study in suspected moderate to severe COVID-19 disease.
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Background Rapid COVID-19 diagnosis in hospital is essential for patient management and identification of infectious patients to limit the potential for nosocomial transmission. The diagnosis is complicated by 30-50% of COVID-19...

» COVID-19 outcomes, risk factors and associations by race: a comprehensive analysis using electronic health records data in Michigan Medicine
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Importance: Blacks/African-Americans are overrepresented in the number of COVID-19 infections, hospitalizations and deaths. Reasons for this disparity have not been well-characterized but may be due to underlying comorbidities or sociode...

» State-wise estimates of current hospital beds, intensive care unit (ICU) beds and ventilators in India: Are we prepared for a surge in COVID-19 hospitalizations?
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The rapid spread of COVID-19 globally has prompted policymakers to evaluate the capacity of health care infrastructure in their communities. Many hard-hit localities have witnessed a large influx of severe cases that strained ...

» Evaluation of specimen types and saliva stabilization solutions for SARS-CoV-2 testing
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Identifying SARS-CoV-2 infections through aggressive diagnostic testing remains critical in tracking and curbing the spread of the COVID-19 pandemic. Collection of nasopharyngeal swabs (NPS), the preferred sample type for SARS-CoV-2 dete...

» Detection of antibodies to the SARS-CoV-2 spike glycoprotein in both serum and saliva enhances detection of infection
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Detecting antibody responses during and after SARS-CoV-2 infection is essential in determining the seroepidemiology of the virus and the potential role of antibody in disease. Scalable, sensitive and specific serological assa...

» KNOWLEDGE AND BEHAVIORS RELATED TO THE COVID-19 PANDEMIC IN MALAWI
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: There are limited data on knowledge and behaviors related to COVID-19, and on the adoption of preventive behaviors, in sub-Saharan countries. Methods: Between April 25th and May 23rd, we contacted 793 individuals aged 18 and ...

» Effect of evacuation of Japanese residents from Wuhan, China, on preventing transmission of novel coronavirus infection: a modelling study
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objective: In late January 2020, the Japanese government carried out three evacuations by aircraft from Wuhan, China, to avoid further cases of coronavirus disease 2019 (COVID-19) among Wuhan's Japanese residents. Evacuation by aircraft ...

» Perceived Challenges of COVID-19 Infection Prevention and Control Preparedness: A Multinational Survey
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives Implementation of effective infection prevention and control (IPC) measures is needed to support global capacity building to limit transmission of coronavirus disease 2019 (COVID-19) and mitigate its impact on health systems. ...

» The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients: A Systematic Review and Meta-regression Analysis
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Importance The antimalarial agents chloroquine (CQ) and hydroxychloroquine (HCQ) have been proposed as a potential treatment for COVID-19 due their effect on several cellular processes that impact viral replication. Although mor...

» Epidemiological characteristics of patients with residual SARS-Cov-2 in Linyi, China
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Patients with 2019 novel Coronavirus infection are probably showing positive testing results again. In order to better treat these patients and provide basis for further control measures, we analyze the epidemiological outcomes and clini...

» Time Course of COVID-19 epidemic in Algeria: Retrospective estimate of the actual burden
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Since December 2019, the five continents have been incrementally invaded by SARS-CoV-2. Africa is the last and least affected to date. However, Algeria is among the first countries affected since February 25, 2020. In order to benefit fr...

» COVID-19 PCR Test Performance For Samples Stored At Ambient Temperature
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The new type of Coronavirus infection had become a pandemic in a very short period since it was first seen in Wuhan. The outbreak had a negative impact on all health care systems throughout the world and overwhelmed the diagn...

» Sensitivity analysis of the effects of non-pharmaceutical interventions on COVID-19 in Europe
17/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The role of non-pharmaceutical interventions (NPIs) on the spread of SARS-CoV-2 has drawn significant attention, both scientific and political. Particularly, an article by the Imperial College COVID-19 Response Team (ICCRT), published on...

» Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Since its emergence in Wuhan, China in late 2019, the origin and evolution of SARS-CoV-2 have been among the most debated issues related to COVID-19. Throughout its spread around the world, the viral genome continued acquiring new mutati...

» in-silica Analysis of SARS-CoV-2 viral strain using Reverse Vaccinology Approach: A Case Study for USA
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The recent pandemic of COVID19 that has struck the world is yet to be battled by a potential cure. Countless lives have been claimed due to the existing pandemic and the societal normalcy has been damaged permanently. As a result, it bec...

» A compound Dirichlet-Multinomial model for provincial level Covid-19 predictions in South Africa
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Accurate prediction of COVID-19 related indicators such as confirmed cases, deaths and recoveries play an important in understanding the spread and impact of the virus, as well as resource planning and allocation. In this study, we appro...

» Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: SARS-CoV-2 is straining healthcare systems globally. The burden on hospitals during the pandemic could be reduced by implementing prediction models that can discriminate between patients requiring hospitalization and those wh...

» Diagnostic accuracy of six commercial SARS-CoV-2 IgG/total antibody assays and identification of SARS-CoV-2 neutralizing antibodies in convalescent sera
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The reliable detection of immunoglobulin G (IgG) or total antibodies directed against the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is important for clinical diagnostics and epidemiological studies. Here, we...

» Reducing SARS-CoV-2 infectious spreading patterns by removing S and R compartments from SIR model equation
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
This research points to the asymptotic instability of SIR model and its variants to predict the behavior of SARS-CoV-2 infection spreading patterns over the population and time aspects. Mainly for the S and R terms of the equation, the p...

» Causes of Death and Comorbidities in Patients with COVID-19
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has caused several hundreds of thousands of deaths worldwide. Patients of higher age and with preexisting chronic health conditions are at an increased...

» The effect of serological screening for SARS-CoV-2 antibodies to participants' attitudes and risk behaviour: a study on a tested population sample of industry workers in Split-Dalmatia County, Croatia
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Rapid serological tests for SARS-CoV-2 antibodies have been questioned by scientists and the public because of unexplored effects of negative test results on behaviour and attitudes, that could lower the level of adherence to protective ...

» National Early Warning Scores (NEWS / NEWS2) and COVID-19 deaths in care homes: a longitudinal ecological study
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives:To investigate whether patterns of National Early Warning Scores (NEWS/NEWS2) in care homes during the COVID pandemic correspond with area-level COVID-19 death registrations from care homes. Study design: Longitudinal ecologic...

» Risk of Depression in Family Caregivers: Unintended Consequence of COVID-19
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: COVID-19 is likely to exacerbate the symptoms of poor mental health family caregivers. To investigate whether rates of depression increased in caregivers during COVID-19 and whether the unintended consequences of health prote...

» Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background COVID-19 pandemic is underway. Some COVID-19 cases re-tested positive for SARS-CoV-2 RNA after discharge raising the public concern on their infectivity. Characterization of re-positive cases are urgently needed for designing ...

» Early impacts of the COVID-19 pandemic on mental health care and on people with mental health conditions: framework synthesis of international experiences and responses
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Purpose The COVID-19 pandemic has many potential impacts on people with mental health conditions and on mental health care, including direct consequences of infection, effects of infection control measures and subsequent societal changes...

» Self-reported food choices before and during COVID-19 lockdown
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Stressful situations can cause changes in individual food choices, most notably, choices of highly rewarding foods that are high in fat or sugar. Few studies have examined how a population's food choices change during a country-wide stre...

» Artificial Intelligence for COVID-19 Risk Classification in Kidney Disease: Can Technology Unmask an Unseen Disease?
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: We developed two unique machine learning (ML) models that predict risk of: 1) a major COVID-19 outbreak in the service county of a local HD population within following week, and 2) a hemodialysis (HD) patient having an undete...

» Delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Frailty, increased vulnerability to physiological stressors, is associated with adverse outcomes. COVID-19 exhibits a more severe disease course in older, co-morbid adults. Awareness of atypical presentations is critical to f...

» Mobility network modeling explains higher SARS-CoV-2 infection rates among disadvantaged groups and informs reopening strategies
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Fine-grained epidemiological modeling of the spread of SARS-CoV-2 -- capturing who is infected at which locations -- can aid the development of policy responses that account for heterogeneous risks of different locations as well as the d...

» Prothrombotic antiphospholipid antibodies in COVID-19
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Patients with coronavirus disease 19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. At the same time, lung histopathology often reveals fibrin-based occlusion of small vessels in patients who succumb to the di...

» Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the pathogenesis and outcome of COVID-19. We aimed to investigate which specific responses from either cellular or hum...

» Human food consumption patterns concerning COVID-19 pandemic
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In recent months, despite being aware of the COVID-19 pandemic, many countries faced increasing epidemic of this disease. Nearly all countries tried to decrease human-to-human contact as the principal mode of transmission of SARS-CoV-2. ...

» Modeling the Post-Containment Elimination of Transmission of COVID-19
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Roughly six months into the COVID-19 pandemic, many countries have managed to contain the spread of the virus by means of strict containment measures including quarantine, tracing and isolation of patients as well strong restrictions on ...

» Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale superspreading event
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
During the 2020 COVID-19 pandemic, an outbreak occurred following attendance of a symptomatic index case at a regular weekly rehearsal on 10 March of the Skagit Valley Chorale (SVC). After that rehearsal, 53 members of the SVC among 61 i...

» A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Despite widespread concern for cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring critically ill patients. We report the clinical application of a machine learning-ba...

» Can the protection be among us? Previous viral contacts and prevalent HLA alleles could be avoiding an even more disseminated COVID-19 pandemic.
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: COVID-19 is bringing scenes of sci-fi movies into real life, and it seems to be far from over. Infected individuals exhibit variable severity, with no relation between the number of cases and mortality, suggesting the involve...

» SARS-CoV-2 Community Transmission During Shelter-in-Place in San Francisco
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
ABSTRACT Background: We characterized SARS-CoV-2 infections in a densely-populated, majority Latinx San Francisco community six-weeks into the city's shelter-in-place order. Methods: We offered SARS-CoV-2 reverse transcription-PCR and an...

» Commercial Airline Protocol during Covid-19 Pandemic: An Experience of Thai Airways International
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction: Coronavirus disease 2019 (COVID-19) pandemic has affected the aviation industry. Existing protocols have relied on scientifically questionable evidence and might not lead to the optimal balance between public health safety ...

» Towards intervention development to increase the uptake of COVID-19 vaccination among those at high risk: outlining evidence-based and theoretically informed future intervention content
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: Development of a vaccine against COVID-19 will be key to controlling the pandemic. We need to understand the barriers and facilitators to receiving a future COVID-19 vaccine so that we can provide recommendations for the desi...

» Seroprevalence of Antibodies to SARS-CoV-2 in Healthcare Workers in Non-epidemic Region: A Report from Iwate Prefecture in Japan
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: As of June 8, 2020, Iwate is the only one of 47 prefectures in Japan with no confirmed coronavirus disease 2019 (COVID-19) cases. Serological survey for COVID-19 antibodies is crucial in area with low prevalence as well as ep...

» Impact of Daily Weather on COVID-19 outbreak in India
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The COVID-19 pandemic has outspread obstreperously in India. As of June 04, 2020, more than 2 lakh cases have been confirmed with a death rate of 2.81%. It has been noticed that, out of each 1000 tests, 53 result positively infected. In ...

» Predictive Modeling on the Number of Covid-19 Death Toll in the United States Considering the Effects of Coronavirus-Related Changes and Covid-19 Recovered Cases
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
COVID-19 is caused by a coronavirus called SARS-CoV-2. Many countries around the world implemented their own policies and restrictions designed to limit the spread of Covid-19 in recent months. Businesses and schools transitioned into wo...

» Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A significant fraction of people who test positive for COVID-19 have chemosensory deficits. However, the reported prevalence of these deficits in smell and/or taste varies widely, and the reason for the differences between studies is unc...

» Identifiability of infection model parameters early in an epidemic
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
It is known that the parameters in the deterministic and stochastic SEIR epidemic models are structurally identifiable. For example, from knowledge of the infected population time series I(t) during the entire epidemic, the parameters ca...

» Time-series analyses of directional sequence changes in SARS-CoV-2 genomes and an efficient search method for advantageous mutations for growth in human cells
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
We first conducted time-series analysis of mono- and dinucleotide composition for over 10,000 SARS-CoV-2 genomes, as well as over 1500 Zaire ebolavirus genomes, and found clear time-series changes in the compositions on a monthly basis, ...

» Decoding of persistent multiscale structures in complex biological networks
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Networks of genes, proteins, and cells exhibit significant multiscale organization, with distinct communities appearing at different spatial resolutions. Here, we apply the concept of 'persistent homology' to identify network communities...

» Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutralizing antibodies. Here we experimentally measure ...

» Detection of SARS-CoV-2 RNA by multiplex RT-qPCR
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The current RT-qPCR assay recommended for SARS-CoV-2 testing in the United States requires analysis of three genomic targets per sample: two viral and one host. To simplify testing and reduce the volume of required reagents, we developed...

» A thermostable, closed, SARS-CoV-2 spike protein trimer.
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. S exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose i...

» Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Identification of host genes essential for SARS-CoV-2 infection may reveal novel therapeutic targets and inform our understanding of COVID-19 pathogenesis. Here we performed a genome-wide CRISPR screen with SARS-CoV-2 and identified know...

» Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2 RNA has been detected in the human breast milk of infected mothers, raising concerns regarding the safety of breastfeeding upon infection. We here show that holder pasteurization inactivates SARS-CoV-2 and provides an alternat...

» Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Main protease (Mpro, also known as 3CLpro) has a major role in the replication of coronavirus life cycle and is one of the most important drug targets for anticoronavirus agents. Here we report the crystal structure of main protease of S...

» High-Accuracy Multiplexed SARS-CoV-2 Antibody Assay with Avidity and Saliva Capability on a Nano-Plasmonic Platform
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The outbreak and rapid spread of SARS-CoV-2 virus has led to a dire global pandemic with millions of people infected and ~ 400,000 deaths thus far. Highly accurate detection of antibodies for COVID-19 is an indispensable part of the effo...

» Pervasive RNA secondary structure in the genomes of SARS-CoV-2 and other coronaviruses - an endeavour to understand its biological purpose
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The ultimate outcome of the COVID-19 pandemic is unknown and is dependent on a complex interplay of its pathogenicity, transmissibility and population immunity. In the current study, the SARS coronavirus 2 (SARS-CoV-2) genome was investi...

» Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The sudden global emergence of SARS-CoV-2 urgently requires an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several omics studies have extended our knowledge of COVID-19 p...

» Rapid assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy
16/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological cause of the coronavirus disease 2019, for which no effective therapeutics are available. The SARS-CoV-2 main protease (Mpro) is essential for viral replicat...

» BRAIN MR SPECTROSCOPIC FINDINGS IN THREE CONSECUTIVE COVID-19 PATIENTS: PRELIMINARY OBSERVATIONS
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Brain magnetic resonance spectroscopic imaging (MRSI) was performed in three consecutive COVID-19 patients, as part of a pilot investigation of the pathophysiological processes underlying the brain involvement by the SARS-CoV-2 infection...

» Risk of death by age and gender from CoVID-19 in Peru, March-May, 2020
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Peru implemented strict social distancing measures during the early phase of the epidemic and is now experiencing one of the largest CoVID-19 epidemics in Latin America. Estimates of disease severity are an essential indicator to inform ...

» Development and validation of a knowledge-driven risk calculator for critical illness in COVID-19 patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Facing the rapidly spreading novel coronavirus disease (COVID-19), evidence to inform decision-making at both the clinical and policy-making level is highly needed. Based on the results of a study by Petrilli et al, we have developed a c...

» A model for COVID-19 transmission in Connecticut
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To support public health policymakers in Connecticut as they begin phased lifting of social distancing restrictions, we developed a county-structured compartmental SEIR-type model of SARS-CoV-2 transmission and COVID-19 disease progressi...

» The Impact of COVID-19 Pandemic on Cardiology Services
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objective: COVID-19 pandemic resulted in prioritisation of NHS resources to cope with the surge in infected patients. However, there have been no studies in the UK looking at the effect of COVID-19 work pattern on the provision of cardio...

» Assessment of Early Mitigation Measures Against COVID-19 in Puerto Rico: March 15-May 15, 2020
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: On March 15, 2020 Puerto Rico implemented non-pharmaceutical interventions (NPIs), including a mandatory curfew, as part of a state of emergency declaration to mitigate the community transmission of the SARS-CoV-2 virus. The ...

» An International Review of Tobacco Use and the COVID-19 Pandemic: Examining Hospitalization, Asymptomatic Cases, and Severity
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background and objectives: Since the World Health Organization (WHO) declared a public health emergency of imminent concern in March 2020, the novel coronavirus (SARS-CoV-2) and its related disease (COVID-19) has become a topic of much-n...

» Understanding the Incidence of Covid-19 among the police force in Maharashtra through a mixed approach
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Background: The study tries to understand the incidence of COVID-19 among police officials along with the challenges they face and their preparedness during the pandemic response in Maharashtra. Method: The study analyzed the da...

» Modeling the Spring 2020 New York City COVID-19 Epidemic: New Criteria and Methods for Prediction
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
We report here on results obtained using the SIR model to study the spring 2020 COVID-19 epidemic in New York City. An approximate solution is derived for this non-linear system which is then used to derive an expression for the time to ...

» Low and high infection dose transmission of SARS-CoV-2 in the first COVID-19 clusters in Northern Germany
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: We used viral genomics to deeply analyze the first SARS-CoV-2 infection clusters in the metropolitan region of Hamburg, Germany. Epidemiological analysis and contact tracing together with a thorough investigation of virus var...

» Are health indicators able to describe the ability to cope of Health Systems with COVID-19 epidemic?
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The Coronavirus Disease 19 epidemic is an infectious disease which was declared as a pandemic and hit all the Countries, all over the world, from the beginning of the year 2020. Despite the emergency vigilance plans, in all the Countries...

» Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The pathogenesis of COVID-19, caused by a novel strain of coronavirus (SARS-CoV-2), involves a complex host-virus interaction and is characterised by an exaggerated immune response, the specific components of which are poorly ...

» Snapshot PCR Surveillance for SARS-CoV-2 in Hospital Staff in England
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background Significant nosocomial transmission of SARS-CoV-2 has been demonstrated. Understanding the prevalence of SARS-CoV-2 carriage amongst HCWs at work is necessary to inform the development of HCW screening programmes to control no...

» Risk and severity of COVID-19 and ABO blood group in transcatheter aortic valve patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Although cardiovascular disease has been associated with an increased risk of coronavirus disease 2019 (COVID-19), no studies have reported its clinical course in patients with aortic stenosis who had undergone transcatheter ...

» Field-deployable, rapid diagnostic testing of saliva samples for SARS-CoV-2.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Rapid, scalable, point-of-need, COVID-19 diagnostic testing is necessary to safely re-open economies and prevent future outbreaks. We developed an assay that detects single copies of SARS-CoV-2 virus directly from saliva and swa...

» Covid-19 rapid test by combining a random forest based web system and blood tests
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The disease caused by the new type of coronavirus, the Covid-19, has posed major public health challenges for many countries. With its rapid spread, since the beginning of the outbreak in December 2019, the disease transmitted by SARS-Co...

» Guillain Barr e syndrome in COVID-19:A scoping review
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction The novel coronavirus (COVID19) can result in several neurological complications. Guillain-Barre Syndrome (GBS) is one of them and has been reported from different parts of the world in this pandemic. It is an acute post-inf...

» Comparison of Mental Health Symptoms Prior to and During COVID-19 among Patients with Systemic Sclerosis from Four Countries: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort Study
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: No studies have reported comparisons of mental health symptoms prior to and during COVID-19 in vulnerable populations. Objectives were to compare anxiety and depression symptoms among people with a pre-existing medical condit...

» Assessment of impact of COVID-19 outbreak & lockdown on mental health status & its associated risk and protective factors in adult Indian population
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Nationwide lockdown to tackle the COVID-19 outbreak in India is anticipated to have psychological impact on the population. Our study aims to study the effect of the outbreak & lockdown on mental health status of adult Indian population ...

» What triggers online help-seeking retransmission during the COVID-19 period? Empirical evidence from Chinese social media
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The past eight months witnessed COVID-19's fast-spreading at the global level. Limited by medical resources shortage and uneven facilities distribution, online help-seeking becomes an essential approach to cope with public health emergen...

» Cohen's kappa statistics as a convenient means to identify accurate SARS-CoV-2 rapid antibody tests
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
There are many available rapid antibody tests, but the performance of such tests remains unclear. Moreover, it is difficult to compare among the various devices regarding their sensitivity & specificity. In order to compare the performan...

» Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan -implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background It is to be determined whether people infected with SARS-CoV-2 will develop long-term immunity against SARS-CoV-2 and retain long-lasting protective antibodies after the infection is resolved. This study was to explore to expl...

» COVID-19: a crash test for biomedical publishing?
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The effect of COVID-19 on biomedical publishing (BP) (i.e. scientific biomedical periodicals continuously published by research communities or commercial publishers) has not been deeply explored. To estimate the immediate COVID-19 impact...

» Spreading Analysis of COVID-19 Epidemic in Bangladesh by Dynamical Mathematical Modelling
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The coronavirus disease 2019 (COVID-19), which emerged from Wuhan, China, is now a pandemic, affecting across the globe. Bangladesh also is experiencing the rapid growth of COVID-19 infection and death cases started from 8th March 2020. ...

» Quantification of SARS-CoV-2 viral copy number in saliva mouthwash samples using digital droplet PCR
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Saliva samples were collected through a simple mouth wash procedure and viral load quantified using a technology called digital droplet PCR. Data suggest ddPCR is allows for precise quantification of viral load in clinical samples infect...

» A systematic review protocol of the antiviral activity of chloroquine and hydroxychloroquine against COVID-19.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction: The recent outbreak of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or COVID-19 with no approved medicines has led to global health threat. Currently, repositioning of old medicines seems the most respo...

» Random time transformation analysis of Covid19 2020
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The SIR epidemiological equations model new affected and removed cases as roughly proportional to the current number of infected cases. The present report adopts an alternative that has been considered in the literature, in which the num...

» Utility of Lung Ultrasound in COVID-19: A Systematic Scoping Review
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Lung ultrasound (LUS) has an established evidence base and has proven useful in previous viral epidemics. An understanding of the utility of LUS in COVID-19 is crucial to determine its most suitable role based on local circumstances. A s...

» What Has Been the Impact of Covid-19 on Safety Culture?
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction Covid-19 has placed an unprecedented demand on healthcare systems worldwide. A positive safety culture is associated with improved patient safety and in turn patient outcomes. To date, no study has evaluated the impact of Co...

» An Extended Laboratory Validation Study and Comparative Performance Evaluation of the Abbott ID NOW COVID-19 Assay in a Coastal California Tertiary Care Medical Center
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract: The Abbott ID NOW COVID-19 assay is a rapid molecular diagnostic test particularly designed for on-site, rapid turnaround point of care (POC) testing. The utilization of rapid diagnostic tests is integral to optimizing workflow...

» Global and local mobility as a barometer for COVID-19 dynamics
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The spreading of infectious diseases including COVID-19 depends on human interactions. In an environment where behavioral patterns and physical contacts are constantly evolving according to new governmental regulations, measuring these i...

» High temperature has no impact on the reproduction number and new cases of COVID-19 in Bushehr, Iran
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: COVID-19 was first reported in Iran on February 19, 2020. Bushehr, one of the warmest provinces of Iran, was the last province confirmed to be infected on March 5, 2020. At the beginning of April, Bushehr was announced as a w...

» Risk factors for critical-ill events of patients with COVID-19 in Wuhan, China: a retrospective cohort study
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background Little is known about the risk factors for critical-ill events (intensive care, invasive ventilation, or death) in patients with COVID-19. Methods Patients with laboratory-confirmed COVID-19 admitted to the Wuhan Leishenshan H...

» Air Quality and COVID-19 Prevalence/Fatality
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To investigate the association of real-time/observed ozone/PM2.5 levels with COVID-19 prevalence/fatality, meta-regression of data from the Northeast megalopolis was conducted. Daily Air Quality Index (AQI) values based on available ozon...

» Thyroid function abnormalities in COVID-19 patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects human thyroid function remains unknown. Methods: 84 hospitalized COVID-19 patients in the F...

» Modeling the dynamics of COVID19 spread during and after social distancing
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Non-pharmaceutical intervention measures, such as social distancing, have so far been the only means to slow the spread of COVID19. In the United States, strict social distancing has resulted in different types infection dynamics. In som...

» Publish or perish: Reporting Characteristics of Peer-reviewed publications, pre-prints and registered studies on the COVID-19 pandemic
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The COVID-19 pandemic has resulted in a mass of academic papers being published in a very brief span of time. Our aim was to compare the amount and reporting characteristics of COVID-19 related peer-reviewed and pre-prints pub...

» Simulation of Non-Pharmaceutical Interventions on COVID-19 with an Agent-based Model of Zonal Restraint
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Non-Pharmaceutical Interventions (NPI) are currently the only mechanism governments can use to mitigate the impact of the COVID-19 epidemic. Similarly to the actual spread of the disease, the dynamics of the contention patterns emerging ...

» Assessing the burden of COVID-19 in Canada
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The burden of COVID-19 in Canada is unequally distributed geographically, with the largest number of cases and fatalities recorded in Quebec and Ontario while other provinces experienced limited outbreaks. To date, however, n...

» Double COVID-19 Confirmed Case Fatality Rate in Countries with High Elderly Female Vitamin D Deficiency Prevalence
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A number of clues point to a possible role of vitamin D in fighting COVID-19: a reduction in case growth speed with solar zenith angle, higher fatality rate in black people, lower fatality rate in populations that spend more time outdoor...

» The inevitability of Covid-19 related distress among healthcare workers: findings from a low caseload country under lockdown
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: To characterize psychological distress and factors associated with distress in healthcare practitioners working during a stringent lockdown in a country (Jordan) with one of the lowest incidence rates of Covid-19 globally. Me...

» Seroprevalence against COVID-19 and follow-up of suspected cases in primary health care in Spain
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background During the coronavirus disease 2019 (COVID-19) pandemic little information has been available about patients with mild or moderate symptoms attended and followed in the primary care setting, most of whom had an unknown status ...

» Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Aging is one of the key contributing factors for chronic obstructive pulmonary diseases (COPD) and other chronic inflammatory lung diseases. Cigarette smoke is a major etiological risk factor that has been shown to alter cellular process...

» Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection prevention strategies in healthcare workers
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Clinical guidelines on infection prevention strategies in healthcare workers (HCWs) play an important role in protecting them during the SARS-CoV-2 pandemic. Poorly constructed guidelines that are not comprehensive and are am...

» Impact of social distancing measures for preventing coronavirus disease 2019 : A systematic review and meta-analysis protocol
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Introduction: Social distancing measures (SDMs) protect public health from the outbreak of coronavirus disease 2019 (COVID-19). However, the impact of SDMs has been inconsistent and unclear. This study aims to assess the effects...

» Predictors of CPAP outcome in hospitalised COVID-19 patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction: Throughout March - April 2020, many patients with COVID-19 presented to Southend University Hospital with Acute Hypoxaemic Respiratory Failure (AHRF). Patients were managed in a Specialist Respiratory High Dependency Unit. ...

» Impact Of Temperature and Sunshine Duration on Daily New Cases and Death due to COVID-19
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The coronavirus pandemic (COVID-19) control has now become a critical issue for public health. Many ecological factors are proven to influence the transmission and survival of the virus. In this study, we aim to determine the...

» Evaluating the Mental Health Impacts of the COVID-19 Pandemic in Urban South Africa: Perceived Risk of COVID-19 Infection and Childhood Trauma Predict Adult Depressive Symptoms
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
South Africa's national lockdown introduced serious threats to public mental health in a society where one in three individuals develop a psychiatric disorder during their life. We aimed to evaluate the mental health impacts of the COVID...

» Mental health service activity during COVID-19 lockdown: South London and Maudsley data on working age community and home treatment team services and mortality from February to mid-May 2020
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The lockdown and social distancing policy response to the COVID-19 pandemic in the UK has a potentially important impact on provision of mental healthcare; however, there has been relatively little quantification of this. Taking advantag...

» Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia. When late administration is too late.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction Tocilizumab is an interleukin 6 receptor antagonist which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), aiming to ameliorate the cytokine release syndrome (CRS) -induced acute respiratory distress syn...

» Is tracking and modeling Covid-19 infection dynamics for Bangladesh using daily data feasible?
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Given the low Covid-19 testing coverage in the country, this study tested whether the daily change in the number of new Covid-19 cases is due to increase (or decrease) in the number of tests done daily. We performed Granger causality tes...

» Covid-19 in Chile. The experience of a Regional reference Center. Preliminary report
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
During the first pandemic wave Covid-19 reached Latin America cities. Aim: To report clinical features and outcomes associated to Covid-19 in a group of patients admitted during the first wave in a regional reference Center in southern C...

» Impact of weather indicators on the COVID-19 outbreak: A multi-state study in India
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The present study examines the impact of weather indicators on the COVID-19 outbreak in the majorly affected states of India. In this study, we hypothesize that the weather indicators could significantly influence the impact of the coron...

» First SARS-CoV-2 detection in river water: implications in low sanitation countries
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Since the beginning of SARS-CoV-2 pandemic studies on viral shedding have reported that this virus is excreted in feces in most patients. High viral loads are found at the sewage pipeline or at the entrance of wastewater treatment plants...

» Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might pr...

» Clinical characteristics of Coronavirus Disease 2019 (COVID-19) patients in Kuwait
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Background: In early December 2019, the first clusters of Coronavirus Disease 2019 (COVID-19) were identified in Wuhan, China and attributed to a novel coronavirus, now known as Severe Acute Respiratory Syndrome Corona Virus 2 (...

» Critical Complications of COVID-19: A systematic Review and Meta-Analysis study
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Coronavirus disease 2019 (COVID-19) is a novel coronavirus infection that has spread worldwide in a short period and caused a pandemic. The goal of this meta-analysis is to evaluate the prevalence of most common symptoms and ...

» Detecting space-time clusters of COVID-19 in Brazil: mortality, inequality, socioeconomic vulnerability, and the relative risk of the disease in Brazilian municipalities
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The first case of COVID-19 in South America occurred in Brazil on February 25th, 2020. By June 7th, 2020, there were 691,758 confirmed cases, 36,455 confirmed deaths, and a mortality rate of 5.3%. To assist with the establishment of meas...

» Remdesivir Efficacy in Coronavirus Disease 2019 (COVID-19): A Systematic Review
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Researchers are working hard to find an effective treatment for the new coronavirus 2019. We performed a comprehensive systematic review to investigate the latest clinical evidence on the treatment efficacy and safety of Remd...

» Symptom clusters in Covid19: A potential clinical prediction tool from the COVID Symptom study app
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As no one symptom can predict disease severity or the need for dedicated medical support in COVID-19, we asked if documenting symptom time series over the first few days informs outcome. Unsupervised time series clustering over symptom p...

» Modelling the Occurrence of the Novel Pandemic COVID-19 Outbreak; A Box and Jenkins Approach
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The corona virus disease 2019 (COVID-19) is a novel pandemic disease that spreads very fast and causes severe respiratory problem to its carrier and thereby results to death in some cases. In this research, we studied the trend, model Ni...

» Predictive accuracy of a hierarchical logistic model of cumulative SARS-CoV-2 case growth
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Infectious disease predictions models, including virtually all epidemiological models describing the spread of the SARS-CoV-2 pandemic up to June 2020, are rarely evaluated. The aim of the present study was to investigate the...

» Clinical Characteristics and Outcomes of Venous Thromboembolism in Patients Hospitalized for COVID-19: Systematic Review and Meta-Analysis
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objective: To investigate the clinical characteristics and outcomes of Coronavirus Disease of 2019 (COVID-19) patients complicated with venous thromboembolism (VTE) Method: We performed a comprehensive literature search of several databa...

» Enhanced comparisons of COVID-19 mortality across populations
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The reported crude case fatality rate (CFR) for COVID-19 varies considerably across countries. Crude CFRs could by biased by larger proportions of older COVID-19 cases in population data, who are also at increased mortality ri...

» Long time frames to detect the impact of changing COVID-19 control measures
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Many countries have implemented population-wide interventions such as physical distancing measures, in efforts to control COVID-19. The extent and success of such measures has varied. Many jurisdictions with declines in repor...

» Impact of Chronic Comorbidities on Progression and Prognosis in Patients with COVID-19: A Retrospective Cohort Study in 1031 Hospitalized Cases in Wuhan, China
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The recent outbreak of COVID-19 has rapidly spread worldwide. A large proportion of COVID-19 patients with chronic underlying complications have been reported to be in severe condition and show unpromising clinical outcomes. B...

» Evaluation of SARS-CoV-2 in Breastmilk from 18 Infected Women
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To The Editor, Currently, the U.S. Centers for Disease Control and Prevention, American Academy of Pediatrics and the World Health Organization advise that women who are infected with SARS-CoV-2 may choose to breastfeed with appropriate ...

» A population-based study of the prevalence of COVID-19 infection in Espirito Santo, Brazil: methodology and results of the first stage
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
BACKGROUND: COVID-19 is affecting almost the entire world, causing more than four hundred thousand deaths and undermining the health care systems, as much as the economy, of the afflicted countries. The strategies for prevention depend o...

» Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19)...

» Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we present a longitudinal sera proteomic resource for 37 COVID-19 patients over nine weeks, in which 2700 proteins ...

» Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Post-infectious anosmias typically follow death of olfactory sensory neurons (OSNs) with a months-long recovery phase associated with parosmias. While profound anosmia is the leading symptom associated with COVID-19 infection, many patie...

» Hypokalemia in Patients with COVID-19
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Patients with COVID-19 may experience multiple conditions (e.g., fever, hyperventilation, anorexia, gastroenteritis, acid-base disorder) that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder that may inc...

» Cumulative effect of aging and SARS-CoV2 infection on poor prognosis in the elderly: Insights from transcriptomic analysis of lung and blood
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The ongoing pandemic COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected over seven million people worldwide to date. It most commonly affects the respiratory system but can also damage kidney, ...

» COVID-19 IN INDIA: MODELLING, FORECASTING AND STATE-WISE COMPARISON
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
COVID-19 has turned the whole world upside down economically and socially. COVID-19 pandemic has caused around five crores of cases and three lakhs deaths globally as of 27 May 2020. This paper adopts four mathematical growth models. Bas...

» COVID-19-related coagulopathy, is transferrin a missing link?
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. Since the ...

» The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are b...

» Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronaviruses, including SARS-CoV-2 the etiological agent of COVID-19 disease, have caused multiple epidemic and pandemic outbreaks in the past 20 years1-3. With no vaccines, and only recently developed antiviral therapeutics, we are ill...

» The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The infection by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes major public health concern and economic burden. Although clinically approved drugs have been repurposed to treat individuals with 2019 Coronavirus ...

» Predicting mammalian hosts in which novel coronaviruses can be generated.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Novel pathogenic coronaviruses - including SARS-CoV and SARS-CoV-2 - frequently arise by homologous recombination in a host cell. This process requires a single host to be infected with multiple coronaviruses, which can then recombine to...

» Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different species
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a huge threat to many countries around the world. However, where is it origin and which animals are sensitive to cross-species transmission is unclear...

» Catch and kill airborne SARS-CoV-2 to control spread of COVID-19 by a heated air disinfection system
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via air-conditioning systems poses a significant threat for the continued escalation of the current coronavirus disease (COVID-19) pandemic. Considerin...

» Bio-JOIE: Joint Representation Learning of Biological Knowledge Bases
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The widespread of Coronavirus has led to a worldwide pandemic with a high mortality rate. Currently, the knowledge accumulated from different studies about this virus is very limited. Leveraging a wide range of biological knowledge, such...

» Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug candidates for rapid clinical deployment. A high-throughput, hig...

» Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Detection of antibodies to upper respiratory pathogens is critical to surveillance, assessment of the immune status of individuals, vaccine development, and basic biology. The urgent need for antibody detection tools has proven particula...

» Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-19 pandemic. However, the cellular mechanism behind the sudden loss of smell has not yet been investigated. The initial step of odour detection takes ...

» TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: Two of the main target tissues of SARS-coronavirus 2 are the oral cavity pharynx-larynx epithelium, the main virus entry site, and the lung epithelium. The virus enters host cells through binding of the Spike protein to ACE2 ...

» Lack of susceptibility of poultry to SARS-CoV-2 and MERS-CoV
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Chickens, turkeys, ducks, quail and geese were challenged with SARS-CoV-2 or MERS-CoV. No disease was observed, no virus replication was detected and antibodies were not detected in serum. Neither virus replicated in embryonating chicken...

» AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND ACE2, THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASE
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated...

» The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike prot...

» Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The COVID-19 pandemic, caused by SARS-CoV-2, is a pressing public health emergency garnering rapid response from scientists across the globe. Host cell invasion is initiated through direct binding of the viral spike protein to the host r...

» Antigenic evolution on global scale reveals potential natural selection of SARS-CoV-2 by pre-existing cross-reactive T cell immunity
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The spreading of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted over 200 countries and regions in the last six month and greatly affected the public health worldwide. It is urgent to reveal the potential evolut...

» Transcriptogram analysis reveals relationship between viral titer and gene sets responses during Corona-virus infection.
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To understand the difference between benign and severe outcomes after Coronavirus infection, we urgently need ways to clarify and quantify the time course of tissue and immune responses. Here we re-analyze 72-hour time-series microarrays...

» Machine Learning Models Identify Inhibitors of SARS-CoV-2
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
With the ongoing SARS-CoV-2 pandemic there is an urgent need for the discovery of a treatment for the coronavirus disease (COVID-19). Drug repurposing is one of the most rapid strategies for addressing this need and numerous compounds ha...

» Genomic modeling as an approach to identify surrogates for use in experimental validation of SARS-CoV-2 and HuNoVs inactivation by UV-C treatment
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic that continues to pose significant public health concerns. While research to deliver vaccines and antivirals are being pursued, various...

» Comparing library preparation methods for SARS-CoV-2 multiplex amplicon sequencing on the Illumina MiSeq platform
15/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Genomic surveillance has a key role in tracking the ongoing COVID-19 pandemic, but information on how different sequencing library preparation approaches affect the data produced are lacking. We compared three library preparation methods...

» Self-reported taste and smell disorders in patients with COVID-19: distinct features in China
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: We aimed to explore the frequencies of nasal symptoms in patients with COVID-19, including loss of smell and taste, as well as their presentation as the first symptom of the disease and their association with the severity of ...

» A discrete-time-evolution model to forecast progress of Covid-19 outbreak
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Based on well-known infection models, we constructed a new model to forecast the propagation of the Covid-19 pandemic which yields a discrete-time evolution with one day interval. The proposed model can be easily implemented with daily u...

» Increased plasma heparanase activity in COVID-19 patients
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Several reports suggest endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase (HPSE) contributes to vascular leakage a...

» Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As the global COVID-19 pandemic continues to escalate, no effective treatment has yet been developed for the severe respiratory complications of this disease. This may be due in large part to the unclear immunopathological basis for the ...

» An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2 is a novel pandemic coronavirus that caused a global health and economic crisis. The development of efficient drugs and vaccines against COVID-19 requires detailed knowledge about SARS-CoV-2 biology. Several techniques to dete...

» Novel ACE2-IgG1 fusions with increased activity against SARS-CoV-2
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2, the etiologic agent of COVID-19, uses ACE2 as a cell entry receptor. Soluble ACE2 has been shown to have neutralizing antiviral activity but has a short half-life and no active transport mechanism from the circulation into th...

» A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug to treat COVID-19, the positive results of passive immune therapy using convalescent serum provides a strong lead. We have developed a new ...

» Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a critical need to produce large quantities of high-quality SARS-CoV-2 Spike (S)...

» The SARSCoV2 spike protein alters barrier function in 2D static and 3D microfluidic in vitro models of the human blood-brain barrier
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As researchers across the globe have focused their attention on understanding SARS-CoV-2, the picture that is emerging is that of a virus that has serious effects on the vasculature in multiple organ systems including the cerebral vascul...

» Genome-wide mapping of therapeutically-relevant SARS-CoV-2 RNA structures
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome of ~30 kb, whose outbreak caused the still ongoing COVID-19 pandemic. The ability of coronaviruses to rapidly evolve, adapt, and cross species barri...

» Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous transmission among humans. Such mutations can occur in the spik...

» Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Emergence of the novel pathogenic coronavirus Sars-CoV-2 and its rapid pandemic spread presents numerous questions and challenges that demand immediate attention. Among these is the urgent need for a better understanding of humoral immun...

» Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Recently, there has been an outbreak associated with the use of e-cigarette or vaping products, associated lung injury (EVALI). The primary components of vaping products, vitamin E acetate (VEA) and medium-chain triglycerides (MCT) may b...

» Interfacial Water Molecules Make RBD of SPIKE Protein and Human ACE2 to Stick Together
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A novel coronavirus (SARS-CoV-2; COVID-19) that initially originates from Wuhan province in China has emerged as a global pandemic, an outbreak that started at the end of 2019 which claims 431,192 (Date: 15th June 2020 (https://covid19.w...

» The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types
14/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Recently, a novel isolate of the SARS-CoV-2 virus carrying a point mutation in the Spike protein (D614G) has emerged and rapidly surpassed others in prevalence, including the original SARS-CoV-2 isolate from Wuhan, China. This Spike vari...

» Impact on mental health care and on mental health service users of the COVID-19 pandemic: a mixed methods survey of UK mental health care staff
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Purpose: The COVID-19 pandemic has potential to disrupt and burden the mental health care system, and to magnify inequalities experienced by mental health service users. Methods: We investigated staff reports regarding the impact of the ...

» Improving effectiveness of different deep learning-based models for detecting COVID-19 from computed tomography (CT) images
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Computerized Tomography (CT )has a prognostic role in the early diagnosis of COVID-19 due to it gives both fast and accurate results. This is very important to help decision making of clinicians for quick isolation and appropriate patien...

» Healthcare Worker COVID-19 Cases in Ontario, Canada: A Cross-sectional Study
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Our objectives were to describe and compare healthcare worker (HCW) and non-HCW COVID-19 cases in Ontario, as well as the frequency of COVID-19 among HCWs household members. Methods: Using reportable disease data at Public He...

» Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Seroconversion appeared early after COVID-19 onset, and convalescent sera therapy benefit some critical patients. However, neutralizing antibody (nAb) in convalescents is largely unknown. We found that 97.01% (65/67) of COVID-19 convales...

» High Incidence of Venous Thrombosis in Patients with Moderate to Severe COVID-19
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
COVID-19 predisposes to venous thromboembolism and there are multiple data regarding high incidence of venous thrombosis in critical COVID-19 patients, however reports on this complication in less severe patients are not widely available...

» Modelling of the second (and subsequent) waves of the coronavirus epidemic. Spain and Germany as case studies
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The first wave of the coronavirus pandemic is waning in many countries. Some of them are starting to lift the confinement measures adopted to control it, but there is considerable uncertainty about if it is too soon and it may cause a se...

» ASSESSING THE POTENTIAL IMPACT OF TRANSMISSION DURING PROLONGED VIRAL SHEDDING ON THE EFFECT OF LOCKDOWN RELAXATION ON COVID-19
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A key parameter in epidemiological modeling which characterizes the spread of an infectious disease is the mean serial interval. There is increasing evidence supporting a prolonged viral shedding window for COVID-19, but the transmissibi...

» How much leeway is there to relax COVID-19 control measures?
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Following successful widespread non-pharmaceutical interventions aiming to control COVID-19, many jurisdictions are moving towards reopening economies and borders. Given that little immunity has developed in most populations, re-establis...

» Analysis of the time evolution of SARS-CoV-2 lethality rate in Italy: Evidence of an unaltered virus potency
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In recent months, the entire world is facing a dramatic health emergency caused by the diffusion of a hitherto unknown coronavirus (SARS-CoV-2). Despite the efforts, the understanding of the many facets of the pandemic is still rather li...

» National Smoking Rates Correlate Inversely with COVID-19 Mortality
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
ABSTRACT Introduction: Recent studies show cigarette smokers are markedly under-represented among patients hospitalized for COVID-19 in over a dozen countries. It is unclear if this may be related to confounding factors such as age distr...

» Evaluating COVID-19 screening strategies based on serological tests
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background. Facing the SARS-CoV-2 epidemic requires intensive testing on the population to early identify and isolate infected subjects. Although RT-PCR is the most reliable technique to detect ongoing infections, serological tests are f...

» COVID-19 Spread in India: Dynamics, Modeling, and Future Projections
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
COVID-19 is an extremely infectious disease with a relatively large virus incubation period in the affected people who may be asymptomatic. Therefore, to reduce the transmission of this pathogen, several countries have taken many interve...

» Critical Questions when Interpreting Coronavirus PCR Diagnostics
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The results of PCR measurements are regarded as unquestionable. This statement must be put into perspective. This relativization is particularly important in connection with the interpretation of SARS-CoV-2 results. Members of the critic...

» Upper-room ultraviolet air disinfection might help to reduce COVID-19 transmission in buildings
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As the world economies get out of the lockdown imposed by the COVID-19 pandemic, there is an urgent need to assess the suitability of known technologies to mitigate COVID-19 transmission in confined spaces such as buildings. This feasibi...

» Nasal-Swab Testing Misses Patients with Low SARS-CoV-2 Viral Loads
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The urgent need for large-scale diagnostic testing for SARS-CoV-2 has prompted pursuit of sample-collection methods of sufficient sensitivity to replace sampling of the nasopharynx (NP). Among these alternatives is collection of nasal-sw...

» Social media as a tool for scientific updating at the time of COVID pandemic
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In the face of the rapid evolution of the COVID-19 pandemic, healthcare professionals on the frontline are in urgent need of frequent updates in the accomplishment of their practice. Hence, clinicians started to search for prompt, valid ...

» Laboratory Testing Implications of Risk-Stratification and Management for Improving Clinical Outcomes of COVID-19 Patients
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The high mortality rate of COVID-19 patients is mainly caused by the progression from mild to critical illness. To identify the key laboratory indicators and stratify high-risk COVID-19 patients with progression to severe/critical illnes...

» ASSESSING THE ROLE OF ZINC IN COVID-19 INFECTIONS AND MORTALITY: IS ZINC DEFICIENCY A RISK FACTOR FOR COVID-19?
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Variables responsible for the differential COVID-19 pandemic severity among countries remain undefined. Zinc, a micronutrient required for immunocompetence, is found deficient in populations. We hypothesized the differential COVID-19 sev...

» Genome sequencing of the first SARS-CoV-2 reported from patients with COVID-19 in Ecuador.
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2, the etiological agent of COVID-19 was first described in Wuhan in December 2019 and has now spread globally. Ecuador was the second country in South America to report confirmed cases. The first case reported in Quito, the cap...

» Transformed time series analysis of first-wave COVID-19: universal similarities found in the Group of Twenty (G20) Countries
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As of April 30, 2020, the number of cumulative confirmed coronavirus disease 2019 (COVID-19) cases exceeded 3 million worldwide and 1 million in the US with an estimated fatality rate of more than 7 percent. Because the patterns of the o...

» Optimal size of sample pooling for RNA pool testing: an avant-garde for scaling up SARS CoV 2 testing
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Introduction-Timely diagnosis is essential for the containment of the disease and breaks in the chain of transmission of SARS-CoV-2. The present situation demands countries to scale up their testing and design innovative strategies to co...

» Asymptomatic and presymptomatic transmission of SARS-CoV-2: A systematic review
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Many of the statutes comprising the shelter-in-place and phased-reopening orders are centered around minimizing asymptomatic and presymptomatic transmission. Assumptions about the presence and relative importance of asymptomatic and pres...

» COVID-19 challenges to dentistry in the new pandemic epicenter: Brazil
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A nationwide survey of dentists was carried out in Brazil, a new pandemic epicenter, to analyze how dental coverage has been affected (public versus private networks), changes in routine and burdens, and how the local prevalence of COVID...

» When is SARS-CoV-2 in your shopping list?
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The pandemic of coronavirus disease 2019 (COVID-19) has caused, by May 24th 2020, more than 5.3 million confirmed cases worldwide. The necessity of keeping open and accessible public commercial establishments such as supermarkets or phar...

» Global research trend in the treatment of the new Coronavirus diseases (COVID-19) : bibliometric analysis.
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The Coronavirus 2019 (COVID-19) pandemic has caused worldwide concern and has become a major medical problem. Vaccines and therapeutics are important interventions for the management of this outbreak. This study aims to used bibliometric...

» Assessment of spread of SARS-CoV-2 by RT-PCR and concomitant serology in children in a region heavily affected by COVID-19 pandemic
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background. Several studies indicated that children seem to be less frequently infected with SARS-CoV-2 and potentially less contagious. To examine the spread of SARS-CoV-2 we combined both RT-PCR testing and serology in children in the ...

» Multiplex Isothermal Amplification Coupled with Nanopore Sequencing for Rapid Detection and Mutation Surveillance of SARS-CoV-2
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Molecular testing and surveillance of the spread and mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical public health measures to combat the pandemic. There is an urgent need for methods that can rapidl...

» COVID-19 Deaths: Which Explanatory Variables Matter the Most?
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spreads around the World, many questions about the disease are being answered; however, many more remain poorly understood. Although the situation is rapidly evolving, with ...

» How to better communicate exponential growth of infectious diseases
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Sustained non-pharmaceutical interventions (NPIs) can contain the spread of infectious disease when vaccines or treatments are not available. The benefit of such behavioural adaptations can be modelled as the deceleration of the exponent...

» Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening of SARS-CoV-2 target cells on a wide variety of animals is missing. ...

» The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications off-label again...

» Calreticulin co-expression supports high level production of a recombinant SARS-CoV-2 spike mimetic in Nicotiana benthamiana
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
An effective prophylactic vaccine is urgently needed to protect against SARS-CoV-2 infection. The viral spike, which mediates entry into cells by interacting with the host angiotensin-converting enzyme 2, is the primary target of most va...

» SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, ...

» X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Pandemic spread of emerging human pathogenic viruses such as the current SARS-CoV2, poses both an immediate and future challenge to human health and society. Currently, effective treatment of infection with SARS-CoV2 is limited and broad...

» In silico multi-epitope vaccine against covid19 showing effective interaction with HLA-B*15:03
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The recent outbreak of severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) causing coronavirus disease (covid19) has posed a great threat to human health. Previous outbreaks of SARS-CoV and Middle East respiratory S...

» Genotypic and antigenic study of SARS-CoV-2 from an Indian isolate.
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronaviruses (CoVs) are one of the largest groups of positive-sense RNA virus families within the Nidovirales order, which are further classified into four genera: alpha, beta, gamma, and delta. Coronaviruses have an extensive range of ...

» Dynamics of the ACE2 - SARS-CoV/SARS-CoV-2 spike protein interface reveal unique mechanisms
13/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health concern. A handful of static structures now provide molecular insights into how SARS-C...

» Overhauling a faulty control in the CDC-recommended SARS-CoV-2 RT-PCR test
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To battle the COVID-19 pandemic, widespread testing for the presence of the SARS-CoV-2 virus is worldwide being employed by specific real-time RT-PCR (rRT-PCR) of viral RNA. The CDC has issued a recommended panel of PCR-based test sets t...

» Receptor utilization of angiotensin converting enzyme 2 (ACE2) indicates a narrower host range of SARS-CoV-2 than that of SARS-CoV
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronavirus pandemics have become a huge threat to the public health worldwide in the recent decades. Typically, SARS-CoV caused SARS pandemic in 2003 and SARS-CoV-2 caused the COVID-19 pandemic recently. Both viruses have been reported ...

» Coronavirus genomes carry the signatures of their habitats
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronaviruses such as SARS-CoV-2 regularly infect host tissues that express antiviral proteins (AVPs) in abundance. Understanding how they evolve to adapt or evade host immune responses is important in the effort to control the spread of...

» WHOLE-GENOME SEQUENCING AND DE NOVO ASSEMBLY OF A 2019 NOVEL CORONAVIRUS (SARS-COV-2) STRAIN ISOLATED IN VIETNAM
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The pandemic COVID-19 caused by the zoonotic virus SARS-CoV-2 has devastated countries worldwide, infecting more than 4.5 million people and leading to more than 300,000 deaths. Whole genome sequencing (WGS) is an effective tool to monit...

» Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An In Silico Approach
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing pandemic of coronavirus disease (COVID-19). No sustainable treatment option is available so far to tackle such a public hea...

» Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The COVID-19 pandemic has had unprecedented health and economic impact, but currently there are no approved therapies. We have isolated an antibody, EY6A, from a late-stage COVID-19 patient and show it neutralises SARS-CoV-2 and cross-re...

» Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4+ T cells from 32 COVID-...

» Cystal structure of inhibitor-bound human MSPL/TMPRSS13 that can activate high pathogenic avian influenza
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
A viral surface envelope glycoprotein, hemagglutinin (HA), is cleaved by host cell proteins of transmembrane protease serine (TMPRSS) family, that triggers a viral infection. The extracellular region of TMPRSS-2, -3, -4, and MSPL are com...

» Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a new rapidly spreading infectious disease. Early reports of hospitalised COVID-19 cases have shown relatively low frequency of chronic lung diseases such as chronic obstructive...

» Colon Cancer and SARS-CoV-2: Impact of ACE2 Expression in Susceptibility to COVID-19
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Novel coronavirus disease (COVID-19) pandemic has become a global health emergency. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with angiotensin-converting enzyme 2 (ACE2) to enter the cells and infects diverse...

» DeepEMhacer: a deep learning solution for cryo-EM volume post-processing
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Cryo-electron microscopy (cryo-EM) maps are among the most valuable sources of information for protein structure modeling. However, due to the loss of contrast at high frequencies, they generally need to be post-processed before modeling...

» Analysis of SARS-CoV-2 Genomes from Southern California Reveals Community Transmission Pathways in the Early Stage of the US COVID-19 Pandemic
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Given the higher mortality rate and widespread phenomenon of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) within the United States (US) population, understanding the mutational pattern of SARS CoV-2 has global implication...

» Impacts of regional climate on the COVID-19 pandemic
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The COVID-19 pandemic has led to six million confirmed cases by May 31, 2020. Impacts of regional weather and climate on epidemics have been investigated but need further study with new methods. We combined the number of monthly confirme...

» Nearly Perfect Forecasting of the Total COVID-19 Cases in India: A Numerical Approach
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
There are standard computational and statistical techniques of forecasting the spread pattern of a pandemic. In this article, we are going to show how close the forecasts can be if we use a simple numerical approach that can be worked ou...

» Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
SARS-CoV-2 was detected in Barcelona sewage long before the declaration of the first COVID-19 case, indicating that the infection was present in the population before the first imported case was reported. Sentinel surveillance of SARS-Co...

» Planning for the aftershocks: a model of post-acute care needs for hospitalized COVID-19 patients
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Since its emergence in late 2019, COVID-19 has caused significant global morbidity and mortality, overwhelming health systems. Considerable attention has been paid to the burden COVID-19 has put on acute care hospitals, with numerous mod...

» Population density and basic reproductive number of COVID-19 across United States counties
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The basic reproductive number (R0) is a function of contact rates among individuals, transmission probability, and duration of infectiousness. We sought to determine the association between population density and R0 of SARS-CoV-2 across ...

» ARB/ACEI use and severe COVID-19: a nationwide case-control study
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: Angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) have anti-inflammatory effects. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the membrane protein angiotensin-conv...

» Heterogeneity in risk, testing and outcome of COVID-19 across outbreak settings in the Greater Toronto Area, Canada: an observational study
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: We compared the risk of, testing for, and death following COVID-19 infection across three settings (long-term care homes (LTCH), shelters, the rest of the population) in the Greater Toronto Area (GTA), Canada. Methods: We sou...

» Dynamics of psychological responses to Covid-19 in India: A longitudinal study
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
To curb the spread of the novel coronavirus, India announced a nationwide lockdown on 24th March 2020 for 21 days, later extended for a longer time. This long period of lockdown greatly disrupted routine life and likely affecting citizen...

» Burnout among healthcare professionals during COVID-19 pandemic: a cross-sectional study
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The unpredictable nature of the new COVID-19 pandemic and the already alarming incidence of healthcare workers being affected can have a significant impact on the psychological well-being of the staff. Objective: To describe ...

» The BCG dilemma: linear versus non-linear correlation models over the time of the COVID-19 pandemic
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
In this work we have analysed the use of two different correlation metrics and two different datasets, detecting differences in the extent and directionality of the correlation between COVID-19 infection and BCG immunization. Correlation...

» A Logistic Model for Age-Specific COVID-19 Case-Fatality Rates
12/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives To develop a mathematical model to characterize age-specific case-fatality rates (CFR) of COVID-19. Materials and Method Based on two large-scale Chinese and Italian CFR data, a logistic model was derived to provide quantitati...

» COVID-19: Dying is Bad--Losing Life is Worse
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: COVID-19 was the leading cause of death in the United States over the three-month period March through May 2020. Another perspective is COVID-19s toll in terms of years of life lost. We calculated years of life lost for COVID...

» A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications.
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The new SARS-CoV-2 infection named COVID-19 has severely hit our Health System. At the time of writing this paper no medical therapy is officially recommended or has shown results in improving the outcomes in COVID-19 patients. With the ...

» Pre exposure Hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Abstract Background: While several trials are ongoing for treatment of COVID-19, scientific research on chemoprophylaxis is still lacking even though it has potential to delay the pandemic allowing us time to complete research on vaccine...

» Hydroxychloroquine plus standard care compared with the standard care alone in COVID-19: a meta-analysis of randomized controlled trials
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background & Objective: The efficacy and safety of Hydroxychloroquine (HCQ) in treating coronavirus disease COVID-19 pandemic is disputed. This study aimed to examine the efficacy and safety of HCQ plus standard of care in COVID-19 patie...

» COVID-19: Comparison between 8-days and extended 4-weeks outbreak periods through socioeconomic and natural factors
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Since mid-March 2020, global COVID-19 pandemic has experienced an exponential growth in process from sporadic to sudden outbreaks. This paper selects the 8-day surge data of daily cases, death and recovery rates (March 19-26, 2020) from ...

» A Comparative Study of Target Reconstruction of Ultra-High-Resolution CT for Patients with Corona-Virus Disease 2019 (COVID-19)
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The corona-virus disease 2019 (COVID-19) pandemic has caused a serious public health risk. Compared with conventional high-resolution CT (C-HRCT, matrix 512), ultra-high resolution CT (U-HRCT, matrix 1024) can increase the ef...

» Prevalence and Predictors of General Psychiatric Disorders and Loneliness during COVID-19 in the United Kingdom: Results from the Understanding Society UKHLS
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Despite ample research on the prevalence of specific psychiatric disorders during COVID-19, we know little about how the pandemic affects the general wellbeing of a wider population. The study investigates the prevalence and predictors o...

» A Fully Automated Deep Learning-based Network ForDetecting COVID-19 from a New And Large Lung CT ScanDataset
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
COVID-19 is a severe global problem that has crippled many industries and killed many people around the world. One of the primary ways to decrease the casualties is the infected person's identification at the proper time. AI can play a s...

» Estimating the COVID-19 epidemic trajectory and hospital capacity requirements in South West England: a mathematical modelling framework
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Objectives: To develop a regional model of COVID-19 dynamics, for use in estimating the number of infections, deaths and required acute and intensive care (IC) beds using the South West of England (SW) as an example case. Design: Open-so...

» Differences in antibody kinetics and functionality between severe and mild SARS-CoV-2 infections.
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
We determined and compared the humoral immune response in severe, hospitalized and mild, non-hospitalized COVID-19 patients. Severe patients (n=38) develop a robust antibody response to SARS-CoV-2, including IgG and IgA antibodies. The g...

» Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS-CoV-2 infection: a retrospective cohort study.
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background The potential benefit of a combination therapy with lopinavir/ritonavir (LPV/r) and hydroxychloroquine (HCQ) on COVID-19 has been speculated. We explored the effect of the timing of LPV/r + HCQ initiation on the outcome of pat...

» Evaluation of Sample Pooling for Screening of SARS-CoV-2
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background: The coronavirus disease (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing. To overcome the challenge of nucleic acid (NA) extraction and testing kit availability efficient metho...

» Oscillations in USA COVID-19 Incidence and Mortality Data reflect societal factors
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The COVID-19 pandemic currently in process differs from other infectious disease calamities that have previously plagued humanity in the vast amount of information that is produces each day, which includes daily estimates of the disease ...

» Point of care lung ultrasound is useful when screening for CoVid-19 in Emergency Department patients.
11/06/20 20:00 from Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Background CoVid-19 can be a life-threatening lung disease or a trivial upper respiratory infection depending on whether the alveoli are involved. Emergency department (ED) screening in symptomatic patients with normal vital signs is fre...