» Distinct electrocardiographic findings of a drug-drug interaction
28/03/24 10:16 from Latest headlines from BMJ
A man in his 80s presented to the emergency department with a one day history of light headedness, dyspnoea, poor appetite, and fatigue. He had a history of hypertension, chronic atrial fibrillation, and atrial flutter, and his drug hist...

» [Obituary] Sidney Wolfe
23/03/24 00:00 from The Lancet
Consumer health advocate and physician. Born on June 12, 1937, in Cleveland, OH, USA, he died of a brain tumour on Jan 1, 2024, in Washington, DC, USA, aged 86 years.

» [Corrections] Correction to Lancet Neurol 2021; 20: 448–59
18/03/24 23:43 from The Lancet Neurology
Weaver NA, Kuijf HJ, Aben HP, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurol 2021; 20: 448–59—In figure 3A of th...

» [Corrections] Correction to Lancet Neurol 2023; 22: 1026–47
18/03/24 23:43 from The Lancet Neurology
GBD Spinal Cord Injuries Collaborators. Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 2023; 22: 1026–47—In this Article, Ted R Mil...

» [In Context] Cristina Tassorelli: making a difference in headache research
18/03/24 23:43 from The Lancet Neurology
Some observers might call Cristina Tassorelli a workaholic. Afterall, when we speak, she had sent her last e-mail late in the previous evening and, at 7am, had her first meeting of the day. Describing herself as highly motivated, curious...

» [In Context] Chantale Branson
18/03/24 23:43 from The Lancet Neurology
Chantale Branson is a specialist in movement and sleep disorders at Morehouse School of Medicine (Atlanta, GA, USA). She completed her medical training, neurology residency, and fellowship training at Boston University School of Medicine...

» [In Context] Hans Krebs and neurology
18/03/24 23:43 from The Lancet Neurology
The biochemist Hans Krebs (1900–81), who won the Nobel Prize for Physiology or Medicine in 1953, is best known for his discoveries of the processes that underpin energy metabolism in most cells. The citric acid cycle, in particular, with...

» [Insight] Unravelling the circuits of movement
18/03/24 23:43 from The Lancet Neurology
The mechanisms underlying the execution of motor tasks are diverse and complex. These motor programs range from the simple, such as breathing, to the elaborate and dependent on training and experience, such as playing the piano. The brai...

» [Review] Genetics of migraine: complexity, implications, and potential clinical applications
18/03/24 23:43 from The Lancet Neurology
Migraine is a common neurological disorder with large burden in terms of disability for individuals and costs for society. Accurate diagnosis and effective treatments remain priorities. Understanding the genetic factors that contribute t...

» [Editorial] Increasing awareness of the need for brain health
18/03/24 23:43 from The Lancet Neurology
Neurological disorders are affecting the lives of increasing numbers of people. New data from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) indicate that, in 2021, 3·4 billion people—more than 40% of the world's po...

» [Comment] The expanding burden of neurological disorders
14/03/24 23:30 from The Lancet Neurology
New estimates of the global, regional, and national burden of disorders affecting the nervous system are reported in an updated analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.1 In their Article i...

» [Comment] Addressing neurological burden in the Americas
14/03/24 23:30 from The Lancet Neurology
Expanding on previous analyses of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), the GBD 2021 Nervous System Disorders Collaborators present one of the most comprehensive estimates of neurological burden available...

» Correction: ICARUS study: prevalence and clinical features of impulse control disorders in Parkinsons disease
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Antonini A, Barone P, Bonuccelli U, et al . ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease J Neurol Neurosurg Psychiatry 2017;88:317–324. doi: 10.1136/jnnp-2016-315277 Since...

» Dissociative seizures in the emergency department: how to solve the problem of diagnostic confusion leading to iatrogenic harm?
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Dissociative seizures are frequently misdiagnosed and treated as epileptic seizures in emergency settings, but simple educational interventions may help Over the last 20 years, there has been a renaissance in the study of functional neur...

» Dissociative seizures in the emergency room: room for improvement
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background Dissociative seizures, also known as functional or psychogenic non-epileptic seizures, account for 11%–27% of all emergency seizure presentations. Misdiagnosis as epileptic seizures is common and leads to ineffective and...

» GPi-DBS-induced brain metabolic activation in cervical dystonia
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background Deep brain stimulation (DBS) of the globus pallidus interna (GPi) is a highly efficacious treatment for cervical dystonia, but its mechanism of action is not fully understood. Here, we investigate the brain metabolic effects o...

» Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background GBA variants increase the risk of developing Parkinson disease (PD) and influence its outcome. Deep brain stimulation (DBS) is a recognised therapeutic option for advanced PD. Data on DBS long-term outcome in GBA carriers are ...

» COVID-19 has no impact on disease activity, progression and cognitive performance in people with multiple sclerosis: a 2-year study
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background Sequelae of COVID-19 in people with multiple sclerosis (PwMS) have not been characterised. We explored whether COVID-19 is associated with an increased risk of disease activity, disability worsening, neuropsychological distres...

» Alzheimers disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background Traumatic brain injury (TBI) is associated with the tauopathies Alzheimer’s disease and chronic traumatic encephalopathy. Advanced immunoassays show significant elevations in plasma total tau (t-tau) early post-TBI, but ...

» Premorbid brain structure influences risk of amyotrophic lateral sclerosis
13/03/24 14:10 from Journal of Neurology, Neurosurgery & Psychiatry current issue
Background Amyotrophic lateral sclerosis (ALS) is a disease of the motor network associated with brain structure and functional connectivity alterations that are implicated in disease progression. Whether such changes have a causal role ...

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