Performers have many different reasons for sharing their stories at the Edinburgh Festival Fringe, the world's largest arts festival, which was held on Aug 1–25, 2025, in Edinburgh, UK. For Keith Alessi, the motivation to perform...
It was a quiet summer, and I was determined to switch off—no clinics, no case logs, just rest. One afternoon, while unpacking a forgotten tote bag, I came across the black diary I had carried through my oncology postings. I opened it...
In the IFM2017-03 trial, use of lenalidomide plus daratumumab, with dexamethasone limited to the first 2 treatment cycles, reduced the risk of progression or death compared with lenalidomide plus dexamethasone, with no additional safety...
First-line ICIs with or without chemotherapy were associated with improved overall survival compared with BRAF and MEK inhibitors in participants with metastatic BRAFV600E-mutated NSCLC, particularly among specific subpopulations. These...
Integrating the genetic statuses of BRAF and TERTp into the AJCC system changes the original risk stages of the AJCC system and significantly improves the accuracy of its mortality risk classification for papillary thyroid cancer.
Childhood and adolescent cancer survivors (age at diagnosis: 0–21 years) face increased risk for long-term health complications and less favourable outcomes in terms of functioning and social participation. Moreover, they often...
Pathological response is a surrogate marker of efficacy of neoadjuvant therapy in various tumour types, but there is no consensus on reporting pathological response for renal cell carcinoma. We aimed to assess the status of pathological...
Countries across Africa are experiencing the dual challenge of rising cancer burden and severe health-care workforce shortages, which threaten to overwhelm its already strained health systems. Simultaneously, advancements in digital...
Since the reform of China's drug review and approval in 2015, it has successfully stimulated the enthusiasm of domestic pharmaceutical companies to carry out innovative drug research and development, especially in oncology. Chinese...
A 57-year-old woman visited Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University (Changsha, Hunan, China) in December, 2024, because of a 1-year history of chest and back pain. She had a...
Roughly 5 years since the emergence of SARS-CoV-2, the post-pandemic world feels increasingly fractured, with rising inequality, distrust in governmental bodies, and disinformation. In many countries, the response to long-term recovery...
A growing list of contemporary phase 3 trials have shown that more drugs (quadruplet therapies) are superior to less drugs (triplet therapies) in patients with newly diagnosed multiple myeloma who are transplant eligible and in those who...
The utility of genotyping tumours to enhance prognostication and guide treatment decision making for patients with differentiated thyroid cancer has been a topic of significant investigation over the past two decades.1 Preoperatively,...
Active surveillance is the preferred standard of care for men with low-risk prostate cancer. Active surveillance uses a combination of serial prostate-specific antigen (PSA) measurements, MRI, and prostate biopsies to monitor the...
The PACE-C trial reported by Alison C Tree and colleagues1 provides pivotal evidence comparing stereotactic body radiotherapy (SBRT) with moderately hypofractionated radiotherapy (MHRT) in patients with intermediate-risk or high-risk...
We thank Lanwei Guo for their interest in the acute toxicity comparison from the PACE-C trial.1 We agree, as acknowledged in the paper, that the differential treatment length between the moderately hypofractionated radiotherapy (MHRT)...
The CONTACT-02 trial by Neeraj Agarwal and colleagues evaluated cabozantinib plus atezolizumab versus an androgen receptor pathway inhibitor (ARPI) switch in patients with metastatic castration-resistant prostate cancer (mCRPC) following...
We acknowledge the Correspondence from Dries Develtere on the CONTACT-02 trial, which raises concerns that the progression-free survival benefit of cabozantinib plus atezolizumab found in our trial was modest with no overall survival...
We read with interest the Article by Mitsue Saito and colleagues.1 The study showed that adding 5 mg olanzapine after chemotherapy to standard anti-emetics improved control of chemotherapy-induced nausea and vomiting (CINV) while...
We appreciate any readers’ interest and comments on our Article1 and we would like to provide a comprehensive response to the Correspondence by Man Sun and colleagues.
The pooled cohort analysis published in the July issue of The Lancet Oncology by Katie O’Brien and colleagues provides important new insight into the relationship between hormone therapy and breast cancer risk in younger women (aged...
We commend Allen S Ho and colleagues for their rigorous effort in advancing prognostic tools for human papillomavirus (HPV)-positive oropharyngeal carcinoma.1 The study's use of large-scale data to refine carcinoma staging is a valuable...
We thank Shaokun Liu and colleagues for their thoughtful correspondence on the American Joint Committee on Cancer and Union for International Cancer Control Version 9 (AJCC9V) staging system for HPV-positive oropharyngeal carcinoma.1
We read with great interest the secondary analysis of the HD21 trial by Justin Ferdinandus and colleagues,1 which sheds light on fertility outcomes in patients with advanced-stage Hodgkin lymphoma treated with chemotherapy. Although a...
We thank Virginie Barraud-Lange and colleagues for their thoughtful comments on our analysis of fertility in the HD21 trial.1 Their letter highlights important nuances in interpreting endocrine recovery, ovarian reserve, and real-world...
Kuemmel S, Graeser M, Schmid P, et al. Chemotherapy-free neoadjuvant pembrolizumab combined with trastuzumab and pertuzumab in HER2-enriched early breast cancer (WSG-KEYRICHED-1): a single-arm, phase 2 trial. Lancet Oncol 2025; 26:...
Hungria V, Robak P, Hus M, et al. Belantamab mafodotin plus bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-7): updated overall survival analysis from a global, randomised, open-label, phase...
Concin N, Matias-Guiu X, Cibula D, et al. ESGO–ESTRO–ESP guidelines for the management of patients with endometrial carcinoma: update 2025. Lancet Oncol 2025; 26: e423–35. In this Policy Review, several typographical, formatting,...
Paloma Shemirani, 23, died after refusing chemotherapy for non-Hodgkin lymphoma despite doctors’ concerns A woman who died after refusing chemotherapy doctors believed would have given her a strong chance of recovery was “adversely...
Photon- and proton-based radiation therapy conferred comparable health-related quality of life for people with breast cancer, according to the largest head-to-head comparison of the modalities for any malignancy. A higher percentage of...
Zeaxanthin, best known for eye health, has been found to boost the tumor-killing power of T cells. Researchers showed it strengthens T-cell receptors, enhances immune signaling, and improves the effects of immunotherapy. Found naturally...
Campaigners urge ministers to close tanning salons across country over dangers posed by UV radiation Sunbeds are so dangerous they should be banned in the UK, cancer experts and campaigners say. They have urged ministers to order the...
NASHVILLE — It is a “scary time” to be a medical student amid new AI technology and distrust in health care, but such developments will never replace the impact of human interaction, Mikhail O. Varshavski, DO, said at OMED. “You don’t...
The first government shutdown in almost 7 years began Wednesday after Congress was unable to come together on legislation to fund the federal government. The disagreement between Republicans and Democrats centers on health care coverage,...
Intensity-modulated radiation therapy did not increase the risk for feeding tube dependence for patients with oropharyngeal squamous cell carcinoma compared with proton therapy, according to results of a randomized phase 3 trial. The...
Adjuvant radiotherapy could substantially reduce risk for locoregional recurrence for patients with advanced muscle-invasive bladder cancer, according to data presented at American Society for Radiation Oncology Annual Meeting. Results...
TikTok is a major source for gastrointestinal health information, but the accuracy and reliability of this content can vary by condition and creator, according to research published in The American Journal of Gastroenterology. To better...
If smoking was the cancer villain of the 20th century, eating ultra-processed food may be its 21st-century counterpart Prof Devi Sridhar is chair of global public health at the University of Edinburgh Cancer used to be seen as part of...
President Donald J. Trump announced an agreement with Pfizer to sell its drug products to Medicaid for much lower prices, while also unveiling TrumpRx, a new direct-to-consumer drug website that will sidestep health insurance companies....
A shorter radiation course improved quality of life among men with intermediate-risk, localized prostate cancer, according to results of a randomized phase 3 trial. However, standard radiation still may offer stronger biochemical cancer...
A genetic test could guide the use of hormone therapy for men with recurrent prostate cancer after surgery, according to data presented at American Society for Radiation Oncology Annual Meeting. Results of a randomized phase 2 trial...
CHICAGO — As physicians increasingly find themselves working as employees rather than owners, understanding tax structures and preserving their income has grown more important, according to a speaker at the 2025 Women in Medicine Summit....
Scientists discovered that inhibiting the enzyme STK17B forces multiple myeloma cells into iron-driven death and makes therapies more effective. Early mouse studies show strong potential for a new treatment approach.
The FDA has removed the Risk Evaluation and Mitigation Strategies program for vandetanib. Vandetanib (Caprelsa, Sanofi), a thyroid cancer medication, is an oral tyrosine kinase inhibitor that targets cell receptors involved in RET, VEGFR...
CHICAGO — Orthopedic surgery residency programs with family-friendly resources listed on the program and Graduate Medical Education websites had a higher proportion of women residents, according to results presented here. “While not all...
Multiple versions of ChatGPT demonstrated efficacy in identifying eligible patients for clinical trial recruitment, showing potential to complement manual chart reviews, according to a study published in Machine Learning: Health....
Among patients with peripheral lung lesions, use of robotic-assisted bronchoscopy plus cone beam CT resulted in a higher diagnostic yield vs. three other bronchoscopy types, according to two studies. These studies were each presented as...
“It doesn’t matter whether you are pursuing success in business, sports, the arts or life in general: The bridge between wishing and accomplishing is discipline.” – Harvey Mackay “Our prime purpose in this life is to help others. And if...
One in 10 hematologic cancers among children and adolescents may be attributable to radiation exposure from medical imaging, according to study results. The risk increased proportionally with higher cumulative doses. “Medical imaging...
After a pronounced increase in heavy alcohol use and binge drinking during the COVID-19 pandemic, rates of alcohol consumption have declined precipitously, reaching a historic low of 54% this year, according to a recent Gallup poll....