Source: www.bostonherald.com Author: Alexi Cohan A saliva-based diagnostic test that can detect HPV-related head and neck cancer has the potential to catch the disease earlier and even serve as a standard screening method, which the...
Adding trastuzumab to chemotherapy for early-stage, HER2-positive breast cancer reduces recurrence of, and mortality from, breast cancer by a third, with worthwhile proportional reductions irrespective of recorded patient and tumour...
In patients with prostate cancer who have a high risk of pelvic nodal disease, the use of elective whole pelvis radiotherapy is still controversial. Two large, randomised, controlled trials (RTOG 9413 and GETUG-01) did not show a benefit...
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain mesenchymal properties, such as increased motility. In...
A 36-year-old female patient presented at the hepatology department of the Post Graduate Institute of Medical Education and Research (Chandigarh, India) in January, 2021, with jaundice, pruritis, and multiple episodes of vomiting for the...
Zhang X, Liang H, Li Z, et al. Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing...
Cancer staging—the anatomical extent to which a cancer has spread at diagnosis—is crucial in guiding the clinical care of individual patients. At the population level, staging provides useful information on health system performance...
“I am proud of the fact that I have done what I set out to do. I always wanted to make a difference to cancer care in my country, and across the African continent, and to change the way people think about cancer.” Verna Vanderpuye,...
GBD 2017 Childhood Cancer Collaborators. The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. Lancet Oncol 2019; 20: 1211–25—In this Article, the order of authors in the...
Ren Z, Xu J, Bai Y, et al. Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study. Lancet Oncol 2021; 22: 977–90—In this Article,...
Balar AV, Kamat AM, Kulkarni GS, et al. Pembrolizumab monotherapy for the treatment of high-risk non-muscle-invasive bladder cancer unresponsive to BCG (KEYNOTE-057): an open-label, single-arm, multicentre, phase 2 study. Lancet Oncol...
Gainor JF, Curigliano G, Kim D-W, et al. Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study. Lancet Oncol 2021; 22: 959–69 —In this Article, in table 1, the IQR for age in...
6 years have passed since Matthew Hellman and colleagues1 proposed major pathological response as a surrogate endpoint of survival for patients undergoing neoadjuvant therapy for operable lung cancer. Since then, an explosion of new...
The multivariable analysis by Ines Pires da Silva and colleagues1 in The Lancet Oncology showed that in patients with anti-PD-(L)1-resistant metastatic melanoma, treatment with a combination of ipilimumab plus anti-PD-1 was associated...
Mengqian Li concluded that in our study,1 the effect of Eastern Cooperative Oncology Group (ECOG) performance status on clinical outcomes was not elaborated on, nor was the better baseline ECOG performance status in the ipilimumab plus...
In the updated CATNON trial, Martin van den Bent and colleagues indicated that adjuvant temozolomide, rather than concurrent chemotherapy, was associated with better survival in patients with 1p/19q non-co-deleted anaplastic glioma and...
In our report on the EORTC CATNON trial,1 we have shown that the administration of 12 cycles of adjuvant temozolomide improves survival in patients with anaplastic glioma without a 1p/19q co-deletion, but only in patients with an...
As part of a new collaboration with Signify Health, a US health-care platform that aims to bring health care into the home, the Children's Oncology Group (COG) announced on June 17, 2021, that it would be expanding participation in the...
Delaware was named after the Delaware River, which in turn derived its name from Thomas West, Lord De La Warr, the English governor of Virginia who first explored the Delaware Bay in 1611. Delaware also is known as the First State...
Researchers have shown that a targeted therapy using non-thermal radio waves is safe to use in the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer, according to a new study. The therapy also showed a...
Treatment-associated frailty appeared associated with neurocognitive declines among a cohort of young-adult cancer survivors, according to study findings from the St. Jude Lifetime Cohort published in Journal of Clinical Oncology....
The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight -- not just a DNA copying error as previously believed, reports a new study. The findings upend long-held beliefs about the mechanisms...
Medical researchers have discovered what appears to be an Achilles' heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.
While melanoma incidence and prevalence in the U.S. increased between 1990 and 2019, mortality rates remained stable over that time, according to findings from a mathematical model. Pushkar Aggarwal, MBA, 1st Lt., of the college of...
In the treatment of locally advanced gastric cancer, apatinib combined with S-1 plus oxaliplatin was a safe and effective neoadjuvant treatment, according to a nonrandomized controlled study. “Neoadjuvant chemotherapy could decrease the...
Four papers offer new insight into long COVID symptoms, duration, onset and prevalence, with one paper documenting more than 200 symptoms of long COVID. The findings were published shortly before President Joe Biden announced efforts to...
Karen Carey always had a notion of participating in the Moylagh JFK 50 Mile Challenge as she saw participants going by her house each year, but she could never have expected that a cancer diagnosis of her own would provide the...
More than 1 in 4 men aged 55 to 69 years and 1 in 3 men aged 70 years and older underwent prostate cancer screening in the previous 12 months, “suggesting potential overuse among some men,” researchers reported. In 2012, the U.S....
Researchers report the identification of a new target for the PARP inhibitor drug talazoparib and show that combination treatment with talazoparib and the WEE1 inhibitor adavosertib results in enhanced anti-cancer effects.
The FDA granted orphan drug designation to TST001 for treatment of gastric and gastroesophageal junction cancers, according to the agent’s manufacturer. An estimated 120,300 people in the United States have gastric cancer, according to...
A pediatric melanoma registry developed at St. Jude Children’s Research Hospital has helped researchers improve the classification of pediatric melanocytic tumors. The registry, called Molecular Analysis of Childhood Melanocytic Tumors...
Source: www.newswise.com Author: Case Western Reserve University Microscopic fungus may have more to do with oral cancer and aging than first thought, according to new research from Case Western Reserve University. Researchers from the...
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer's development and significantly increase the likelihood of survival, according to a new study in mice.
Source: www.2minutemedicine.com Author: Davy Lau and Alex Chan Survivors of head and neck cancer (HNC) from rural American counties had double the rate of suicides compared to HNC survivors from metropolitan and urban counties. Evidence...
“Lots of us men feel uncomfortable getting checked, especially with things like our prostate, but it’s so important. So what, if it keeps you alive, who cares? There is no shame in it.”
A longer duration of extended hormone therapy provided no benefit for postmenopausal women with hormone receptor-positive breast cancer who had received 5 years of adjuvant endocrine therapy, according to randomized phase 3 study...
Using advanced imaging technology, scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper identifies aspects of how...
In an attempt to find out why the long-term outcomes are poorer for patients with lobular breast cancer -- which affects some 40,000 women a year -- researchers began looking at the role of the protein MDC1 in tumor cells.
According to a study published in Therapeutic Advances in Gastroenterology, internal endoscopic drainage should be the first line endoscopic treatment of anastomotic fistulas when possible. “Endoscopic treatment of gastric fistulas...
Many transgender men and nonbinary people assigned female at birth, or TMNB, reported barriers to cervical cancer screening, according to results of a cross-sectional survey of these underserved populations. “[Transgender men] and...
Total annual costs associated with metastatic breast cancer in the U.S. could exceed $152 billion in 2030, according to a study published in JNCI Cancer Spectrum. Researchers attributed the estimated increase to a rise in cases among...
Healthy lifestyle factors such as abstinence from smoking and drinking, low body mass index, and exercise correlated with decreased cancer incidence, even in individuals with a high genetic risk.
Transvaginal ultrasound used to determine appropriateness of endometrial cancer biopsy missed nearly five times more cases of the disease among Black women vs. white women, according to a simulated cohort study published in JAMA...