Abnormal EEG spectral power and coherence measures during pre-motor stage in Amyotrophic Lateral Sclerosis
Monday, March 3, 2025
Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive motor decline. Studies of electroencephalographic (EEG) activity during rest and motor execution have captured network changes in ALS. However, the nature of network-level impairment in the pre-motor activity in ALS remains unclear. Assessing the (dys)function of motor networks engaged p... .. read more..

Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth
Sunday, February 16, 2025
Developing bones can be severely impaired by a range of disorders where muscular loading is abnormal. Recent work has indicated that the effects of absent skeletal muscle on bones are more severe early in development, with rudiment length and mineralization lengths being almost normal in muscle-less limbs just prior to birth. However, the impact of abnormal mechanical loading on the nanoscale s... .. read more..

Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy?
Friday, February 7, 2025
CONCLUSIONS: Gait impairments in children with CP were associated with muscle synergies that deviated from normative. Participants who demonstrated the most substantial improvements in clinical scores following RGT exhibited multiple changes in the muscle synergies. However, no statistically significant correlations were identified at the group level. Future studies relying on larger datasets a... .. read more..

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Tuesday, January 7, 2025
Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth (i.e., precocial). Precocial species, such as goats, develop advanced skeletal maturity in utero, making them useful models for studying the dynamics of bone formation under mechanical load. Here, we used microcomputed tomography and histology to ch... .. read more..

Multiphysics modelling of the impact of skin deformation and strain on microneedle-based transdermal therapeutic delivery
Sunday, December 22, 2024
Microneedle patches (MNs) hold enormous potential to facilitate the minimally-invasive delivery of drugs and vaccines transdermally. However, the micro-mechanics of skin deformation significantly influence the permeation of therapeutics through the skin. Previous studies often fail to appreciate the complexities in microneedle-skin mechanical interactions. This may impede the accuracy of MNs pr... .. read more..

Synergy-Dependent Center-of-Mass Control Strategies During Sit-to-Stand Movements
Wednesday, November 20, 2024
The characterization, through the concept of muscle synergies, of clinical functional tests is a valid tool that has been widely adopted in the research field. While this theory has been exploited for a description of the motor control strategies underlying the biomechanical task, the biomechanical correlate of the synergistic activity is yet to be fully described. In this paper, the relationsh... .. read more..

Machine learning and artificial intelligence: Enabling the clinical translation of atomic force microscopy-based biomarkers for cancer diagnosis
Monday, November 11, 2024
The influence of biomechanics on cell function has become increasingly defined over recent years. Biomechanical changes are known to affect oncogenesis; however, these effects are not yet fully understood. Atomic force microscopy (AFM) is the gold standard method for measuring tissue mechanics on the micro- or nano-scale. Due to its complexity, however, AFM has yet to become integrated in routi... .. read more..

A Novel Deep Ensemble Method for Selective Classification of Electrocardiograms
Tuesday, October 8, 2024
CONCLUSION: The proposed method demonstrates the feasibility of accurately detecting AF from STSL ECG recordings. The selective classification approach offers a substantial enhancement to automated ECG interpretation algorithms in telehealth solutions. .. read more..

Consensus for experimental design in electromyography (CEDE) project: Application of EMG to estimate muscle force
Sunday, July 28, 2024
Skeletal muscles power movement. Deriving the forces produced by individual muscles has applications across various fields including biomechanics, robotics, and rehabilitation. Since direct in vivo measurement of muscle force in humans is invasive and challenging, its estimation through non-invasive methods such as electromyography (EMG) holds considerable appeal. This matrix, developed by the ... .. read more..

Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Tuesday, July 16, 2024
Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδTCR, leaving the apical TCR surface bioavailable. We reveal that a second γδTCR ligand co-engages ... .. read more..