Muscle synergy analysis for clinical characterization of upper limb motor recovery after stroke
Sunday, June 8, 2025
CONCLUSIONS: In individuals with stroke undergoing upper limb motor rehabilitation, changes in the synergy merging pattern may serve as a potential marker to distinguish responders from non-responders. .. read more..

Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines
Thursday, June 5, 2025
Quininib is a small molecule antagonist of cysteinyl leukotriene receptor 1 (CysLT(1)), which is increasingly recognized for its role in cancer progression. Overexpression of CysLT(1) has been documented in colorectal cancer, renal cell carcinoma, breast cancer, and uveal melanoma (UM). However, quininib's poor aqueous solubility presents a significant barrier to its clinical development. The a... .. read more..

Pattern-pulses and pattern-reversals evoke different cascades of cortical sources in the multifocal visual evoked potential
Monday, June 2, 2025
The multifocal visual evoked potential (mVEP), elicited by either pattern-pulses or pattern-reversals, provides an effective means to study visual processing and to identify retinal damage and visual field defects. It is often assumed that the first components of these VEPs, the C1 and N75, respectively, are generated in V1, based on source modeling and their polarity reversal between upper- an... .. read more..

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Tuesday, May 13, 2025
CONCLUSIONS: These findings implicate ambulatory loading in postnatal bone development of precocial goats and identify a novel postnatal synostosis event in the caprine metacarpal epiphysis. .. read more..

On the Feasibility of Adapting the LiVec Tactile Sensing Principle to Non-Planar Surfaces: A Thin, Flexible Tactile Sensor
Saturday, April 26, 2025
Tactile sensation across the whole hand, including the fingers and palm, is essential for manipulation and, therefore, is expected to be similarly useful for enabling dexterous robot manipulation. Tactile sensation would ideally be distributed (over large surface areas), have a high precision, and provide measurements in multiple axes, allowing for effective manipulation and interaction with ob... .. read more..

Dissociable encoding of evolving beliefs and momentary belief updates in distinct neural decision signals
Friday, April 25, 2025
Making accurate decisions in noisy environments requires integrating evidence over time. Studies of simple perceptual decisions in static environments have identified two human neurophysiological signals that evolve with similar integration dynamics, with one - the centroparietal positivity - appearing to compute the running integral and continuously feed it to the other - motor beta lateralisa... .. read more..

Abnormal EEG spectral power and coherence measures during pre-motor stage in Amyotrophic Lateral Sclerosis
Monday, March 3, 2025
Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive motor decline. Studies of electroencephalographic (EEG) activity during rest and motor execution have captured network changes in ALS. However, the nature of network-level impairment in the pre-motor activity in ALS remains unclear. Assessing the (dys)function of motor networks engaged p... .. read more..

Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth
Sunday, February 16, 2025
Developing bones can be severely impaired by a range of disorders where muscular loading is abnormal. Recent work has indicated that the effects of absent skeletal muscle on bones are more severe early in development, with rudiment length and mineralization lengths being almost normal in muscle-less limbs just prior to birth. However, the impact of abnormal mechanical loading on the nanoscale s... .. read more..

Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy?
Friday, February 7, 2025
CONCLUSIONS: Gait impairments in children with CP were associated with muscle synergies that deviated from normative. Participants who demonstrated the most substantial improvements in clinical scores following RGT exhibited multiple changes in the muscle synergies. However, no statistically significant correlations were identified at the group level. Future studies relying on larger datasets a... .. read more..