Prior probability cues bias sensory encoding with increasing task exposure
Tuesday, April 2, 2024
When observers have prior knowledge about the likely outcome of their perceptual decisions, they exhibit robust behavioural biases in reaction time and choice accuracy. Computational modelling typically attributes these effects to strategic adjustments in the criterion amount of evidence required to commit to a choice alternative - usually implemented by a starting point shift - but recent work... .. read more..

An eye on equity: faricimab-driven health equity improvements in diabetic macular oedema using a distributional cost-effectiveness analysis from a UK societal perspective
Saturday, March 30, 2024
CONCLUSIONS: Long-acting therapies with fewer injections, such as faricimab, may reduce costs, improve health outcomes and increase health equity. Extended economic evaluation frameworks capturing additional value elements, such as DCEA, enable a more comprehensive valuation of interventions, which is of relevance to decision-makers, healthcare professionals and patients. .. read more..

Consensus for experimental design in electromyography (CEDE) project: Checklist for reporting and critically appraising studies using EMG (CEDE-Check)
Thursday, March 28, 2024
The diversity in electromyography (EMG) techniques and their reporting present significant challenges across multiple disciplines in research and clinical practice, where EMG is commonly used. To address these challenges and augment the reproducibility and interpretation of studies using EMG, the Consensus for Experimental Design in Electromyography (CEDE) project has developed a checklist (CED... .. read more..

Role of arm reaching movement kinematics in friction perception at initial contact with smooth surfaces
Thursday, March 28, 2024
When manipulating objects, humans begin adjusting their grip force to friction within 100 ms of contact. During motor adaptation, subjects become aware of the slipperiness of touched surfaces. Previously, we have demonstrated that humans cannot perceive frictional differences when surfaces are brought in contact with an immobilised finger, but can do so when there is submillimeter lateral displ... .. read more..

Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease
Tuesday, March 26, 2024
CONCLUSION: The results support the application of acoustic features to objectively quantify speech impairment and disease severity in HD in multilanguage studies. .. read more..

Energy-Efficient Sleep Apnea Detection Using a Hyperdimensional Computing Framework Based on Wearable Bracelet Photoplethysmography
Thursday, March 14, 2024
CONCLUSION: The simplicity of hypervector operations in HDC and the novel 1D-BlockLBP encoding effectively preserve pulse rate signal characteristics with high computational efficiency. .. read more..

Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington's disease
Thursday, March 7, 2024
CONCLUSIONS: Results suggest the potential for long-term monitoring of sleep patterns using wrist-worn wearable devices as part of symptom management in HD. .. read more..

Geotemporal Fluorophore Biodistribution Mapping of Colorectal Cancer: Micro and Macroscopic Insights
Friday, February 23, 2024
CONCLUSION: This study demonstrates the time course diffusion patterns of ICG through both benign and malignant tumours in vivo in human patients at both macroscopic and microscopic levels, demonstrating important cellular drivers and features of geolocalisation and how they differ longitudinally after exposure to ICG. .. read more..

Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions
Saturday, February 17, 2024
Neural representations of perceptual decision formation that are abstracted from specific motor requirements have previously been identified in humans using non-invasive electrophysiology; however, it is currently unclear where these originate in the brain. Here we capitalized on the high spatiotemporal precision of intracranial EEG to localize such abstract decision signals. Participants under... .. read more..

Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint
Thursday, February 8, 2024
Mechanical stimuli arising from fetal movements are critical factors underlying joint growth. Abnormal fetal movements negatively affect joint shape features with important implications for joint health, but the mechanisms by which mechanical forces from fetal movements influence joint growth are still unclear. In this research, we quantify zebrafish jaw joint growth in 3D in free-to-move and i... .. read more..

Electroencephalographic β-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis
Thursday, January 18, 2024
CONCLUSIONS: β-Band spectral power in the sensorimotor cortex reflects clinically evaluated motor impairment in ALS. This technology merits further investigation as a biomarker of progressive functional disability. .. read more..

Open-Source Instrumented Object to Study Dexterous Object Manipulation
Tuesday, January 2, 2024
Humans use tactile feedback to perform skillful manipulation. When tactile sensory feedback is unavailable, for instance, if the fingers are anesthetized, dexterity is severely impaired. Imaging the deformation of the finger pad skin when in contact with a transparent plate provides information about the tactile feedback received by the central nervous system. Indeed, skin deformations are tran... .. read more..