A physiologically inspired hybrid CPG/Reflex controller for cycling simulations that generalizes to walking
Friday, September 12, 2025
Predictive simulations based on explicit, physiologically inspired, control policies, can be used to test theories on motor control and to evaluate the effect of interventions on the different components of control. Several control architectures have been proposed for simulating locomotor tasks, based on fully feedback, reflex-based, controllers, or on feedforward architectures mimicking the Ce... .. read more..

Microneedle electrodes for electromyography
Wednesday, September 10, 2025
Surface electromyography (sEMG) is the measurement of the electrical activity of muscle and is extensively used in fundamental research and across many applications in health and sport. Conventional surface electrode technology can suffer from poor signal quality, particularly when used outside the laboratory, requires careful skin preparation prior to electrode application, and can be challeng... .. read more..

Automated system of analysis to quantify pediatric hip morphology
Friday, August 29, 2025
Developmental dysplasia of the hip (DDH), a developmental deformity with an incidence of 0.1-3.4%, lacks an objective and reliable definition and assessment metric by which to conduct timely diagnosis. This work aims to address this challenge by developing a system of analysis to accurately detect 22 key anatomical landmarks in anteroposterior pelvic radiographs of the juvenile hip, from which ... .. read more..

The evolution of hominin bipedalism in two steps
Wednesday, August 27, 2025
Bipedalism is a human-defining trait^(1-3). It is made possible by the familiar, bowl-shaped pelvis, whose short, wide iliac blades curve along the sides of the body to stabilize walking and support internal organs and a large-brained, broad-shouldered baby^(4-6). The ilium changes compared with living primates are an evolutionary novelty⁷. However, how this evolution came about remains unknown... .. read more..

Distinct audio and visual accumulators co-activate motor preparation for multisensory detection
Friday, August 15, 2025
Detecting targets in multisensory environments is an elemental brain function, but it is not yet known whether information from different sensory modalities is accumulated by distinct processes, and, if so, whether the processes are subject to separate decision criteria. Here we address this in two experiments (n = 22, n = 21) using a paradigm design that enables neural evidence accumulation to... .. read more..

Regressing away common neural choice signals does not make them artifacts: Comment on Frömer et al. 2024
Wednesday, August 13, 2025
Frӧmer et al. (2024, Nature Human Behaviour) apply a deconvolution method to correct for component overlap in the event-related potential. They report that this method eliminates signatures of sensory evidence accumulation from response-aligned measurements of the centro-parietal positivity (CPP), suggesting that these signatures arise artifactually. Here, we argue that the analysis and interpr... .. read more..

Maternal exercise rescues fetal akinesia-impaired joint and bone development
Wednesday, July 16, 2025
Fetal movements exert mechanical forces that shape the developing skeleton. Conditions that impair fetal movements can cause skeletal defects, but interventions are limited. Here, we show that maternal wheel running exercise regulates fetal skeletal development in mice. In wild-type fetuses, maternal exercise stimulated joint and bone morphogenesis. We reasoned that these effects occurred throu... .. read more..

SC10X/U: A high-density electrode system for standardised surface recording of neural activity of the cervical spinal cord
Sunday, July 6, 2025
CONCLUSION: The system defines electrode locations to promote standardized recordings across individuals and research centres. The evoked potentials recorded using the system conformed to the existing neurophysiological and neuroanatomical literature.s. .. read more..

Muscle Synergy Analysis for Clinical Characterization of Upper Limb Motor Recovery After Stroke
Sunday, June 8, 2025
CONCLUSIONS: In individuals with stroke undergoing upper limb motor rehabilitation, changes in the synergy merging pattern may serve as a potential marker to distinguish responders from non-responders. .. read more..

Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines
Thursday, June 5, 2025
Quininib is a small molecule antagonist of cysteinyl leukotriene receptor 1 (CysLT(1)), which is increasingly recognized for its role in cancer progression. Overexpression of CysLT(1) has been documented in colorectal cancer, renal cell carcinoma, breast cancer, and uveal melanoma (UM). However, quininib's poor aqueous solubility presents a significant barrier to its clinical development. The a... .. read more..

Pattern-pulses and pattern-reversals evoke different cascades of cortical sources in the multifocal visual evoked potential
Monday, June 2, 2025
The multifocal visual evoked potential (mVEP), elicited by either pattern-pulses or pattern-reversals, provides an effective means to study visual processing and to identify retinal damage and visual field defects. It is often assumed that the first components of these VEPs, the C1 and N75, respectively, are generated in V1, based on source modeling and their polarity reversal between upper- an... .. read more..

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Tuesday, May 13, 2025
CONCLUSIONS: These findings implicate ambulatory loading in postnatal bone development of precocial goats and identify a novel postnatal synostosis event in the caprine metacarpal epiphysis. .. read more..