Specific targeting of MR1-antigen complexes using nanobodies
Friday, April 3, 2026
T cell receptor mimic (TCRm) antibodies and nanobodies that specifically bind peptide-HLA complexes have great therapeutic potential, as they can target polymorphic HLA on tumour cells furnishing peptides derived from tumour-associated antigens. MR1 is an MHC class-I-like molecule that exhibits limited polymorphism that binds and presents conserved metabolites, such as 5-OP-RU, derived from mic... .. read more..

Multi-dimensional characterization and tracking of motor unit action potentials
Thursday, April 2, 2026
Objective.Decomposition of high-density surface electromyography (HDsEMG) signals allows identification of individual motor unit firing times and provides a spatiotemporal image of their action potential waveforms. The ability to reliably match and track motor unit action potentials (MUAPs) from the same motor unit across multiple recordings allows changes in their recruitment and firing proper... .. read more..

Redefining morbidity and mortality meetings in ophthalmology: a wider remit for improved learning
Tuesday, March 24, 2026
No abstract .. read more..

A pullulan-based bilayer film for buccal delivery of a GLP-1 peptide analogue
Saturday, March 14, 2026
The buccal route has re-emerged as an alternative non-injectable route for peptide delivery. However, buccal peptide bioavailability is low, necessitating new formulation strategies. Pullulan, a water-soluble carbohydrate polymer, offers potential as a film-forming agent for buccal peptide delivery. Our aim was to co-administer a glucagon-like peptide-1 receptor agonist (GLP-1 RA) model analogu... .. read more..

Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast
Friday, March 13, 2026
Initial afferent activation of V1, indexed by the C1 component of the human VEP, is often considered to be a rudimentary stage of visual processing, operating mostly as a conduit for later stages with limited cognitive penetrability. The full suite of visual analysis entails activity across several visual areas and feedback from later areas to earlier ones. This raises the question of whether t... .. read more..

A Soft-Robotic Biomimetic Benchtop Model for Esophageal Motility Simulation
Friday, March 13, 2026
Large animal models, while valuable, are expensive, time-consuming, and limited to discrete interventional or terminal timepoints, while existing benchtop models do not offer an accurate representation of the esophageal environment. Moreover, current pre-clinical models cannot effectively simulate swallowing dysfunction (dysphagia), restricting progress in understanding motility disorders like ... .. read more..

Normal or Not? Acetabular Morphology Is Not a Binary Classification
Wednesday, March 11, 2026
Orthopaedic surgical decision making is a combination of clinical intuition, radiological measurements, and referenced standards. As clinicians and researchers, we consider hip pathology as a mechanical problem described in geometric and statistical language. For a clinical measurement to be useful, it must be easy to perform, reproducible, and demonstrably associated with the risk of the condi... .. read more..

Task-dependent intermuscular coherence between postural muscles during voluntary upright reaching
Tuesday, March 10, 2026
Intermuscular coherence provides a window into the neural mechanisms coordinating posture and movement. This study investigated task-dependent modulation of coherence between postural muscles in healthy young adults performing upright forward and lateral reaching tasks. Bilateral electromyographic activity was recorded from trunk and ankle muscles from both the dominant and non-dominant reachin... .. read more..

TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signaling
Sunday, March 1, 2026
CONCLUSION: Together, our findings suggest that the TWEAK/NF-κB/STAT3 axis represents an attractive target to tune inflammatory stroma/monocyte crosstalk. .. read more..

Fatigue-Induced Neuromuscular Responses Differ Between Endurance- and Strength-Trained Males
Wednesday, February 25, 2026
This study aimed to investigate the effect of training background on neuromuscular responses to submaximal isometric fatiguing contraction. Eleven strength-trained (ST) and 11 endurance-trained (ET) males performed maximal voluntary isometric knee extension contractions (MVIC) and a torque steadiness task at 20% MVIC before and immediately after a submaximal isometric contraction at 30% MVIC pe... .. read more..

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals
Saturday, February 21, 2026
Conductive polymer coatings have been extensively explored as a means of improving the quality of neural signals recorded with chronically implanted electrodes. They offer enhanced biocompatibility along with reduced electrode impedance and are reported to improve signal-to-noise ratio and signal amplitude. The mechanisms by which poly(3,4ethylenedioxythiophene) (PEDOT) and its derivatives enha... .. read more..

A Movement-Independent Signature of Urgency during Human Perceptual Decision-Making
Thursday, January 29, 2026
How does the brain adjust its decision processes to ensure timely decision completion? Computational modeling and electrophysiological investigations have pointed to dynamic "urgency" processes that serve to progressively reduce the quantity of evidence required to reach choice commitment as time elapses. In humans, such urgency dynamics have been observed exclusively in neural signals that acc... .. read more..

Additive Manufacturing of Polymeric Bioresorbable Stents: A Mechanical Performance Perspective
Monday, January 26, 2026
The integration of biomaterials and additive manufacturing (AM) has revolutionized the design, manufacturing, and clinical applications of permanent and bioresorbable implants. AM offers design flexibility and potential for mass customization but poses challenges for scalable manufacturing. Unlike other high-commodity implantable devices that are already clinically approved, stent AM is still i... .. read more..

Maternal Exercise Rescues Fetal Akinesia-Impaired Joint and Bone Development
Saturday, December 13, 2025
Fetal movements exert mechanical forces that shape the developing skeleton. Conditions that impair fetal movement can cause skeletal defects, but interventions are limited. Here, we show that maternal wheel running exercise regulates fetal skeletal development in mice. In wild-type fetuses, maternal exercise stimulated joint morphogenesis and bone development. These changes could not be fully e... .. read more..

Oromucosal films for peptide delivery: formulation strategies using permeation enhancers and polymers
Sunday, December 7, 2025
Buccal and sublingual mucosae offer highly vascularized, patient-acceptable routes for systemic peptide delivery, providing a promising alternative to peptide injections and conventional oral peptide dosage forms that suffer from enzymatic degradation, limited permeability, and hepatic first-pass metabolism. Despite these advantages, achieving consistent peptide bioavailability from oromucosal ... .. read more..