Specific targeting of MR1-antigen complexes using nanobodies
Friday, April 3, 2026
T cell receptor mimic (TCRm) antibodies and nanobodies that specifically bind peptide-HLA complexes have great therapeutic potential, as they can target polymorphic HLA on tumour cells furnishing peptides derived from tumour-associated antigens. MR1 is an MHC class-I-like molecule that exhibits limited polymorphism that binds and presents conserved metabolites, such as 5-OP-RU, derived from mic... .. read more..

Multi-dimensional characterization and tracking of motor unit action potentials
Thursday, April 2, 2026
Objective.Decomposition of high-density surface electromyography (HDsEMG) signals allows identification of individual motor unit firing times and provides a spatiotemporal image of their action potential waveforms. The ability to reliably match and track motor unit action potentials (MUAPs) from the same motor unit across multiple recordings allows changes in their recruitment and firing proper... .. read more..

Redefining morbidity and mortality meetings in ophthalmology: a wider remit for improved learning
Tuesday, March 24, 2026
No abstract .. read more..

A pullulan-based bilayer film for buccal delivery of a GLP-1 peptide analogue
Saturday, March 14, 2026
The buccal route has re-emerged as an alternative non-injectable route for peptide delivery. However, buccal peptide bioavailability is low, necessitating new formulation strategies. Pullulan, a water-soluble carbohydrate polymer, offers potential as a film-forming agent for buccal peptide delivery. Our aim was to co-administer a glucagon-like peptide-1 receptor agonist (GLP-1 RA) model analogu... .. read more..

Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast
Friday, March 13, 2026
Initial afferent activation of V1, indexed by the C1 component of the human VEP, is often considered to be a rudimentary stage of visual processing, operating mostly as a conduit for later stages with limited cognitive penetrability. The full suite of visual analysis entails activity across several visual areas and feedback from later areas to earlier ones. This raises the question of whether t... .. read more..

A Soft-Robotic Biomimetic Benchtop Model for Esophageal Motility Simulation
Friday, March 13, 2026
Large animal models, while valuable, are expensive, time-consuming, and limited to discrete interventional or terminal timepoints, while existing benchtop models do not offer an accurate representation of the esophageal environment. Moreover, current pre-clinical models cannot effectively simulate swallowing dysfunction (dysphagia), restricting progress in understanding motility disorders like ... .. read more..

Normal or Not? Acetabular Morphology Is Not a Binary Classification
Wednesday, March 11, 2026
Orthopaedic surgical decision making is a combination of clinical intuition, radiological measurements, and referenced standards. As clinicians and researchers, we consider hip pathology as a mechanical problem described in geometric and statistical language. For a clinical measurement to be useful, it must be easy to perform, reproducible, and demonstrably associated with the risk of the condi... .. read more..

Task-dependent intermuscular coherence between postural muscles during voluntary upright reaching
Tuesday, March 10, 2026
Intermuscular coherence provides a window into the neural mechanisms coordinating posture and movement. This study investigated task-dependent modulation of coherence between postural muscles in healthy young adults performing upright forward and lateral reaching tasks. Bilateral electromyographic activity was recorded from trunk and ankle muscles from both the dominant and non-dominant reachin... .. read more..