Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Tuesday, January 7, 2025
Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth (i.e., precocial). Precocial species, such as goats, develop advanced skeletal maturity in utero, making them useful models for studying the dynamics of bone formation under mechanical load. Here, we used microcomputed tomography and histology to ch... .. read more..

Multiphysics modelling of the impact of skin deformation and strain on microneedle-based transdermal therapeutic delivery
Sunday, December 22, 2024
Microneedle patches (MNs) hold enormous potential to facilitate the minimally-invasive delivery of drugs and vaccines transdermally. However, the micro-mechanics of skin deformation significantly influence the permeation of therapeutics through the skin. Previous studies often fail to appreciate the complexities in microneedle-skin mechanical interactions. This may impede the accuracy of MNs pr... .. read more..

Synergy-Dependent Center-of-Mass Control Strategies During Sit-to-Stand Movements
Wednesday, November 20, 2024
The characterization, through the concept of muscle synergies, of clinical functional tests is a valid tool that has been widely adopted in the research field. While this theory has been exploited for a description of the motor control strategies underlying the biomechanical task, the biomechanical correlate of the synergistic activity is yet to be fully described. In this paper, the relationsh... .. read more..

Machine learning and artificial intelligence: Enabling the clinical translation of atomic force microscopy-based biomarkers for cancer diagnosis
Monday, November 11, 2024
The influence of biomechanics on cell function has become increasingly defined over recent years. Biomechanical changes are known to affect oncogenesis; however, these effects are not yet fully understood. Atomic force microscopy (AFM) is the gold standard method for measuring tissue mechanics on the micro- or nano-scale. Due to its complexity, however, AFM has yet to become integrated in routi... .. read more..

A Novel Deep Ensemble Method for Selective Classification of Electrocardiograms
Tuesday, October 8, 2024
CONCLUSION: The proposed method demonstrates the feasibility of accurately detecting AF from STSL ECG recordings. The selective classification approach offers a substantial enhancement to automated ECG interpretation algorithms in telehealth solutions. .. read more..

Consensus for experimental design in electromyography (CEDE) project: Application of EMG to estimate muscle force
Sunday, July 28, 2024
Skeletal muscles power movement. Deriving the forces produced by individual muscles has applications across various fields including biomechanics, robotics, and rehabilitation. Since direct in vivo measurement of muscle force in humans is invasive and challenging, its estimation through non-invasive methods such as electromyography (EMG) holds considerable appeal. This matrix, developed by the ... .. read more..