Synergy-Dependent Center-of-Mass Control Strategies During Sit-to-Stand Movements
Wednesday, November 20, 2024
The characterization, through the concept of muscle synergies, of clinical functional tests is a valid tool that has been widely adopted in the research field. While this theory has been exploited for a description of the motor control strategies underlying the biomechanical task, the biomechanical correlate of the synergistic activity is yet to be fully described. In this paper, the relationsh... .. read more..

Machine learning and artificial intelligence: Enabling the clinical translation of atomic force microscopy-based biomarkers for cancer diagnosis
Monday, November 11, 2024
The influence of biomechanics on cell function has become increasingly defined over recent years. Biomechanical changes are known to affect oncogenesis; however, these effects are not yet fully understood. Atomic force microscopy (AFM) is the gold standard method for measuring tissue mechanics on the micro- or nano-scale. Due to its complexity, however, AFM has yet to become integrated in routi... .. read more..

A Novel Deep Ensemble Method for Selective Classification of Electrocardiograms
Tuesday, October 8, 2024
CONCLUSION: The proposed method demonstrates the feasibility of accurately detecting AF from STSL ECG recordings. The selective classification approach offers a substantial enhancement to automated ECG interpretation algorithms in telehealth solutions. .. read more..

Consensus for experimental design in electromyography (CEDE) project: Application of EMG to estimate muscle force
Sunday, July 28, 2024
Skeletal muscles power movement. Deriving the forces produced by individual muscles has applications across various fields including biomechanics, robotics, and rehabilitation. Since direct in vivo measurement of muscle force in humans is invasive and challenging, its estimation through non-invasive methods such as electromyography (EMG) holds considerable appeal. This matrix, developed by the ... .. read more..

Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Tuesday, July 16, 2024
Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδTCR, leaving the apical TCR surface bioavailable. We reveal that a second γδTCR ligand co-engages ... .. read more..

Estimation of Gait Parameters in Huntington's Disease Using Wearable Sensors in the Clinic and Free-living Conditions
Friday, May 31, 2024
In Huntington's disease (HD), wearable inertial sensors could capture subtle changes in motor function. However, disease-specific validation of methods is necessary. This study presents an algorithm for walking bout and gait event detection in HD using a leg-worn accelerometer, validated only in the clinic and deployed in free-living conditions. Seventeen HD participants wore shank- and thigh-w... .. read more..

Prior probability cues bias sensory encoding with increasing task exposure
Tuesday, April 2, 2024
When observers have prior knowledge about the likely outcome of their perceptual decisions, they exhibit robust behavioural biases in reaction time and choice accuracy. Computational modelling typically attributes these effects to strategic adjustments in the criterion amount of evidence required to commit to a choice alternative - usually implemented by a starting point shift - but recent work... .. read more..

An eye on equity: faricimab-driven health equity improvements in diabetic macular oedema using a distributional cost-effectiveness analysis from a UK societal perspective
Saturday, March 30, 2024
CONCLUSIONS: Long-acting therapies with fewer injections, such as faricimab, may reduce costs, improve health outcomes and increase health equity. Extended economic evaluation frameworks capturing additional value elements, such as DCEA, enable a more comprehensive valuation of interventions, which is of relevance to decision-makers, healthcare professionals and patients. .. read more..

Consensus for experimental design in electromyography (CEDE) project: Checklist for reporting and critically appraising studies using EMG (CEDE-Check)
Thursday, March 28, 2024
The diversity in electromyography (EMG) techniques and their reporting present significant challenges across multiple disciplines in research and clinical practice, where EMG is commonly used. To address these challenges and augment the reproducibility and interpretation of studies using EMG, the Consensus for Experimental Design in Electromyography (CEDE) project has developed a checklist (CED... .. read more..

Role of arm reaching movement kinematics in friction perception at initial contact with smooth surfaces
Thursday, March 28, 2024
When manipulating objects, humans begin adjusting their grip force to friction within 100 ms of contact. During motor adaptation, subjects become aware of the slipperiness of touched surfaces. Previously, we have demonstrated that humans cannot perceive frictional differences when surfaces are brought in contact with an immobilised finger, but can do so when there is submillimeter lateral displ... .. read more..

Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease
Tuesday, March 26, 2024
CONCLUSION: The results support the application of acoustic features to objectively quantify speech impairment and disease severity in HD in multilanguage studies. .. read more..

Energy-Efficient Sleep Apnea Detection Using a Hyperdimensional Computing Framework Based on Wearable Bracelet Photoplethysmography
Thursday, March 14, 2024
CONCLUSION: The simplicity of hypervector operations in HDC and the novel 1D-BlockLBP encoding effectively preserve pulse rate signal characteristics with high computational efficiency. .. read more..