Maternal exercise rescues fetal akinesia-impaired joint and bone development
Wednesday, July 16, 2025
Fetal movements exert mechanical forces that shape the developing skeleton. Conditions that impair fetal movements can cause skeletal defects, but interventions are limited. Here, we show that maternal wheel running exercise regulates fetal skeletal development in mice. In wild-type fetuses, maternal exercise stimulated joint and bone morphogenesis. We reasoned that these effects occurred throu... .. read more..

SC10X/U: A high-density electrode system for standardised surface recording of neural activity of the cervical spinal cord
Sunday, July 6, 2025
CONCLUSION: The system defines electrode locations to promote standardized recordings across individuals and research centres. The evoked potentials recorded using the system conformed to the existing neurophysiological and neuroanatomical literature.s. .. read more..

Muscle synergy analysis for clinical characterization of upper limb motor recovery after stroke
Sunday, June 8, 2025
CONCLUSIONS: In individuals with stroke undergoing upper limb motor rehabilitation, changes in the synergy merging pattern may serve as a potential marker to distinguish responders from non-responders. .. read more..

Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines
Thursday, June 5, 2025
Quininib is a small molecule antagonist of cysteinyl leukotriene receptor 1 (CysLT(1)), which is increasingly recognized for its role in cancer progression. Overexpression of CysLT(1) has been documented in colorectal cancer, renal cell carcinoma, breast cancer, and uveal melanoma (UM). However, quininib's poor aqueous solubility presents a significant barrier to its clinical development. The a... .. read more..

Pattern-pulses and pattern-reversals evoke different cascades of cortical sources in the multifocal visual evoked potential
Monday, June 2, 2025
The multifocal visual evoked potential (mVEP), elicited by either pattern-pulses or pattern-reversals, provides an effective means to study visual processing and to identify retinal damage and visual field defects. It is often assumed that the first components of these VEPs, the C1 and N75, respectively, are generated in V1, based on source modeling and their polarity reversal between upper- an... .. read more..

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Tuesday, May 13, 2025
CONCLUSIONS: These findings implicate ambulatory loading in postnatal bone development of precocial goats and identify a novel postnatal synostosis event in the caprine metacarpal epiphysis. .. read more..