Compound shows promise for minimizing erratic movements in Parkinson’s patients
Wednesday, December 1, 2021
A new study has identified a promising drug candidate to minimize uncontrolled, erratic muscle movements, called dyskinesia, associated with Parkinson's disease.

Targeting the brain’s immune cells may help prevent or treat Alzheimer’s disease
Wednesday, December 1, 2021
A gene mutation linked to Alzheimer's disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study. The team also found that blocking the pathway -- with a drug that's currently being tested in cancer clinical trials -- protects against many...

Effectiveness of ointment that kills antibiotic-resistant bacteria shown
Wednesday, December 1, 2021
New research shows that use of a topical drug, called AB569, a combination of acidified nitrite and EDTA (or ethylenediaminetetraacetic acid) promotes killing of antibiotic-resistant bacteria while enhancing the healing of wounds in a variety of burn injuries.

Researchers identify key RNA 'gatekeeper' in gene expression, pointing to possible new drug targets
Wednesday, December 1, 2021
Researchers have identified the first non-coding RNA that controls formation of chromosome loops, which govern gene expression. Jpx RNA was previously thought to be involved only in X chromosome inactivation, a necessary step in development of female embryos. This discovery could create new targe...

Researchers crack the synthetic code of rare molecules sought after in drug development
Monday, December 6, 2021
A research team has succeeded in producing two molecules that are otherwise only formed by microorganisms from extremely contaminated wastewater in an abandoned mine in South Korea. The method, which took four years to develop, could pave the way for new types of drugs.

Discovering new drugs with help from Darwinian principles
Monday, December 6, 2021
Our body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognise the enemy and trigger the best possible immune response. Scientists use these antibodies to for therapeutic purposes to target proteins and disrupt t...

Synthetic tissue can repair hearts, muscles, and vocal cords
Tuesday, November 30, 2021
Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

In children with multiple sclerosis, teriflunomide tempers lesion growth
Tuesday, November 30, 2021
A phase 3 clinical trial tested the safety and efficacy of teriflunomide, an oral immunomodulatory drug, in children with multiple sclerosis. Although the medication did not prevent disease relapses to a greater extent than placebo, the option for some patients to switch from placebo to terifluno...

Why cannabis smells skunky
Wednesday, December 1, 2021
As cannabis is legalized in more areas, it has become increasingly popular as a medicinal and recreational drug. This plant produces a pungent, skunk-like odor that is pleasing to some but repulsive to others. Now, researchers have discovered a new family of prenylated volatile sulfur compounds (...

Parallels in human, dog oral tumors could speed new therapies
Monday, November 29, 2021
Recent research compared the genetic expression profiles of a nonlethal canine tumor and the rare, devastating human oral tumor it resembles, laying the groundwork for potential translational medicine down the road.

Potential new treatment for Alzheimer’s disease would be relatively cheap
Tuesday, November 30, 2021
Researchers have discovered a protein involved in the development of Alzheimer's disease. Studies in mice showed that eliminating this protein entirely or using drugs to block its function reduced physical changes in the brain associated with the disease and improved memory. Drug therapy that aim...

'Transformational' approach to machine learning could accelerate search for new disease treatments
Monday, November 29, 2021
Researchers have developed a new approach to machine learning that 'learns how to learn' and out-performs current machine learning methods for drug design, which in turn could accelerate the search for new disease treatments.

Hepatitis drug increases antibiotic potency, limits antibiotic resistance, study finds
Tuesday, November 23, 2021
A cellular study of telaprevir shows that the antiviral blocks the function of essential proteins in bacteria, revealing opportunity to repurpose drug to use alongside antibiotics.

Why You Can’t Find Cheap At-Home Covid Tests
Monday, November 22, 2021
You probably won’t be testing everyone at your Thanksgiving table for covid because the tests are expensive and hard to find. Why? The federal government is partly to blame.

KHN’s ‘What the Health?’: Boosting Confusion
Thursday, November 18, 2021
Federal health officials appear poised to extend a recommendation for covid boosters to all adults, following moves by some governors and mayors to broaden the eligible booster pool as caseloads rise. Meanwhile, the Food and Drug Administration finally has a nominee to head the agency: former FDA...

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