A needle that softens on intravenous insertion
Friday, December 22, 2023

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Mechanical characterisation of commercial artificial skin models
Sunday, September 17, 2023

Understanding of the mechanical properties of skin is crucial in evaluating the performance of skin-interfacing medical devices. Artificial skin models (ASMs) have rapidly gained attention as they are able to overcome the challenges in ethically sourcing consistent and representative ex vivo anim... .. read more..

Metallic Microneedles for Transdermal Drug Delivery: Applications, Fabricatio...
Saturday, January 21, 2023

Current procedures for transdermal drug delivery (TDD) have associated limitations including poor administration of nucleic acid, small or large drug molecules, pain and stress for needle phobic people. A painless micro-sized device capable of delivering drugs easily and efficiently, eliminating ... .. read more..

A therapeutic convection-enhanced macroencapsulation device for enhancing β c...
Friday, September 10, 2021

Islet transplantation for type 1 diabetes treatment has been limited by the need for lifelong immunosuppression regimens. This challenge has prompted the development of macroencapsulation devices (MEDs) to immunoprotect the transplanted islets. While promising, conventional MEDs are faced with in... .. read more..

Insights into the mechanics of solid conical microneedle array insertion into...
Tuesday, September 7, 2021

In order to develop optimum microneedle designs, researchers must first develop robust, repeatable and adaptable test methods which are representative of in vivo conditions. However, there is a lack of experimental tools which can accurately comparatively interrogate functional microneedle penetr... .. read more..

Additive Manufacturing of Multi-Scale Porous Soft Tissue Implants That Encour...
Thursday, June 24, 2021

Medical devices, such as silicone-based prostheses designed for soft tissue implantation, often induce a suboptimal foreign-body response which results in a hardened avascular fibrotic capsule around the device, often leading to patient discomfort or implant failure. Here, it is proposed that add... .. read more..

In silico design of additively manufacturable composite synthetic va...
Tuesday, March 16, 2021

Benchtop testing of endovascular medical devices under accurately simulated physiological conditions is a critical part of device evaluation prior to clinical assessment. Currently, glass, acrylic and silicone vascular models are predominantly used as anatomical simulator test beds for in vitro t... .. read more..

A Radial Clutch Needle for Facile and Safe Tissue Compartment Access
Monday, October 12, 2020

Efficient and safe access to targeted therapeutic sites is a universal challenge in minimally invasive medical intervention. Percutaneous and transluminal needle insertion is often performed blindly and requires significant user skill and experience to avoid complications associated with the dama... .. read more..

A biomimetic urethral model to evaluate urinary catheter lubricity and epithe...
Saturday, May 30, 2020

The standard method of evaluating the lubricity of intermittent urinary catheters with coefficient of friction (CoF) testing is not physiologically relevant, while there is also a dearth of published research on catheter-associated urethral micro-trauma. We developed a novel human urethral epithe... .. read more..

Vascular Endothelial Growth Factor-Releasing Microspheres Based on Poly(ε-Cap...
Sunday, October 27, 2019

Pancreatic islet transplantation is a promising advanced therapy that has been used to treat patients suffering from diabetes type 1. Traditionally, pancreatic islets are infused via the portal vein, which is subsequently intended to engraft in the liver. Severe immunosuppressive treatments are n... .. read more..

Simple and customizable method for fabrication of high-aspect ratio microneed...
Friday, October 25, 2019

We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer. As opposed to conventional microneedle fabrication methods, this technique neither requires complex and expensive manufacturing facilities nor expertise in microfabrication. While ... .. read more..

Synthetic bioresorbable poly-α-hydroxyesters as peripheral nerve guidance con...
Thursday, October 3, 2019

Implantable tubular devices known as nerve guidance conduits (NGCs) have drawn considerable interest as an alternative to autografting in the repair of peripheral nerve injuries. At present, there exists a lack of biodegradable, biocompatible materials for the fabrication of NGCs with physical pr... .. read more..

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