» Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
01/05/24 00:00 from Latest Results for Diabetologia
Abstract Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and therefore represent attractive therapeutic targets to pro...
» Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes
01/05/24 00:00 from Latest Results for Diabetologia
Abstract Aims/hypothesis A precision medicine approach in type 2 diabetes could enhance targeting specific glucose-lowering therapies to individual patients most likely to benefit. We aimed to use the recently developed Bayesian causal f...
» Protocol for the STEADY intervention for type 1 diabetes and disordered eating: Safe management of people with Type 1 diabetes and EAting Disorders studY
13/03/24 16:21 from Diabetic Medicine
Diabetic Medicine, Volume 41, Issue 4, April 2024.
» Intergenerational differences in healthy eating beliefs among British Pakistanis with type 2 diabetes
13/03/24 16:21 from Diabetic Medicine
Diabetic Medicine, Volume 41, Issue 4, April 2024.
» Real‐world lived experience of older adults with type 1 diabetes after an automated insulin delivery trial
13/03/24 16:21 from Diabetic Medicine
Diabetic Medicine, Volume 41, Issue 4, April 2024.
» Roles and competencies of the clinical psychologist in adult diabetes care—A consensus report
22/02/24 15:33 from Diabetic Medicine
Diabetic Medicine, EarlyView.
» Participants' experiences of attending a structured education course (DAFNEplus) informed by behavioural science
15/02/24 18:00 from Diabetic Medicine
Diabetic Medicine, EarlyView.
» Mouse islet‐derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function
07/01/24 18:50 from Diabetic Medicine
Diabetic Medicine, EarlyView.
» The antidiabetic SGLT2 inhibitor canagliflozin reduces mitochondrial metabolism in a model of skeletal muscle insulin resistance
23/12/23 11:43 from Diabetic Medicine
Diabetic Medicine, EarlyView.
» Real‐world study of the concomitant use of biphasic insulin aspart 30/70 with GLP‐1 receptor agonist versus first‐generation basal insulin with GLP‐1 receptor agonist in type 2 diabetes
13/12/23 08:00 from Diabetic Medicine
Diabetic Medicine, EarlyView.
» Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice
24/02/23 00:00 from Diabetes Journal current issue
Dysfunction of glucagon-secreting α-cells participates in the progression of diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR antagonism upregulates glucagon and glucagon-like p...
» Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
23/02/23 00:00 from Diabetes Journal current issue
NADPH oxidases (NOXs) are major players in generating reactive oxygen species (ROS) and are implicated in various neurodegenerative ocular pathologies. The aim of this study was to investigate the role of a NOX4 inhibitor (GLX7013114) in...
» Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
22/02/23 00:00 from Diabetes Journal current issue
Ectopic lipid accumulation in renal tubules is closely related to the pathogenesis of diabetic kidney disease (DKD), and mitochondrial dysfunction is thought to play a key role in lipid accumulation. Therefore, maintaining mitochondrial ...
» Controversies Around the Measurement of Blood Ketones to Diagnose and Manage Diabetic Ketoacidosis
17/01/22 00:00 from Diabetes Care Journal current issue
The measurement of blood ketones in preference to urine ketones has become a well-established tool in the diagnosis and management of diabetic ketoacidosis (DKA). However, there remains considerable disparity between diabetes guidelines ...
» Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation
17/01/22 00:00 from Diabetes Care Journal current issue
OBJECTIVE Total pancreatectomy with islet autotransplantation (TPIAT) is indicated to alleviate debilitating pancreas-related pain and mitigate diabetes in patients with acute recurrent and chronic pancreatitis when medical/endoscopic th...
» Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial
29/11/21 00:00 from Diabetes Care Journal current issue
OBJECTIVE To assess the efficacy and safety of closed-loop insulin delivery compared with sensor-augmented pump therapy among older adults with type 1 diabetes. RESEARCH DESIGN AND METHODS This open-label, randomized (1:1), crossover tri...