Influenza hemagglutinin subunit vaccines are more effective and offer better cross protection against various influenza virus challenges when combined with a mucosal adjuvant that enhances the body's immune response, according to a study...
As summer ushers in peak mosquito season, health and vector control officials are bracing for the possibility of another year of historic rates of dengue.
Research shows RSV leads to high hospitalization rates in adults, emphasizing the importance of enhanced surveillance and diagnostic measures in healthcare.
Scientists have discovered a stealthy mechanism that cytomegalovirus (CMV)—the leading infectious cause of birth defects in the U.S.—uses to infiltrate blood vessel cells while evading immune detection. The virus forms a hidden protein...
Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The protective effect is likely linked...
New research from the University of Pittsburgh School of Medicine and La Jolla Institute for Immunology, published today in Nature Microbiology, reveals an opportunity for developing a therapy against cytomegalovirus (CMV), the leading...
In the early days of the West Texas measles outbreak, Thang Nguyen eyed the rising number of cases and worried. His 4-year-old son was at risk because he had received only the first of the vaccine's two doses.
As fired and retired scientists rallied outside in the Atlanta heat, an advisory panel that Robert F. Kennedy Jr. handpicked to replace experts he'd fired earlier met inside the Centers for Disease Control and Prevention's headquarters...
Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early surge could double as an alarm bell and a target for stop-it-early treatments.
In the midst of a multi-state measles outbreak, a new poll by Harvard T.H. Chan School of Public Health and the de Beaumont Foundation finds that most U.S. adults (79%) say parents should be required to have children vaccinated against...
Hot tubs don't just feel great, they may actually outperform saunas when it comes to health perks. A study found that soaking in hot water raises core body temperature more than dry or infrared saunas, triggering stronger heart, blood...
A new multi-state study led by the Centers for Disease Control and Prevention's (CDC) VISION Network – including Regenstrief Institute – has provided the most comprehensive assessment to date of the effectiveness of 2023-2024 COVID-19...
US infants lacking Bifidobacterium in their gut microbiome face significant changes in microbial composition, metabolic function, and immune-related health risks. This large, nationally representative study links early-life...
Major depressive disorder affects hundreds of millions worldwide, but a key to understanding its origins may lie in the brain’s immune system. New findings spotlight astrocytes—previously overshadowed by microglia—as major players in...
Scientists have uncovered a stealthy tactic used by the SARS-CoV-2 virus: one of its proteins can leap from infected cells to healthy ones, effectively tricking the immune system into attacking the body’s own tissues.
Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes...
A new study shows how person-to-person variation in antibody immunity plays a key role in shaping which influenza (flu) strains dominate in a population.
Chronic inflammatory bowel disease is challenging to treat and carries a risk of complications, including the development of bowel cancer. Young people are particularly affected: when genetic predisposition and certain factors coincide,...
An international clinical trial shows an innovative CAR-T cell immunotherapy is promising against aggressive T cell cancers and has manageable side effects.
In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new study shows that a series of vaccines can coax the immune system to produce powerful antibodies capable of blocking a wide range of...
A study explains how age reshapes the blood system. In both humans and mice, a few stem cells out-compete their neighbors and gradually take over blood production. The loss of diversity results in a blood system that has a preference for...
By studying Chikungunya virus, scientists shed light on how immune responses to viral infections may lead to persistent symptoms of autoimmune disease.
Researchers have published the first description of the role of the ZFP36 family of RNA binding proteins in regulatory T cells (Tregs). Tregs are key to maintaining balance in the immune system and essential to preventing autoimmune...
A decades-long scientific challenge in HIV vaccine development has been finding a way to train the immune system to produce antibodies that can target many variants of the virus. Traditional approaches haven't worked -- largely because...
New polymer microparticles can be used to deliver vaccines at different times. The work could lead to childhood vaccines given just once, eliminating the need for booster doses.
Most vaccines -- and boosters -- are injected directly into muscle tissue, usually in the upper arm, to kickstart the body's immune system in the fight against disease. But for respiratory diseases like COVID-19, it can be important to...
Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, a Stanford Medicine team found. They also identified compounds that could treat it.
A research team has achieved a significant breakthrough in developing broadly protective, live-attenuated influenza vaccines (LAIV). These innovative LAIV platforms offer potential to develop universal influenza vaccines that induce a...
The recent global monkeypox (mpox) outbreak, with a new and aggressive variant, has underscored the dire need for safe, broadly effective, and accessible vaccines. The LC16m8 vaccine, an attenuated vaccinia virus strain originally...
Scientists have uncovered a promising new way to enhance the effectiveness of vaccines by tapping into the potential of a specific type of immune cell, opening the door to long-lasting vaccines for viruses and enhanced cancer therapies....
People who are given a vaccine for shingles have a 23% lower risk of cardiovascular events, including stroke, heart failure, and coronary heart disease, according to a recent study of more than a million people. The protective effect of...
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of 'good' microbes in the gut is linked to rheumatoid arthritis and, potentially,...
A new study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses.
Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease the brain appears to play a major role by...
Researchers have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 T cells, teaching them how to mount...
Antibodies are best known for their ability to latch onto and neutralize bacteria, viruses and other pathogens. But these immune proteins can do more than that: They also activate other components of the immune system, which then go to...
A team led by researchers say public ignorance and apathy towards bird flu (highly pathogenic avian influenza, or HPAI) could pose a serious obstacle to containing the virus and preventing a larger-scale public health crisis.
A vaccine under development has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu. The work focuses on the H5N1 variant known as 2.3.4.4b, which has caused widespread outbreaks in wild...
Scientists have pioneered an influenza virus vector-based nasal spray vaccine platform and developed a nasal spray H5N1 avian influenza vaccine. During the early COVID-19 pandemic, this platform enabled the rapid development of a nasal...
Researchers have shown that differences in the entire rotavirus genome -- not just its two surface proteins -- affect how well vaccines work, helping to explain why some strains are more likely to infect vaccinated individuals.
New research could aid in improving whooping cough vaccines to once again push this disease toward eradication by targeting two key weaknesses in the infection.
Low vaccination rates for influenza viruses and the lack of an HSV vaccine underscore the need for a new approach to reduce viral transmission. Researchers have now used a clinical-grade antiviral chewing gum to substantially reduce...
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis.