» Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: Sepsis and trauma are common health problems and provide great challenges in critical care. Diverse patient responses to these conditions further complicate patient management and outcome prediction. Whole blood transcriptomi...

» Biomarkers of Delirium Duration and Delirium Severity in the ICU*
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: Both delirium duration and delirium severity are associated with adverse patient outcomes. Serum biomarkers associated with delirium duration and delirium severity in ICU patients have not been reliably identified. We conduct...

» Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: We sought to characterize 1) the difference in the diffusion gradient of cellular oxygen delivery and 2) the presence of diffusion limitation physiology in hypoxic-ischemic brain injury patients with brain hypoxia, as defined...

» Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials*
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: Epinephrine is frequently used as an inotropic and vasopressor agent in critically ill patients requiring hemodynamic support. Data from observational trials suggested that epinephrine use is associated with a worse outcome a...

» Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: To develop evidence-based recommendations for clinicians caring for adults with acute or acute on chronic liver failure in the ICU. Design: The guideline panel comprised 29 members with expertise in aspects of care of the cri...

» The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: We performed a national cross-sectional survey to determine the epidemiologic characteristics of patients with sepsis in ICU in China. Design: A cross-section survey study. Setting: Forty-four hospitals in mainland China from...

» Promotion of Regular Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in Long-Stay ICU Patients. A Multicenter, Phase II, Sham-Controlled, Randomized Trial: The PROPEL Study
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: To evaluate the effect of esophageal stimulation on nutritional adequacy in critically ill patients at risk for enteral feeding intolerance. Design: A multicenter randomized sham-controlled clinical trial. Setting: Twelve ICU...

» Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: We sought to evaluate the impact of transitions of care among staff intensivists on the compliance with evidence-based processes of care. Design: Cohort study using data from the Toronto Intensive Care Observational Registry....

» Relative Hypoglycemia in Diabetic Patients With Critical Illness
01/03/20 06:00 from Critical Care Medicine - Current Issue
Objectives: Relative hypoglycemia is a decrease in glucose greater than or equal to 30% below prehospital admission levels (estimated by hemoglobin A1C) but not to absolute hypoglycemia levels. It is a recognized pathophysiologic phenome...

» Non-invasive oscillometric versus invasive arterial blood pressure measurements in critically ill patients: A post hoc analysis of a prospective observational study
23/02/20 12:35 from ScienceDirect Publication: Journal of Critical Care
Publication date: Available online 22 February 2020 Source: Journal of Critical Care Author(s): Thomas Kaufmann, Eline G.M. Cox, Renske Wiersema, Bart Hiemstra, Ruben J. Eck, Geert Koster, Thomas W.L. Scheeren, Frederik Keus, Bernd Sauge...

» Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study
22/02/20 12:17 from ScienceDirect Publication: Journal of Critical Care
Publication date: Available online 21 February 2020 Source: Journal of Critical Care Author(s): Tinka Bakker, Joanna E. Klopotowska, Nicolette F. de Keizer, Rob van Marum, Heleen van der Sijs, Dylan W. de Lange, Evert de Jonge, Ameen Abu...

» Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis
22/02/20 00:00 from Critical Care - Latest Articles
In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. Howeve...