» Chip-Based Digital PCR Approach for Improved SARS-CoV-2 Quantification for Endemic Wastewater Surveillance
17/04/26 20:00 from coronavirus
The COVID-19 pandemic has revealed the importance of wastewater-based epidemiology (WBE) due to its advantages over traditional surveillance systems. However, low viral prevalence poses a significant challenge for reliable detection of S...

» Changes in cardiovascular health and physical functioning in non-hospitalized, adult COVID-19 patients after 3 years of follow-up
17/04/26 20:00 from coronavirus
Long-term cardiovascular consequences of COVID-19 remain unclear, particularly in non-hospitalized individuals. We investigated longitudinal changes (~3 years) in cardiovascular risk factors, cardiac biomarkers, physical functioning, and...

» Chip-Based Digital PCR Approach for Improved SARS-CoV-2 Quantification for Endemic Wastewater Surveillance
17/04/26 20:00 from sars-cov-2
The COVID-19 pandemic has revealed the importance of wastewater-based epidemiology (WBE) due to its advantages over traditional surveillance systems. However, low viral prevalence poses a significant challenge for reliable detection of S...

» Factors Associated With Examinations for Diabetic Complications During the COVID-19 Epidemic
17/04/26 20:00 from covid-19
This study investigated examinations for diabetes complications and associated factors during the COVID-19 epidemic in Korea. We used data from the 2021 Korea Community Health Survey (n = 28 477). Overall, 42.7% underwent fundus examinat...

» Joint Bayesian Nowcasting of Severe Acute Respiratory Illness and COVID-19 Positives in Brazil
17/04/26 20:00 from coronavirus
Surveillance of severe acute respiratory illness (SARI) in Brazil provides an early warning system for respiratory outbreaks, including COVID-19, and statistical nowcasting methods are vital for correcting long and variable reporting del...

» Changes in cardiovascular health and physical functioning in non-hospitalized, adult COVID-19 patients after 3 years of follow-up
17/04/26 20:00 from sars-cov-2
Long-term cardiovascular consequences of COVID-19 remain unclear, particularly in non-hospitalized individuals. We investigated longitudinal changes (~3 years) in cardiovascular risk factors, cardiac biomarkers, physical functioning, and...

» Chip-Based Digital PCR Approach for Improved SARS-CoV-2 Quantification for Endemic Wastewater Surveillance
17/04/26 20:00 from covid-19
The COVID-19 pandemic has revealed the importance of wastewater-based epidemiology (WBE) due to its advantages over traditional surveillance systems. However, low viral prevalence poses a significant challenge for reliable detection of S...

» Joint Bayesian Nowcasting of Severe Acute Respiratory Illness and COVID-19 Positives in Brazil
17/04/26 20:00 from sars-cov-2
Surveillance of severe acute respiratory illness (SARI) in Brazil provides an early warning system for respiratory outbreaks, including COVID-19, and statistical nowcasting methods are vital for correcting long and variable reporting del...

» Changes in cardiovascular health and physical functioning in non-hospitalized, adult COVID-19 patients after 3 years of follow-up
17/04/26 20:00 from covid-19
Long-term cardiovascular consequences of COVID-19 remain unclear, particularly in non-hospitalized individuals. We investigated longitudinal changes (~3 years) in cardiovascular risk factors, cardiac biomarkers, physical functioning, and...

» Joint Bayesian Nowcasting of Severe Acute Respiratory Illness and COVID-19 Positives in Brazil
17/04/26 20:00 from covid-19
Surveillance of severe acute respiratory illness (SARI) in Brazil provides an early warning system for respiratory outbreaks, including COVID-19, and statistical nowcasting methods are vital for correcting long and variable reporting del...

» Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms
16/04/26 20:00 from Sars-Cov-2 origins
Several studies have documented reverse zoonotic transmission of SARS-CoV-2, including in farmed mink which are susceptible to human respiratory viruses and are known for serving as a reservoir capable of generating new virus variants in...

» Mapping global evidence on compassion fatigue among healthcare workers during COVID-19: insights and implications for future preparedness - a scoping review
16/04/26 20:00 from coronavirus
CONCLUSIONS: Compassion fatigue is a multifactorial, context-dependent hazard disproportionately affecting vulnerable HCWs. Effective mitigation requires longitudinal research, inclusive global representation, and multi-level strategies ...

» Perception of Lebanese Obstetricians Toward COVID-19 Vaccination During Pregnancy and Breastfeeding
16/04/26 20:00 from coronavirus
CONCLUSIONS: Our results provided an overview of Lebanese obstetricians' attitudes and practices regarding the COVID-19 vaccine and identified some of the factors that hinder the recommendation of the vaccine. Such information might be h...

» Mapping global evidence on compassion fatigue among healthcare workers during COVID-19: insights and implications for future preparedness - a scoping review
16/04/26 20:00 from sars-cov-2
CONCLUSIONS: Compassion fatigue is a multifactorial, context-dependent hazard disproportionately affecting vulnerable HCWs. Effective mitigation requires longitudinal research, inclusive global representation, and multi-level strategies ...

» Temporal Trends in Physician Burnout During and After the COVID-19 Pandemic in Japan: A Repeated Cross-Sectional Study
16/04/26 20:00 from coronavirus
CONCLUSIONS: Burnout among Japanese internists and primary care physicians declined significantly from the peak of the COVID-19 pandemic to the recovery phase. However, approximately one-quarter of physicians remained affected in 2024.

» Correction to 'RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation'
16/04/26 20:00 from sars-cov-2
No abstract

» Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy
16/04/26 20:00 from coronavirus
CONCLUSION: The pandemic did not induce diagnosis-specific increases in acute psychiatric admissions but substantially altered their temporal organization. Differences across countries highlight how healthcare structure-particularly the ...

» Anti-GQ1b-Positive Miller Fisher Syndrome Following Pfizer Bivalent COVID-19 Vaccination
16/04/26 20:00 from sars-cov-2
Miller Fisher syndrome (MFS) is a rare, immune-mediated variant of Guillain-Barré syndrome characterized by acute onset of ataxia, areflexia, and ophthalmoplegia. It typically develops following an antecedent event, such as an infection ...

» Humoral immunity and infection status of PLWH following vaccination after the BA.5/BF.7 wave
16/04/26 20:00 from coronavirus
CONCLUSION: Hybrid immunity resulting from vaccination and BA.5/BF.7 BTI enhances humoral immune responses in PLWH, which may contribute to improved protection against COVID-19. However, this hybrid immunity offers limited protection aga...

» Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy
16/04/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: The pandemic did not induce diagnosis-specific increases in acute psychiatric admissions but substantially altered their temporal organization. Differences across countries highlight how healthcare structure-particularly the ...

» Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy
16/04/26 20:00 from sars-cov-2
CONCLUSION: The pandemic did not induce diagnosis-specific increases in acute psychiatric admissions but substantially altered their temporal organization. Differences across countries highlight how healthcare structure-particularly the ...

» Combining label-free Raman spectroscopy and machine learning to identify early biomarkers of COVID-19 disease severity and mortality
16/04/26 20:00 from coronavirus
CONCLUSIONS: These results suggest the potential of Raman spectroscopy and machine learning modeling to stratify COVID-19 patients at admission, individualize care, and improve survival rates.

» Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms
16/04/26 20:00 from sars-cov-2
Several studies have documented reverse zoonotic transmission of SARS-CoV-2, including in farmed mink which are susceptible to human respiratory viruses and are known for serving as a reservoir capable of generating new virus variants in...

» Conservation of Bacterial Lipopolysaccharide Binding by SARS-CoV-2 Spike across Major Viral Variants
16/04/26 20:00 from coronavirus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial...

» Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms
16/04/26 20:00 from Covid-19 origins
Several studies have documented reverse zoonotic transmission of SARS-CoV-2, including in farmed mink which are susceptible to human respiratory viruses and are known for serving as a reservoir capable of generating new virus variants in...

» Humoral immunity and infection status of PLWH following vaccination after the BA.5/BF.7 wave
16/04/26 20:00 from sars-cov-2
CONCLUSION: Hybrid immunity resulting from vaccination and BA.5/BF.7 BTI enhances humoral immune responses in PLWH, which may contribute to improved protection against COVID-19. However, this hybrid immunity offers limited protection aga...

» ANCA-Negative Pauci-Immune Necrotizing Glomerulonephritis in the Setting of Multisystem Inflammatory Syndrome in Children
16/04/26 20:00 from coronavirus
Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disorder that occurs in previously healthy pediatric patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure or mild infection...

» Sex- and Age-Dependent Neuroimmune Dysregulation and Early Neurodegenerative Signatures Following SARS-CoV-2 Infection in Golden Syrian Hamsters
16/04/26 20:00 from sars-cov-2
Post-acute sequelae of SARS-CoV-2 infection, or Long-COVID, affects millions globally and is characterized by persistent symptoms affecting multiple organs, yet the underlying mechanisms remain poorly defined. Here, we used Golden Syrian...

» Reduced COVID-19 severity in Africa: a systematic review of host genetic and immunological responses to SARS-CoV-2 infection
16/04/26 20:00 from coronavirus
CONCLUSION: The findings suggest that immune and genetic adaptations in African populations may have modulated susceptibility and severity of SARS-CoV-2 infection outcomes in Africans.

» Combining label-free Raman spectroscopy and machine learning to identify early biomarkers of COVID-19 disease severity and mortality
16/04/26 20:00 from sars-cov-2
CONCLUSIONS: These results suggest the potential of Raman spectroscopy and machine learning modeling to stratify COVID-19 patients at admission, individualize care, and improve survival rates.

» Regulation of histones in thromboinflammation
16/04/26 20:00 from coronavirus
Extracellular histones, once regarded solely as nuclear structural proteins, are now recognized as potent mediators of thrombo-inflammation which is the pathological interface of coagulation and immunity. Released during necrosis, apopto...

» Conservation of Bacterial Lipopolysaccharide Binding by SARS-CoV-2 Spike across Major Viral Variants
16/04/26 20:00 from sars-cov-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial...

» Understanding the Psychological Impacts of Shielding From COVID-19 for Immunocompromised Individuals
16/04/26 20:00 from coronavirus
CONCLUSION: The findings from this study indicate that individuals who are shielding continue to experience profound difficulties that require attention. Measures must be introduced to mitigate the impact of COVID in the immunocompromise...

» Impact of in-hospital SARS-CoV-2 infection on mortality and outcomes in patients admitted for heart failure: a nationwide analysis in Brazil
16/04/26 20:00 from sars-cov-2
CONCLUSION: In-hospital COVID-19 infection significantly worsens outcomes and increases healthcare costs among patients admitted for HF in Brazil. These findings underscore the need for preventive strategies, including vaccination and ti...

» Spreading quality improvement in bronchiolitis care: A qualitative study of barriers and facilitators to de-implementation efforts across Alberta's healthcare settings
16/04/26 20:00 from coronavirus
CONCLUSIONS: Successful de-implementation requires interdisciplinary approaches with supportive leadership and contextually tailored strategies. "One-size-fits-all" models are insufficient; future quality improvement initiatives should b...

» ANCA-Negative Pauci-Immune Necrotizing Glomerulonephritis in the Setting of Multisystem Inflammatory Syndrome in Children
16/04/26 20:00 from sars-cov-2
Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disorder that occurs in previously healthy pediatric patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure or mild infection...

» Long-Term Health and Economic Impacts of COVID-19 Disruptions on Bowel Cancer Inequalities in Victoria, Australia: A Modelling Study
16/04/26 20:00 from coronavirus
CONCLUSION: Our study underscores the significant impact of COVID-19 disruptions on worsening cancer inequalities. Targeted CRC screening interventions are essential to protect vulnerable populations. Enhanced demographic data from scree...

» SKIN AS A POTENTIAL ENTRY POINT FOR SARS-COV-2
16/04/26 20:00 from sars-cov-2
The primary route of SARS-CoV-2 entry is via respiratory epithelium. However, many COVID-19 patients developed dermatological lesions, and SARS-CoV-2 RNA has been detected in the patients' skin. Inflammatory skin diseases, psoriasis and ...

» From extrapolation to evidence: BNT162b2 (Pfizer-BioNTech COVID-19 vaccine) safety and immunogenicity in adolescents with juvenile immune-mediated inflammatory disease
16/04/26 20:00 from covid-19
No abstract

» Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice
16/04/26 20:00 from sars-cov-2
Cognitive impairment is a disabling feature of Long COVID, with data supporting neuroinflammation and maladaptive glial responses as primary drivers. Nasal administration of an anti-CD3 monoclonal antibody (aCD3 mAb) has shown therapeuti...

» High-speed 3D single-virus tracking reveals actin-aided viral trafficking of SARS-CoV-2 on the plasma membrane
16/04/26 20:00 from sars-cov-2
Early interactions between viruses and live cells are difficult to resolve due to rapid extracellular motion, 3D nature of the cell membrane, and the fast, nanoscale interactions involved. While actin is a central regulator of viral entr...

» The Role of Positive Childhood Experiences in Intergenerational Violence and Elder Abuse
16/04/26 20:00 from covid-19
A previous study revealed that individuals with a high number of adverse childhood experiences (ACEs) have an increased risk of perpetrating physical and psychological abuse against older adults (≥65 years). However, whether two types of...

» Reduced COVID-19 severity in Africa: a systematic review of host genetic and immunological responses to SARS-CoV-2 infection
16/04/26 20:00 from sars-cov-2
CONCLUSION: The findings suggest that immune and genetic adaptations in African populations may have modulated susceptibility and severity of SARS-CoV-2 infection outcomes in Africans.

» Associations of COVID-19 history, substance use, and mental illness with mental health treatment utilization in the United States: age and gender differences
16/04/26 20:00 from covid-19
This study examined the associations of COVID-19 history, substance use, and mental health problems with mental health treatment (MHT) utilization among U.S. adults in 2022 and explored age- and gender-related differences in these relati...

» Mapping global evidence on compassion fatigue among healthcare workers during COVID-19: insights and implications for future preparedness - a scoping review
16/04/26 20:00 from covid-19
CONCLUSIONS: Compassion fatigue is a multifactorial, context-dependent hazard disproportionately affecting vulnerable HCWs. Effective mitigation requires longitudinal research, inclusive global representation, and multi-level strategies ...

» Psychological Distress and Presenteeism During the Pandemic Period: A Quantitative Study Among Nurses From Emergency and Critical Care
16/04/26 20:00 from covid-19
CONCLUSIONS: More than one-third of nurses working in ED and ICU settings experienced psychological distress, and a high prevalence of presenteeism was identified. Presenteeism was associated with higher levels of psychological distress.

» Stability analysis and optimal control of the fractional-order SEIQR epidemic model with logistic input
16/04/26 20:00 from covid-19
This article mainly investigates a fractional-order SEIQR model with a logistic input and a saturated incidence rate, and formulates a fractional optimal control problem (FOCP). The nonnegativity of solutions is analyzed, and the existen...

» Correction to 'RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation'
16/04/26 20:00 from covid-19
No abstract

» Perception of Lebanese Obstetricians Toward COVID-19 Vaccination During Pregnancy and Breastfeeding
16/04/26 20:00 from covid-19
CONCLUSIONS: Our results provided an overview of Lebanese obstetricians' attitudes and practices regarding the COVID-19 vaccine and identified some of the factors that hinder the recommendation of the vaccine. Such information might be h...

» Anti-GQ1b-Positive Miller Fisher Syndrome Following Pfizer Bivalent COVID-19 Vaccination
16/04/26 20:00 from covid-19
Miller Fisher syndrome (MFS) is a rare, immune-mediated variant of Guillain-Barré syndrome characterized by acute onset of ataxia, areflexia, and ophthalmoplegia. It typically develops following an antecedent event, such as an infection ...

» Impact of the COVID-19 Pandemic on Coronary Heart Disease Admissions and Mortality in Mexico: An Ecological Study
16/04/26 20:00 from covid-19
CONCLUSION: The COVID-19 pandemic in Mexico was associated with a decline in CHD hospital admissions alongside a significant rise in in-hospital CFR, with segmented regression showing partial recovery following the initial drop, undersco...

» Temporal Trends in Physician Burnout During and After the COVID-19 Pandemic in Japan: A Repeated Cross-Sectional Study
16/04/26 20:00 from covid-19
CONCLUSIONS: Burnout among Japanese internists and primary care physicians declined significantly from the peak of the COVID-19 pandemic to the recovery phase. However, approximately one-quarter of physicians remained affected in 2024.

» Nasotracheal Versus Orotracheal Intubation in Critically Ill COVID-19 Patients: A Retrospective Study
16/04/26 20:00 from covid-19
CONCLUSION: In this retrospective study of patients with severe COVID-19 pneumonia, NTI was associated with reduced sedative, analgesic, and NMBA requirements, a lower risk of tracheotomy, and fewer oral complications, without increasing...

» Sex and racial/ethnic disparities in motor vehicle crash fatalities among U.S. Teens aged 15-19 years, 2015-2023
16/04/26 20:00 from covid-19
INTRODUCTION: Motor vehicle crashes (MVCs) remain the leading cause of injury and death among U.S. teens. Although disparities in crash fatalities by sex and race/ethnicity are well documented, few studies have focused specifically on te...

» Lockdown COVID-19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy
16/04/26 20:00 from covid-19
CONCLUSION: The pandemic did not induce diagnosis-specific increases in acute psychiatric admissions but substantially altered their temporal organization. Differences across countries highlight how healthcare structure-particularly the ...

» Clinical characteristics and etiological analysis of deep fungal infections in a general hospital in Southwest China (2020-2024)
16/04/26 20:00 from covid-19
CONCLUSIONS: Compared with earlier research (2015-2019), the number of deep fungal infection cases from 2020 to 2024 has shown a significant and sustained increase. Moreover, the threat posed by Aspergillus and Cryptococcus has increased...

» Respiratory viruses as key drivers of pulmonary fibrosis: integrated pathways from barrier injury to immune-fibrotic crosstalk
16/04/26 20:00 from coronavirus
Pulmonary fibrosis (PF), a highly heterogeneous form of interstitial lung disease, presents substantial challenges for both basic research and clinical management due to its complex pathogenesis and poor clinical outcomes. In recent year...

» Distinct plasma cytokine and chemokine profiles in severe COVID-19 and septic shock
16/04/26 20:00 from coronavirus
CONCLUSION: At day 7 after diagnosis, both groups exhibited active proinflammatory responses, but only the sepsis group showed prominent anti-inflammatory responses. The persistent elevation of GM-CSF in the COVID-19 group, even with ste...

» Covalent conjugation of TLR9 agonists to phospholipids enhances mRNA-LNP delivery efficiency and dendritic cell cross-priming
16/04/26 20:00 from sars-cov-2
Current mRNA-LNP systems face challenges in efficient co-delivery of nucleic acid adjuvants, limiting their capacity to elicit robust cellular immunity. To overcome the dissociation limitations of physically admixed CpG in conventional l...

» Hybrid feature-selection and diversity-guided stacking framework for interpretable ensemble learning: Application to COVID-19 mortality prediction
16/04/26 20:00 from coronavirus
CONCLUSIONS: The hybrid feature-selection and diversity-guided stacking framework improves predictive accuracy and interpretability while maintaining computational efficiency. Although validated using COVID-19 mortality data, the approac...

» Mapping the evidence: a scoping review of the impact of COVID-19 on non-communicable disease care in Sub-Saharan Africa
16/04/26 20:00 from Covid-19 origins
Non-communicable diseases (NCDs) are the leading cause of mortality globally and account for a growing proportion of the disease burden in sub-Saharan Africa (SSA), where health systems face significant resource constraints. The COVID-19...

» COVID-19 in hemodialysis patients: New insights into metabolomic profile dynamics from 60 days pre- to 60 days post-diagnosis
16/04/26 20:00 from coronavirus
CONCLUSIONS: These findings suggest that early metabolic changes before COVID-19 diagnosis may be detected in routine serum samples, offering opportunities to develop predictive models for early detection. Identifying these unique metabo...

» Building resilient and self-reliant systems for health for migrants and refugees in crisis-prone areas: lessons from the Thai-Myanmar border
16/04/26 20:00 from covid-19
Migrants and other vulnerable populations remain insufficiently integrated into health security preparedness and universal health coverage (UHC) in the Asia-Pacific region. Following the COVID-19 pandemic, which disproportionately affect...

» Genetic polymorphisms and expression of SARS-CoV-2 host entry genes associate with COVID-19 severity in an unvaccinated Moroccan cohort
16/04/26 20:00 from sars-cov-2
No abstract

» New transcription signals in SARS-CoV-2 reshape virus-host interactions
16/04/26 20:00 from coronavirus
Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blo...

» COVID-19 vaccination hesitancy in pediatrics: a systematic review
16/04/26 20:00 from covid-19
CONCLUSION: The study points to interventions for reversing parental hesitation towards pediatric COVID-19 vaccination, like tailored education programs, streamlining distribution procedures, creating public acceptance through local comm...

» Designing effective SARS-CoV-2 wastewater surveillance system: lessons learnt from sustained monitoring in Delhi, India
16/04/26 20:00 from sars-cov-2
No abstract

» Autopsy findings in COVID-19-related deaths in forensic practice - analysis of 184 cases
16/04/26 20:00 from coronavirus
COVID-19, caused by the SARS-CoV-2 virus, has posed a major burden on both healthcare systems and society, while autopsies provide insight into the mechanisms of death, the extent of organ involvement, and the true contribution of infect...

» Covalent conjugation of TLR9 agonists to phospholipids enhances mRNA-LNP delivery efficiency and dendritic cell cross-priming
16/04/26 20:00 from covid-19
Current mRNA-LNP systems face challenges in efficient co-delivery of nucleic acid adjuvants, limiting their capacity to elicit robust cellular immunity. To overcome the dissociation limitations of physically admixed CpG in conventional l...

» COVID-19 and risk of first-time major depressive disorder in patients without history of psychiatric disorders
16/04/26 20:00 from sars-cov-2
No abstract

» Adolescent Cannabis Use After Cannabis Legalization and the COVID-19 Pandemic
16/04/26 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this large, retrospective cross-sectional study, adolescent cannabis use increased following RCL and decreased following the COVID-19 pandemic, returning to prelegalization rates by 2024. These results have ...

» Why organizations forget or retain lessons learned from a crisis over time: tracking COVID-19 lessons in an academic hospital in the Netherlands
16/04/26 20:00 from covid-19
No abstract

» Viral variant but not host factors associate with SARS-CoV-2 viral kinetics
16/04/26 20:00 from sars-cov-2
CONCLUSIONS: Altogether, our work shows that observed peak VL and shedding duration should be cautiously interpreted as predictors of viral fitness.

» A novel TaqMan-based RT-qPCR assay for the detection of PEDV and discrimination of the G2c subtype
16/04/26 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) G2c subtype has emerged as an increasingly prevalent variant causing widespread epidemic, high mortality and severe economic losses in the Chinese swine industry. The lack of specific and efficient ...

» Genetic polymorphisms and expression of SARS-CoV-2 host entry genes associate with COVID-19 severity in an unvaccinated Moroccan cohort
16/04/26 20:00 from covid-19
No abstract

» Distinct plasma proteome signature at 3 months post-COVID-19 infection irrespective of post-COVID condition
16/04/26 20:00 from sars-cov-2
Persistent symptoms following SARS-CoV-2 infection are the hallmark of post-COVID condition (PCC), also referred to as long COVID. However, the underlying molecular mechanisms remain poorly understood. In this study, we employed data-ind...

» Effectiveness of oral antivirals in reducing adverse outcomes in asthmatic patients with non-severe COVID-19: A multi-institutional retrospective cohort study
16/04/26 20:00 from coronavirus
Preventing the progression of coronavirus disease 2019 (COVID-19) is a critical issue, particularly in patients with comorbidities such as asthma. However, real-world data on the effectiveness of oral antivirals in patients with asthma a...

» A novel TaqMan-based RT-qPCR assay for the detection of PEDV and discrimination of the G2c subtype
16/04/26 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) G2c subtype has emerged as an increasingly prevalent variant causing widespread epidemic, high mortality and severe economic losses in the Chinese swine industry. The lack of specific and efficient ...

» Regional and temporal trends in workplace violence and presenteeism among healthcare professionals: a comparative analysis of Europe and South Korea during the COVID-19 pandemic
16/04/26 20:00 from covid-19
No abstract

» Target Trial Emulation of Vaccine Effectiveness in 5- to 17-years-olds with Prior SARS-CoV-2 Infection
16/04/26 20:00 from sars-cov-2
The effectiveness of COVID-19 vaccination in children and adolescents with prior SARS-CoV-2 infection remains unclear, particularly for Omicron subvariants. We evaluate vaccine effectiveness against reinfection with Omicron BA.1/BA.2, BA...

» "You Could Have Prevented It!": attributions of responsibility toward COVID-19 unvaccinated vs. vaccinated individuals
16/04/26 20:00 from covid-19
No abstract

» The immune response of the mRNA vaccine CS-2034 as a heterologous booster before and after breakthrough infection: A follow-up study
16/04/26 20:00 from sars-cov-2
CONCLUSIONS: mRNA vaccines induce stronger neutralizing antibodies and broader immunity than inactivated vaccines. Breakthrough infections boost antibody levels more in mRNA recipients than in inactivated vaccine recipients. Antibody dec...

» Designing effective SARS-CoV-2 wastewater surveillance system: lessons learnt from sustained monitoring in Delhi, India
16/04/26 20:00 from covid-19
No abstract

» Differential outcomes of viral co-infections with high pathogenicity avian influenza A(H5N6) and SARS-CoV-2 in mammalian in vitro systems
16/04/26 20:00 from sars-cov-2
Co-infection with two highly pathogenic viruses is often expected to worsen disease severity. However, increasing evidence suggests that viral interactions can be antagonistic, with one virus suppressing the other. In this study, we used...

» COVID-19 and risk of first-time major depressive disorder in patients without history of psychiatric disorders
16/04/26 20:00 from covid-19
No abstract

» Respiratory viruses as key drivers of pulmonary fibrosis: integrated pathways from barrier injury to immune-fibrotic crosstalk
16/04/26 20:00 from sars-cov-2
Pulmonary fibrosis (PF), a highly heterogeneous form of interstitial lung disease, presents substantial challenges for both basic research and clinical management due to its complex pathogenesis and poor clinical outcomes. In recent year...

» Associations between Vicarious Anti-Black and Anti-Asian Racism and Sleep in Black, Asian, and White Young Adults during the COVID-19 Pandemic
16/04/26 20:00 from covid-19
No abstract

» Age-dependent clinical and molecular rhinovirus epidemiology, 2018 to 2023
16/04/26 20:00 from sars-cov-2
CONCLUSIONS: The circulation of rhinoviruses is predominant in children throughout the year. Their peaks are caused by high genotypic diversity. The SARS-CoV-2 pandemic had an impact on the circulation of rhinoviruses, but to a lesser ex...

» Viral variant but not host factors associate with SARS-CoV-2 viral kinetics
16/04/26 20:00 from covid-19
CONCLUSIONS: Altogether, our work shows that observed peak VL and shedding duration should be cautiously interpreted as predictors of viral fitness.

» Distinct plasma cytokine and chemokine profiles in severe COVID-19 and septic shock
16/04/26 20:00 from sars-cov-2
CONCLUSION: At day 7 after diagnosis, both groups exhibited active proinflammatory responses, but only the sepsis group showed prominent anti-inflammatory responses. The persistent elevation of GM-CSF in the COVID-19 group, even with ste...

» Covalent conjugation of TLR9 agonists to phospholipids enhances mRNA-LNP delivery efficiency and dendritic cell cross-priming
16/04/26 20:00 from sars-cov-2 spike protein
Current mRNA-LNP systems face challenges in efficient co-delivery of nucleic acid adjuvants, limiting their capacity to elicit robust cellular immunity. To overcome the dissociation limitations of physically admixed CpG in conventional l...

» Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy
16/04/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: The pandemic did not induce diagnosis-specific increases in acute psychiatric admissions but substantially altered their temporal organization. Differences across countries highlight how healthcare structure-particularly the ...

» Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development
15/04/26 20:00 from sars-cov-2 spike protein
CONCLUSIONS: SARS-CoV-2 SP drives lung injury, fibrosis, and tumorigenesis through a TYMP-dependent mechanism involving STAT3 signaling and inflammatory microenvironment remodeling. COVID-19 significantly increases lung cancer risk, espe...

» Identifying context-specific community understanding of COVID-19 and mental health in Haiti, Malawi, and Rwanda
15/04/26 20:00 from sars-cov-2
CONCLUSION: CHWs have substantial gaps in information about COVID-19 and mental health. Knowledge of areas of misinformation can differ between countries. Constructing country-specific educational messages to address these areas can bett...

» Identifying context-specific community understanding of COVID-19 and mental health in Haiti, Malawi, and Rwanda
15/04/26 20:00 from coronavirus
CONCLUSION: CHWs have substantial gaps in information about COVID-19 and mental health. Knowledge of areas of misinformation can differ between countries. Constructing country-specific educational messages to address these areas can bett...

» Beyond Predestined Failure: Reassessing Structural Determinism in South Korea's COVID-19 Response
15/04/26 20:00 from covid-19
This letter responds to "The Predestined Failure of the Market Mechanism." While ambitious, its structurally determinist framing underplays the role of government policy discretion. The central thesis risks creating a tautological argume...

» COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants
15/04/26 20:00 from sars-cov-2
CONCLUSION: Although willingness to use COVID-19 antivirals was relatively high among diverse essential workers with risk factors for severe COVID-19, there was variation based on demographic and health factors. This study identifies key...

» Case Report: COVID-19 unmasks factor H mutation-driven hemolytic uremic syndrome in a previously undiagnosed septuagenarian kidney transplant recipient
15/04/26 20:00 from Covid-19 origins
Thrombotic microangiopathy (TMA) after kidney transplantation presents a significant diagnostic and therapeutic challenge. Complement-mediated thrombotic microangiopathy (CM-TMA), caused by dysregulation of the alternative complement pat...

» Fuimos olvidados y descuidados [Forgotten and Neglected]: Lessons Learned and Findings From On-Farm COVID-19 Education and Vaccine Clinics for Agricultural Workers and Their Multigenerational Families in Texas
15/04/26 20:00 from covid-19
CONCLUSION/APPLICATION TO PRACTICE: Over $4.5 million in grant monies were leveraged to help advocate for agricultural worker health, safety, and well-being as well as their multigenerational households in rural Texas. This report unders...

» Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development
15/04/26 20:00 from sars-cov-2
CONCLUSIONS: SARS-CoV-2 SP drives lung injury, fibrosis, and tumorigenesis through a TYMP-dependent mechanism involving STAT3 signaling and inflammatory microenvironment remodeling. COVID-19 significantly increases lung cancer risk, espe...

» Sequential Extracorporeal Organ Support in Refractory Septic Shock: A Novel Combo Approach with Complete Recovery: A Case Report and Literature Review
15/04/26 20:00 from coronavirus
CONCLUSION: This case report demonstrates how coordinated extracorporeal organ support can produce beneficial effects in patients with refractory septic shock. The combined treatment provided renal, respiratory, and immunologic support t...

» Identifying context-specific community understanding of COVID-19 and mental health in Haiti, Malawi, and Rwanda
15/04/26 20:00 from covid-19
CONCLUSION: CHWs have substantial gaps in information about COVID-19 and mental health. Knowledge of areas of misinformation can differ between countries. Constructing country-specific educational messages to address these areas can bett...

» Real-world immune dynamics following COVID-19 vaccination and breakthrough infection: a paired-sample study in Zhejiang Province, China
15/04/26 20:00 from sars-cov-2
CONCLUSION: This paired-sample, population-based study suggests that BTI may further enhance humoral responses and be accompanied by changes in inflammatory/immunoregulatory markers on top of prior vaccine-induced immunity, while reducin...

» The evolving global burden of asthma among children and adolescents, 1990-2040: trends, disparities, and future projections based on Global Burden of Disease (GBD) 2021
15/04/26 20:00 from coronavirus
CONCLUSIONS: The global burden of asthma among children and adolescents has declined, but regional, sex, and age disparities persist. These findings highlight the need for targeted healthcare strategies and policies that address age, gen...

» Effect of Austerity Measures on Infant Mortality: Evidence From Greece
15/04/26 20:00 from covid-19
Governments frequently adopt austerity policies when facing economic crises, yet their long-term consequences for population health remain incompletely understood. This paper examines the impact of large-scale fiscal austerity on infant ...

» Knowledge, Attitude, and Perception of Urban Indian population towards Corona Virus Vaccination
15/04/26 20:00 from sars-cov-2
CONCLUSION: The study confirmed that participants had reasonable knowledge and favorable attitudes and perceptions regarding COVID-19 vaccination. Nevertheless, misinformation and unverified content on social media contributed to hesitan...

» Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development
15/04/26 20:00 from coronavirus
CONCLUSIONS: SARS-CoV-2 SP drives lung injury, fibrosis, and tumorigenesis through a TYMP-dependent mechanism involving STAT3 signaling and inflammatory microenvironment remodeling. COVID-19 significantly increases lung cancer risk, espe...

» Long-term trajectories of reproductive and pituitary-adrenal-thyroid hormones in young males following Omicron BA.2 infection: a two-year prospective cohort study
15/04/26 20:00 from sars-cov-2
CONCLUSION: Among young males, testosterone remained robustly stable over two years following Omicron BA.2 infection, while other endocrine markers displayed measurable longitudinal dynamics relative to the 3-month post-infection convale...

» Real-world immune dynamics following COVID-19 vaccination and breakthrough infection: a paired-sample study in Zhejiang Province, China
15/04/26 20:00 from coronavirus
CONCLUSION: This paired-sample, population-based study suggests that BTI may further enhance humoral responses and be accompanied by changes in inflammatory/immunoregulatory markers on top of prior vaccine-induced immunity, while reducin...

» Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review
15/04/26 20:00 from sars-cov-2
No abstract

» Testosterone protects from metabolic syndrome-associated lung dysfunction in a high-fat diet rabbit model
15/04/26 20:00 from covid-19
Metabolic syndrome (MetS), including obesity, dyslipidemia, hypertension, insulin resistance, and often testosterone (T) deficiency, is increasingly linked to impaired lung function, worsened by systemic inflammation. COVID-19 highlighte...

» Knowledge, Attitude, and Perception of Urban Indian population towards Corona Virus Vaccination
15/04/26 20:00 from coronavirus
CONCLUSION: The study confirmed that participants had reasonable knowledge and favorable attitudes and perceptions regarding COVID-19 vaccination. Nevertheless, misinformation and unverified content on social media contributed to hesitan...

» Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children
15/04/26 20:00 from sars-cov-2
CONCLUSIONS: Our findings highlight the time-dependent nature of correlates of protection, emphasizing the need for employing mathematical models to reinforce the accuracy and reliability of clinical analysis so as to prevent overrelianc...

» An Autopsy Case of a Patient With Corticobasal Degeneration and a History of Acute Restlessness and Stupor
15/04/26 20:00 from covid-19
Some patients with corticobasal degeneration (CBD) present with neuropsychiatric symptoms, including frontal lobe symptoms. However, stupor is rarely reported. Here, we report a case of acute restlessness at onset, which was clinically d...

» Long-term trajectories of reproductive and pituitary-adrenal-thyroid hormones in young males following Omicron BA.2 infection: a two-year prospective cohort study
15/04/26 20:00 from coronavirus
CONCLUSION: Among young males, testosterone remained robustly stable over two years following Omicron BA.2 infection, while other endocrine markers displayed measurable longitudinal dynamics relative to the 3-month post-infection convale...

» Trust, Transparency, and the Fragile Promise of Data Governance in the Era of Modernization
15/04/26 20:00 from sars-cov-2
Public health data modernization in the United States has accelerated since COVID-19 exposed systemic weaknesses in fragmented data infrastructure and governance. Technical solutions have advanced, but legal and relational barriers still...

» Psychosocial risks in Latin America: trends and research gaps
15/04/26 20:00 from covid-19
This study analyzes the scientific evolution of psychosocial risks in Latin America through a bibliometric analysis of 1,866 articles indexed in Scopus and Web of Science between 1963 and 2026. The results show sustained growth in academ...

» Analysis of COVID-19-Related Influencing Variables and Post-Traumatic Growth Differences Depending on the Type of Depressive Symptoms Using Latent Profile Analysis
15/04/26 20:00 from coronavirus
CONCLUSION: Considering the identified predictors, effective strategies need to be established to prevent the aggravation of depressive symptoms and to provide adequate interventions.

» Accelerated Increase in Candida auris Bloodstream Infections during COVID-19 Pandemic, South Africa
15/04/26 20:00 from sars-cov-2
The COVID-19 pandemic coincided with rising secondary bloodstream infections (BSIs) from multidrug-resistant organisms, including Candida auris. To assess candidemia trends, we conducted a retrospective analysis of blood culture isolates...

» Commentary: 1-year risks of cancers associated with COVID-19 vaccination: a large population-based cohort study in South Korea
15/04/26 20:00 from covid-19
No abstract

» Neurological manifestations of respiratory viral infections
15/04/26 20:00 from coronavirus
PURPOSE OF REVIEW: This review summarizes current evidence on the general epidemiology, routes of central nervous system (CNS) invasion, clinical manifestations, diagnostic approaches, and treatment considerations associated with neurolo...

» Trends and age-period-cohort analysis of bacteriologically confirmed pulmonary tuberculosis: a population-based study in Hunan Province, China, 2009-2023
15/04/26 20:00 from covid-19
CONCLUSION: APC analysis of bacteriologically confirmed PTB in Hunan Province showed a shifting epidemiology. These findings suggest that tuberculosis control efforts should prioritize the increasing burden in older adults and closely mo...

» Sequential Extracorporeal Organ Support in Refractory Septic Shock: A Novel Combo Approach with Complete Recovery: A Case Report and Literature Review
15/04/26 20:00 from covid-19
CONCLUSION: This case report demonstrates how coordinated extracorporeal organ support can produce beneficial effects in patients with refractory septic shock. The combined treatment provided renal, respiratory, and immunologic support t...

» Trust, Transparency, and the Fragile Promise of Data Governance in the Era of Modernization
15/04/26 20:00 from coronavirus
Public health data modernization in the United States has accelerated since COVID-19 exposed systemic weaknesses in fragmented data infrastructure and governance. Technical solutions have advanced, but legal and relational barriers still...

» COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants
15/04/26 20:00 from covid-19
CONCLUSION: Although willingness to use COVID-19 antivirals was relatively high among diverse essential workers with risk factors for severe COVID-19, there was variation based on demographic and health factors. This study identifies key...

» Accelerated Increase in Candida auris Bloodstream Infections during COVID-19 Pandemic, South Africa
15/04/26 20:00 from coronavirus
The COVID-19 pandemic coincided with rising secondary bloodstream infections (BSIs) from multidrug-resistant organisms, including Candida auris. To assess candidemia trends, we conducted a retrospective analysis of blood culture isolates...

» A Scoping Review Protocol of Lung Ultrasound in Pediatric COVID-19: Clinical Utility and Lessons for Future Pandemics
15/04/26 20:00 from covid-19
CONCLUSION: This review will provide a comprehensive overview of LUS use in pediatric COVID-19, supporting its integration into clinical practice and informing preparedness for future respiratory outbreaks.

» The evolving global burden of asthma among children and adolescents, 1990-2040: trends, disparities, and future projections based on Global Burden of Disease (GBD) 2021
15/04/26 20:00 from covid-19
CONCLUSIONS: The global burden of asthma among children and adolescents has declined, but regional, sex, and age disparities persist. These findings highlight the need for targeted healthcare strategies and policies that address age, gen...

» Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development
15/04/26 20:00 from covid-19
CONCLUSIONS: SARS-CoV-2 SP drives lung injury, fibrosis, and tumorigenesis through a TYMP-dependent mechanism involving STAT3 signaling and inflammatory microenvironment remodeling. COVID-19 significantly increases lung cancer risk, espe...

» Real-world immune dynamics following COVID-19 vaccination and breakthrough infection: a paired-sample study in Zhejiang Province, China
15/04/26 20:00 from covid-19
CONCLUSION: This paired-sample, population-based study suggests that BTI may further enhance humoral responses and be accompanied by changes in inflammatory/immunoregulatory markers on top of prior vaccine-induced immunity, while reducin...

» Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review
15/04/26 20:00 from sars-cov-2
No abstract

» Long-term trajectories of reproductive and pituitary-adrenal-thyroid hormones in young males following Omicron BA.2 infection: a two-year prospective cohort study
15/04/26 20:00 from coronavirus
CONCLUSION: Among young males, testosterone remained robustly stable over two years following Omicron BA.2 infection, while other endocrine markers displayed measurable longitudinal dynamics relative to the 3-month post-infection convale...

» Commentary: 1-year risks of cancers associated with COVID-19 vaccination: a large population-based cohort study in South Korea
15/04/26 20:00 from covid-19
No abstract

» Sequential Extracorporeal Organ Support in Refractory Septic Shock: A Novel Combo Approach with Complete Recovery: A Case Report and Literature Review
15/04/26 20:00 from covid-19
CONCLUSION: This case report demonstrates how coordinated extracorporeal organ support can produce beneficial effects in patients with refractory septic shock. The combined treatment provided renal, respiratory, and immunologic support t...

» COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants
15/04/26 20:00 from covid-19
CONCLUSION: Although willingness to use COVID-19 antivirals was relatively high among diverse essential workers with risk factors for severe COVID-19, there was variation based on demographic and health factors. This study identifies key...

» The evolving global burden of asthma among children and adolescents, 1990-2040: trends, disparities, and future projections based on Global Burden of Disease (GBD) 2021
15/04/26 20:00 from covid-19
CONCLUSIONS: The global burden of asthma among children and adolescents has declined, but regional, sex, and age disparities persist. These findings highlight the need for targeted healthcare strategies and policies that address age, gen...

» Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review
15/04/26 20:00 from sars-cov-2
No abstract

» Long-term trajectories of reproductive and pituitary-adrenal-thyroid hormones in young males following Omicron BA.2 infection: a two-year prospective cohort study
15/04/26 20:00 from coronavirus
CONCLUSION: Among young males, testosterone remained robustly stable over two years following Omicron BA.2 infection, while other endocrine markers displayed measurable longitudinal dynamics relative to the 3-month post-infection convale...

» Commentary: 1-year risks of cancers associated with COVID-19 vaccination: a large population-based cohort study in South Korea
15/04/26 20:00 from covid-19
No abstract

» Sequential Extracorporeal Organ Support in Refractory Septic Shock: A Novel Combo Approach with Complete Recovery: A Case Report and Literature Review
15/04/26 20:00 from covid-19
CONCLUSION: This case report demonstrates how coordinated extracorporeal organ support can produce beneficial effects in patients with refractory septic shock. The combined treatment provided renal, respiratory, and immunologic support t...

» COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants
15/04/26 20:00 from covid-19
CONCLUSION: Although willingness to use COVID-19 antivirals was relatively high among diverse essential workers with risk factors for severe COVID-19, there was variation based on demographic and health factors. This study identifies key...

» The evolving global burden of asthma among children and adolescents, 1990-2040: trends, disparities, and future projections based on Global Burden of Disease (GBD) 2021
15/04/26 20:00 from covid-19
CONCLUSIONS: The global burden of asthma among children and adolescents has declined, but regional, sex, and age disparities persist. These findings highlight the need for targeted healthcare strategies and policies that address age, gen...

» Post-COVID: An inventory focusing on the key complaints PEM and POTS
15/04/26 20:00 from Coronavirus origins
CONCLUSIONS: Post-exertional malaise and postural tachycardia syndrome are typical and characteristic post-COVID symptoms. Current scientific findings underscore the SARS-CoV-2-related organic origin of post-COVID symptoms.

» Post-COVID: An inventory focusing on the key complaints PEM and POTS
15/04/26 20:00 from Sars-Cov-2 origins
CONCLUSIONS: Post-exertional malaise and postural tachycardia syndrome are typical and characteristic post-COVID symptoms. Current scientific findings underscore the SARS-CoV-2-related organic origin of post-COVID symptoms.

» Mental and physical health differences between youth infected and uninfected by SARS-CoV-2: data from 2021 to 2023
15/04/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Baseline data from a large cohort study indicate that the physical functioning of youth infected with SARS-CoV-2 was worse than that of uninfected youth, but mental health concerns were comparable. Data may reflect the direc...

» Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensors
15/04/26 20:00 from covid-19 and viral hemorrhagic fevers
The Dengue virus (DENV) like many other RNA viruses exhibits high genome sequence diversity. This poses a challenge to nucleic acid-based diagnostics, rendering them inefficient at detecting the diverse DENV strains circulating in a popu...

» Comparison of lymphocyte populations, cytokine, and autoantibody profile in patients with rheumatoid arthritis: a study of cases with COVID-19 and controls without COVID-19
15/04/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Long-term follow-up did not demonstrate statistically significant alterations in the immunological profile of RA patients with SARS-CoV-2 infection. Nevertheless, further prospective studies are required to elucidate potenti...

» Post-COVID: An inventory focusing on the key complaints PEM and POTS
15/04/26 20:00 from Covid-19 origins
CONCLUSIONS: Post-exertional malaise and postural tachycardia syndrome are typical and characteristic post-COVID symptoms. Current scientific findings underscore the SARS-CoV-2-related organic origin of post-COVID symptoms.

» Longitudinal stability of cognitive impairments in post-COVID-19 syndrome assessed with the tablet-based Oxford Cognitive Screen-Plus
15/04/26 20:00 from coronavirus
In a previous cross-sectional study using the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus), deficits in delayed memory, attention, and executive functioning were identified in working-age patients with post-COVID-19 syndrome (PCS...

» Longitudinal evaluation of neurocognitive outcomes in a cohort with persistent post-COVID olfactory dysfunction
15/04/26 20:00 from coronavirus
Persistent COVID-19-associated olfactory dysfunction (C19OD), along with other neurologic and cognitive deficits are common features of long COVID. This study aims to evaluate longitudinal trends in neurocognitive performance within a co...

» Exploring the Association Between Lipid-Lowering Medications and Dry Eye Disease in COVID-19 Patients
14/04/26 20:00 from coronavirus
CONCLUSION: Statin use is inversely associated with the development of DED in SARS-CoV-2 hospitalized patients. The anti-inflammatory and cholesterol-lowering effects of statins provide a robust framework for understanding the underlying...

» A Rare Case of Pulmonary Ossification Findings That Rapidly Progressed and Improved During the Course of COVID-19 Pneumonia
14/04/26 20:00 from coronavirus
An 88-year-old man with a history of myocardial infarction, non-valvular atrial fibrillation and hypothyroidism was admitted to our hospital with a diagnosis of coronavirus disease. On admission, he had hypoxemia, with peripheral blood o...

» Assessing a facilitated social network intervention for health outcomes in lonely and socially isolated people: the pragmatic, cluster-randomized PALS trial
14/04/26 20:00 from coronavirus
INTRODUCTION: Loneliness has received attention in recent years as an important public health issue due to its associations with poorer mental and physical health. This study aimed to assess the effectiveness and cost-effectiveness of a ...

» Isolation, identification and pathogenicity analysis of BCoV epidemic strains in Xinjiang
14/04/26 20:00 from coronavirus
Bovine coronavirus (BCoV) causes diarrhea in calves, winter dysentery in adult cattle, and respiratory diseases, posing a significant threat to the cattle industry. In this study, a BCoV strain was isolated from intestinal lymph node tis...

» A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation
14/04/26 20:00 from Cell entry mechanisms of SARS-CoV-2
The SARS-CoV-2 spike protein binds its receptor ACE2 to initiate target-cell infection. To engage ACE2, at least one of the three receptor-binding domains (RBDs) of the spike must adopt the up orientation. Here we describe S22, a potent,...

» A needle-free intradermal PEDV S protein vaccine elicits protective lactogenic immunity in piglets
14/04/26 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with genotype II (GII) strains causing nearly 100% mortality in neonatal piglets. Current vaccination strategies and biosafety control measures p...

» Clinical Predictors of Weaning Failure and Mortality in Individuals With COVID-19 Undergoing Invasive Mechanical Ventilation: A Retrospective Cohort Study
14/04/26 20:00 from coronavirus
CONCLUSION: Advanced age, the length of hospitalization, prolonged IMV duration, and compromised respiratory mechanics were the predictors of WF. Furthermore, individuals who experienced WF presented a higher mortality rate compared with...

» Overcoming Barriers to One Health Surveillance Implementation
14/04/26 20:00 from Covid-19 origins
The zoonotic origin of the COVID-19 pandemic renewed calls for establishing and improving One Health surveillance capabilities globally, yet a lack of universally recognized best practices and clear guidance on how to implement coordinat...

» Epidemiological Changes in Mycoplasma pneumoniae Infections in Children and Adolescents Before and After COVID-19: A Systematic Review and Meta-Analysis
14/04/26 20:00 from coronavirus
Mycoplasma pneumoniae (M. pneumoniae) is a major cause of respiratory tract infections in children and adolescents, yet its epidemiological burden before, during, and after the COVID-19 pandemic remains unclear. This meta-analysis, which...

» Burden and Characteristics of Respiratory Syncytial Virus-Associated Bronchiolitis in Hospitalized Infants in Italy: A Systematic Review
14/04/26 20:00 from coronavirus
CONCLUSIONS: Nationwide RSV immunization programmes and improved diagnostics are crucial to ease the strain on pediatric intensive care units. Recent recommendations for widespread RSV long-acting monoclonal antibody use in infants offer...

» Decoding NK Cell Subset Dysregulation in SARS-CoV-2 Infection: Phenotypic, Functional, and Transcriptomic Insights Into COVID-19 Pathogenesis
14/04/26 20:00 from coronavirus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects innate immune responses, particularly those of natural killer (NK) cells, which play an important role in antiviral defence. This review combine...

» Exploring the Association Between Lipid-Lowering Medications and Dry Eye Disease in COVID-19 Patients
14/04/26 20:00 from sars-cov-2
CONCLUSION: Statin use is inversely associated with the development of DED in SARS-CoV-2 hospitalized patients. The anti-inflammatory and cholesterol-lowering effects of statins provide a robust framework for understanding the underlying...

» A needle-free intradermal PEDV S protein vaccine elicits protective lactogenic immunity in piglets
14/04/26 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with genotype II (GII) strains causing nearly 100% mortality in neonatal piglets. Current vaccination strategies and biosafety control measures p...

» Exploring the Association Between Lipid-Lowering Medications and Dry Eye Disease in COVID-19 Patients
14/04/26 20:00 from covid-19
CONCLUSION: Statin use is inversely associated with the development of DED in SARS-CoV-2 hospitalized patients. The anti-inflammatory and cholesterol-lowering effects of statins provide a robust framework for understanding the underlying...

» A Rare Case of Pulmonary Ossification Findings That Rapidly Progressed and Improved During the Course of COVID-19 Pneumonia
14/04/26 20:00 from covid-19
An 88-year-old man with a history of myocardial infarction, non-valvular atrial fibrillation and hypothyroidism was admitted to our hospital with a diagnosis of coronavirus disease. On admission, he had hypoxemia, with peripheral blood o...

» Ugi-Tetrazole-Derived alpha-Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV-2 3CLpro
14/04/26 20:00 from sars-cov-2
The SARS-CoV-2 main protease (3CLpro) is a well-validated target for structure-guided inhibitor discovery. Here, we report α-aminomethyl tetrazole inhibitors accessed via the Ugi tetrazole multicomponent reaction (UT-4CR), enabling rapid...

» Rehabilitation assistive technology transfer in the AI era: network dynamics and public health impacts in the Yangtze River Delta, China
14/04/26 20:00 from covid-19
Against the backdrop of rapid global advances in artificial intelligence (AI), growing concerns surrounding public health and stressful environmental conditions, this study examines the Yangtze River Delta (YRD) of China by using social ...

» A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation
14/04/26 20:00 from sars-cov-2
The SARS-CoV-2 spike protein binds its receptor ACE2 to initiate target-cell infection. To engage ACE2, at least one of the three receptor-binding domains (RBDs) of the spike must adopt the up orientation. Here we describe S22, a potent,...

» Assessing a facilitated social network intervention for health outcomes in lonely and socially isolated people: the pragmatic, cluster-randomized PALS trial
14/04/26 20:00 from covid-19
INTRODUCTION: Loneliness has received attention in recent years as an important public health issue due to its associations with poorer mental and physical health. This study aimed to assess the effectiveness and cost-effectiveness of a ...

» Modeling the effects of routine screening for accidental lab-acquired infections on the risk of potential pandemic pathogen escape from high-biosafety research facilities
14/04/26 20:00 from sars-cov-2
INTRODUCTION: Accidental lab-acquired infections (LAIs) risk releasing potential pandemic pathogens from high-biosafety (BSL-3 or BSL-4) research facilities. We constructed a stochastic network infectious disease model to simulate how fo...

» Isolation, identification and pathogenicity analysis of BCoV epidemic strains in Xinjiang
14/04/26 20:00 from covid-19
Bovine coronavirus (BCoV) causes diarrhea in calves, winter dysentery in adult cattle, and respiratory diseases, posing a significant threat to the cattle industry. In this study, a BCoV strain was isolated from intestinal lymph node tis...