» Telehealth in the US for patients with end-stage kidney disease: its utilization and impact on social, economic and health outcomes
17/04/25 20:00 from Coronavirus origins
The use of telehealth in the United States accelerated in 2020 when a coronavirus disease of 2019 (COVID-19) related public health emergency (PHE) was declared. Centers for Medicare and Medicaid Services issued emergency waivers that rel...

» mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients
17/04/25 20:00 from sars-cov-2
CONCLUSION: Overall, a three-dose mRNA-1273 primary series elicited Th-1-biased CD4^(+) T-cell responses among SOTRs that were improved with an additional dose.

» Prevalence and risk factors of depression in rural Chinese hemodialysis patients during the COVID-19 pandemic: a multicenter cross-sectional study
17/04/25 20:00 from covid-19
CONCLUSION: During the COVID-19 pandemic in rural China, mild depression were common among MHD patients. Mandatory behavioral interventions did not contribute to depression, while discomfort during dialysis and infection worry emerged as...

» Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network
17/04/25 20:00 from sars-cov-2
The CEPI-Centralized Laboratory Network (CLN) has significantly contributed to the development of several approved SARS-CoV-2 vaccines by conducting over 70,000 clinical samples for testing from various vaccine developers. A centralized ...

» Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19
17/04/25 20:00 from sars-cov-2
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conduc...

» Lessons learned for preventing health disparities in future pandemics: the role of social vulnerabilities among children diagnosed with severe COVID-19 early in the pandemic
17/04/25 20:00 from sars-cov-2
CONCLUSIONS AND RELEVANCE: The high rates of severe COVID-19 observed in Hispanic children early in the pandemic appeared to be secondary to underlying co-morbidities and social vulnerabilities that may have influenced access to care, su...

» A model based on PT-INR and age serves as a promising predictor for evaluating mortality risk in patients with SARS-CoV-2 infection
17/04/25 20:00 from sars-cov-2
COVID-19 caused by the coronavirus SARS-CoV-2 has resulted in a global pandemic. Considering some patients with COVID-19 rapidly develop respiratory distress and hypoxemia, early assessment of the prognosis for COVID-19 patients is impor...

» Heparan sulfate proteoglycans remodel SARS-CoV-2 spike conformation to allow integrin interaction and infection of endothelial cells
17/04/25 20:00 from sars-cov-2
SARS-CoV-2 infects ACE2-negative primary HL-mECs through the interaction of an RGD motif, included in all spike proteins, up to the Omicron BA.1 subvariant, with α(v)β(3) integrin. Following its entry, SARS-CoV-2 remodels ECs phenotype a...

» Effects of COVID-19 pandemic on management of patients with chronic pain
17/04/25 20:00 from coronavirus
CONCLUSION: There is an urgent need to develop various training programs for health-care providers and patients to have better utilization of resources to provide uninterrupted and safe treatment services for chronic pain patients during...

» Effects of COVID-19 pandemic on management of patients with chronic pain
17/04/25 20:00 from covid-19
CONCLUSION: There is an urgent need to develop various training programs for health-care providers and patients to have better utilization of resources to provide uninterrupted and safe treatment services for chronic pain patients during...

» Phospholipid scramblase 1: a frontline defense against viral infections
17/04/25 20:00 from sars-cov-2
Phospholipid scramblase 1 (PLSCR1) is the most studied member of the phospholipid scramblase protein family. Its main function is to catalyze calcium (Ca^(2+))-dependent, ATP-independent, bidirectional and non-specific translocation of p...

» Validation of the Zwolle Risk Score in STEMI Patients Undergoing Primary PCI: Insights from the ISCAS-STEMI COVID-19 Registry
17/04/25 20:00 from sars-cov-2
CONCLUSION: This study is the first to demonstrate the good prognostic performance of the ZRS in a large-scale contemporary global multicenter validation set. Similar results were obtained both in the pre-pandemic and the COVID-19 era. Z...

» Tele-exercise in individuals with spinal cord injury: a systematic review
17/04/25 20:00 from covid-19
CONCLUSIONS: Tele-exercise interventions, predominantly utilizing synchronous methods and emphasizing muscle strength and aerobic training, are effective and feasible for individuals with SCI. These interventions contribute to improved h...

» Tele-exercise in individuals with spinal cord injury: a systematic review
17/04/25 20:00 from coronavirus
CONCLUSIONS: Tele-exercise interventions, predominantly utilizing synchronous methods and emphasizing muscle strength and aerobic training, are effective and feasible for individuals with SCI. These interventions contribute to improved h...

» Telehealth in the US for patients with end-stage kidney disease: its utilization and impact on social, economic and health outcomes
17/04/25 20:00 from Covid-19 origins
The use of telehealth in the United States accelerated in 2020 when a coronavirus disease of 2019 (COVID-19) related public health emergency (PHE) was declared. Centers for Medicare and Medicaid Services issued emergency waivers that rel...

» Telehealth in the US for patients with end-stage kidney disease: its utilization and impact on social, economic and health outcomes
17/04/25 20:00 from covid-19
The use of telehealth in the United States accelerated in 2020 when a coronavirus disease of 2019 (COVID-19) related public health emergency (PHE) was declared. Centers for Medicare and Medicaid Services issued emergency waivers that rel...

» A Transformer-Based Framework for Counterfactual Estimation of Antihypertensive Treatment Effect on COVID-19 Infection Risk - A Proof-of-Concept Study
17/04/25 20:00 from sars-cov-2
CONCLUSIONS: ACEIs do not substantially increase the risk of COVID-19 infection while the protective effects of BBs and CCBs warrant further investigation. This study highlights the potential of transformer-based causal inference models ...

» Telehealth in the US for patients with end-stage kidney disease: its utilization and impact on social, economic and health outcomes
17/04/25 20:00 from coronavirus
The use of telehealth in the United States accelerated in 2020 when a coronavirus disease of 2019 (COVID-19) related public health emergency (PHE) was declared. Centers for Medicare and Medicaid Services issued emergency waivers that rel...

» mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients
17/04/25 20:00 from sars-cov-2 spike protein
CONCLUSION: Overall, a three-dose mRNA-1273 primary series elicited Th-1-biased CD4^(+) T-cell responses among SOTRs that were improved with an additional dose.

» Variation in subsequent viral load testing and outcomes by visit type patterns in the first year of the COVID-19 pandemic at a large academic medical center in North Carolina
17/04/25 20:00 from coronavirus
While telehealth was widely used to provide human immunodeficiency virus (HIV) care during the coronavirus disease 2019 (COVID-19) pandemic, research evaluating viral suppression by visit type is conflicting. This study assessed variatio...

» Variation in subsequent viral load testing and outcomes by visit type patterns in the first year of the COVID-19 pandemic at a large academic medical center in North Carolina
17/04/25 20:00 from covid-19
While telehealth was widely used to provide human immunodeficiency virus (HIV) care during the coronavirus disease 2019 (COVID-19) pandemic, research evaluating viral suppression by visit type is conflicting. This study assessed variatio...

» When medical consultations are not face-to-face: a pilot study of patient-centred care communication during coronavirus disease 2019
17/04/25 20:00 from coronavirus
CONCLUSIONS: The findings suggest that more emphasis should be placed on training doctors to practice PCC communication in OMCs especially when the interactions are text-based. The results highlight that consideration must also be given ...

» Evolution and pathogenicity of SARS-CoVs: A microcanonical analysis of receptor-binding motifs
17/04/25 20:00 from sars-cov-2
The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the...

» mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients
17/04/25 20:00 from coronavirus
CONCLUSION: Overall, a three-dose mRNA-1273 primary series elicited Th-1-biased CD4^(+) T-cell responses among SOTRs that were improved with an additional dose.

» Heparan sulfate proteoglycans remodel SARS-CoV-2 spike conformation to allow integrin interaction and infection of endothelial cells
17/04/25 20:00 from sars-cov-2 spike protein
SARS-CoV-2 infects ACE2-negative primary HL-mECs through the interaction of an RGD motif, included in all spike proteins, up to the Omicron BA.1 subvariant, with α(v)β(3) integrin. Following its entry, SARS-CoV-2 remodels ECs phenotype a...

» When medical consultations are not face-to-face: a pilot study of patient-centred care communication during coronavirus disease 2019
17/04/25 20:00 from covid-19
CONCLUSIONS: The findings suggest that more emphasis should be placed on training doctors to practice PCC communication in OMCs especially when the interactions are text-based. The results highlight that consideration must also be given ...

» Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network
17/04/25 20:00 from coronavirus
The CEPI-Centralized Laboratory Network (CLN) has significantly contributed to the development of several approved SARS-CoV-2 vaccines by conducting over 70,000 clinical samples for testing from various vaccine developers. A centralized ...

» Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19
17/04/25 20:00 from coronavirus
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conduc...

» Evolution and pathogenicity of SARS-CoVs: A microcanonical analysis of receptor-binding motifs
17/04/25 20:00 from sars-cov-2 spike protein
The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the...

» A model based on PT-INR and age serves as a promising predictor for evaluating mortality risk in patients with SARS-CoV-2 infection
17/04/25 20:00 from coronavirus
COVID-19 caused by the coronavirus SARS-CoV-2 has resulted in a global pandemic. Considering some patients with COVID-19 rapidly develop respiratory distress and hypoxemia, early assessment of the prognosis for COVID-19 patients is impor...

» mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients
17/04/25 20:00 from covid-19
CONCLUSION: Overall, a three-dose mRNA-1273 primary series elicited Th-1-biased CD4^(+) T-cell responses among SOTRs that were improved with an additional dose.

» Heparan sulfate proteoglycans remodel SARS-CoV-2 spike conformation to allow integrin interaction and infection of endothelial cells
17/04/25 20:00 from coronavirus
SARS-CoV-2 infects ACE2-negative primary HL-mECs through the interaction of an RGD motif, included in all spike proteins, up to the Omicron BA.1 subvariant, with α(v)β(3) integrin. Following its entry, SARS-CoV-2 remodels ECs phenotype a...

» Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network
17/04/25 20:00 from covid-19
The CEPI-Centralized Laboratory Network (CLN) has significantly contributed to the development of several approved SARS-CoV-2 vaccines by conducting over 70,000 clinical samples for testing from various vaccine developers. A centralized ...

» Phospholipid scramblase 1: a frontline defense against viral infections
17/04/25 20:00 from coronavirus
Phospholipid scramblase 1 (PLSCR1) is the most studied member of the phospholipid scramblase protein family. Its main function is to catalyze calcium (Ca^(2+))-dependent, ATP-independent, bidirectional and non-specific translocation of p...

» Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19
17/04/25 20:00 from covid-19
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conduc...

» Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity
17/04/25 20:00 from coronavirus
CONCLUSIONS: The study indicates age and sex-dependent genome-wide genetic overlap between IPF and severe COVID-19 and highlights specific shared biological mechanisms underlying both conditions. This could also imply that individuals wi...

» Postpartum Depression and Anxiety in COVID-19-Positive and COVID-19-Negative Mothers: Insights From a Dedicated Hospital in Eastern India
17/04/25 20:00 from covid-19
Objective Women experienced mental health issues during pregnancy and postpartum, with the prevalence of depression and anxiety varying across different regions during the pandemic. A study was conducted to evaluate the symptoms of postp...

» Evolution and pathogenicity of SARS-CoVs: A microcanonical analysis of receptor-binding motifs
17/04/25 20:00 from coronavirus
The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the...

» Evaluating Treatment Outcomes of Vitamin B12 and Folic Acid Supplementation in Obsessive-Compulsive Disorder Patients With Deficiencies: A Comparative Analysis
17/04/25 20:00 from covid-19
Introduction Obsessive-compulsive disorder (OCD) imposes a considerable impact on day-to-day functioning. Many people experience insufficient symptom relief even after taking the optimum dose of OCD medications. Reduced levels of folic a...

» Descriptive analysis of TikTok content on vaccination in Arabic
17/04/25 20:00 from covid-19
The extensive impact of social media on communication of public health information is a growing concern. This is particularly worrying in the context of vaccination. Thus, we investigated the quality of TikTok videos regarding vaccinatio...

» Lessons learned for preventing health disparities in future pandemics: the role of social vulnerabilities among children diagnosed with severe COVID-19 early in the pandemic
17/04/25 20:00 from covid-19
CONCLUSIONS AND RELEVANCE: The high rates of severe COVID-19 observed in Hispanic children early in the pandemic appeared to be secondary to underlying co-morbidities and social vulnerabilities that may have influenced access to care, su...

» Medical students' distress during the transition to the endemic phase of COVID-19 in China: The association with temperament traits and attachment styles
17/04/25 20:00 from covid-19
CONCLUSIONS: Dimensions of both affective temperaments and attachment styles were associated with stress in the medical students during the transition to the endemic phase. The investigations of these psychological variables provided new...

» Workload increases nurses' quiet quitting, turnover intention, and job burnout: evidence from Greece
17/04/25 20:00 from covid-19
CONCLUSION: We found that workload was associated with quiet quitting, turnover intention, and job burnout in nurses. Thus, appropriate interventions should be applied to reduce nursing workloads to improve productivity and the healthcar...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from Coronavirus origins
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from coronavirus
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Colorectal Cancer Screening Amid COVID-19 in Japan: Analysis From the 2021-2022 JACSIS Study
17/04/25 20:00 from coronavirus
CONCLUSIONS: Although CRC screening rates increased from 2021 to 2022, a significant proportion of respondents still reported not undergoing screening, highlighting the importance of assessing the long-term impact of COVID-19 and identif...

» Impact of COVID-19 on Renal Transplant Recipients in a National Transplant Center
17/04/25 20:00 from coronavirus
CONCLUSION: This study highlights the heightened vulnerability of renal transplant recipients to COVID-19 as significant portion of the studied patients tested positive for COVID-19, with a notable mortality rate among these patients. Th...

» Enrichment of G-to-U Substitution in SARS-CoV-2 Functional Regions and Its Compensation via Concurrent Mutations
17/04/25 20:00 from coronavirus
We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS-CoV-2 genomes. Among 10 012 SNVs, APOBEC-mediated C-to-U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing-related substi...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from Sars-Cov-2 origins
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Impact of Acute Respiratory Infections on Medical Absenteeism Among Military Personnel: Retrospective Cohort Study
17/04/25 20:00 from covid-19
CONCLUSIONS: Compared to HRV/HEV, influenza infections were significantly associated with longer medical certificate duration. Nonetheless, there were no significant differences in the overall duration of medical absenteeism across patho...

» Impact of Acute Respiratory Infections on Medical Absenteeism Among Military Personnel: Retrospective Cohort Study
17/04/25 20:00 from sars-cov-2
CONCLUSIONS: Compared to HRV/HEV, influenza infections were significantly associated with longer medical certificate duration. Nonetheless, there were no significant differences in the overall duration of medical absenteeism across patho...

» Respiratory fitness for occupational diving, what is new?
17/04/25 20:00 from covid-19
Diving diseases originating from lung-related pathology are not the most prominent but are considered the most severe. To minimize this risk, a good respiratory tract assessment is important. Organizations like the British Thoracic Socie...

» Hemodialysis Central Venous Catheter Use and Infections Before and After the COVID-19 Pandemic: Data from a National Dialysis Provider
17/04/25 20:00 from covid-19
No abstract

» Detecting and Preventing Imposter Participants: Methods and Recommendations for Qualitative Researchers
17/04/25 20:00 from covid-19
During the COVID-19 pandemic, many qualitative researchers were forced to alter their data collection methods as traditional face-to-face interviews and focus groups were prohibited by social distancing requirements. While the shift to r...

» A cross-sectional study on depression, anxiety, and stress among the Bangladeshi population amid COVID-19
17/04/25 20:00 from covid-19
Depression, anxiety, and stress have surged worldwide, including in Bangladesh during the COVID-19 pandemic. This study aimed to assess the mental health condition of the Bangladeshi population during this pandemic. A cross-sectional stu...

» The impact of COVID-19 pandemic on the incidence, presentation, and management of type 1 diabetes in children and adolescents: a narrative review
17/04/25 20:00 from sars-cov-2
Type 1 diabetes (T1D) is an autoimmune condition affecting approximately 1.5 million children and adolescents worldwide, with an incidence of approximately 2-3% each year and rising. During the recent COVID-19 pandemic, a significant inc...

» The impact of COVID-19 pandemic on the incidence, presentation, and management of type 1 diabetes in children and adolescents: a narrative review
17/04/25 20:00 from covid-19
Type 1 diabetes (T1D) is an autoimmune condition affecting approximately 1.5 million children and adolescents worldwide, with an incidence of approximately 2-3% each year and rising. During the recent COVID-19 pandemic, a significant inc...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from sars-cov-2
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from covid-19
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Colorectal Cancer Screening Amid COVID-19 in Japan: Analysis From the 2021-2022 JACSIS Study
17/04/25 20:00 from sars-cov-2
CONCLUSIONS: Although CRC screening rates increased from 2021 to 2022, a significant proportion of respondents still reported not undergoing screening, highlighting the importance of assessing the long-term impact of COVID-19 and identif...

» Comparing Venous vs. Capillary Blood Collection Methods for Proteomic Measurement in Peripheral Blood
17/04/25 20:00 from covid-19
CONCLUSIONS: Proteomic measurement utilising capillary blood collection provides very similar results to using venous blood collection. This is a promising sign for the validity and reliability of studies using capillary blood collection...

» Colorectal Cancer Screening Amid COVID-19 in Japan: Analysis From the 2021-2022 JACSIS Study
17/04/25 20:00 from covid-19
CONCLUSIONS: Although CRC screening rates increased from 2021 to 2022, a significant proportion of respondents still reported not undergoing screening, highlighting the importance of assessing the long-term impact of COVID-19 and identif...

» Impact of COVID-19 on Renal Transplant Recipients in a National Transplant Center
17/04/25 20:00 from covid-19
CONCLUSION: This study highlights the heightened vulnerability of renal transplant recipients to COVID-19 as significant portion of the studied patients tested positive for COVID-19, with a notable mortality rate among these patients. Th...

» Impact of COVID-19 on Renal Transplant Recipients in a National Transplant Center
17/04/25 20:00 from sars-cov-2
CONCLUSION: This study highlights the heightened vulnerability of renal transplant recipients to COVID-19 as significant portion of the studied patients tested positive for COVID-19, with a notable mortality rate among these patients. Th...

» How can the illness risk representation framework be used to explain flu, whooping cough and Covid-19 vaccination uptake amongst pregnant women? A qualitative study
17/04/25 20:00 from covid-19
To explore how the illness risk representation framework explains vaccination uptake in pregnant women. Pregnant women were recruited via hospitals and community groups. Semi-structured interviews with pregnant women, explored factors in...

» Enrichment of G-to-U Substitution in SARS-CoV-2 Functional Regions and Its Compensation via Concurrent Mutations
17/04/25 20:00 from sars-cov-2
We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS-CoV-2 genomes. Among 10 012 SNVs, APOBEC-mediated C-to-U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing-related substi...

» Respiratory fitness for occupational diving, what is new?
17/04/25 20:00 from Covid-19 origins
Diving diseases originating from lung-related pathology are not the most prominent but are considered the most severe. To minimize this risk, a good respiratory tract assessment is important. Organizations like the British Thoracic Socie...

» Understanding coping and social support among U.S. college students during the pandemic: A 3-year examination of qualitative descriptions and their links to perceived health
17/04/25 20:00 from covid-19
This exploratory study examined U.S. college students' (N = 1003) self-reported coping strategies during the COVID-19 pandemic, perceived impact of the pandemic on social support, and their associations with perceived physical and mental...

» IgA pemphigus following SARS-Cov-2 vaccine
17/04/25 20:00 from sars-cov-2
No abstract

» Effectiveness of telerehabilitation-supported exercises in patients with temporomandibular disorders with probable sleep bruxism during the COVID-19 pandemic: A randomized controlled trial
17/04/25 20:00 from covid-19
CONCLUSIONS: Telerehabilitation effectively reduced TMDs-SB symptoms, offering a promising alternative to unsupervised exercises during the pandemic. Given this unique context, conducting studies outside the pandemic's conditions would e...

» Enrichment of G-to-U Substitution in SARS-CoV-2 Functional Regions and Its Compensation via Concurrent Mutations
17/04/25 20:00 from sars-cov-2 spike protein
We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS-CoV-2 genomes. Among 10 012 SNVs, APOBEC-mediated C-to-U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing-related substi...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from covid-19 and viral hemorrhagic fevers
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» Enrichment of G-to-U Substitution in SARS-CoV-2 Functional Regions and Its Compensation via Concurrent Mutations
17/04/25 20:00 from covid-19
We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS-CoV-2 genomes. Among 10 012 SNVs, APOBEC-mediated C-to-U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing-related substi...

» Epidemic Outbreaks Related to Yellow Fever Viruses
17/04/25 20:00 from Covid-19 origins
Epidemic outbreaks related to yellow fever viruses, added to the climate of fear resulting from the COVID-19 pandemic, raise a spectrum of concern and need for preparation in different research, epidemiology, and health groups. This ques...

» IgA pemphigus following SARS-Cov-2 vaccine
17/04/25 20:00 from covid-19
No abstract

» Innate lymphoid cells, immune functional dynamics, epithelial parallels, and therapeutic frontiers in infections
16/04/25 20:00 from covid-19
Innate lymphoid cells (ILCs) have emerged as pivotal players in the field of immunology, expanding our understanding of innate immunity beyond conventional paradigms. This comprehensive review delves into the multifaceted world of ILCs, ...

» Innate lymphoid cells, immune functional dynamics, epithelial parallels, and therapeutic frontiers in infections
16/04/25 20:00 from coronavirus
Innate lymphoid cells (ILCs) have emerged as pivotal players in the field of immunology, expanding our understanding of innate immunity beyond conventional paradigms. This comprehensive review delves into the multifaceted world of ILCs, ...

» Psychological counselling services at a Southern Italian university: utilization rates and characteristics of university students asking help
16/04/25 20:00 from covid-19
AIM: To assess the utilization rate of a university psychological counselling center in Southern Italy, a retrospective analysis of data collected from September 2018 to December 2023 was conducted.

» Methodological limitations and confounders in dermal toxicity evaluation of aqueous test substance by OECD technical guidelines 402, 410: our experience of testing ethanol based hand sanitizer
16/04/25 20:00 from covid-19
CONCLUSION: In both the studies, ethanol based hand sanitizer (EBHS) was found to be non-irritant with LD(50) of > 2000 mg/kg and classified as Class 5/Unclassified according to GHS classification. Although, spongiotic changes were obser...

» The legal and socioeconomic considerations of spine telemedicine in Canada
16/04/25 20:00 from covid-19
Telemedicine, or virtual care offers a platform for remote assessments, for either initial consultations or follow-up care. Telemedicine is a broad term and may refer to video conferences/assessments, telephone visits, messages through o...

» Psychological counselling services at a Southern Italian university: utilization rates and characteristics of university students asking help
16/04/25 20:00 from coronavirus
AIM: To assess the utilization rate of a university psychological counselling center in Southern Italy, a retrospective analysis of data collected from September 2018 to December 2023 was conducted.

» Corrigendum: Global transmission of monkeypox virus-a potential threat under the COVID-19 pandemic
16/04/25 20:00 from covid-19
[This corrects the article DOI: 10.3389/fimmu.2023.1174223.].

» Methodological limitations and confounders in dermal toxicity evaluation of aqueous test substance by OECD technical guidelines 402, 410: our experience of testing ethanol based hand sanitizer
16/04/25 20:00 from coronavirus
CONCLUSION: In both the studies, ethanol based hand sanitizer (EBHS) was found to be non-irritant with LD(50) of > 2000 mg/kg and classified as Class 5/Unclassified according to GHS classification. Although, spongiotic changes were obser...

» The legal and socioeconomic considerations of spine telemedicine in Canada
16/04/25 20:00 from coronavirus
Telemedicine, or virtual care offers a platform for remote assessments, for either initial consultations or follow-up care. Telemedicine is a broad term and may refer to video conferences/assessments, telephone visits, messages through o...

» Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients
16/04/25 20:00 from covid-19
The understanding of how the host immune response differs in T-cell phenotype and memory formation during SARS-CoV-2 infection in liver transplant recipients (LTRs) remains limited. LTRs who recovered from COVID-19 infection without prio...

» Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients
16/04/25 20:00 from coronavirus
The understanding of how the host immune response differs in T-cell phenotype and memory formation during SARS-CoV-2 infection in liver transplant recipients (LTRs) remains limited. LTRs who recovered from COVID-19 infection without prio...

» Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation
16/04/25 20:00 from covid-19
SARS-CoV-2 has claimed more than 7 million lives worldwide and has been associated with prolonged inflammation, immune dysregulation and persistence of symptoms following severe infection. Understanding the T cell mediated immune respons...

» Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation
16/04/25 20:00 from coronavirus
SARS-CoV-2 has claimed more than 7 million lives worldwide and has been associated with prolonged inflammation, immune dysregulation and persistence of symptoms following severe infection. Understanding the T cell mediated immune respons...

» Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
16/04/25 20:00 from covid-19
CONCLUSIONS: Taken together, our results show that Bacillus spores are able to regulate both innate and adaptive immunity, providing heterologous protection against a variety of important respiratory viruses of high global disease burden.

» Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease
16/04/25 20:00 from covid-19
CONCLUSION: These findings demonstrate that human SP-A variants differentially modulate SARS-CoV-2-induced lung injury and disease severity by differentially inhibiting viral infectivity and regulating immune-related gene expressions.

» Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
16/04/25 20:00 from coronavirus
CONCLUSIONS: Taken together, our results show that Bacillus spores are able to regulate both innate and adaptive immunity, providing heterologous protection against a variety of important respiratory viruses of high global disease burden.

» Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease
16/04/25 20:00 from coronavirus
CONCLUSION: These findings demonstrate that human SP-A variants differentially modulate SARS-CoV-2-induced lung injury and disease severity by differentially inhibiting viral infectivity and regulating immune-related gene expressions.

» Assessing the perceived influence of religion on brain health among adults in the United Arab Emirates-the Global Brain Health Survey: a cross-sectional study
16/04/25 20:00 from covid-19
CONCLUSION: Our study found a significant link between religious practices and brain health, suggesting that faith- and spirituality-based approaches may be important for addressing brain health issues. These findings highlight the need ...

» Dosimetric advantage of ipsilateral lung and cardiac sparing of left breast cancer prone position compared with supine free breathing in the COVID-19 era and personalized medicine
16/04/25 20:00 from coronavirus
CONCLUSION: Prone conferred substantial lung sparing without dose-deterioration to other structures, providing a significant advantage as compared with supine free-breathing radiotherapy in left-breast cancer patients.

» Prevention strategies against academic burnout: the perspective of Romanian health sciences students in the aftermath of the COVID-19 pandemic
16/04/25 20:00 from covid-19
CONCLUSION: These results may be useful in designing more sustainable and effective burnout prevention strategies in health sciences academic settings.

» Impact of the COVID-19 Pandemic on Children's Physical Activity As Perceived by Their Parents
16/04/25 20:00 from covid-19
Background Since the outbreak and global spread of COVID-19, countries rapidly introduced a range of preventative measures and isolation protocols to ensure safety, which ultimately led to the implementation of total lockdowns. As a resu...

» Nipah virus: Preventing the next outbreak
16/04/25 20:00 from coronavirus
Nipah is a deadly viral infection which has come to the news highlight recently, due to its fresh onslaught in Southern India. As the world continues to recover from coronavirus disease 2019, the World Health Organization has identified ...

» Association Between Housing Status and COVID-19 Severity, Morbidity, and Mortality in the United States: A Propensity Score-Matched Analysis of the National Inpatient Sample
16/04/25 20:00 from covid-19
The influence of unstable housing on COVID-19 health outcomes remains inadequately elucidated in existing literature. Prevailing assumptions suggest that individuals with unstable housing are more likely to have limited access to healthc...

» Healthcare provider and patient perspectives on COVID-19 vaccination among persons with HIV, hypertension, and/or Diabetes mellitus at two regional referral hospitals in Uganda
16/04/25 20:00 from coronavirus
CONCLUSION: Fear of COVID-19, trust in the vaccine, family and social support facilitated COVID-19 vaccination uptake. Conversely, fear of side effects, vaccine and medication interaction, misinformation and inadequate sensitization hind...

» Spike Protein-Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
16/04/25 20:00 from covid-19
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with...

» Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses
16/04/25 20:00 from coronavirus
No abstract

» Supply chain resilience: A review from the inventory management perspective
16/04/25 20:00 from covid-19
The COVID-19 pandemic has exposed vulnerabilities in global supply chains, leading to economic damage and product shortages caused by demand surges and supply disruptions. Concurrently, geopolitical conflicts and the rising frequency of ...

» Incidence and predictive factors of hyperventilation syndrome in patients after COVID 19 pneumonia: a prospective cohort study
16/04/25 20:00 from coronavirus
CONCLUSION: HVS is prevalent in the post-COVID-19 phase, affecting 15.6 % of survivors. Identified predictive factors suggest the convergence of psychosomatic pathophysiological mechanisms. Further research is crucial for a detailed unde...

» Comparison of Patients With or Without COVID-19 and Without Hematological Diseases Treated for Invasive Pulmonary Aspergillosis: A 5-Year Retrospective Cohort Study with Propensity-Based Adjustment
16/04/25 20:00 from coronavirus
CONCLUSIONS: Patients with CAPA have fewer comorbid conditions and higher fungal burden than those with PIPA, but clinical outcomes are similar between groups. Isavuconazole was an independent predictor for clinical cure, and serum GM po...

» Outcomes of lung transplantation from SARS-CoV-2 positive donors during the Omicron wave
16/04/25 20:00 from coronavirus
Early observations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission via lung transplantation have led to frequent discard of lungs from donors with positive SARS-CoV-2 tests. We compared survival between lung ...

» Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
16/04/25 20:00 from sars-cov-2 spike protein
CONCLUSIONS: Taken together, our results show that Bacillus spores are able to regulate both innate and adaptive immunity, providing heterologous protection against a variety of important respiratory viruses of high global disease burden.

» Psychological counselling services at a Southern Italian university: utilization rates and characteristics of university students asking help
16/04/25 20:00 from sars-cov-2
AIM: To assess the utilization rate of a university psychological counselling center in Southern Italy, a retrospective analysis of data collected from September 2018 to December 2023 was conducted.

» Methodological limitations and confounders in dermal toxicity evaluation of aqueous test substance by OECD technical guidelines 402, 410: our experience of testing ethanol based hand sanitizer
16/04/25 20:00 from sars-cov-2
CONCLUSION: In both the studies, ethanol based hand sanitizer (EBHS) was found to be non-irritant with LD(50) of > 2000 mg/kg and classified as Class 5/Unclassified according to GHS classification. Although, spongiotic changes were obser...

» Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients
16/04/25 20:00 from sars-cov-2
The understanding of how the host immune response differs in T-cell phenotype and memory formation during SARS-CoV-2 infection in liver transplant recipients (LTRs) remains limited. LTRs who recovered from COVID-19 infection without prio...

» Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation
16/04/25 20:00 from sars-cov-2
SARS-CoV-2 has claimed more than 7 million lives worldwide and has been associated with prolonged inflammation, immune dysregulation and persistence of symptoms following severe infection. Understanding the T cell mediated immune respons...

» Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: Taken together, our results show that Bacillus spores are able to regulate both innate and adaptive immunity, providing heterologous protection against a variety of important respiratory viruses of high global disease burden.

» Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease
16/04/25 20:00 from sars-cov-2
CONCLUSION: These findings demonstrate that human SP-A variants differentially modulate SARS-CoV-2-induced lung injury and disease severity by differentially inhibiting viral infectivity and regulating immune-related gene expressions.

» Spike Protein-Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
16/04/25 20:00 from sars-cov-2
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with...

» Variability of Clinical Metrics in Small Population Communities Drive Perceived Wastewater and Environmental Surveillance Data Quality: Ontario, Canada-Wide Study
16/04/25 20:00 from sars-cov-2
The emergence of COVID-19 in Canada has led to over 4.9 million cases and 59,000 deaths by May 2024. Traditional clinical surveillance metrics (hospital admissions and clinical laboratory-positive cases) were complemented with wastewater...

» Smoking attitudes among medical personnel: A cross-sectional study at Mureș County Hospital, Romania
16/04/25 20:00 from sars-cov-2
No abstract

» The completeness, accuracy and impact on alerts, of wearable vital signs monitoring in hospitalised patients
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: Agreement between vital signs recorded by wearable sensors and concurrent traditional vitals is poor. In this context, data from wearable sensors should not be used in existing track and trigger systems.

» Incidence and predictive factors of hyperventilation syndrome in patients after COVID 19 pneumonia: a prospective cohort study
16/04/25 20:00 from sars-cov-2
CONCLUSION: HVS is prevalent in the post-COVID-19 phase, affecting 15.6 % of survivors. Identified predictive factors suggest the convergence of psychosomatic pathophysiological mechanisms. Further research is crucial for a detailed unde...

» COVID-19 Reinfections in the City of São Paulo, Brazil: Prevalence and Socioeconomic Factors
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: COVID-19 reinfection rates were heavily influenced by socioeconomic disparities and variant-specific factors. Regions with lower Human Development Index and worse socioeconomic conditions experienced higher reinfection rates...

» Outcomes of lung transplantation from SARS-CoV-2 positive donors during the Omicron wave
16/04/25 20:00 from sars-cov-2
Early observations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission via lung transplantation have led to frequent discard of lungs from donors with positive SARS-CoV-2 tests. We compared survival between lung ...

» Case Report: Primary adrenal insufficiency due to bilateral adrenal infarction and antiphospholipid syndrome in Covid19 - A complicate case of cardiogenic shock
16/04/25 20:00 from sars-cov-2
We report a clinical case of multifactorial shock and primary adrenal insufficiency (PAI), caused by bilateral adrenal hemorrhage in the context of catastrophic antiphospholipid syndrome (CAPS) triggered by a COVID-19 infection. A 54-yea...

» Changes in self-reported physical and mental health, behaviour and economic status among adults by known seropositivity and sociodemographic factors before and after the COVID-19 pandemic outbreak in Ischgl, Austria
16/04/25 20:00 from sars-cov-2
CONCLUSION: The population of Ischgl demonstrated a high level of resilience to the pandemic as measured by health. However, certain segments of the population were disproportionately affected, particularly with regard to mental health a...

» Large-Scale Deep Learning-Enabled Infodemiological Analysis of Substance Use Patterns on Social Media: Insights From the COVID-19 Pandemic
16/04/25 20:00 from covid-19
CONCLUSIONS: This study demonstrates the potential of leveraging social media data for real-time detection of SU trends during global crises. By uncovering how factors such as mental health and economic stress drive SU spikes, particular...

» Bilateral Fundus Hypopigmentation in a Patient With Glaucoma
16/04/25 20:00 from covid-19
No abstract

» New Reflections on COVID-19's Implications for Neurocognition
16/04/25 20:00 from covid-19
No abstract

» Disparities in Digital Health Care Use in 2022
16/04/25 20:00 from covid-19
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US adults from MHSVI most and least vulnerable counties, digital health care use varied by participant characteristics. Some traditionally underserved groups self-reported highe...

» Methylated Reprimo Cell-Free DNA as a Non-Invasive Biomarker for Gastric Cancer
16/04/25 20:00 from Covid-19 origins
Restrictions resulting from the COVID-19 pandemic abruptly reversed the slow decline of the diagnosis and mortality rates of gastric cancer (GC). This scenario highlights the importance of developing cost-effective methods for mass scree...

» COVID-19 Pandemic-Related Exposures and Cognitive Function in Middle-Aged Women
16/04/25 20:00 from covid-19
CONCLUSIONS AND RELEVANCE: This cohort study of middle-aged women found that the COVID-19 pandemic and pandemic-related events were not associated with cognitive decline up to 2.5 years after the onset of the pandemic. Future studies are...

» Disparities in United States Nationwide County-Level PrEP Rate and PrEP to Need Ratio During the COVID-19 Pandemic
16/04/25 20:00 from covid-19
CONCLUSION: Although PrEP use began increasing from pre-pandemic levels by 2021, PNR increases did not occur until 2022. Increases in PNR did not occur in areas with greater concentrations non-Hispanic Black individuals, suggesting dispa...

» Unlocking the potential of remdesivir: innovative approaches to drug delivery
16/04/25 20:00 from covid-19
Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as an antiviral agent is critical. While several reviews have explored the efficacy of remdesivir, few have comprehen...

» Leptospirosis and coinfections leading to fatal multiple organ and system failure
16/04/25 20:00 from covid-19 and viral hemorrhagic fevers
Coinfection with leptospirosis and other infectious agents pose major challenges in medical practice, often due to difficulties in isolating these agents, symptoms overlap, and lack of specific investigation protocols in areas with emerg...

» The impact of the COVID-19 pandemic on the diagnosis, treatment, and prognosis of ovarian cancer in the United States: a retrospective cohort study based on the SEER database
16/04/25 20:00 from covid-19
CONCLUSIONS: The survival outcomes of the pre-COVID-19 group and the post-COVID-19 group were relatively consistent, likely due to the short follow-up. Future research is necessary to continue monitoring the outcomes of patients in the p...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from sars-cov-2 spike protein
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from Cell entry mechanisms of SARS-CoV-2
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Correction to: Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ)
16/04/25 20:00 from covid-19
No abstract

» Elements of misinformation in the public perception of the dengue vaccine in Brazil: an analysis of comments on social media
16/04/25 20:00 from covid-19 and viral hemorrhagic fevers
In 2024, dengue in Brazil reached alarming epidemiological rates, being considered potentially the worst year in history. In this context, the arrival of vaccines against the disease represents a great advance for Brazil's public health....

» Disparities in Digital Health Care Use in 2022
16/04/25 20:00 from sars-cov-2
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US adults from MHSVI most and least vulnerable counties, digital health care use varied by participant characteristics. Some traditionally underserved groups self-reported highe...

» Impact of the COVID-19 pandemic on the respiratory syncytial virus infections in children admitted with community acquired pneumonia: a retrospective study at a tertiary hospital of Northeast China
16/04/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 pandemic has profoundly transformed the infection landscape of RSV in pediatric CAP patients, as evidenced by shifts in positivity rates, demographic characteristics, co-infection patterns, and seasonal trends.

» SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury
16/04/25 20:00 from covid-19
CONCLUSIONS: In summary, we identified the SARS-CoV-2 N protein as a key mediator of kidney injury in AKI and demonstrated that it exacerbates the injury through a Mincle-dependent mechanism. Targeting Mincle may represent a novel therap...

» COVID-19 Pandemic-Related Exposures and Cognitive Function in Middle-Aged Women
16/04/25 20:00 from sars-cov-2
CONCLUSIONS AND RELEVANCE: This cohort study of middle-aged women found that the COVID-19 pandemic and pandemic-related events were not associated with cognitive decline up to 2.5 years after the onset of the pandemic. Future studies are...

» COVID-19 and cognitive impairment: a review of the emerging evidence
16/04/25 20:00 from covid-19
The recent surge of COVID-19 cases has raised concerns about its potential long-term effects on cognitive function. This review explores the growing body of research investigating the link between COVID-19 infection and cognitive impairm...

» SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: In summary, we identified the SARS-CoV-2 N protein as a key mediator of kidney injury in AKI and demonstrated that it exacerbates the injury through a Mincle-dependent mechanism. Targeting Mincle may represent a novel therap...

» Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2
16/04/25 20:00 from covid-19
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literatur...

» Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2
16/04/25 20:00 from sars-cov-2
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literatur...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from sars-cov-2
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Methylated Reprimo Cell-Free DNA as a Non-Invasive Biomarker for Gastric Cancer
16/04/25 20:00 from covid-19
Restrictions resulting from the COVID-19 pandemic abruptly reversed the slow decline of the diagnosis and mortality rates of gastric cancer (GC). This scenario highlights the importance of developing cost-effective methods for mass scree...

» Neurological Impact of SARS-CoV-2 Changing Variants: A 4-Year DW-MRI Study on Olfactory and Taste-Related Brain Regions
16/04/25 20:00 from sars-cov-2
Neurological symptoms such as impaired smell and taste have been recognized as hallmark manifestations of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. This study investigates and quantifies microstructural change...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from covid-19
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Leukocyte telomere length and telomerase activity in Long COVID patients from Rio de Janeiro, Brazil
16/04/25 20:00 from sars-cov-2
BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by the new coronavirus 2 (severe acute respiratory syndrome coronavirus 2 - SARS-CoV-2). Long COVID is a new condition associated with persistent COVID-19 symptoms and/or new emer...

» Factors modulating maternofetal transfer of IgG antibodies following SARS-CoV-2 gestational infection
16/04/25 20:00 from sars-cov-2
Early infant immunity to SARS-CoV-2 depends on maternofetal transfer of antibodies. We aimed to analyze the factors modulating the maternofetal transfer of anti-SARS-CoV-2 IgG antibodies following gestational infection during the pandemi...

» Tocilizumab and IVIG experience during the service follow-up in patients with severe COVID-19 pneumonia
16/04/25 20:00 from sars-cov-2
Most SARS-CoV-2 infections are asymptomatic or cause only mild illness, but severe respiratory disease can develop, sometimes requiring oxygen support. Immunopathological damage resulting from an abnormal inflammatory response in patient...

» Emerging Viral Infections during Pregnancy: Understanding the Risks to Maternal and Fetal Health
16/04/25 20:00 from sars-cov-2
Viral infections during pregnancy pose significant risks to both maternal and fetal health. While several viruses are well known to cause adverse pregnancy outcomes, often little is known about emerging viruses. This review summaries the...

» Maternal care for preterm infants in the context of the COVID-19 pandemic: a qualitative systematic review
16/04/25 20:00 from sars-cov-2
Preterm birth and hospitalization of the newborn are potentially traumatic events for mothers and children. The COVID-19 pandemic, along with its social impacts and additional concerns, has exacerbated maternal distress and anxiety, adve...

» In Vivo Engineered CAR-T Cell Therapy: Lessons Built from COVID-19 mRNA Vaccines
16/04/25 20:00 from sars-cov-2
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy but continues to face significant challenges that limit its broader application, such as antigen targeting, the tumor microenvironment, and cell per...

» Discrimination and Quality of Life During the COVID-19 Pandemic: Experiences of Racial/Ethnic Minority Nursing Staff in the United States
16/04/25 20:00 from sars-cov-2
CONCLUSION: Our findings revealed that while discrimination, fear, and perceived risk were negatively related to minority nursing staff's QoL, resilience and social support were crucial in promoting their QoL, with no significant differe...

» Disparities in Digital Health Care Use in 2022
16/04/25 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US adults from MHSVI most and least vulnerable counties, digital health care use varied by participant characteristics. Some traditionally underserved groups self-reported highe...

» Subgenomic RNA and Limited Cross-Reactive Neutralising Antibodies Point to Potential Improvements in SARS-CoV-2 Clinical Handling
16/04/25 20:00 from sars-cov-2
The current clinical management of SARS-CoV-2 disease control and immunity may be not optimal anymore. Reverse transcription polymerase chain reaction (RT-PCR) of genomic viral RNA is broadly used for diagnosis, even though the virus may...

» COVID-19 Pandemic-Related Exposures and Cognitive Function in Middle-Aged Women
16/04/25 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: This cohort study of middle-aged women found that the COVID-19 pandemic and pandemic-related events were not associated with cognitive decline up to 2.5 years after the onset of the pandemic. Future studies are...

» SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury
16/04/25 20:00 from coronavirus
CONCLUSIONS: In summary, we identified the SARS-CoV-2 N protein as a key mediator of kidney injury in AKI and demonstrated that it exacerbates the injury through a Mincle-dependent mechanism. Targeting Mincle may represent a novel therap...

» Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2
16/04/25 20:00 from coronavirus
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literatur...

» Concomitant Pathologies and Their Impact on Parkinson Disease: A Narrative Overview of Current Evidence
16/04/25 20:00 from sars-cov-2
Many clinico-pathological studies point to the presence of multiple comorbidities/co-pathologies in the course of Parkinson disease (PD). Lewy body pathology, the morphological hallmark of PD, rarely exists in isolation, but is usually a...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from coronavirus
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Neurological Impact of SARS-CoV-2 Changing Variants: A 4-Year DW-MRI Study on Olfactory and Taste-Related Brain Regions
16/04/25 20:00 from coronavirus
Neurological symptoms such as impaired smell and taste have been recognized as hallmark manifestations of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. This study investigates and quantifies microstructural change...

» IMPACT OF THE COVID-19 QUARANTINE ON THE MENTAL AND EMOTIONAL HEALTH OF POST-BARIATRIC SURGERY WOMEN: A QUALITATIVE STUDY
16/04/25 20:00 from coronavirus
CONCLUSIONS: The study showed a negative impact of the COVID-19 pandemic on aspects of mental and emotional health mostly due to lockdown measures, which led to social isolation and an increased burden with household chores.

» Leukocyte telomere length and telomerase activity in Long COVID patients from Rio de Janeiro, Brazil
16/04/25 20:00 from coronavirus
BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by the new coronavirus 2 (severe acute respiratory syndrome coronavirus 2 - SARS-CoV-2). Long COVID is a new condition associated with persistent COVID-19 symptoms and/or new emer...

» Factors modulating maternofetal transfer of IgG antibodies following SARS-CoV-2 gestational infection
16/04/25 20:00 from coronavirus
Early infant immunity to SARS-CoV-2 depends on maternofetal transfer of antibodies. We aimed to analyze the factors modulating the maternofetal transfer of anti-SARS-CoV-2 IgG antibodies following gestational infection during the pandemi...

» Tocilizumab and IVIG experience during the service follow-up in patients with severe COVID-19 pneumonia
16/04/25 20:00 from coronavirus
Most SARS-CoV-2 infections are asymptomatic or cause only mild illness, but severe respiratory disease can develop, sometimes requiring oxygen support. Immunopathological damage resulting from an abnormal inflammatory response in patient...

» Maternal care for preterm infants in the context of the COVID-19 pandemic: a qualitative systematic review
16/04/25 20:00 from coronavirus
Preterm birth and hospitalization of the newborn are potentially traumatic events for mothers and children. The COVID-19 pandemic, along with its social impacts and additional concerns, has exacerbated maternal distress and anxiety, adve...

» In Vivo Engineered CAR-T Cell Therapy: Lessons Built from COVID-19 mRNA Vaccines
16/04/25 20:00 from coronavirus
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy but continues to face significant challenges that limit its broader application, such as antigen targeting, the tumor microenvironment, and cell per...

» Machine Learning-Guided Screening and Molecular Docking for Proposing Naturally Derived Drug Candidates Against MERS-CoV 3CL Protease
16/04/25 20:00 from coronavirus
In this study, we utilized machine learning techniques to identify potential inhibitors of the MERS-CoV 3CL protease. Among the models evaluated, the Random Forest (RF) algorithm exhibited the highest predictive performance, achieving an...

» Discrimination and Quality of Life During the COVID-19 Pandemic: Experiences of Racial/Ethnic Minority Nursing Staff in the United States
16/04/25 20:00 from coronavirus
CONCLUSION: Our findings revealed that while discrimination, fear, and perceived risk were negatively related to minority nursing staff's QoL, resilience and social support were crucial in promoting their QoL, with no significant differe...

» Subgenomic RNA and Limited Cross-Reactive Neutralising Antibodies Point to Potential Improvements in SARS-CoV-2 Clinical Handling
16/04/25 20:00 from coronavirus
The current clinical management of SARS-CoV-2 disease control and immunity may be not optimal anymore. Reverse transcription polymerase chain reaction (RT-PCR) of genomic viral RNA is broadly used for diagnosis, even though the virus may...

» Search Volume of Insomnia and Suicide as Digital Footprints of Global Mental Health During the COVID-19 Pandemic: 3-Year Infodemiology Study
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: Our findings highlight how the mental health impact of the pandemic varied across income groups and evolved over time. The mediating effect of stay-at-home behaviors was significant in the early phases but diminished in late...

» Search Volume of Insomnia and Suicide as Digital Footprints of Global Mental Health During the COVID-19 Pandemic: 3-Year Infodemiology Study
16/04/25 20:00 from coronavirus
CONCLUSIONS: Our findings highlight how the mental health impact of the pandemic varied across income groups and evolved over time. The mediating effect of stay-at-home behaviors was significant in the early phases but diminished in late...

» Application of an Innovative Methodology to Build Infrastructure for Digital Transformation of Health Systems: Developmental Program Evaluation
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: Evaluation of the digital health platform development process informed our decisions to integrate the research team more cohesively with the development team, a practice that is currently uncommon given the use of external t...

» Behavioral insights during the COVID-19 pandemic in the Federation of Bosnia and Herzegovina: the role of trust, health literacy, risk and fairness perceptions in compliance with public health and social measures
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: This study contributes to the body of research on factors influencing compliance with PHSM. It emphasizes the importance of behavioral monitoring through repeated surveys to understand and improve compliance. The study also ...

» Insights into the implementation of a whole genome sequencing report form (SRF) to reduce nosocomial SARS-CoV-2 in UK hospitals within an unfolding pandemic: A qualitative process evaluation using normalisation process theory
16/04/25 20:00 from sars-cov-2
CONCLUSION: We show preliminary support for this SRF being an acceptable, useable and potentially scalable way of enhancing existing IPC activities for viral respiratory infections. However, the context of both the trial and the alpha wa...

» Application of an Innovative Methodology to Build Infrastructure for Digital Transformation of Health Systems: Developmental Program Evaluation
16/04/25 20:00 from coronavirus
CONCLUSIONS: Evaluation of the digital health platform development process informed our decisions to integrate the research team more cohesively with the development team, a practice that is currently uncommon given the use of external t...

» Should I stay or should I go-Medical assistants´ experiences and coping with patient demand and lack of appreciation during the Covid-19 pandemic
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: The study underlines the urgent need for societal and political awareness regarding the challenges faced by MAs, especially during public health crises. The perceived social egoism in patient behavior, coupled with a lack of...

» Behavioral insights during the COVID-19 pandemic in the Federation of Bosnia and Herzegovina: the role of trust, health literacy, risk and fairness perceptions in compliance with public health and social measures
16/04/25 20:00 from coronavirus
CONCLUSIONS: This study contributes to the body of research on factors influencing compliance with PHSM. It emphasizes the importance of behavioral monitoring through repeated surveys to understand and improve compliance. The study also ...

» Outdoor recreation's association with mental health and well-being during the COVID-19 pandemic
16/04/25 20:00 from sars-cov-2
Outdoor recreation provided a crucial way to maintain physical activity, reduce stress, and preserve a sense of normalcy during the COVID-19 pandemic. This study assessed the relationship between outdoor recreation and mental health in t...

» Insights into the implementation of a whole genome sequencing report form (SRF) to reduce nosocomial SARS-CoV-2 in UK hospitals within an unfolding pandemic: A qualitative process evaluation using normalisation process theory
16/04/25 20:00 from coronavirus
CONCLUSION: We show preliminary support for this SRF being an acceptable, useable and potentially scalable way of enhancing existing IPC activities for viral respiratory infections. However, the context of both the trial and the alpha wa...

» Promising biological activities of prodigionins
16/04/25 20:00 from sars-cov-2
Prodigionins is large family of at least 34 pyrrolic compounds including the well-studied red pigment prodigiosin. Prodigionins are produced by several microorganisms displaying broad biological activities including antimicrobial, antivi...

» Febrile infant with bacteremia caused by group B Streptococcus and coronavirus disease 2019 during the pandemic
16/04/25 20:00 from coronavirus
No abstract

» Should I stay or should I go-Medical assistants´ experiences and coping with patient demand and lack of appreciation during the Covid-19 pandemic
16/04/25 20:00 from coronavirus
CONCLUSIONS: The study underlines the urgent need for societal and political awareness regarding the challenges faced by MAs, especially during public health crises. The perceived social egoism in patient behavior, coupled with a lack of...

» Large-Scale Deep Learning-Enabled Infodemiological Analysis of Substance Use Patterns on Social Media: Insights From the COVID-19 Pandemic
16/04/25 20:00 from sars-cov-2
CONCLUSIONS: This study demonstrates the potential of leveraging social media data for real-time detection of SU trends during global crises. By uncovering how factors such as mental health and economic stress drive SU spikes, particular...

» Outdoor recreation's association with mental health and well-being during the COVID-19 pandemic
16/04/25 20:00 from coronavirus
Outdoor recreation provided a crucial way to maintain physical activity, reduce stress, and preserve a sense of normalcy during the COVID-19 pandemic. This study assessed the relationship between outdoor recreation and mental health in t...

» Large-Scale Deep Learning-Enabled Infodemiological Analysis of Substance Use Patterns on Social Media: Insights From the COVID-19 Pandemic
16/04/25 20:00 from coronavirus
CONCLUSIONS: This study demonstrates the potential of leveraging social media data for real-time detection of SU trends during global crises. By uncovering how factors such as mental health and economic stress drive SU spikes, particular...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from sars-cov-2
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from coronavirus
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study
16/04/25 20:00 from Cell entry mechanisms of SARS-CoV-2
The entry and infection of the Severe Acute Respiratory Syndrome Coronavirus 2 virus (SARS-CoV-2) involve recognition and binding of the receptor-binding domain (RBD) of the virus surface spike protein to the peptidase domain (PD) of the...

» Use of portable air cleaners within an ambulance workspace
16/04/25 20:00 from covid-19
Emergency medical service (EMS) providers face significant exposure to infectious aerosols during outbreaks like the COVID-19 pandemic. Most ambulances lack ventilation controls to reduce EMS worker exposure to these aerosols. Ambulances...

» Association Between Social Distancing Compliance and Public Place Crowding During the COVID-19 Pandemic: Cross-Sectional Observational Study Using Computer Vision to Analyze Surveillance Footage
16/04/25 20:00 from covid-19
CONCLUSIONS: The direct positive relationship between crowding and distancing violations suggests that potential transmission encounters can be identified by simply counting the number of people present in a location. Our findings thus p...

» Search Volume of Insomnia and Suicide as Digital Footprints of Global Mental Health During the COVID-19 Pandemic: 3-Year Infodemiology Study
16/04/25 20:00 from covid-19
CONCLUSIONS: Our findings highlight how the mental health impact of the pandemic varied across income groups and evolved over time. The mediating effect of stay-at-home behaviors was significant in the early phases but diminished in late...

» Application of an Innovative Methodology to Build Infrastructure for Digital Transformation of Health Systems: Developmental Program Evaluation
16/04/25 20:00 from covid-19
CONCLUSIONS: Evaluation of the digital health platform development process informed our decisions to integrate the research team more cohesively with the development team, a practice that is currently uncommon given the use of external t...

» Behavioral insights during the COVID-19 pandemic in the Federation of Bosnia and Herzegovina: the role of trust, health literacy, risk and fairness perceptions in compliance with public health and social measures
16/04/25 20:00 from covid-19
CONCLUSIONS: This study contributes to the body of research on factors influencing compliance with PHSM. It emphasizes the importance of behavioral monitoring through repeated surveys to understand and improve compliance. The study also ...

» Insights into the implementation of a whole genome sequencing report form (SRF) to reduce nosocomial SARS-CoV-2 in UK hospitals within an unfolding pandemic: A qualitative process evaluation using normalisation process theory
16/04/25 20:00 from covid-19
CONCLUSION: We show preliminary support for this SRF being an acceptable, useable and potentially scalable way of enhancing existing IPC activities for viral respiratory infections. However, the context of both the trial and the alpha wa...

» Febrile infant with bacteremia caused by group B Streptococcus and coronavirus disease 2019 during the pandemic
16/04/25 20:00 from covid-19
No abstract

» Should I stay or should I go-Medical assistants experiences and coping with patient demand and lack of appreciation during the Covid-19 pandemic
16/04/25 20:00 from covid-19
CONCLUSIONS: The study underlines the urgent need for societal and political awareness regarding the challenges faced by MAs, especially during public health crises. The perceived social egoism in patient behavior, coupled with a lack of...

» Outdoor recreation's association with mental health and well-being during the COVID-19 pandemic
16/04/25 20:00 from covid-19
Outdoor recreation provided a crucial way to maintain physical activity, reduce stress, and preserve a sense of normalcy during the COVID-19 pandemic. This study assessed the relationship between outdoor recreation and mental health in t...

» A qualitative analysis of lived experiences, mental health treatment needs, and psychotherapeutic applications among veterans with long COVID
16/04/25 20:00 from covid-19
Long COVID remains a pressing health concern among Americans, with current data suggesting that 45% of those infected by COVID-19 experience at least one symptom of Long COVID. Veterans are a particularly at-risk population due to their ...

» Correction: Impact of the COVID-19 pandemic on dengue in Brazil: Interrupted time series analysis of changes in surveillance and transmission
16/04/25 20:00 from covid-19
[This corrects the article DOI: 10.1371/journal.pntd.0012726.].

» Clinical leadership in nursing in an ever-changing world: a bibliometric analysis
16/04/25 20:00 from covid-19
PURPOSE: Leadership plays a critical role in improving the quality of care, minimizing risks to patients and staff and improving patient care outcomes. The purpose of this study is to analyze the structure of publications in the field of...

» Promising biological activities of prodigionins
16/04/25 20:00 from covid-19
Prodigionins is large family of at least 34 pyrrolic compounds including the well-studied red pigment prodigiosin. Prodigionins are produced by several microorganisms displaying broad biological activities including antimicrobial, antivi...

» Bilateral Fundus Hypopigmentation in a Patient With Glaucoma
16/04/25 20:00 from covid-19
No abstract

» Gastrointestinal and hepatic manifestations among hospitalized COVID-19 children
16/04/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Although most COVID-19 patients present with GI manifestations, we could not determine the relationship between GI and hepatic manifestations and disease severity in this study.