» Participation of Civil Society Organisations and Academia in COVID-19 Governance: Insights from a Six Country Study
15/05/26 20:00 from covid-19
This paper focuses on the engagement of persons and groups with diverse interests in the governance of the COVID-19 pandemic. During emergencies, involving diverse perspectives in governance mechanisms can contribute to more equitable an...

» Clinical and economic benefits of seasonal COVID-19 vaccination in Germany: results from the ROUTINE-COV19 Study, September 2022 to March 2024
15/05/26 20:00 from sars-cov-2
BACKGROUNDVaccinations against COVID-19 were integrated into routine care in Germany in April 2023. However, evidence of the impact of seasonal vaccination remains limited.AIMTo assess the clinical and economic impact of COVID-19 vaccina...

» Clinical and economic benefits of seasonal COVID-19 vaccination in Germany: results from the ROUTINE-COV19 Study, September 2022 to March 2024
15/05/26 20:00 from coronavirus
BACKGROUNDVaccinations against COVID-19 were integrated into routine care in Germany in April 2023. However, evidence of the impact of seasonal vaccination remains limited.AIMTo assess the clinical and economic impact of COVID-19 vaccina...

» Interim 2025/26 LP.8.1 vaccine effectiveness estimates against COVID-19 from the Canadian Sentinel Practitioner Surveillance Network (SPSN): insights into possible impact of influenza and other respiratory virus co-circulation
15/05/26 20:00 from sars-cov-2
BACKGROUNDThe Canadian Sentinel Practitioner Surveillance Network routinely undertakes multiplex respiratory virus testing, vaccine effectiveness (VE) estimation by test-negative design (TND), and whole genome sequencing (WGS) of vaccine...

» Structural moral distress among nurse middle managers in crisis
15/05/26 20:00 from covid-19
BackgroundAt a time marked by ongoing global instability and health emergencies, the ethical and operational burdens on healthcare systems derived from the COVID-19 crisis, remain urgently relevant. Positioned between frontline staff and...

» Interim 2025/26 LP.8.1 vaccine effectiveness estimates against COVID-19 from the Canadian Sentinel Practitioner Surveillance Network (SPSN): insights into possible impact of influenza and other respiratory virus co-circulation
15/05/26 20:00 from coronavirus
BACKGROUNDThe Canadian Sentinel Practitioner Surveillance Network routinely undertakes multiplex respiratory virus testing, vaccine effectiveness (VE) estimation by test-negative design (TND), and whole genome sequencing (WGS) of vaccine...

» Clinical and economic benefits of seasonal COVID-19 vaccination in Germany: results from the ROUTINE-COV19 Study, September 2022 to March 2024
15/05/26 20:00 from covid-19
BACKGROUNDVaccinations against COVID-19 were integrated into routine care in Germany in April 2023. However, evidence of the impact of seasonal vaccination remains limited.AIMTo assess the clinical and economic impact of COVID-19 vaccina...

» Highly pathogenic avian influenza A(H5N1) in poultry and domestic cats and occupational exposure among veterinary and other first responders, Germany, February 2026
15/05/26 20:00 from coronavirus
In February 2026, a highly pathogenic avian influenza (HPAI) A(H5N1) outbreak in a poultry holding in Sigmaringen, Germany, affected poultry and domestic cats, with infection confirmed by RT-qPCR. A One Health investigation identified 17...

» Surveillance and vaccine effectiveness of pertussis, the Netherlands, 2012 to 2024, with an unprecedented surge in 2023 and 2024
15/05/26 20:00 from covid-19
BACKGROUNDA surge in pertussis occurred in the Netherlands in 2023-24. Infant vaccination uptake decreased from 95% in 2011 to ca 86% in 2024. Maternal vaccination was introduced in 2019, with uptake ca 70%.AIMTo describe pertussis epide...

» Anticipating impact of implementing PCV20 or PCV21 vaccines for older adults in the immunisation programme for invasive pneumococcal disease, using nationwide surveillance data, Israel, 2009 to 2024
15/05/26 20:00 from covid-19
BACKGROUNDPneumococcal conjugate vaccines (PCVs) have reduced vaccine-type (VT) invasive pneumococcal disease (IPD) in older adults through direct and indirect effects. However, non-vaccine-type serotypes have emerged. Since the recently...

» Interim 2025/26 LP.8.1 vaccine effectiveness estimates against COVID-19 from the Canadian Sentinel Practitioner Surveillance Network (SPSN): insights into possible impact of influenza and other respiratory virus co-circulation
15/05/26 20:00 from covid-19
BACKGROUNDThe Canadian Sentinel Practitioner Surveillance Network routinely undertakes multiplex respiratory virus testing, vaccine effectiveness (VE) estimation by test-negative design (TND), and whole genome sequencing (WGS) of vaccine...

» Inequalities in adolescent HPV, Td/IPV and MenACWY vaccination coverage by socio-economic status: an ecological study, England, 2017 to 2024
15/05/26 20:00 from covid-19
BACKGROUNDMany countries use school-based vaccination for adolescent vaccination; it has been shown to reduce inequities in uptake compared with other delivery routes. In England, coverage for human papillomavirus (HPV), meningococcal gr...

» Decreases in influenza vaccination coverage among nursing home healthcare workers and in measures to promote influenza vaccination, France, 2007/08 to 2024/25
15/05/26 20:00 from covid-19
BACKGROUNDVaccination of residents and healthcare workers (HCWs) against influenza in nursing homes is an important prevention strategy.AIMTo describe trends in influenza vaccination coverage (VC) among HCWs working in nursing homes in F...

» Highly pathogenic avian influenza A(H5N1) in poultry and domestic cats and occupational exposure among veterinary and other first responders, Germany, February 2026
15/05/26 20:00 from covid-19
In February 2026, a highly pathogenic avian influenza (HPAI) A(H5N1) outbreak in a poultry holding in Sigmaringen, Germany, affected poultry and domestic cats, with infection confirmed by RT-qPCR. A One Health investigation identified 17...

» Associations of Job Strain and Health: Differences Among Nurses and Personal Support Workers in Residential Care Homes During the COVID-19 Pandemic
15/05/26 20:00 from covid-19
CONCLUSIONS: Differences among nurses and PSWs demonstrate the importance of understanding variations in roles, occupational experiences and policies regulating health care workers.

» Productivity and genetic stability of a novel baculovirus vector for multigene expression from independent transgene loci
14/05/26 20:00 from Coronavirus origins
The baculovirus expression vector system is an established platform for large-scale production of (glyco)proteins, subunit vaccines, virus-like particles, and recombinant adeno-associated virus (rAAV) vectors. We engineered a novel bacmi...

» Productivity and genetic stability of a novel baculovirus vector for multigene expression from independent transgene loci
14/05/26 20:00 from Covid-19 origins
The baculovirus expression vector system is an established platform for large-scale production of (glyco)proteins, subunit vaccines, virus-like particles, and recombinant adeno-associated virus (rAAV) vectors. We engineered a novel bacmi...

» Selective Targeting of SARS-CoV-2 Spike Protein by Isatin-Hydrazide Hybrids: Synergistic In vitro and Molecular Dynamics Approaches
14/05/26 20:00 from Covid-19 origins
CONCLUSION: The results of these in vitro and in silico experiments suggest their medical potential in treating SARS-CoV-2 infection with high potency. Therefore, these tiny compounds have the potential to be therapeutic agents.

» Productivity and genetic stability of a novel baculovirus vector for multigene expression from independent transgene loci
14/05/26 20:00 from Sars-Cov-2 origins
The baculovirus expression vector system is an established platform for large-scale production of (glyco)proteins, subunit vaccines, virus-like particles, and recombinant adeno-associated virus (rAAV) vectors. We engineered a novel bacmi...

» Selective Targeting of SARS-CoV-2 Spike Protein by Isatin-Hydrazide Hybrids: Synergistic In vitro and Molecular Dynamics Approaches
14/05/26 20:00 from Sars-Cov-2 origins
CONCLUSION: The results of these in vitro and in silico experiments suggest their medical potential in treating SARS-CoV-2 infection with high potency. Therefore, these tiny compounds have the potential to be therapeutic agents.

» Beyond Breakfast: Exploring What Works for Schools Delivering School Breakfast Programs in Queensland, Australia
14/05/26 20:00 from covid-19
CONCLUSION: This study demonstrates how successful SBFR programs can operate as adaptable, equity-focused interventions that create supportive environments, reduce stigma, and strengthen social connectedness while addressing food insecur...

» Beyond Breakfast: Exploring What Works for Schools Delivering School Breakfast Programs in Queensland, Australia
14/05/26 20:00 from sars-cov-2
CONCLUSION: This study demonstrates how successful SBFR programs can operate as adaptable, equity-focused interventions that create supportive environments, reduce stigma, and strengthen social connectedness while addressing food insecur...

» Long-term cardiovascular function and cardiopulmonary performance in athletes after COVID-19: results from the COSMO study
14/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Athletes recovering from mild SARS-CoV-2 infection show no evidence of impaired myocardial structure, strain, or cardiopulmonary performance at 12 months post-infection. Minor variations in diastolic indices and body composit...

» Decoding pain and mental health patterns in youth with chronic pain during COVID-19
14/05/26 20:00 from covid-19
BACKGROUND: The COVID-19 pandemic led to major disruptions in healthcare services, resulting in increased pain and co-occurring mental health issues among youth with chronic pain. However, heterogeneity in these symptoms has not been exp...

» Development and diagnostic performance of a novel scoring system for predicting COVID-19 severity in a national referral hospital
14/05/26 20:00 from sars-cov-2
Coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical manifestations, ranging from mild illness to severe and critical disease. Early identification of patients at risk of deterioration remains important for timely clinic...

» The Impact of Health Literacy on COVID-19 Preventive Practices Among Rehabilitation Students in Eastern Iran: A Cross-Sectional Study
14/05/26 20:00 from covid-19
CONCLUSION: The study highlights the importance of improving health literacy to promote better preventive behaviors against COVID-19. Customized educational methods that address each program's specific needs are crucial. To boost student...

» Mild Encephalopathy With a Reversible Splenial Lesion Type II in a Probable Post-infectious SARS-CoV-2 Context: A Case Report
14/05/26 20:00 from sars-cov-2
Mild encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by acute encephalopathy and a transient lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). We r...

» A qualitative mystery shopper study that de(codes) the experiences of English and Spanish-speaking patients who call to schedule a first-time primary care appointment in the Los Angeles, Houston, and New York Metropolitan Statistical Areas
14/05/26 20:00 from covid-19
CONCLUSION: This study shows disparities in access to care between English and Spanish-speaking patients at the time of scheduling a first-time appointment, highlighting an important point for future intervention.

» Development and diagnostic performance of a novel scoring system for predicting COVID-19 severity in a national referral hospital
14/05/26 20:00 from covid-19
Coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical manifestations, ranging from mild illness to severe and critical disease. Early identification of patients at risk of deterioration remains important for timely clinic...

» Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms
14/05/26 20:00 from sars-cov-2
Respiratory virus infections in cattle cause an estimated more than $1 billion in production losses and can threaten human health. During February 2024 to May 2025, we employed a One Health approach to surveil for respiratory viruses amo...

» Molecular survey of mammalian orthoreovirus and Rotavirus A in Italian dogs and cats
14/05/26 20:00 from covid-19
Mammalian orthoreoviruses (MRVs) and Rotavirus A (RVA) are double-stranded RNA viruses with zoonotic potential that can infect a wide range of mammalian hosts, including companion animals. Data on their circulation in dogs and cats remai...

» A phase 1 clinical trial of a multi-antigen SARS-CoV DNA vaccine as a booster after dose three spike-based mRNA vaccinations
14/05/26 20:00 from sars-cov-2
The COVID-19 pandemic was controlled by active vaccination, but emergence of viral mutations in the receptor-binding domain (RBD) of the spike (S) protein supported the need for vaccines targeting genetically stable viral domains. We dev...

» Patient with Acute-On-Chronic Cholecystitis Complicated by Portal Vein Thrombosis Following "Long COVID-19": A Case Report
14/05/26 20:00 from covid-19
Portal vein thrombosis (PVT) is a rare but serious complication of hypercoagulable states or conditions that increase portal pressure, such as liver cirrhosis, inherited or acquired coagulation cascade abnormalities, myeloproliferative d...

» Productivity and genetic stability of a novel baculovirus vector for multigene expression from independent transgene loci
14/05/26 20:00 from sars-cov-2
The baculovirus expression vector system is an established platform for large-scale production of (glyco)proteins, subunit vaccines, virus-like particles, and recombinant adeno-associated virus (rAAV) vectors. We engineered a novel bacmi...

» Patient-Provider Discussions on Lung Cancer Screening: Insights From the Health Information National Trends Survey (HINTS)
14/05/26 20:00 from covid-19
Background Lung cancer risk is significantly elevated in individuals with chronic lung diseases (CLDs), including asthma, emphysema, and chronic bronchitis. Despite this, lung cancer screening (LCS) remains underutilized in this high-ris...

» Systems vaccinology analysis of saRNA immunization identifies an acute innate immune signature correlated with adaptive immunity
14/05/26 20:00 from sars-cov-2
Self-amplifying ribonucleic acid (saRNA) vaccines are a next-generation RNA vaccine platform with great potential. Systems vaccinology provides a potent tool to interrogate vaccine-induced responses in volunteers and to dissect the mecha...

» Mild Encephalopathy With a Reversible Splenial Lesion Type II in a Probable Post-infectious SARS-CoV-2 Context: A Case Report
14/05/26 20:00 from covid-19
Mild encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by acute encephalopathy and a transient lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). We r...

» Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function
14/05/26 20:00 from sars-cov-2
Engineered plasma cells (ePCs) offer a durable strategy for in vivo delivery of therapeutic antibodies, but standard immunodeficient mouse models lack human immune factors critical for PC survival and function. We utilized a humanized mo...

» Sinus Arrest Associated With a COVID-19 Nasopharyngeal Swab Procedure: A Case Report
14/05/26 20:00 from covid-19
During the COVID-19 pandemic, nasal swabs became a routine test for infection. This non-invasive procedure is typically regarded as benign and rarely associated with complications. However, physical stimulation of the nasopharynx and tri...

» Acupuncture for cognitive functions in post-COVID-19 condition: study protocol of a three-armed, randomized controlled trial with multimodal MRI
14/05/26 20:00 from sars-cov-2
BACKGROUND: Post-COVID-19 condition (PCC), commonly called long COVID, is a prevalent sequela of SARS-CoV-2 infection and can affect multiple organ systems. Cognitive dysfunction is one of the most common symptoms in PCC, with a prevalen...

» Long-term cardiovascular function and cardiopulmonary performance in athletes after COVID-19: results from the COSMO study
14/05/26 20:00 from sars-cov-2
CONCLUSION: Athletes recovering from mild SARS-CoV-2 infection show no evidence of impaired myocardial structure, strain, or cardiopulmonary performance at 12 months post-infection. Minor variations in diastolic indices and body composit...

» Virtual Neuropsychological Assessment After Severe or Critical COVID-19: The NeuroCov Pilot Feasibility Study
14/05/26 20:00 from covid-19
Purpose Survivors of COVID-19 experience a myriad of psychological and cognitive complications that persist beyond the period of acute illness. Neuropsychological assessment has traditionally involved in-person testing, which may be inco...

» Epidemiology of respiratory infectious diseases after the relaxation of COVID-19 policies: a retrospective study in Xiamen, China
14/05/26 20:00 from sars-cov-2
CONCLUSION: This study provides a detailed epidemiological snapshot of post-pandemic respiratory pathogens in Xiamen, highlighting distinct age-specific vulnerabilities and seasonal patterns. These findings offer practical guidance for d...

» Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms
14/05/26 20:00 from covid-19
Respiratory virus infections in cattle cause an estimated more than $1 billion in production losses and can threaten human health. During February 2024 to May 2025, we employed a One Health approach to surveil for respiratory viruses amo...

» Selective Targeting of SARS-CoV-2 Spike Protein by Isatin-Hydrazide Hybrids: Synergistic In vitro and Molecular Dynamics Approaches
14/05/26 20:00 from sars-cov-2
CONCLUSION: The results of these in vitro and in silico experiments suggest their medical potential in treating SARS-CoV-2 infection with high potency. Therefore, these tiny compounds have the potential to be therapeutic agents.

» Bayesian Spatial Functional Data Clustering: Applications in Disease Surveillance
14/05/26 20:00 from covid-19 and viral hemorrhagic fevers
The ability to accurately cluster contiguous regions with similar disease risk evolution is crucial for effective public health response and resource allocation. In this article, we propose a novel spatial functional clustering model des...

» The impact of culturally tailored video interventions for Long COVID among Hispanic/Latino populations
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: Culturally tailored Long COVID videos effectively enhanced knowledge among Hispanic/Latino audiences, mitigating educational disparities and engaging individuals with diverse experiences. While cultural design elements had l...

» A phase 1 clinical trial of a multi-antigen SARS-CoV DNA vaccine as a booster after dose three spike-based mRNA vaccinations
14/05/26 20:00 from covid-19
The COVID-19 pandemic was controlled by active vaccination, but emergence of viral mutations in the receptor-binding domain (RBD) of the spike (S) protein supported the need for vaccines targeting genetically stable viral domains. We dev...

» Intimate Partner Violence in Sedgwick County (SGC) Pre- and Post-COVID-19 Pandemic: A retrospective longitudinal analysis of Wichita Family Crisis Center services
14/05/26 20:00 from covid-19
CONCLUSIONS: In SGC, IPV-related calls and services decreased during the pandemic and increased steadily in the post-COVID period. These patterns may reflect reduced access to care or changes in service availability during the pandemic, ...

» Fathering in a Pandemic: Low-Income Black Fathers' Experiences and Mental Health Stressors
14/05/26 20:00 from sars-cov-2
COVID-19 interventions disrupted family life, disproportionately affecting low-income Black fathers. Although family relationships are critical aspects of men's mental health and overall well-being, studies examining the effect of the pa...

» Serological Benefit of SARS-CoV-2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: We identified a significant serological benefit of SCV2 vaccination relative to infection, in terms of antibody avidity, level, and durability. These data can support clinicians in making evidence-based vaccine recommendatio...

» Comparing Genetic Testing Completion among Breast Cancer Patients When Ordered by a Surgeon Versus a Genetic Specialist
14/05/26 20:00 from covid-19
CONCLUSIONS: Offering genetic testing directly within the breast surgeon's clinic was associated with significantly higher completion rates compared with referral-based testing. Integrating genetic testing into surgical consultations may...

» Beyond Breakfast: Exploring What Works for Schools Delivering School Breakfast Programs in Queensland, Australia
14/05/26 20:00 from coronavirus
CONCLUSION: This study demonstrates how successful SBFR programs can operate as adaptable, equity-focused interventions that create supportive environments, reduce stigma, and strengthen social connectedness while addressing food insecur...

» Development and diagnostic performance of a novel scoring system for predicting COVID-19 severity in a national referral hospital
14/05/26 20:00 from coronavirus
Coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical manifestations, ranging from mild illness to severe and critical disease. Early identification of patients at risk of deterioration remains important for timely clinic...

» Molecular survey of mammalian orthoreovirus and Rotavirus A in Italian dogs and cats
14/05/26 20:00 from coronavirus
Mammalian orthoreoviruses (MRVs) and Rotavirus A (RVA) are double-stranded RNA viruses with zoonotic potential that can infect a wide range of mammalian hosts, including companion animals. Data on their circulation in dogs and cats remai...

» Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms
14/05/26 20:00 from coronavirus
Respiratory virus infections in cattle cause an estimated more than $1 billion in production losses and can threaten human health. During February 2024 to May 2025, we employed a One Health approach to surveil for respiratory viruses amo...

» Selective Targeting of SARS-CoV-2 Spike Protein by Isatin-Hydrazide Hybrids: Synergistic In vitro and Molecular Dynamics Approaches
14/05/26 20:00 from sars-cov-2 spike protein
CONCLUSION: The results of these in vitro and in silico experiments suggest their medical potential in treating SARS-CoV-2 infection with high potency. Therefore, these tiny compounds have the potential to be therapeutic agents.

» Productivity and genetic stability of a novel baculovirus vector for multigene expression from independent transgene loci
14/05/26 20:00 from coronavirus
The baculovirus expression vector system is an established platform for large-scale production of (glyco)proteins, subunit vaccines, virus-like particles, and recombinant adeno-associated virus (rAAV) vectors. We engineered a novel bacmi...

» Systems vaccinology analysis of saRNA immunization identifies an acute innate immune signature correlated with adaptive immunity
14/05/26 20:00 from coronavirus
Self-amplifying ribonucleic acid (saRNA) vaccines are a next-generation RNA vaccine platform with great potential. Systems vaccinology provides a potent tool to interrogate vaccine-induced responses in volunteers and to dissect the mecha...

» Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function
14/05/26 20:00 from coronavirus
Engineered plasma cells (ePCs) offer a durable strategy for in vivo delivery of therapeutic antibodies, but standard immunodeficient mouse models lack human immune factors critical for PC survival and function. We utilized a humanized mo...

» Epidemiology of respiratory infectious diseases after the relaxation of COVID-19 policies: a retrospective study in Xiamen, China
14/05/26 20:00 from coronavirus
CONCLUSION: This study provides a detailed epidemiological snapshot of post-pandemic respiratory pathogens in Xiamen, highlighting distinct age-specific vulnerabilities and seasonal patterns. These findings offer practical guidance for d...

» The impact of culturally tailored video interventions for Long COVID among Hispanic/Latino populations
14/05/26 20:00 from coronavirus
CONCLUSIONS: Culturally tailored Long COVID videos effectively enhanced knowledge among Hispanic/Latino audiences, mitigating educational disparities and engaging individuals with diverse experiences. While cultural design elements had l...

» Fathering in a Pandemic: Low-Income Black Fathers' Experiences and Mental Health Stressors
14/05/26 20:00 from coronavirus
COVID-19 interventions disrupted family life, disproportionately affecting low-income Black fathers. Although family relationships are critical aspects of men's mental health and overall well-being, studies examining the effect of the pa...

» Coronary thrombosis without underlying atherosclerotic plaque in patients with Omicron variant of coronavirus disease 2019: a case series
14/05/26 20:00 from coronavirus
CONCLUSIONS: This case series highlights that infection with the Omicron variant of COVID-19 virus (especially its critical and severe type) can increase thrombogenicity and contribute to coronary thrombosis without underlying atheroscle...

» Serological response to feline coronavirus in the UK domestic cat population
14/05/26 20:00 from Coronavirus origins
Feline coronavirus (FCoV) is a ubiquitous virus of cats, with highly variable seroprevalence, ranging between 4 and 95% worldwide in the domestic cat population. It is the causative agent of feline infectious peritonitis (FIP), a disease...

» Serological response to feline coronavirus in the UK domestic cat population
14/05/26 20:00 from Sars-Cov-2 origins
Feline coronavirus (FCoV) is a ubiquitous virus of cats, with highly variable seroprevalence, ranging between 4 and 95% worldwide in the domestic cat population. It is the causative agent of feline infectious peritonitis (FIP), a disease...

» SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: Collectively, these findings establish N dephosphorylation as a critical regulatory step in SARS-CoV-2 assembly and virion release. In ERGIC, this M protein-mediated process recruits host PP2A to dephosphorylate N, thus supp...

» Death and ICU Admission Associated with Sars-Cov-2 Variants in Immunocompromised Hospitalised Individuals: A National Observational Study
14/05/26 20:00 from sars-cov-2
CONCLUSION: Immunocompromised status was independently associated with higher odds of adverse hospital outcomes, including ICU admission and in-hospital mortality, regardless of the circulating SARS-CoV-2 variant.

» Exclusive: NIH ousts infectious-disease leaders as COVID scientists face US charges
14/05/26 20:00 from sars-cov-2
No abstract

» Inequalities and determinants of unmet need for SARS-CoV-2 testing in Ghana, Burkina Faso and Madagascar (2020 - 2021)
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: Our findings reveal critical weaknesses in health system preparedness that call for urgent measures to strengthen testing capacity and ensure equitable access for both routine care provision and future health crises.

» Integrated immune, apoptotic and mitochondrial gene dysregulation in Long COVID and their association with symptom burden at 10 months post-infection
14/05/26 20:00 from sars-cov-2
Long COVID is characterized by persistent symptoms following acute SARS-CoV-2 infection, yet its biological mechanisms remain incompletely understood. Emerging evidence suggests that immune dysregulation, mitochondrial dysfunction, and a...

» ThermiQuant™ AquaStream: A portable instrument for quantitative colorimetric isothermal nucleic acid amplification reactions in paper and tube formats
14/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Microfluidic paper-based analytical devices (µPADs) are an attractive format for colorimetric nucleic acid amplification tests (NAATs) because they enable low-cost, portable diagnostics in resource-limited settings. However, researchers ...

» Venous and arterial thromboembolic events after COVID-19 during the Omicron period in three European countries
14/05/26 20:00 from sars-cov-2
Patients with earlier SARS-CoV-2 variants are at increased risk of venous and arterial thromboembolic (VTE, ATE) events. Here we aimed to contextualise the incidence of thromboembolic events among patients with COVID-19 during the Omicro...

» SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production
14/05/26 20:00 from coronavirus
CONCLUSIONS: Collectively, these findings establish N dephosphorylation as a critical regulatory step in SARS-CoV-2 assembly and virion release. In ERGIC, this M protein-mediated process recruits host PP2A to dephosphorylate N, thus supp...

» Serological response to feline coronavirus in the UK domestic cat population
14/05/26 20:00 from Covid-19 origins
Feline coronavirus (FCoV) is a ubiquitous virus of cats, with highly variable seroprevalence, ranging between 4 and 95% worldwide in the domestic cat population. It is the causative agent of feline infectious peritonitis (FIP), a disease...

» Mental health symptoms during the Covid-19 pandemic and hypertension in Morocco
14/05/26 20:00 from sars-cov-2
The Covid-19 pandemic has had well-established effects on mental health. However, few studies have examined its specific impact on people with hypertension. To address this gap, a study was conducted in the Beni Mellal province, Morocco,...

» Increased mortality and Acinetobacter baumannii predominance despite stable healthcare-associated infection rates during the COVID-19 pandemic
14/05/26 20:00 from coronavirus
CONCLUSION: Despite similar HAIs rates, in-hospital mortality increased during the pandemic. This was accompanied by higher disease severity, reflected by increased cardiopulmonary resuscitation rates, and a shift toward Acinetobacter ba...

» Near-Source Wastewater Surveillance of SARS-CoV-2, Influenza A, and Respiratory Syncytial Virus With Spatiotemporal Evaluation of Pepper Mild Mottle Virus as a Fecal Indicator
14/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Wastewater-based epidemiology (WBE) is increasingly transitioning from treatment plant scale monitoring toward community-scale surveillance to provide higher spatial resolution. However, the influence of monitoring scale on signal stabil...

» Respiratory viruses in adult community-acquired pneumonia identified by a multiplex PCR panel: a single-center retrospective study
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: In routine CAP practice, diverse non-influenza and non-SARS-CoV-2 respiratory viruses were detected, with clear seasonal variation. Multiple-virus positivity was rare and associated with younger age.

» Death and ICU Admission Associated with Sars-Cov-2 Variants in Immunocompromised Hospitalised Individuals: A National Observational Study
14/05/26 20:00 from coronavirus
CONCLUSION: Immunocompromised status was independently associated with higher odds of adverse hospital outcomes, including ICU admission and in-hospital mortality, regardless of the circulating SARS-CoV-2 variant.

» Cross-Species Transmission and Structural Adaptive Evolution: Implications of the FCoV-23 Pandemic for the Evolution of Coronaviruses
14/05/26 20:00 from covid-19 and viral infections in pigs
Two recent studies identified feline coronavirus 23 (FCoV-23), a recombinant feline coronavirus responsible for severe feline infectious peritonitis outbreaks in Cyprus. Recombination analysis revealed two breakpoints flanking a region s...

» Gut microbiome shift in long COVID: impact of disease and montelukast treatment
14/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Long COVID is characterised by a significant restructure of the gut ecosystem. This qualitative dysbiosis reflects a shift in homeostatic balance, where the core microbial community remains present, but its proportions are a...

» Innovative lipid nanoparticle formulations: Bridging the gap toward decentralized personalized gene therapies
14/05/26 20:00 from sars-cov-2
Lipid nanoparticles (LNPs) have become a key technology for delivering nucleic acids, playing a critical role in the success of mRNA vaccines and RNA-based therapeutics. Established manufacturing methods, including microfluidic mixing an...

» Mental health symptoms during the Covid-19 pandemic and hypertension in Morocco
14/05/26 20:00 from coronavirus
The Covid-19 pandemic has had well-established effects on mental health. However, few studies have examined its specific impact on people with hypertension. To address this gap, a study was conducted in the Beni Mellal province, Morocco,...

» The cost-effectiveness of vaccination against COVID-19 in at-risk populations and older adults in the United Kingdom: Projections using a dynamic transmission model
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: Vaccinating adults aged ≥65 years and high-risk individuals 6 months-64 years remains cost-effective compared both to no vaccination and vaccination of the narrower population.

» Respiratory viruses in adult community-acquired pneumonia identified by a multiplex PCR panel: a single-center retrospective study
14/05/26 20:00 from coronavirus
CONCLUSIONS: In routine CAP practice, diverse non-influenza and non-SARS-CoV-2 respiratory viruses were detected, with clear seasonal variation. Multiple-virus positivity was rare and associated with younger age.

» SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production
14/05/26 20:00 from covid-19
CONCLUSIONS: Collectively, these findings establish N dephosphorylation as a critical regulatory step in SARS-CoV-2 assembly and virion release. In ERGIC, this M protein-mediated process recruits host PP2A to dephosphorylate N, thus supp...

» Quality of reporting of systematic reviews with meta-analysis of diagnostic test accuracy of rapid antigen tests for SARS-CoV-2 according to PRISMA-DTA: A meta-epidemiological survey
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: Our meta-epidemiological survey reveals persistent shortcomings in the reporting quality of systematic reviews evaluating rapid antigen test accuracy for SARS-CoV-2. While some items were consistently addressed, numerous cri...

» The cost-effectiveness of vaccination against COVID-19 in at-risk populations and older adults in the United Kingdom: Projections using a dynamic transmission model
14/05/26 20:00 from coronavirus
CONCLUSIONS: Vaccinating adults aged ≥65 years and high-risk individuals 6 months-64 years remains cost-effective compared both to no vaccination and vaccination of the narrower population.

» Increased mortality and Acinetobacter baumannii predominance despite stable healthcare-associated infection rates during the COVID-19 pandemic
14/05/26 20:00 from covid-19
CONCLUSION: Despite similar HAIs rates, in-hospital mortality increased during the pandemic. This was accompanied by higher disease severity, reflected by increased cardiopulmonary resuscitation rates, and a shift toward Acinetobacter ba...

» Single-cell RNA sequencing reveals mucosal BPIFA1-high-expressing neutrophils aid immune defense in SARS-CoV-2 breakthrough infection
14/05/26 20:00 from sars-cov-2
CONCLUSIONS: BPI+ neutrophils in the respiratory mucosa are pivotal in driving immune responses during breakthrough infection by modulating macrophage activity via the NF-κB pathway. It may trigger the production of interleukin-6, the im...

» Effect of infection temperature on infectivity and host response of human coronavirus OC43
14/05/26 20:00 from coronavirus
This study aimed to investigate the changes in human coronavirus (HCoV)-OC43-infected cells upon the viral infection temperature and the associated intracellular mechanisms. To examine the influence of temperature during viral propagatio...

» Death and ICU Admission Associated with Sars-Cov-2 Variants in Immunocompromised Hospitalised Individuals: A National Observational Study
14/05/26 20:00 from covid-19
CONCLUSION: Immunocompromised status was independently associated with higher odds of adverse hospital outcomes, including ICU admission and in-hospital mortality, regardless of the circulating SARS-CoV-2 variant.

» Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses
14/05/26 20:00 from sars-cov-2
Biological predictors of variable vaccine responses are lacking. We hypothesized that variability in prevaccine innate immune responses, specifically for type I interferons (IFN-I), is predictive of postvaccine antigen-specific responses...

» Closantel, an FDA-approved veterinary drug, suppresses PEDV replication via targeting main protease
14/05/26 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) continues to pose a global threat to the swine industry, causing fatal neonatal diarrhea with a mortality rate approaching 100%. Currently, no effective targeted drugs have been approved. The corona...

» Exclusive: NIH ousts infectious-disease leaders as COVID scientists face US charges
14/05/26 20:00 from covid-19
No abstract

» Effect of age, severity of diarrhoea, number of pathogens present and blooming of E. coli on metagenomic characteristics of stools from Danish dairy calves with diarrhoea
14/05/26 20:00 from coronavirus
CONCLUSIONS: Long-read metagenomics revealed insignificant influence of severity of diarrhoea, age below 4 weeks and number of pathogens detected in stool samples on diversity and microbial communities in diarrheic dairy calves. In contr...

» TP53 mutations and baseline lymphocytes indicate response to glofitamab in relapsed or refractory diffuse large B-cell lymphoma
14/05/26 20:00 from covid-19
Although CAR-T cell therapy has emerged as a promising therapeutic option for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), long manufacturing time, high cost and toxicities limit its clinical use. T-cell engagers (TCE...

» Quality of reporting of systematic reviews with meta-analysis of diagnostic test accuracy of rapid antigen tests for SARS-CoV-2 according to PRISMA-DTA: A meta-epidemiological survey
14/05/26 20:00 from coronavirus
CONCLUSIONS: Our meta-epidemiological survey reveals persistent shortcomings in the reporting quality of systematic reviews evaluating rapid antigen test accuracy for SARS-CoV-2. While some items were consistently addressed, numerous cri...

» Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses
14/05/26 20:00 from coronavirus
Biological predictors of variable vaccine responses are lacking. We hypothesized that variability in prevaccine innate immune responses, specifically for type I interferons (IFN-I), is predictive of postvaccine antigen-specific responses...

» Descriptive assessment of cardiac changes in cats with feline infectious peritonitis
14/05/26 20:00 from coronavirus
CONCLUSIONS AND CLINICAL IMPORTANCE: Cats with FIP can present with increases in cTnI and ventricular wall thickening, findings suggestive of myocarditis or myocardial injury.

» Nutritional Status as a Severity Predictor in Critical Pediatric Patients With COVID-19
13/05/26 20:00 from coronavirus
CONCLUSION: Independent association was identified between low weight in children with COVID-19 in Pediatric Intensive Care Units and longer length of hospital stay, need for IMV, ARDS and higher risk of mortality.

» Nutritional Status as a Severity Predictor in Critical Pediatric Patients With COVID-19
13/05/26 20:00 from sars-cov-2
CONCLUSION: Independent association was identified between low weight in children with COVID-19 in Pediatric Intensive Care Units and longer length of hospital stay, need for IMV, ARDS and higher risk of mortality.

» Peptide Probe-Based NanoLC-MS/MS PRM for Ultrasensitive Detection of SARS-CoV-2 Proteins in Environmental Samples
13/05/26 20:00 from coronavirus
CONCLUSION: The study successfully developed a sensitive and reliable peptide probe-based approach for detecting SARS-CoV-2 in various environmental samples. The use of the PRM method targeting the S and N proteins of SARS-CoV-2 provides...

» Endosomal maturation leads to nucleocapsid conformation change in seasonal coronaviruses
13/05/26 20:00 from coronavirus
As seen in the coronavirus pandemic, the social impact of the spread of emerging and re-emerging viral infections is significant. Whilst seasonal human coronaviruses with common cold symptoms have long been identified, there are only few...

» Novel 20th century rotavirus alphagastroenteritidis strains identified in formalin-fixed and ethanol-preserved museum specimens
13/05/26 20:00 from sars-cov-2
Archival specimens held in biorepositories (e.g. natural history collections) offer rare temporal snapshots of global biodiversity. These collections not only preserve species morphology and aspects of ecology, but increasingly provide a...

» SARS-CoV-2 intra-host evolution during acute infection in COVID-19 patients
13/05/26 20:00 from coronavirus
INTRODUCTION: The intra-host evolution represents the mechanism causing the continued emergence of new, highly divergent SARS-CoV-2 variants. The aim of this work was to investigate the intra-host evolution to ass the conditions associat...

» COVID-19 and Congenital Cleft Lip and Palate: A Systematic Review Focusing on Nonsyndromic Neonatal Outcomes
13/05/26 20:00 from sars-cov-2
Craniofacial anomalies (CFAs), such as cleft lip and palate, are among the most frequent birth defects, often necessitating multidisciplinary care. The COVID-19 pandemic raised concerns that maternal SARS-CoV-2 infection and associated f...

» Mental health outcomes among United States remote-eligible working adults post COVID-19: national evidence
13/05/26 20:00 from coronavirus
CONCLUSION: With the projected aging workforce, the need for targeted screening, equitable and culturally responsive mental health care, and equitable mental health care services to address unmet mental health needs is crucial with the e...

» Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell-Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
13/05/26 20:00 from sars-cov-2
CONCLUSIONS: ME/CFS and LC-ME/CFS demonstrate partially overlapping immune cell-associated EV alterations. Mitochondrial membrane potential alterations within selected immune-derived EV subsets, particularly B cell-associated EVs, sugges...

» A retrospective cohort study of viral and sociodemographic determinants of long COVID among Idaho veterans
13/05/26 20:00 from coronavirus
CONCLUSION: This study is perhaps the largest to investigate viral variant effects on long COVID using sequence rather than date-based variant definitions, and is also unique in its focus on a population living in one of the most rural s...

» Experience of COVID-19 universal screening in obstetrical units in Quebec, Canada
13/05/26 20:00 from sars-cov-2
CONCLUSIONS: Non-universal strategies such as symptom-based screening and personal protective equipment may be more practical and cost effective for future respiratory pandemics.

» Disrupted fluid homeostasis in patients with post-Covid-19 syndrome - a case series
13/05/26 20:00 from coronavirus
The post-covid-syndrome (PCS) is characterized by severe persisting fatigue and other long haul symptoms following COVID-19 infection. Disease-driving mechanisms are elusive, biomarkers are missing, treatment options few, and yet million...

» Accessible ethics and legal advice for wastewater surveillance: The WWS ethics adviser app
13/05/26 20:00 from sars-cov-2
Wastewater surveillance (WWS) has a long history in infectious disease management, from the detection of Salmonella Paratyphi B in sewers by Moore in 1948, to its role in global poliovirus eradication and more recently the deployment of ...

» How does prior infection and vaccination relate to the risk of incident SARS-CoV-2 infection/reinfection? A prospective cohort study among nine clinical sites in the USA, February 2021 to January 2023
13/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: In our real-world observational sample, vaccination (with two and ≥three vaccine doses of any Food and Drug Administration Emergency Use Authorization approved vaccine) and prior infection conferred benefits for protection ag...

» Treatment of a case of bilateral long-standing temporomandibular joint dislocation indirectly associated with COVID-19 using eminectomy and mandibular traction
13/05/26 20:00 from coronavirus
CONCLUSION: Care must be taken to avoid overlooking oral diseases in individuals wearing masks.

» Peptide Probe-Based NanoLC-MS/MS PRM for Ultrasensitive Detection of SARS-CoV-2 Proteins in Environmental Samples
13/05/26 20:00 from sars-cov-2
CONCLUSION: The study successfully developed a sensitive and reliable peptide probe-based approach for detecting SARS-CoV-2 in various environmental samples. The use of the PRM method targeting the S and N proteins of SARS-CoV-2 provides...

» Nutritional Status as a Severity Predictor in Critical Pediatric Patients With COVID-19
13/05/26 20:00 from covid-19
CONCLUSION: Independent association was identified between low weight in children with COVID-19 in Pediatric Intensive Care Units and longer length of hospital stay, need for IMV, ARDS and higher risk of mortality.

» Using a longitudinal k-means clustering method to explore nursing home factors associated with SARS-CoV-2 infection peak and resilience to a COVID-19 surge
13/05/26 20:00 from coronavirus
CONCLUSIONS: The facility-level characteristics associated with lower SARS-CoV-2 infection peaks may indicate resiliency and help evaluate the capacity of nursing homes to endure stressors such as respiratory viruses and other communicab...

» SARS-CoV-2 intra-host evolution during acute infection in COVID-19 patients
13/05/26 20:00 from sars-cov-2
INTRODUCTION: The intra-host evolution represents the mechanism causing the continued emergence of new, highly divergent SARS-CoV-2 variants. The aim of this work was to investigate the intra-host evolution to ass the conditions associat...

» Disruption in the Host-Phage Dynamics and Altered Microbial Diversity in the Upper Respiratory Tract of SARS-CoV-2-Infected Individuals
13/05/26 20:00 from sars-cov-2
CONCLUSION: SARS-CoV-2 infection alters URT microbiome composition, increasing microbial diversity but disrupting host-phage dynamics. SARS-CoV-2 Viral load correlates with the shifts in microbial abundance, indicating infection-driven s...

» The longitudinal trajectories of mental health outcomes in healthcare workers in England during the COVID-19 pandemic
13/05/26 20:00 from coronavirus
CONCLUSIONS: While many HCWs reported consistently low mental health symptom levels, almost a third belonged to a latent class characterized by persistently high symptoms across all time points. These findings underscore the need for men...

» Novel 20th century rotavirus alphagastroenteritidis strains identified in formalin-fixed and ethanol-preserved museum specimens
13/05/26 20:00 from covid-19
Archival specimens held in biorepositories (e.g. natural history collections) offer rare temporal snapshots of global biodiversity. These collections not only preserve species morphology and aspects of ecology, but increasingly provide a...

» Mental health outcomes among United States remote-eligible working adults post COVID-19: national evidence
13/05/26 20:00 from sars-cov-2
CONCLUSION: With the projected aging workforce, the need for targeted screening, equitable and culturally responsive mental health care, and equitable mental health care services to address unmet mental health needs is crucial with the e...

» The sigma-1 receptor agonist fluvoxamine alleviates endotoxin-induced acute lung injury in mice
13/05/26 20:00 from covid-19
CONCLUSION: Overall, FLU mitigates LPS-induced pulmonary inflammation and functional deterioration primarily via S1R signaling, highlighting a receptor-specific mechanism underlying its protective effects. Thus, targeting S1R may be an e...

» Pandemic Shadows: Unmasking Gender Disparities in Academic Productivity and Work-Family Conflict
13/05/26 20:00 from coronavirus
Women academics experience inequalities across multiple facets in the university context, including research productivity; teaching, advising and mentoring responsibilities; service workload; and cross-over stress between work and family...

» A retrospective cohort study of viral and sociodemographic determinants of long COVID among Idaho veterans
13/05/26 20:00 from sars-cov-2
CONCLUSION: This study is perhaps the largest to investigate viral variant effects on long COVID using sequence rather than date-based variant definitions, and is also unique in its focus on a population living in one of the most rural s...

» Neoadjuvant almonertinib as a bridging strategy to surgery in resectable lung cancer with active COVID-19: a case report
13/05/26 20:00 from covid-19
While surgical postponement is recommended for patients with resectable non-small cell lung cancer (NSCLC) and active COVID-19, safe and effective bridging therapies during the delay remain poorly defined, especially for epidermal growth...

» How does prior infection and vaccination relate to the risk of incident SARS-CoV-2 infection/reinfection? A prospective cohort study among nine clinical sites in the USA, February 2021 to January 2023
13/05/26 20:00 from coronavirus
CONCLUSION: In our real-world observational sample, vaccination (with two and ≥three vaccine doses of any Food and Drug Administration Emergency Use Authorization approved vaccine) and prior infection conferred benefits for protection ag...

» Novel 20th century rotavirus alphagastroenteritidis strains identified in formalin-fixed and ethanol-preserved museum specimens
13/05/26 20:00 from Sars-Cov-2 origins
Archival specimens held in biorepositories (e.g. natural history collections) offer rare temporal snapshots of global biodiversity. These collections not only preserve species morphology and aspects of ecology, but increasingly provide a...

» COVID-19 and Congenital Cleft Lip and Palate: A Systematic Review Focusing on Nonsyndromic Neonatal Outcomes
13/05/26 20:00 from covid-19
Craniofacial anomalies (CFAs), such as cleft lip and palate, are among the most frequent birth defects, often necessitating multidisciplinary care. The COVID-19 pandemic raised concerns that maternal SARS-CoV-2 infection and associated f...

» Hemophagocytic Lymphohistiocytosis Triggered by Legionella pneumophila and SARS-CoV-2 Infection in GATA2 Deficiency
13/05/26 20:00 from sars-cov-2
Germline GATA2 deficiency predisposes to bone marrow failure, myeloid neoplasia, and immune dysregulation. The syndrome is often complicated by infection with intracellular pathogens and viruses, autoimmunity, and inflammation. Hemophago...

» Calm after the storm; transition from crisis: Iranian nurses' experiences of the COVID-19 pandemic - a qualitative study
13/05/26 20:00 from coronavirus
CONCLUSIONS: The findings suggest that, like other crises, the COVID-19 pandemic represents a temporary disruption. However, certain factors can expedite the transition back to normalcy. These include enhanced awareness of the disease, e...

» Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell-Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
13/05/26 20:00 from covid-19
CONCLUSIONS: ME/CFS and LC-ME/CFS demonstrate partially overlapping immune cell-associated EV alterations. Mitochondrial membrane potential alterations within selected immune-derived EV subsets, particularly B cell-associated EVs, sugges...

» Disrupted fluid homeostasis in patients with post-Covid-19 syndrome - a case series
13/05/26 20:00 from sars-cov-2
The post-covid-syndrome (PCS) is characterized by severe persisting fatigue and other long haul symptoms following COVID-19 infection. Disease-driving mechanisms are elusive, biomarkers are missing, treatment options few, and yet million...

» Accessible ethics and legal advice for wastewater surveillance: The WWS ethics adviser app
13/05/26 20:00 from Sars-Cov-2 origins
Wastewater surveillance (WWS) has a long history in infectious disease management, from the detection of Salmonella Paratyphi B in sewers by Moore in 1948, to its role in global poliovirus eradication and more recently the deployment of ...

» Creation of an Open-Access Lung POCUS Image Database for Deep Learning and Neural Network Applications
13/05/26 20:00 from covid-19
BACKGROUND: Lung point of care ultrasound (POCUS) offers advantages over traditional imaging for diagnosing pulmonary conditions, with superior accuracy compared to chest X-ray and lower cost compared to computed tomography. Despite thes...

» Using a longitudinal k-means clustering method to explore nursing home factors associated with SARS-CoV-2 infection peak and resilience to a COVID-19 surge
13/05/26 20:00 from sars-cov-2
CONCLUSIONS: The facility-level characteristics associated with lower SARS-CoV-2 infection peaks may indicate resiliency and help evaluate the capacity of nursing homes to endure stressors such as respiratory viruses and other communicab...

» The longitudinal trajectories of mental health outcomes in healthcare workers in England during the COVID-19 pandemic
13/05/26 20:00 from sars-cov-2
CONCLUSIONS: While many HCWs reported consistently low mental health symptom levels, almost a third belonged to a latent class characterized by persistently high symptoms across all time points. These findings underscore the need for men...

» Current Use and Barriers to POCUS in Women's Health: A National Survey of Veterans Affairs Medical Centers
13/05/26 20:00 from covid-19
CONCLUSION: This national survey highlighted the low utilization of maternal POCUS among WH clinicians in the VA healthcare system and pointed to critical barriers, including equipment shortages and training gaps. Addressing these barrie...

» Practice behavior of first-year university music students: thriving in unusual times
13/05/26 20:00 from covid-19
INTRODUCTION: The way in which university music students practice is crucial for their development and critical for their lifelong success. Once they begin attending a music university, practice strategies change and evolve, influenced b...

» Trends in Utilization of Acupuncture in the U.S. Health System, 2016-2022
13/05/26 20:00 from covid-19
CONCLUSIONS: Acupuncture use in the MHS expanded ∼2-fold among patients and 3-fold among facilities since 2014. Diagnoses are consistent with pain control, and there was a shift toward nonphysician providers. Promotion of acupuncture in ...

» Novel 20th century rotavirus alphagastroenteritidis strains identified in formalin-fixed and ethanol-preserved museum specimens
13/05/26 20:00 from Covid-19 origins
Archival specimens held in biorepositories (e.g. natural history collections) offer rare temporal snapshots of global biodiversity. These collections not only preserve species morphology and aspects of ecology, but increasingly provide a...

» Experience of COVID-19 universal screening in obstetrical units in Quebec, Canada
13/05/26 20:00 from covid-19
CONCLUSIONS: Non-universal strategies such as symptom-based screening and personal protective equipment may be more practical and cost effective for future respiratory pandemics.

» Accessible ethics and legal advice for wastewater surveillance: The WWS ethics adviser app
13/05/26 20:00 from covid-19
Wastewater surveillance (WWS) has a long history in infectious disease management, from the detection of Salmonella Paratyphi B in sewers by Moore in 1948, to its role in global poliovirus eradication and more recently the deployment of ...

» Accessible ethics and legal advice for wastewater surveillance: The WWS ethics adviser app
13/05/26 20:00 from Covid-19 origins
Wastewater surveillance (WWS) has a long history in infectious disease management, from the detection of Salmonella Paratyphi B in sewers by Moore in 1948, to its role in global poliovirus eradication and more recently the deployment of ...

» Peptide Probe-Based NanoLC-MS/MS PRM for Ultrasensitive Detection of SARS-CoV-2 Proteins in Environmental Samples
13/05/26 20:00 from covid-19
CONCLUSION: The study successfully developed a sensitive and reliable peptide probe-based approach for detecting SARS-CoV-2 in various environmental samples. The use of the PRM method targeting the S and N proteins of SARS-CoV-2 provides...

» Exploring the Relationship Between Comorbidities and Prolonged Viral Shedding in COVID-19: A Cycle Threshold Value-Based Investigation
13/05/26 20:00 from covid-19
CONCLUSION: This study shows that COVID-19 patients with HIV-AIDS have prolonged viral shedding compared to patients with other comorbidities.

» Patient Navigation Programs in Canada for People With Dementia, Their Caregivers and Care Providers: An Environmental Scan
13/05/26 20:00 from covid-19
As the rates of dementia continue to rise across Canada, accessing care remains a challenge for people living with dementia, their caregivers, and members of the care team. Patient navigation offers a promising approach to reducing these...

» Basal Medium Affects the Biological Characteristics and Immunomodulatory Functions of MSCs
13/05/26 20:00 from coronavirus
Human mesenchymal stromal cells (MSCs) possess extensive therapeutic potential, and their biological characteristics and functions can be modulated by culture media. This study aimed to systematically evaluate the effects of two basal me...

» Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants
13/05/26 20:00 from Sars-Cov-2 origins
CONCLUSIONS: Limnetrelvir was found to be a moderate CYP3A4 inhibitor and substrate, suggesting that dosing adjustment or careful monitoring may be necessary when coadministered with medications highly metabolized by CYP3A4 or with stron...

» Establishment of a human coronavirus HKU1 infection evaluation system using apical-out airway organoids
13/05/26 20:00 from coronavirus
Human coronavirus HKU1 (HCoV-HKU1) is difficult to study because it does not propagate in standard cell lines. Consequently, research has relied on the air-liquid interface model, which is limited by long culture periods and the absence ...

» Factors influencing COVID-19 vaccine hesitancy in socially vulnerable Latinx communities in North Texas
13/05/26 20:00 from coronavirus
In the United States, COVID-19 vaccines are widely available, but vaccine hesitancy and vaccine disparities remain. Healthcare providers and community organizational leaders who serve as frontline workers and interact with vaccine-hesita...

» Assessing diaphragm dysfunction in ICU patients with COVID-19 pneumonia: A prospective observational cohort study
13/05/26 20:00 from coronavirus
ObjectiveUltrasonography has been commonly employed during the Coronavirus Disease 2019 (COVID-19) pandemic to assess lung and heart conditions; however, diaphragm ultrasonography (DU) has not been as widely acknowledged. This study aime...

» COVID-19 and Influenza Vaccine Acceptance and Hesitancy Among Caregivers of Children With Cancer
13/05/26 20:00 from covid-19
CONCLUSION: Caregiver attitudes significantly influenced vaccine acceptance. Interventions that strengthen provider communication, address safety and efficacy concerns, and acknowledge caregiver perceptions may help reduce hesitancy in t...

» Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants
13/05/26 20:00 from Covid-19 origins
CONCLUSIONS: Limnetrelvir was found to be a moderate CYP3A4 inhibitor and substrate, suggesting that dosing adjustment or careful monitoring may be necessary when coadministered with medications highly metabolized by CYP3A4 or with stron...

» Adversity, psychological strengths, and well-being during collective trauma: Results from a nationally representative, probability-based U.S. sample
13/05/26 20:00 from covid-19
CONCLUSIONS: Combinations of psychological strengths and adversity exposure correlated with well-being-related outcomes during collective trauma. Results underscore the value of including strengths-based, person-centered approaches in mu...

» Impaired microvascular reactivity in post-COVID-19 syndrome is independent of cardiorespiratory fitness
13/05/26 20:00 from covid-19
Current evidence demonstrates that patients that suffer from long-term SARS-CoV-2 symptoms (i.e., post-COVID-19 syndrome, PCS) often present muscle fatigue and dyspnea. This is discussed to be a result of vascular dysfunction and oxidati...

» Impaired microvascular reactivity in post-COVID-19 syndrome is independent of cardiorespiratory fitness
13/05/26 20:00 from sars-cov-2
Current evidence demonstrates that patients that suffer from long-term SARS-CoV-2 symptoms (i.e., post-COVID-19 syndrome, PCS) often present muscle fatigue and dyspnea. This is discussed to be a result of vascular dysfunction and oxidati...

» Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants
13/05/26 20:00 from covid-19
CONCLUSIONS: Limnetrelvir was found to be a moderate CYP3A4 inhibitor and substrate, suggesting that dosing adjustment or careful monitoring may be necessary when coadministered with medications highly metabolized by CYP3A4 or with stron...

» Basal Medium Affects the Biological Characteristics and Immunomodulatory Functions of MSCs
13/05/26 20:00 from covid-19
Human mesenchymal stromal cells (MSCs) possess extensive therapeutic potential, and their biological characteristics and functions can be modulated by culture media. This study aimed to systematically evaluate the effects of two basal me...

» Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants
13/05/26 20:00 from sars-cov-2
CONCLUSIONS: Limnetrelvir was found to be a moderate CYP3A4 inhibitor and substrate, suggesting that dosing adjustment or careful monitoring may be necessary when coadministered with medications highly metabolized by CYP3A4 or with stron...

» Establishment of a human coronavirus HKU1 infection evaluation system using apical-out airway organoids
13/05/26 20:00 from covid-19
Human coronavirus HKU1 (HCoV-HKU1) is difficult to study because it does not propagate in standard cell lines. Consequently, research has relied on the air-liquid interface model, which is limited by long culture periods and the absence ...

» Factors influencing COVID-19 vaccine hesitancy in socially vulnerable Latinx communities in North Texas
13/05/26 20:00 from sars-cov-2
In the United States, COVID-19 vaccines are widely available, but vaccine hesitancy and vaccine disparities remain. Healthcare providers and community organizational leaders who serve as frontline workers and interact with vaccine-hesita...

» Inhalable viromimetic polymer nanoparticle vaccine (iVPNVax) in a subcutaneous-prime/inhalation-boost vaccination schedule for eliciting durable mucosal and systemic immune protection
13/05/26 20:00 from sars-cov-2
Injectable vaccines seldom establish durable mucosal immunity in airways, permitting recurrent outbreaks of respiratory viruses. Although inhalation targets the respiratory mucosa directly, effective inhalable vaccines remain limited due...

» Factors influencing COVID-19 vaccine hesitancy in socially vulnerable Latinx communities in North Texas
13/05/26 20:00 from covid-19
In the United States, COVID-19 vaccines are widely available, but vaccine hesitancy and vaccine disparities remain. Healthcare providers and community organizational leaders who serve as frontline workers and interact with vaccine-hesita...

» Assessing diaphragm dysfunction in ICU patients with COVID-19 pneumonia: A prospective observational cohort study
13/05/26 20:00 from sars-cov-2
ObjectiveUltrasonography has been commonly employed during the Coronavirus Disease 2019 (COVID-19) pandemic to assess lung and heart conditions; however, diaphragm ultrasonography (DU) has not been as widely acknowledged. This study aime...

» Navigating acceptance: challenges and barriers to nipah virus vaccine uptake in Malaysia's muslim-majority context
13/05/26 20:00 from covid-19
INTRODUCTION: The development of Nipah virus (NiV) vaccine offers a vital opportunity for pandemic preparedness in Southeast Asia, especially in Malaysia, where the first outbreak occurred. However, vaccine acceptance must be understood ...

» Inhalable viromimetic polymer nanoparticle vaccine (iVPNVax) in a subcutaneous-prime/inhalation-boost vaccination schedule for eliciting durable mucosal and systemic immune protection
13/05/26 20:00 from covid-19
Injectable vaccines seldom establish durable mucosal immunity in airways, permitting recurrent outbreaks of respiratory viruses. Although inhalation targets the respiratory mucosa directly, effective inhalable vaccines remain limited due...

» From Resilience Gap to Recovery: A Longitudinal Study of Nurse Job Satisfaction, Seniority, and Managerial Interventions in the Postpandemic Era
13/05/26 20:00 from covid-19
CONCLUSION: The findings conceptualize resilience as a dynamic regulatory capacity within the JD-R framework, reflecting the ongoing balance between job demands and available resources. The observed recovery suggests that proactive, gene...

» Assessing diaphragm dysfunction in ICU patients with COVID-19 pneumonia: A prospective observational cohort study
13/05/26 20:00 from covid-19
ObjectiveUltrasonography has been commonly employed during the Coronavirus Disease 2019 (COVID-19) pandemic to assess lung and heart conditions; however, diaphragm ultrasonography (DU) has not been as widely acknowledged. This study aime...

» Comparing Bayesian and frequentist inference in biological models: A comparative analysis of accuracy, uncertainty, and identifiability
13/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Mathematical models are widely used to study ecological and epidemiological systems, but the accuracy of the resulting inferences and forecasts depends on the estimation framework. This study compares Bayesian and frequentist approaches ...

» Comparison of the performance of four clinical prediction rules for mortality in patients with COVID-19
13/05/26 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: In this Peruvian cohort, the q-CSI score exhibited the best predictive performance and highest feasibility for in-hospital mortality among patients with COVID-19 pneumonia. While the HL test indicated a lack of fit, the anal...

» Trust vs. knowledge during COVID-19: the dominance of trust in promoting preventive behaviours and its role in technology acceptance in Germany and India
13/05/26 20:00 from coronavirus
CONCLUSIONS: This study adds to existing discussions on the role of knowledge, finding that trust showed a stronger association with adherence to COVID-19 measures. Comparing Germany and India, findings show that despite vast differences...

» The impact of psychological distress on working memory during COVID-19 by disentangling cognitive deficits from emotional burden
13/05/26 20:00 from coronavirus
The COVID-19 pandemic has had a profound impact on public health and human cognitive functioning, with studies highlighting deficits in attention, executive function, and working memory. In this study, we examine the relationship between...

» Changes in postoperative pneumonia incidence after the pandemic: a retrospective observational study using a common data model
13/05/26 20:00 from coronavirus
CONCLUSIONS: The COVID-19 pandemic did not substantially change the overall incidence of postoperative pneumonia, although variations existed across hospitals and age groups. Older age remained the strongest risk factor. Further studies ...

» Exponential signal amplification through coupled rolling circle transcription and CRISPR/Cas13a cleavage for ultrasensitive molecular diagnostics
13/05/26 20:00 from coronavirus
Rapid, sensitive nucleic acid detection is crucial for clinical diagnostics, food safety, and environmental monitoring. We present the Sensitive Padlock Rolling-circle INtegrated Transcription with clustered regularly interspaced short p...

» Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts
12/05/26 20:00 from coronavirus
CONCLUSIONS: Ensitrelvir administered to household contacts of a patient with Covid-19 within 72 hours after symptom onset in the index patient was effective in preventing Covid-19 in the contacts. (Funded by Shionogi; SCORPIO-PEP Japan ...

» Procalcitonin use in Acute Medicine in the United Kingdom: a survey of practice, barriers and facilitators
12/05/26 20:00 from coronavirus
CONCLUSIONS: There is widespread variation in practice, driven in part by inconsistency around local guidelines and a lack of national guidance to inform the use of this biomarker. We recommend the development of national, evidence-based...

» CROI 2026: Acute and Postacute COVID-19
12/05/26 20:00 from coronavirus
The 2026 Conference on Retroviruses and Opportunistic Infections (CROI) furthered our understanding of acute COVID-19, long COVID, postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viral immunity, and SA...

» Collectin-11, a complement pattern recognition molecule, mediates pulmonary SARS-CoV-2 neutralization and protection
12/05/26 20:00 from coronavirus
CONCLUSION: CL-11 binds different SARS-CoV-2 variants and neutralizes SARS-CoV-2 in an antibody-independent manner, suggesting a crucial role in early-stage infection control.

» Survival and life expectancy inequality by gender in Thai provinces: Trends from 2015 to 2023
12/05/26 20:00 from coronavirus
CONCLUSIONS: Persistent and geographically uneven gender disparities in life expectancy underscore the necessity for localized, gender-sensitive interventions targeting male mortality and environmental health risks.

» Multicenter retrospective observational study on the clinical effectiveness of butyrate-producing Clostridium butyricum containing probiotics in patients with COVID-19
12/05/26 20:00 from coronavirus
Butyrate-producing bacteria, which are components of the gut microbiome, activate host defense mechanisms against several types of infections, including respiratory viral infections. However, the clinical effectiveness of butyrate-produc...

» COVID-19 pandemic stressors and their longer-term association with young people's wellbeing
12/05/26 20:00 from coronavirus
There is a significant body of research on adolescent wellbeing during the pandemic but less attention to the pathways through which the pandemic might be driving longer-term impacts on wellbeing. This paper addresses this gap using pros...

» Global inequities in biologic and targeted DMARD use in rheumatoid arthritis: cross-sectional data from the international COVAD-2 cohort
12/05/26 20:00 from coronavirus
CONCLUSION: Marked continent- and HDI-based inequities in biologic and targeted DMARD use persist globally, demanding coordinated action from the rheumatology community to ensure equitable RA care across resource settings.

» Regional Virtual Acute Care Helpline in Singapore at a National University Health System Virtual Care Centre: Retrospective Study
12/05/26 20:00 from coronavirus
CONCLUSIONS: The NUHS VCC provides a feasible and safe model for virtual acute care triage within the public health care system. It effectively diverted lower-acuity cases from the ED and ensured continuity of care, offering a scalable a...

» Broad Neutralizing Activity of Monoclonal Antibodies Against the Omicron Variants Isolated From Patients With Early Severe Acute Respiratory Syndrome Coronavirus-2
12/05/26 20:00 from coronavirus
Since its emergence in 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic driven by rapid mutation and high transmissibility. Current therapeutic strategies may not effectively address the con...

» A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol
12/05/26 20:00 from coronavirus
AbstractInfluenza A viruses (IAVs) cause severe outbreaks with high mortality in birds and humans. A deeper understanding of cell-intrinsic defense mechanisms against influenza viruses is therefore crucial for developing novel antiviral ...

» Acute Respiratory Distress Syndrome in a Dog With Canine Respiratory Coronavirus Infection
12/05/26 20:00 from coronavirus
OBJECTIVE: To describe the clinical progression of acute respiratory distress syndrome (ARDS) associated with canine respiratory coronavirus and suspected aspiration in a previously healthy young dog.

» Pentoxifylline in patients with COVID-19 and with liver cirrhosis or metabolic dysfunction-associated steatotic liver disease: Emerging insights
12/05/26 20:00 from coronavirus
Coronavirus (CoV) disease 2019 (COVID-19) deteriorates existing hepatopathies, such as liver cirrhosis and metabolic-associated syndrome liver disease (MASLD), which in turn increases the risk of serious complications. The pathophysiolog...

» N-terminal pyroglutamylation of an HLA-A24-restricted immunodominant epitope enhances SARS-CoV-2-specific T-cell responses
12/05/26 20:00 from coronavirus
T-cell responses play a critical role in the control of SARS-CoV-2 infections. Here, we examined the T-cell response to a conserved, immunodominant HLA-A*24:02-restricted SARS-CoV-2 spike protein epitope, QI9/A24 (QYIKWPWYI; residues 120...

» Clinical Performance of the Loop-Mediated Isothermal Amplification Method Compared With Reverse Transcriptase Polymerase Chain Reaction for COVID-19 Diagnosis in Indonesia and the Philippines
12/05/26 20:00 from coronavirus
Real-time reverse transcriptase polymerase chain reaction (RT-PCR) is considered the gold standard for the diagnosis of coronavirus disease 2019 (COVID-19); however, this method is expensive, time-consuming, and requires skilled personne...

» COVID-19 vaccination before immune checkpoint inhibitor initiation and the overall survival of patients with advanced cancer: A cohort study
12/05/26 20:00 from covid-19
CONCLUSIONS: In this cohort including multiple cancer types, administration of COVID-19 mRNA vaccine within 100 days before ICI initiation was independently associated with superior long-term overall survival. These data warrant prospect...

» Inorganic Antibody-Mimetic H-Zeolite Blocks Airborne Viruses via E340-Targeted Biorecognition
12/05/26 20:00 from sars-cov-2 spike protein
Respiratory viruses pose a persistent threat to human health, demanding effective strategies to block airborne transmission at the individual protection level. Traditional personal protective materials often lack intrinsic virucidal acti...

» Broad Neutralizing Activity of Monoclonal Antibodies Against the Omicron Variants Isolated From Patients With Early Severe Acute Respiratory Syndrome Coronavirus-2
12/05/26 20:00 from sars-cov-2 spike protein
Since its emergence in 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic driven by rapid mutation and high transmissibility. Current therapeutic strategies may not effectively address the con...

» Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts
12/05/26 20:00 from covid-19
CONCLUSIONS: Ensitrelvir administered to household contacts of a patient with Covid-19 within 72 hours after symptom onset in the index patient was effective in preventing Covid-19 in the contacts. (Funded by Shionogi; SCORPIO-PEP Japan ...

» COVID-19 vaccination before immune checkpoint inhibitor initiation and the overall survival of patients with advanced cancer: A cohort study
12/05/26 20:00 from sars-cov-2
CONCLUSIONS: In this cohort including multiple cancer types, administration of COVID-19 mRNA vaccine within 100 days before ICI initiation was independently associated with superior long-term overall survival. These data warrant prospect...