» Behavioral Health Trainee Satisfaction at the US Department of Veterans Affairs During the COVID-19 Pandemic
19/08/25 20:00 from covid-19
CONCLUSIONS: Understanding the VA trainee experience is important for identifying how to improve behavioral health care professional education and training. This study suggests potential areas of concern that can be addressed during futu...

» Metformin on the Presence of COVID-19 Symptoms Over 6 Months: The ACTIV-6 Randomized Clinical Trial
19/08/25 20:00 from sars-cov-2
CONCLUSIONS: The posterior probability of efficacy for metformin preventing the primary endpoint did not exceed the prespecified threshold of 0.975 for declaring efficacy. Secondary outcomes were numerically better with metformin.

» Advancing dementia care: a review of Italy's public health response within the WHO Global Action Plan and European strategies
19/08/25 20:00 from covid-19
INTRODUCTION: Dementia is a growing global public health priority, with the WHO Global Action Plan (GAP) calling for coordinated efforts worldwide. Italy, one of the oldest nations globally, faces a significant challenge with approximate...

» School masking and COVID-19 community transmission: a synthetic control study
19/08/25 20:00 from sars-cov-2
BACKGROUND: K-12 schools play a crucial role not only as educational settings but also as hubs for social interaction among children, making them potential drivers of disease transmission within families and the broader community. Little...

» Impact of the COVID-19 Pandemic on Diagnosis and Multidisciplinary Treatment of NSCLC in Ontario, Canada
19/08/25 20:00 from covid-19
CONCLUSIONS: NSCLC care delivery in Ontario remained stable during the early pandemic period. Declines in diagnosis warrant further investigation using longer-term data. Real-time data systems are essential for future pandemic preparedne...

» Toehold-VISTA: A machine learning approach to decipher programmable RNA sensor-target interactions
19/08/25 20:00 from sars-cov-2
RNA-based biosensors have emerged as essential tools in synthetic biology and diagnostics, enabling precise and programmable responses to diverse RNA inputs. However, the time to design, produce, and screen high-performance RNA sensors r...

» Coping Strategies and Related Factors among Patients with Cancer During the COVID-19 Pandemic in Tehran, Iran (2021-2022)
19/08/25 20:00 from covid-19
CONCLUSIONS: The findings indicate that patients with cancer frequently used emotion-based strategies to manage their stress and anxiety during the COVID-19 pandemic. It appears that coping strategies adopted by patients differ somewhat ...

» Temporal Shifts in Climate-Influenza Dynamics: A Multi-Subtype Analysis in Southern China Spanning the COVID-19 Era
19/08/25 20:00 from sars-cov-2
Background: The COVID-19 pandemic disrupted global influenza transmission. We aimed to elucidate how meteorological and air pollution drivers influenced seasonal influenza A subtypes and B lineage in Southern China pre-, during-, and pos...

» Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses
19/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
INTRODUCTION: In Brazil, three COVID-19 vaccines were among the first widely used (CoronaVac, ChAdOx1, and BNT162b2), which aimed to induce neutralizing antibodies (NAbs) against the original SARS-CoV-2 strain. Although effective against...

» Burnout as a Consequence of Unavoidable Care Provision; Iranian Nurses' Experiences While Caring for Patients with COVID-19: A Qualitative Study
19/08/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 outbreak and its challenges had a significant impact on nurses' mental health. Nurses were constantly concerned about their patients, their families, and their own well-being. A shortage of staff, equipment, and...

» DFT Investigations and Molecular Docking as Potent Inhibitors of SARS-CoV-2 Main Protease of Novel Pyrimidine Dione Derivatives
19/08/25 20:00 from sars-cov-2
The global outbreak of SARS-CoV-2 has emerged as a major public health crisis due to its rapid transmission and significant morbidity and mortality rates. In response, there is an urgent need to discover novel antiviral agents targeting ...

» Kidney disease screening among adults with HIV in Uganda: a missed priority for a high-risk population
19/08/25 20:00 from covid-19
Chronic kidney disease affects 850 million people worldwide, with Sub-Saharan Africa bearing a significant burden. People living with HIV (PWH) are at increased risk due to nephrotoxicity of antiretroviral therapy (ART), in part due to w...

» Prevalence of COVID-19 vaccine hesitancy in Brazil: a systematic review and meta-analysis
19/08/25 20:00 from sars-cov-2
CONCLUSION: In the first meta-analysis conducted in Brazil, vaccine hesitancy was more prevalent among parents of children and adolescents, and vaccine hesitancy decreased in the second pandemic wave. Public policies must be developed to...

» Metformin on the Presence of COVID-19 Symptoms Over 6 Months: The ACTIV-6 Randomized Clinical Trial
19/08/25 20:00 from covid-19
CONCLUSIONS: The posterior probability of efficacy for metformin preventing the primary endpoint did not exceed the prespecified threshold of 0.975 for declaring efficacy. Secondary outcomes were numerically better with metformin.

» Mental symptoms in post-COVID syndrome and post-COVID-19 vaccination syndrome: results of a representative population survey
19/08/25 20:00 from sars-cov-2
CONCLUSION: Mental symptoms are relatively common after both SARS-CoV-2 infection and vaccination and show overlap, especially fatigue. These findings highlight how difficult it is to distinguish PCS from PCVS and emphasize the need to c...

» School masking and COVID-19 community transmission: a synthetic control study
19/08/25 20:00 from covid-19
BACKGROUND: K-12 schools play a crucial role not only as educational settings but also as hubs for social interaction among children, making them potential drivers of disease transmission within families and the broader community. Little...

» Correction: Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021-2022
19/08/25 20:00 from sars-cov-2
[This corrects the article DOI: 10.3389/fpubh.2025.1549159.].

» Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the All of Us Research Program
19/08/25 20:00 from covid-19
CONCLUSIONS: Greater pre-illness symptom burden and lower self-rated mental health increased the odds of long COVID symptoms, after adjusting for demographics, variant, functional status, and individual symptoms. Long COVID represents a ...

» COVID-19 global risk evaluation: rankings, reducing surveillance bias, and infodemic
19/08/25 20:00 from sars-cov-2
This study examines how public health institutions estimate regional COVID-19 burdens, pursuing two primary objectives: (1) to analyze the methodologies employed for regional risk assessment, and (2) to perform spatial and Spearman rank ...

» Telehealth Care for Adolescents and Young Adults with HIV: Practices and Perspectives from a National Mixed-Methods Study of U.S. HIV Care Providers
19/08/25 20:00 from covid-19
CONCLUSIONS: While telehealth improves access for YWH, hybrid care models and targeted provider training are needed to address privacy, communication, and trust when discussing sensitive health concerns.

» Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1
19/08/25 20:00 from sars-cov-2
INTRODUCTION: COVID-19, caused by SARS-CoV-2, remains a global health challenge despite the availability of vaccines and antiviral treatments. The emergence of immune escape variants and the persistence of long COVID symptoms continue to...

» Impact of the COVID-19 Pandemic on Diagnosis and Multidisciplinary Treatment of NSCLC in Ontario, Canada
19/08/25 20:00 from coronavirus
CONCLUSIONS: NSCLC care delivery in Ontario remained stable during the early pandemic period. Declines in diagnosis warrant further investigation using longer-term data. Real-time data systems are essential for future pandemic preparedne...

» The Impact of National Context on COVID-19 Vaccine Hesitancy Across Europe: A Multi-Level Approach
19/08/25 20:00 from covid-19
This study investigates vaccine hesitancy among the 50+ population in Europe and Israel during the COVID-19 pandemic, focusing on the role of national contexts alongside individual determinants. Utilizing data from the SHARE Corona Surve...

» Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses
19/08/25 20:00 from sars-cov-2
INTRODUCTION: In Brazil, three COVID-19 vaccines were among the first widely used (CoronaVac, ChAdOx1, and BNT162b2), which aimed to induce neutralizing antibodies (NAbs) against the original SARS-CoV-2 strain. Although effective against...

» Toehold-VISTA: A machine learning approach to decipher programmable RNA sensor-target interactions
19/08/25 20:00 from covid-19
RNA-based biosensors have emerged as essential tools in synthetic biology and diagnostics, enabling precise and programmable responses to diverse RNA inputs. However, the time to design, produce, and screen high-performance RNA sensors r...

» Dietary supplementation with nano-zinc modulates the expression of the antiviral immune gene IRF3: a novel report
19/08/25 20:00 from sars-cov-2
In the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the application of zinc has increased worldwide. It has the potential to increase the body's antioxidant status and provide better immune makeup. Currently, zinc...

» Automated Annotation and Validation of Human Respiratory Virus Sequences using VADR
19/08/25 20:00 from coronavirus
Accurate annotation of viral genomes is essential for reliable downstream analysis and public data sharing. While NCBI's Viral Annotation DefineR (VADR) pipeline provides standardized annotation and quality control, it only supports six ...

» A handheld microfluidic manifold for massively multiplexed CRISPR-based nucleic acid detection
19/08/25 20:00 from covid-19
Multiplexed methods for nucleic acid detection are immensely challenging to deploy outside of laboratory settings. Conversely, field-deployable methods are limited to low levels of multiplexing. During the COVID-19 pandemic, we developed...

» Immune pressure is key to understanding observed patterns of respiratory virus evolution in prolonged infections
19/08/25 20:00 from sars-cov-2
Analyses of viral samples from prolonged SARS-CoV-2 infections as well as from prolonged infections with other respiratory viruses have indicated that there are several consistent patterns of evolution observed across these infections. T...

» Stress and Resilience Factors Characterizing Pandemic Experiences of Low-Income Pregnant and Postpartum Latina Mothers
19/08/25 20:00 from covid-19
Lingering effects of the COVID-19 pandemic are still of grave concern to families within the U.S. Latine community, as pre-pandemic disparities in healthcare and economic stability were significantly exacerbated by the global crisis (Mar...

» 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab
19/08/25 20:00 from sars-cov-2
This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019 (COVID-19), developed by the Infectious Diseases Society of America. The guideline panel ...

» Temporal Shifts in Climate-Influenza Dynamics: A Multi-Subtype Analysis in Southern China Spanning the COVID-19 Era
19/08/25 20:00 from coronavirus
Background: The COVID-19 pandemic disrupted global influenza transmission. We aimed to elucidate how meteorological and air pollution drivers influenced seasonal influenza A subtypes and B lineage in Southern China pre-, during-, and pos...

» Temporal Shifts in Climate-Influenza Dynamics: A Multi-Subtype Analysis in Southern China Spanning the COVID-19 Era
19/08/25 20:00 from covid-19
Background: The COVID-19 pandemic disrupted global influenza transmission. We aimed to elucidate how meteorological and air pollution drivers influenced seasonal influenza A subtypes and B lineage in Southern China pre-, during-, and pos...

» Exploring Europium Complex With Aggregation Induced Emission Properties for Immune Fluorescence Test Strips Applications
19/08/25 20:00 from sars-cov-2
Highly luminescent nanospheres have been demonstrated to enhance the sensitivity of lateral flow immunoassay (LFIA) due to their loading of numerous luminescent dyes. Herein, aggregation-induced emission (AIE) luminogens (AIEgens)-embedd...

» Prevalence of COVID-19 vaccine hesitancy in Brazil: a systematic review and meta-analysis
19/08/25 20:00 from coronavirus
CONCLUSION: In the first meta-analysis conducted in Brazil, vaccine hesitancy was more prevalent among parents of children and adolescents, and vaccine hesitancy decreased in the second pandemic wave. Public policies must be developed to...

» Mental symptoms in post-COVID syndrome and post-COVID-19 vaccination syndrome: results of a representative population survey
19/08/25 20:00 from coronavirus
CONCLUSION: Mental symptoms are relatively common after both SARS-CoV-2 infection and vaccination and show overlap, especially fatigue. These findings highlight how difficult it is to distinguish PCS from PCVS and emphasize the need to c...

» Correction: Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021-2022
19/08/25 20:00 from coronavirus
[This corrects the article DOI: 10.3389/fpubh.2025.1549159.].

» COVID-19 global risk evaluation: rankings, reducing surveillance bias, and infodemic
19/08/25 20:00 from coronavirus
This study examines how public health institutions estimate regional COVID-19 burdens, pursuing two primary objectives: (1) to analyze the methodologies employed for regional risk assessment, and (2) to perform spatial and Spearman rank ...

» Lessons learnt in the response to COVID-19 in Mozambique: enabling readiness for the next pandemic
19/08/25 20:00 from coronavirus
CONCLUSION: The lessons learned from the COVID-19 response in Mozambique, which could be considered when preparing for an effective and equitable response to future pandemics, are in essence the following: there should be government lead...

» Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses
19/08/25 20:00 from coronavirus
INTRODUCTION: In Brazil, three COVID-19 vaccines were among the first widely used (CoronaVac, ChAdOx1, and BNT162b2), which aimed to induce neutralizing antibodies (NAbs) against the original SARS-CoV-2 strain. Although effective against...

» Dietary supplementation with nano-zinc modulates the expression of the antiviral immune gene IRF3: a novel report
19/08/25 20:00 from coronavirus
In the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the application of zinc has increased worldwide. It has the potential to increase the body's antioxidant status and provide better immune makeup. Currently, zinc...

» 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab
19/08/25 20:00 from coronavirus
This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019 (COVID-19), developed by the Infectious Diseases Society of America. The guideline panel ...

» Exploring Europium Complex With Aggregation Induced Emission Properties for Immune Fluorescence Test Strips Applications
19/08/25 20:00 from coronavirus
Highly luminescent nanospheres have been demonstrated to enhance the sensitivity of lateral flow immunoassay (LFIA) due to their loading of numerous luminescent dyes. Herein, aggregation-induced emission (AIE) luminogens (AIEgens)-embedd...

» Distinct platelet transcriptomic heterogeneity in respiratory illnesses and modulation by corticosteroids and immune antibody treatments
19/08/25 20:00 from coronavirus
CONCLUSIONS: A systematic investigation of platelet transcriptomic heterogeneity in respiratory infections, combined with the delineation of its therapeutic modulation by dexamethasone and tocilizumab, advances the understanding of plate...

» Prospective study of safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine in tuberous sclerosis complex children on sirolimus
19/08/25 20:00 from coronavirus
While sirolimus is widely used in tuberous sclerosis complex (TSC), its impact on coronavirus disease 2019 (COVID-19) vaccination remains unclear. To evaluate the safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine on th...

» "Have you considered that it could be burnout?"-psychologization and stigmatization of self-reported long COVID or post-COVID-19 vaccination syndrome
19/08/25 20:00 from coronavirus
CONCLUSIONS: People reporting LC or PCVS are subject to stigmatization and psychologization. From a patient perspective, psychologization appears to be an important driver of stigmatization and negative outcomes.

» Characterization of a MERS-related betacoronavirus in Danish brown long-eared bats (Plecotus auritus)
18/08/25 20:00 from Sars-Cov-2 origins
CONCLUSION: This is the first report of MERS-related beta-CoVs in bats from Denmark. Phylogenetic analyses reveal that these novel viruses belong to the HKU25 clade, a clade with known ACE2 receptor preference. Experimental validation is...

» Characterization of a MERS-related betacoronavirus in Danish brown long-eared bats (Plecotus auritus)
18/08/25 20:00 from Coronavirus origins
CONCLUSION: This is the first report of MERS-related beta-CoVs in bats from Denmark. Phylogenetic analyses reveal that these novel viruses belong to the HKU25 clade, a clade with known ACE2 receptor preference. Experimental validation is...

» Both Corticosteroids and Intravenous Immunoglobulin Protect From Aneurysms in Children With Multisystem Inflammatory Syndrome (MIS-C): A Multicenter Ambispective Study
18/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Corticosteroids, IVIG and their combination appear to be protective against aneurysms in children with MIS-C compared with no immunomodulatory treatment. Although the 3 therapies showed no significant differences when compar...

» Association of parental education with adolescents' COVID-19 vaccine uptake: A nationwide register-based study in Finland
18/08/25 20:00 from Covid-19 origins
CONCLUSION: Parental education was a strong predictor of adolescents' COVID-19 vaccine uptake in Finland. Parental vaccination status emerged as an important mediator of the association, possibly indicating general vaccine hesitancy. Oth...

» Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia
18/08/25 20:00 from Covid-19 origins
Activation of the subventricular zone (SVZ) following cerebral ischemia is one of the brain's early responses to counteract neuron loss and minimize tissue damage. Impaired brain regions communicate with the SVZ through various chemotact...

» Characterization of a MERS-related betacoronavirus in Danish brown long-eared bats (Plecotus auritus)
18/08/25 20:00 from Covid-19 origins
CONCLUSION: This is the first report of MERS-related beta-CoVs in bats from Denmark. Phylogenetic analyses reveal that these novel viruses belong to the HKU25 clade, a clade with known ACE2 receptor preference. Experimental validation is...

» Human T Cell Responses to Flavivirus Vaccines
17/08/25 20:00 from coronavirus
Flaviviruses are major human pathogens that continue to pose a global health threat, and vaccination is an effective strategy to protect against disease from several flaviviruses. Flavivirus vaccines are believed to confer protection pri...

» Comparing Approaches to Teaching Patients How to Use an App-Based Home Spirometer: Randomized Controlled Trial
17/08/25 20:00 from covid-19
CONCLUSIONS: There is no meaningful difference in spirometry measurement between patients taught to use a home spirometer remotely (virtual or self-directed) versus traditional face-to-face treatment. Patients' feedback was favorable to ...

» Human T Cell Responses to Flavivirus Vaccines
17/08/25 20:00 from covid-19
Flaviviruses are major human pathogens that continue to pose a global health threat, and vaccination is an effective strategy to protect against disease from several flaviviruses. Flavivirus vaccines are believed to confer protection pri...

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from coronavirus
No abstract

» Access through Community Health Worker Engagement: Summary of a Vaccine Ambassador Program to Address Vaccine Hesitancy
17/08/25 20:00 from covid-19
COVID-19 does not affect all populations equally. From November 2021 to June 2024, the Vaccine Ambassador Program (VAP) employed peer workers across 15 cities to engage three focus populations. The VAP model has changed the way these org...

» Clinical functioning information tool - coronavirus disease 2019 (ClinFIT COVID-19): psychometric evaluation and development of an interval-scaled functioning score across the care continuum
17/08/25 20:00 from coronavirus
CONCLUSION: This study found the psychometric properties of ClinFIT COVID-19 acceptable. Future studies are needed to validate the use of the transformation tables to monitor functioning and evaluate intervention impact.

» Dissecting Interactions between RNA and Coronavirus Nucleocapsid Proteins Using Native Mass Spectrometry
17/08/25 20:00 from coronavirus
The nucleocapsid protein is the most abundant protein in the SARS-CoV virus and plays critical roles in RNA packaging and storage, yet the nature of the protein's interactions with RNA remain elusive owing to the presence of multiple dis...

» Impacts of Access to Hospital and Emergency Care on Rural Mortality in Tennessee, 2010-2019: A GIS-Informed Study
17/08/25 20:00 from covid-19
Rural Tennessee's health and economic disparities have worsened since 2010 (while the state led the nation in hospital closures per capita). Guided by the Vulnerable Populations Conceptual Model, we examined the relationship between Tenn...

» Improving Health Equity During the COVID-19 Pandemic
17/08/25 20:00 from covid-19
The COVID-19 pandemic highlighted national health disparities for African American people compared with other races. An urban health district in Georgia developed innovative strategies to improve equity for COVID-19 outcomes among this p...

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from covid-19
No abstract

» Optimising cardiac surgery outcomes in people with diabetes: the OCTOPuS pilot feasibility study
17/08/25 20:00 from covid-19
CONCLUSION: There remains an urgent need to improve the surgical outcomes for people with diabetes. This project demonstrated that it is possible to develop a clinical pathway to improve diabetes management prior to admission.

» Understanding the structure of measles virus and its implications for novel drug discovery
17/08/25 20:00 from covid-19
INTRODUCTION: Despite having a stably effectively vaccine for decades, the Measles virus (MV) still causes periodic outbreaks given its highly contagious nature and a consistent decline in immunization coverage, which was further exacerb...

» The renin-angiotensin system in healthy human platelets: expressed but inactive
17/08/25 20:00 from covid-19
Platelets play a crucial role in arterial thrombus formation, offering potential for new antiplatelet therapies with reduced bleeding risk. Here, we investigated the role of the renin-angiotensin system (RAS) in human platelets and explo...

» Clinical functioning information tool - coronavirus disease 2019 (ClinFIT COVID-19): psychometric evaluation and development of an interval-scaled functioning score across the care continuum
17/08/25 20:00 from covid-19
CONCLUSION: This study found the psychometric properties of ClinFIT COVID-19 acceptable. Future studies are needed to validate the use of the transformation tables to monitor functioning and evaluate intervention impact.

» Patient and healthcare professional perspectives on telehealth in the care of interstitial lung disease
17/08/25 20:00 from covid-19
BackgroundWhile telehealth has been used for specialist care during the COVID-19 pandemic, its benefits and barriers to use for delivering care in interstitial lung disease (ILD) remain unclear. We aimed to explore perspectives of patien...

» Dissecting Interactions between RNA and Coronavirus Nucleocapsid Proteins Using Native Mass Spectrometry
17/08/25 20:00 from covid-19
The nucleocapsid protein is the most abundant protein in the SARS-CoV virus and plays critical roles in RNA packaging and storage, yet the nature of the protein's interactions with RNA remain elusive owing to the presence of multiple dis...

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from covid-19
No abstract

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from coronavirus
No abstract

» Clinical functioning information tool - coronavirus disease 2019 (ClinFIT COVID-19): psychometric evaluation and development of an interval-scaled functioning score across the care continuum
17/08/25 20:00 from covid-19
CONCLUSION: This study found the psychometric properties of ClinFIT COVID-19 acceptable. Future studies are needed to validate the use of the transformation tables to monitor functioning and evaluate intervention impact.

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from covid-19
No abstract

» Clinical functioning information tool - coronavirus disease 2019 (ClinFIT COVID-19): psychometric evaluation and development of an interval-scaled functioning score across the care continuum
17/08/25 20:00 from covid-19
CONCLUSION: This study found the psychometric properties of ClinFIT COVID-19 acceptable. Future studies are needed to validate the use of the transformation tables to monitor functioning and evaluate intervention impact.

» Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time"
17/08/25 20:00 from coronavirus
No abstract

» Modelling transmission of Middle East respiratory syndrome coronavirus in camel populations and the potential impact of animal vaccination
17/08/25 20:00 from coronavirus
Outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans are driven by recurring zoonotic spillover from camels, leading to demand for camel vaccination. With two vaccine candidates shown to reduce infectiousness, t...

» TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein
17/08/25 20:00 from coronavirus
As an acute respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19) exhibits remarkable contagiousness and has emerged as a critical global public health ...

» CT changes in a randomized trial comparing early therapies in an outpatient population at high risk of severe COVID19 disease
17/08/25 20:00 from coronavirus
Although in vitro studies suggest that neutralization by monoclonal antibodies (mAbs) against SARS CoV2 Omicron sub lineages is reduced, in vivo virological response data are lacking. MONET (EudraCT: 2021-004188-28) was multi-centric pha...

» Cytokine Profile and Early Immune Response to SARS-CoV-2 in Occupationally Lead-Exposed Individuals: A Cross-Sectional Study
17/08/25 20:00 from coronavirus
CONCLUSION: Elevated levels of APRIL, BAFF, IL-20, sTNF-R2, and PTX-3 in lead-exposed individuals with recent SARS-CoV-2 infection may indicate robust dendritic cell and B cell activation and enhanced modulation of tumor necrosis factor-...

» Evaluating Clinical Decision Tools for Intensive Care Unit Admission Prediction in Patients With Coronavirus Disease 2019
17/08/25 20:00 from coronavirus
INTRODUCTION: During the coronavirus disease 2019 pandemic, several clinical decision rules were promulgated to support triage and optimize resource allocation, particularly regarding intensive care unit admissions. This retrospective co...

» Multicomponent Assembly of High-Component Covalent Organic Cages
17/08/25 20:00 from coronavirus
Multicomponent reactions (MCRs), a powerful strategy for generating desired products by employing more than two starting materials in one-pot reactions, have been determined to be a superior synthetic strategy to achieve structural compl...

» Infectivity duration of HCoV-OC43, a surrogate for SARS-CoV-2, in artificial bodily fluids on stainless steel simulating common nonporous surfaces
17/08/25 20:00 from coronavirus
We investigated the infectivity and persistence of SARS-CoV-2 on environmental surfaces by enlisting human beta-coronavirus OC43 as a surrogate. This study evaluated its stability on nonporous stainless steel surfaces under two absolute ...

» Survival and transmission fitness of SARS-CoV-2 over the time-of-flight in an aerosolization chamber
17/08/25 20:00 from covid-19
The impact of various environmental factors on SARS-CoV-2 transmission remains debated, partly due to limited physical experiments with infectious virus that closely replicate real-world conditions. Using a novel, self-contained containm...

» Association of Coronavirus Infection with Higher Mortality Rate and Longer Hospital Stay in Patients with Major Extremity Fractures
17/08/25 20:00 from coronavirus
CONCLUSIONS: 1. Patients with COVID-19 exhibited a markedly longer LOS than those without COVID-19, with this effect being more pronounced in patients with lower extremity fractures. 2. When all patients had major extremity fractures, pa...

» The Impact of Tokenizer Selection in Genomic Language Models
17/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
MOTIVATION: Genomic language models have recently emerged as a new method to decode, interpret, and generate genetic sequences. Existing genomic language models have utilized various tokenization methods, including character tokenization...

» Comparing Implementation and Effectiveness Outcomes for Two Implementation Strategies of the Keep It Up! Digital HIV Prevention Program: A Type 3 Hybrid Effectiveness-Implementation Trial
17/08/25 20:00 from covid-19
This study sought to compare implementation and effectiveness outcomes for two delivery strategies of a digital HIV prevention intervention: community-based organization (CBO) versus direct-to-consumer (DTC). A type III hybrid effectiven...

» Stroke-associated pneumonia with low PaO₂/FiO₂ ratio in acute large vessel occlusion after endovascular therapy: risk factors and prognosis
17/08/25 20:00 from coronavirus
CONCLUSION: SAP with PaO(2)/FiO(2) ratio ≤ 240 is shown in significant relevance to the prolonged in-hospital stays among post-interventional patients. Older ages, baseline GCS scores of 3-8, and higher WBC counts after SAP diagnosis can...

» Immunological orchestration and dysregulation in COVID-19 pneumonia: from viral pathogenesis to precision therapeutics in the post-pandemic era
17/08/25 20:00 from covid-19
The COVID-19 pandemic revolutionized our understanding and treatment of pneumonia, particularly highlighting its complex immunological aspects. In this review, we synthesized recent research on COVID-19 clinical management, shedding ligh...

» The integration of machine learning into traditional Chinese medicine
17/08/25 20:00 from coronavirus
Traditional Chinese medicine (TCM) is an ancient medical system distinctive and effective in treating cancer, depression, coronavirus disease 2019 (COVID-19), and other diseases. However, the relatively abstract diagnostic methods of TCM...

» A Bayesian modelling framework with model comparison for epidemics with super-spreading
17/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary ca...

» Immunogenicity and Safety of the COVID-19 mRNA Vaccine Coadministered with Influenza and 23-valent Pneumococcal Polysaccharide Vaccines
17/08/25 20:00 from covid-19
CONCLUSION: Co-administering COVID-19, Influenza, and PPSV23 vaccines seems feasible, without significantly impairing neutralizing antibody responses. These findings support the recommendation for vaccine coadministration in adults.

» Transcriptomic profiling reveals SARS-CoV-2-infected humanized MHC mice recapitulate human post vaccination immune responses
17/08/25 20:00 from coronavirus
CONCLUSIONS: These results confirm that the hMHC murine model can serve as an effective platform for vaccine research, providing a theoretical foundation for the application of humanized MHC mice and offering new insights into viral infe...

» Adolescents' health and well-being into the COVID-19 pandemic: A two-wave prospective investigation- The HUNT study
17/08/25 20:00 from covid-19
CONCLUSION: Except for mental distress in boys, general health and life quality did not deteriorate in the study period, although loneliness increased in both sexes. In the low SEP group, girls seemed to cope better than boys where healt...

» Heat-killed Lactobacillus acidophilus suppresses SARS-CoV-2 infection in the human intestinal epithelial cell line Caco-2
17/08/25 20:00 from coronavirus
BACKGROUND: The gastrointestinal (GI) tract is suspected to be a possible source for the systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as a reservoir of long coronavirus disease (COVID). Thus, t...

» Potential ecological risk and accumulation of heavy metal(loid)s in soils of Macao in China as a non-industrial and tourist City
17/08/25 20:00 from covid-19
With rapid industrialization, the accumulation and contamination of heavy metal(loid)s in soil often has occurred. However, the accumulation of heavy metal(loid)s in soil in non-industrial and tourist cities with high population densitie...

» Evaluation of synthetic mRNA with selected UTR sequences and alternative poly(A) tail, in vitro and in vivo
17/08/25 20:00 from coronavirus
Messenger RNA (mRNA) has emerged as an attractive new technology of drugs. The efficacy of mRNA technology depends on both the efficiency of mRNA delivery and translation. Untranslated regions (UTRs) and the poly(A) tail play a crucial r...

» The impact of COVID-19 pandemic on hospitalization rate, clinical impairment and mortality of cirrhotic patients: comment
17/08/25 20:00 from covid-19
No abstract

» Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses
17/08/25 20:00 from coronavirus
The threat of future coronavirus pandemics requires developing effective vaccine technologies that provide broad and long-lasting protection against circulating and emerging strains. Here we report a multivalent liposomal hydrogel vaccin...

» Substance use in Spanish adolescent gamblers before and after the COVID-19 pandemic state of alarm: a population-based study
17/08/25 20:00 from covid-19
This observational study described the prevalence and associated factors of substance use (SU) among adolescent gamblers, comparing data from pre and post pandemic surveys among 7,960 adolescents between 14 and 18 years old from a Nation...

» Neurological and Immunological Insights Into Post-COVID-19 Syndrome: A Single-Center Retrospective Study
17/08/25 20:00 from coronavirus
Introduction Following the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), post-COVID-19 syndrome (PCS) has emerged as a major health concern, affecting approximately ...

» Author Correction: Evaluating the COVID-19 vaccination program in Japan, 2021 using the counterfactual reproduction number
17/08/25 20:00 from covid-19
No abstract

» Uptake of COVID-19 vaccine among female healthcare workers in Syria: results from a 2022 cross-sectional survey
17/08/25 20:00 from covid-19
BACKGROUND: Healthcare workers play an important role in administering COVID-19 vaccines, particularly in conflict-affected settings. Syria has endured a protracted conflict for over a decade and while most of the healthcare workers in t...

» Survival and transmission fitness of SARS-CoV-2 over the time-of-flight in an aerosolization chamber
17/08/25 20:00 from sars-cov-2
The impact of various environmental factors on SARS-CoV-2 transmission remains debated, partly due to limited physical experiments with infectious virus that closely replicate real-world conditions. Using a novel, self-contained containm...

» In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
17/08/25 20:00 from covid-19
CONCLUSIONS: Our data suggest that SARS-CoV-2 infection alone does not cause sustained proteomic alterations in most children. However, MIS-C is associated with a distinct inflammatory and vascular injury signature. Several candidate dia...

» A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership
17/08/25 20:00 from covid-19
No abstract

» Immunological orchestration and dysregulation in COVID-19 pneumonia: from viral pathogenesis to precision therapeutics in the post-pandemic era
17/08/25 20:00 from sars-cov-2
The COVID-19 pandemic revolutionized our understanding and treatment of pneumonia, particularly highlighting its complex immunological aspects. In this review, we synthesized recent research on COVID-19 clinical management, shedding ligh...

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from covid-19
No abstract

» Immunogenicity and Safety of the COVID-19 mRNA Vaccine Coadministered with Influenza and 23-valent Pneumococcal Polysaccharide Vaccines
17/08/25 20:00 from sars-cov-2
CONCLUSION: Co-administering COVID-19, Influenza, and PPSV23 vaccines seems feasible, without significantly impairing neutralizing antibody responses. These findings support the recommendation for vaccine coadministration in adults.

» Modelling transmission of Middle East respiratory syndrome coronavirus in camel populations and the potential impact of animal vaccination
17/08/25 20:00 from covid-19
Outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans are driven by recurring zoonotic spillover from camels, leading to demand for camel vaccination. With two vaccine candidates shown to reduce infectiousness, t...

» In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
17/08/25 20:00 from sars-cov-2
CONCLUSIONS: Our data suggest that SARS-CoV-2 infection alone does not cause sustained proteomic alterations in most children. However, MIS-C is associated with a distinct inflammatory and vascular injury signature. Several candidate dia...

» Psychological and Spiritual Well-Being Among Church of England Clergy and Laity three years After the COVID-19 Lockdowns
17/08/25 20:00 from covid-19
The COVID-19 pandemic lockdowns caused declines in psychological wellbeing among both clergy and lay people in the Church of England. This study uses a convenience sample of 3,826 clergy and lay people from the Church 2024 survey to exam...

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from sars-cov-2
No abstract

» TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein
17/08/25 20:00 from sars-cov-2
As an acute respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19) exhibits remarkable contagiousness and has emerged as a critical global public health ...

» CT changes in a randomized trial comparing early therapies in an outpatient population at high risk of severe COVID19 disease
17/08/25 20:00 from sars-cov-2
Although in vitro studies suggest that neutralization by monoclonal antibodies (mAbs) against SARS CoV2 Omicron sub lineages is reduced, in vivo virological response data are lacking. MONET (EudraCT: 2021-004188-28) was multi-centric pha...

» European countries policy responses against SARS-Cov-2 in the context of vaccinations
17/08/25 20:00 from sars-cov-2
Non-pharmaceutical interventions (NPIs) are essential tools for containing or mitigating the spread of a novel virus until vaccination becomes available. Given their well-known side effects, NPIs should be employed only as long as necess...

» Cytokine Profile and Early Immune Response to SARS-CoV-2 in Occupationally Lead-Exposed Individuals: A Cross-Sectional Study
17/08/25 20:00 from sars-cov-2
CONCLUSION: Elevated levels of APRIL, BAFF, IL-20, sTNF-R2, and PTX-3 in lead-exposed individuals with recent SARS-CoV-2 infection may indicate robust dendritic cell and B cell activation and enhanced modulation of tumor necrosis factor-...

» Trends in Rhinovirus/Enterovirus Healthcare-Associated Infections at a Large Academic Hospital from July 2018 to June 2024
17/08/25 20:00 from sars-cov-2
This report identifies rhinovirus/enterovirus as the second most prevalent cause of healthcare-associated respiratory viral infections (HA-RVIs) at a large academic hospital with >950 inpatient beds, after SARS-CoV-2 from FY 2019-2024. H...

» PCR-generated DNA templates enable efficient, rapid, and cost-effective mRNA synthesis
17/08/25 20:00 from sars-cov-2
In vitro transcription (IVT) is a widely used technique for mRNA synthesis in both basic research and the development mRNA-based vaccines and therapies. The efficiency of IVT critically depends on the quality and integrity of the linear ...

» Research priorities in Infection Prevention and Control in Alberta, Canada: a modified Delphi process
17/08/25 20:00 from sars-cov-2
CONCLUSIONS: This consensus exercise identified IPC research questions that were important to healthcare workers, healthcare leaders, researchers, and patients. This work may generate a pan-Canadian dialogue to develop a national researc...

» A Finger-Actuated Microfluidic System for Point-Of-Care Detection of SARS-CoV-2 and Influenza A
17/08/25 20:00 from sars-cov-2
The cocirculation and infection of SARS-CoV-2 and influenza A viruses significantly impact the transmission dynamics of infectious diseases and increase the public health burden on communities. Nucleic acid amplification testing (NAAT), ...

» Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased beta-amyloid pathology
17/08/25 20:00 from sars-cov-2
No abstract

» The Impact of Tokenizer Selection in Genomic Language Models
17/08/25 20:00 from sars-cov-2
MOTIVATION: Genomic language models have recently emerged as a new method to decode, interpret, and generate genetic sequences. Existing genomic language models have utilized various tokenization methods, including character tokenization...

» TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein
17/08/25 20:00 from sars-cov-2 spike protein
As an acute respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19) exhibits remarkable contagiousness and has emerged as a critical global public health ...

» PCR-generated DNA templates enable efficient, rapid, and cost-effective mRNA synthesis
17/08/25 20:00 from sars-cov-2 spike protein
In vitro transcription (IVT) is a widely used technique for mRNA synthesis in both basic research and the development mRNA-based vaccines and therapies. The efficiency of IVT critically depends on the quality and integrity of the linear ...

» SARS-CoV-2 XBB.1.5 infects wild-type C57BL/6 mice and induces a protective CD4(+) T cell response required for viral clearance
17/08/25 20:00 from sars-cov-2 spike protein
Mouse models are critical for studying SARS-CoV-2 pathogenesis and evaluating therapeutic and preventive strategies. Standard C57BL/6 mice are generally resistant to infection with the ancestral SARS-CoV-2 strain due to inefficient bindi...

» Evaluation of synthetic mRNA with selected UTR sequences and alternative poly(A) tail, in vitro and in vivo
17/08/25 20:00 from sars-cov-2 spike protein
Messenger RNA (mRNA) has emerged as an attractive new technology of drugs. The efficacy of mRNA technology depends on both the efficiency of mRNA delivery and translation. Untranslated regions (UTRs) and the poly(A) tail play a crucial r...

» Correlation between SARS-CoV-2-specific antibody titers and the hormones DHEA, cortisol, testosterone, and progesterone
17/08/25 20:00 from sars-cov-2 spike protein
Hormones, such as DHEA, cortisol, testosterone, and progesterone play an important part in the regulation of the human immune system. However, the exact role of endocrine factors in the production of antibodies, in this case SARS-CoV-2-s...

» The impact of COVID-19 pandemic on hospitalization rate, clinical impairment and mortality of cirrhotic patients: comment
17/08/25 20:00 from covid-19
No abstract

» Author Correction: Evaluating the COVID-19 vaccination program in Japan, 2021 using the counterfactual reproduction number
17/08/25 20:00 from covid-19
No abstract

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from covid-19
No abstract

» In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
17/08/25 20:00 from sars-cov-2
CONCLUSIONS: Our data suggest that SARS-CoV-2 infection alone does not cause sustained proteomic alterations in most children. However, MIS-C is associated with a distinct inflammatory and vascular injury signature. Several candidate dia...

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from sars-cov-2
No abstract

» Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased beta-amyloid pathology
17/08/25 20:00 from sars-cov-2
No abstract

» In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
17/08/25 20:00 from sars-cov-2
CONCLUSIONS: Our data suggest that SARS-CoV-2 infection alone does not cause sustained proteomic alterations in most children. However, MIS-C is associated with a distinct inflammatory and vascular injury signature. Several candidate dia...

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from sars-cov-2
No abstract

» Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased beta-amyloid pathology
17/08/25 20:00 from sars-cov-2
No abstract

» The impact of COVID-19 pandemic on hospitalization rate, clinical impairment and mortality of cirrhotic patients: comment
17/08/25 20:00 from covid-19
No abstract

» Author Correction: Evaluating the COVID-19 vaccination program in Japan, 2021 using the counterfactual reproduction number
17/08/25 20:00 from covid-19
No abstract

» Epidemiology of globe injury repair mechanisms in the TriNetX US collaborative network database: retrospective cohort study
17/08/25 20:00 from covid-19
No abstract