» Characterisation and Management of Children and Young People Referred to a Paediatric Tertiary Post-COVID Service
02/04/25 20:00 from coronavirus
PURPOSE: Post-COVID condition (PCC) emerged following the 2020 coronavirus pandemic and required rapid service development to manage affected patients. This evaluation describes the demographics, medical background, management and six-mo...

» Long-term effects of SARS-CoV-2 infection on blood vessels and blood pressure - LOCHINVAR
02/04/25 20:00 from coronavirus
CONCLUSIONS: Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension and cardiovascular disease.

» A systematic review of the avian antibody (IgY) therapeutic effects on human bacterial infections over the decade
02/04/25 20:00 from coronavirus
The overuse of antibiotics worldwide, especially during the Coronavirus pandemic, has raised concerns about the rise of antibiotic resistance and its side effects. Immunoglobulin Y, a natural protein that specifically targets foreign ant...

» Preparing for the next pandemic: insights from Aotearoa New Zealand's Covid-19 response
02/04/25 20:00 from coronavirus
In 2020 Aotearoa New Zealand, like many other countries, faced the coronavirus pandemic armed with an influenza-based pandemic plan. The country adapted rapidly to mount a highly strategic and effective elimination response to the SARS-C...

» Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
02/04/25 20:00 from coronavirus
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that evade immunity elicited by vaccination has posed a global challenge to the control of the coronavirus disease 2019 (COVID-19) pandemic. The...

» Clinical manifestations of Long-COVID: an observational perspective
02/04/25 20:00 from coronavirus
CONCLUSION: This study's findings show the effects Long COVID-19 has on the general population, which includes various symptoms affecting physical, mental and emotional needs. The findings also suggest potential gender differences in Lon...

» Impact of the COVID-19 pandemic on prehospital emergency medical service: a scoping review
02/04/25 20:00 from coronavirus
CONCLUSIONS: The heterogeneity of the studies is considerable; overall, there appears to have been a decline in emergency calls, particularly EMS operations. Clear patterns, e.g., by region, cannot be identified.

» Epidemiological characteristics of respiratory syncytial virus among inpatients in a children's hospital in Shenzhen City from 2020 to 2023
02/04/25 20:00 from coronavirus
This study analyzed the epidemiological characteristics and trends of respiratory syncytial virus (RSV) infections among inpatients with acute respiratory infections (ARI) in a children's hospital in Shenzhen City inpatients from 2020 to...

» Analysis of 12 Pathogens in surveillance cases of febrile respiratory syndrome in Daxing district of Beijing City from 2018 to 2023
02/04/25 20:00 from coronavirus
A total of 1 557 cases were included in the Febrile Respiratory Syndrome (FRS) surveillance conducted in Daxing District between 2018 and 2023. Twelve respiratory pathogens were investigated: human influenza virus (HIFV), human respirato...

» Clinical Characteristics of SARS-COV-2 Omicron Variant in Acute Myeloid Leukemia and Acute Lymphocytic Leukemia Patients: A Multi-Center Retrospective Study
02/04/25 20:00 from coronavirus
CONCLUSION: Early antiviral treatment may reduce viral shedding duration and potentially mitigate symptom severity and mortality in AL patients with COVID-19. Neutropenia emerged as a critical factor influencing outcomes. These findings ...

» Occurrence Of Long COVID In Healthcare Workers At A University Hospital And Challenges In Insurance And Compensation Evaluation
02/04/25 20:00 from coronavirus
INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developed in 2019, led to the outbreak of the COVID-19 pandemic state, which have significantly impacted on healthcare systems worldwide. During the pandemic sta...

» Imaging Characteristics and Radiological Analysis of Rhinoorbital - Cerebral Mucormycosis
02/04/25 20:00 from coronavirus
CONCLUSIONS: MRI plays a very crucial role in the prompt and early diagnosis of rhino-orbito-cerebral mucormycosis, as it is used to evaluate the invasion of the disease into the surrounding structures, as well as in preoperative plannin...

» Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada
02/04/25 20:00 from Sars-Cov-2 origins
CONCLUSIONS: These detections reaffirm the need for extensive genomic surveillance of IAVs in swine populations to monitor reassortments that might become public health concerns. They also highlight the need for closer surveillance of IA...

» Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada
02/04/25 20:00 from Covid-19 origins
CONCLUSIONS: These detections reaffirm the need for extensive genomic surveillance of IAVs in swine populations to monitor reassortments that might become public health concerns. They also highlight the need for closer surveillance of IA...

» Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023
02/04/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 pandemic has altered the landscape of respiratory viruses causing SVP in children. The presence of underlying health conditions, particularly acute leukemia, other malignancies, and immunodeficiency, significant...

» Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: Endostatin at ICU admission was independently associated with AKI, RRT, and 90-day mortality in ICU patients with COVID-19. In addition, endostatin improved the prediction of AKI and 90-day mortality, highlighting its potent...

» Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out
02/04/25 20:00 from sars-cov-2
No abstract

» Assessing the Impact of Haulage Drivers in Uganda's COVID-19 Delta Wave
02/04/25 20:00 from covid-19
CONCLUSIONS: Our findings suggest that truck drivers were a transient core risk group with limited impact on onward spread. However, uncertainties remain regarding the extent of their role, and interventions like testing and result waiti...

» First-episode psychosis requiring electroconvulsive therapy following SARS-CoV-2 infection - Description of two cases
02/04/25 20:00 from sars-cov-2
COVID-19 is a systemic disease. Since the beginning of the pandemic, there have been increasing reports of neuropsychiatric complications of the infection. The excessive inflammatory response during the infection induces changes in neuro...

» Long-term effects of SARS-CoV-2 infection on blood vessels and blood pressure - LOCHINVAR
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension and cardiovascular disease.

» Psychological Problems and Academic Motivation in University Students: A Cross-Sectional Study One Year after the COVID-19 Lockdown in Italy
02/04/25 20:00 from covid-19
This study was aimed at exploring students' psychological condition (operationalized through psychological distress and perceived loneliness) one year after the COVID-19 lockdown and testing its role in predicting academic motivation. Th...

» Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: Since coughing is one of the primary forms of transmission for SARS-CoV-2, the observed reduction of coughing might be highly beneficial, particularly for patients living in crowded, poorly ventilated, or confined environments.

» Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: These detections reaffirm the need for extensive genomic surveillance of IAVs in swine populations to monitor reassortments that might become public health concerns. They also highlight the need for closer surveillance of IA...

» Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19
02/04/25 20:00 from covid-19
CONCLUSIONS: Endostatin at ICU admission was independently associated with AKI, RRT, and 90-day mortality in ICU patients with COVID-19. In addition, endostatin improved the prediction of AKI and 90-day mortality, highlighting its potent...

» Preparing for the next pandemic: insights from Aotearoa New Zealand's Covid-19 response
02/04/25 20:00 from sars-cov-2
In 2020 Aotearoa New Zealand, like many other countries, faced the coronavirus pandemic armed with an influenza-based pandemic plan. The country adapted rapidly to mount a highly strategic and effective elimination response to the SARS-C...

» The importance of political and religious affiliation in explaining county-level COVID-19 Vaccine Hesitancy
02/04/25 20:00 from covid-19
The authors use county-level data to test whether an array of socioeconomic, demographic, political and religious variables explain COVID-19 vaccination rates. Results presented here build upon previous investigations of COVID-19 vaccine...

» Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
02/04/25 20:00 from sars-cov-2
Booster vaccinations are highly recommended in combating the SARS-CoV-2 Omicron variant and its subvariants. However, the optimal booster vaccination strategies and related immune mechanisms with different prior vaccinations are under-re...

» The Pandemic Effect: Secondary Impact on the Diagnosis of Clinically Significant Congenital Heart Disease and Role of Deprivation Index
02/04/25 20:00 from covid-19
We sought to determine the impact of the COVID-19 on prenatal diagnosis (PND) of clinically significant congenital heart disease (CHD) and the role of socioeconomic status (SES), complexity of diagnosis, and proximity to advance testing....

» TPCs: From plant to human
02/04/25 20:00 from covid-19
In 2005, the Arabidopsis thaliana two-pore channel TPC1 channel was identified as a vacuolar Ca^(²⁺)-release channel. In 2009 three independent groups published studies on mammalian TPCs as NAADP-activated endolysosomal Ca^(2+) release c...

» Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
02/04/25 20:00 from sars-cov-2
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that evade immunity elicited by vaccination has posed a global challenge to the control of the coronavirus disease 2019 (COVID-19) pandemic. The...

» Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out
02/04/25 20:00 from covid-19
No abstract

» Emotional and sleep disturbances among patients previously hospitalized due to COVID-19
02/04/25 20:00 from covid-19
CONCLUSIONS: During follow-up, most patients with COVID-19 suffer from ESDs that are predicted by hemoglobin levels. The ESDs increase the risk of concomitant BFS. The ESDs, particularly sadness, restlessness, insomnia, and excessive day...

» Low Molecular Weight Heparin Dosing in Relation to Postoperative Bleeding After Tracheotomy in Patients Infected With SARS-CoV-2-A Descriptive Study
02/04/25 20:00 from sars-cov-2
CONCLUSION: Decreased doses of LMWH on the day of surgery were not associated with a risk reduction for post-surgical bleeding in patients with SARS-CoV-2 who received tracheotomy. Increasing age was a risk factor for post-surgical bleed...

» First-episode psychosis requiring electroconvulsive therapy following SARS-CoV-2 infection - Description of two cases
02/04/25 20:00 from covid-19
COVID-19 is a systemic disease. Since the beginning of the pandemic, there have been increasing reports of neuropsychiatric complications of the infection. The excessive inflammatory response during the infection induces changes in neuro...

» VirusWarn: A mutation-based early warning system to prioritize concerning SARS-CoV-2 and influenza virus variants from sequencing data
02/04/25 20:00 from sars-cov-2
The rapid evolution of respiratory viruses is characterized by the emergence of variants with concerning phenotypes that are efficient in antibody escape or show high transmissibility. This necessitates timely identification of such vari...

» Protein to biomaterials: Unraveling the antiviral and proangiogenic activities of Ac-Tβ_1-17 peptide, a thymosin β4 metabolite, and its implications in peptide-scaffold preparation
02/04/25 20:00 from sars-cov-2
Peptide metabolites are emerging biomolecules with numerous possibilities in biomaterial-based regenerative medicine due to their inherent bioactivities. These small, naturally occurring compounds are intermediates or byproducts of large...

» Characterisation and Management of Children and Young People Referred to a Paediatric Tertiary Post-COVID Service
02/04/25 20:00 from covid-19
PURPOSE: Post-COVID condition (PCC) emerged following the 2020 coronavirus pandemic and required rapid service development to manage affected patients. This evaluation describes the demographics, medical background, management and six-mo...

» Phenothiazine-linked glutamic acid dendrons: an easy access and a new class of SARS-CoV-2 main protease inhibitors
02/04/25 20:00 from sars-cov-2
In this report, a structurally unique phenothiazine (PTZ) core is linked with glutamic acid-based dendrons through a solid-phase peptide synthesis approach to access a variety of PTZ-linked dendrons conveniently. Inferior cytotoxicity of...

» A neuroscience perspective on the plasticity of the social and relational brain
02/04/25 20:00 from covid-19
Over the past two decades, the fields of social and contemplative neurosciences have made significant strides. Initial research utilizing fMRI identified neuronal networks involved in empathy, mentalizing, and compassion, as well as comp...

» Impact of the COVID-19 pandemic on prehospital emergency medical service: a scoping review
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: The heterogeneity of the studies is considerable; overall, there appears to have been a decline in emergency calls, particularly EMS operations. Clear patterns, e.g., by region, cannot be identified.

» Understanding the intersectionality of the rural Hispanic/Latino Veteran population: a scoping review of health-related challenges
02/04/25 20:00 from covid-19
CONCLUSIONS: Increased research on health-related challenges experienced by rural H/L Veterans is needed. Of specific importance is research that emphasizes the intersectionality of rural H/L Veterans, acknowledges intra-ethnic diversity...

» Long-term effects of SARS-CoV-2 infection on blood vessels and blood pressure - LOCHINVAR
02/04/25 20:00 from covid-19
CONCLUSIONS: Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension and cardiovascular disease.

» Anti-masking Posts on Instagram: Content Analysis During the COVID-19 Pandemic
02/04/25 20:00 from sars-cov-2
CONCLUSION: Science denial and propaganda shared among Instagram users may represent an onramp to consumption of broader conspiracy theories and government distrust, in addition to having negative health effects and social consequences f...

» Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
02/04/25 20:00 from covid-19
CONCLUSIONS: Since coughing is one of the primary forms of transmission for SARS-CoV-2, the observed reduction of coughing might be highly beneficial, particularly for patients living in crowded, poorly ventilated, or confined environments.

» Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out
02/04/25 20:00 from sars-cov-2
No abstract

» Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out
02/04/25 20:00 from covid-19
No abstract

» Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
02/04/25 20:00 from covid-19
CONCLUSIONS: Since coughing is one of the primary forms of transmission for SARS-CoV-2, the observed reduction of coughing might be highly beneficial, particularly for patients living in crowded, poorly ventilated, or confined environments.

» Religious group membership and conspiracy beliefs influence vaccine uptake: Insights from 20 European countries
02/04/25 20:00 from covid-19
Reports of lower vaccine uptake within religious communities pose a significant public health challenge. While religious group membership is often associated with health benefits, recent research has revealed a paradox: it may also be li...

» Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada
02/04/25 20:00 from covid-19 and viral infections in pigs
CONCLUSIONS: These detections reaffirm the need for extensive genomic surveillance of IAVs in swine populations to monitor reassortments that might become public health concerns. They also highlight the need for closer surveillance of IA...

» Meanings of hope constructed by users of mental health services during the COVID-19 pandemic
02/04/25 20:00 from covid-19
CONCLUSION: Pre-constructed discourses elsewhere on spirituality/religiosity, solidarity, disease model and resilience permeate the production of meanings of hope in the discourses of mental health services users. It is important to enab...

» Platelet activating histone/antihistone IgG complexes in anti-PF4 negative thrombosis and thrombocytopenia syndrome
02/04/25 20:00 from covid-19
Thrombosis and Thrombocytopenia syndromes (TTS) describe immune mediated thrombotic adverse reactions following vaccination against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a well-known sub-entity of TTS, ca...

» Patient Factors Associated With the Use of Online Portal Health Information in the Postpandemic Era: Cross-Sectional Analysis of a National Survey
02/04/25 20:00 from covid-19
CONCLUSIONS: This study demonstrates that most Americans use patient portals, though certain patient populations such as those with less than college degree education or living in nonmetropolitan areas continue to face greater difficulty...

» Infoveillance of COVID-19 Infections in Dentistry Using Platform X: Descriptive Study
02/04/25 20:00 from covid-19
CONCLUSIONS: The data suggest that analyses of X information in populations of affected areas may provide useful information regarding the impact of a pandemic on the dental profession and demonstrate a correlation with suspected and con...

» Lessons Learned From Physiotherapists Working During the COVID-19 Pandemic: A Qualitative Approach
02/04/25 20:00 from covid-19
This qualitative study aimed to explore the perceptions and experiences of physiotherapists related to their working situations amidst the COVID-19 pandemic in Spain. Between April and June 2020, we conducted 16 semi-structured personal ...

» Bridging theory and praxis in the comprehensive treatment of conflict-related sexual violence in the Great Lakes Region of Africa
02/04/25 20:00 from covid-19
ABSTRACTThe holistic care model was designed to address the multifaceted medical, psychosocial, socioeconomic, and legal needs of survivors of conflict-related sexual violence (CRSV). However, the extent to which this model aligns with s...

» Medicaid Expansion and US Mortality Rates During the COVID-19 Pandemic, 2018-2022
02/04/25 20:00 from covid-19
Objectives. To examine the association of state Medicaid expansion status with mortality changes during the COVID-19 pandemic in the United States. Methods. Deaths among individuals 20 to 64 years of age in 3142 counties were identified ...

» Attitudes and beliefs regarding COVID-19 and COVID-19 Omicron booster vaccine among adults in the vaccine safety datalink, 2022-2023
02/04/25 20:00 from covid-19
COVID-19 vaccination rates are decreasing despite vaccination being the most effective tool against severe disease from COVID-19. From October 1, 2022, to February 1, 2023, we conducted a cross-sectional study among adults in the Vaccine...

» Worker Safety in US Meat and Poultry Slaughterhouses, Including Impact of COVID-19
02/04/25 20:00 from covid-19
From Upton Sinclair's The Jungle published in 1906 to the 2019 Report by Human Rights Watch, When We're Dead and Buried Our Bones Will Keep Hurting, the continuous hazardous working conditions facing workers in meat and poultry slaughter...

» NIH cancels research grants for COVID-19 and future pandemics
02/04/25 20:00 from covid-19
Scientists reject claim that the work is no longer needed.

» Using artificial intelligence tools to automate data extraction for living evidence syntheses
02/04/25 20:00 from covid-19
Living evidence synthesis (LES) involves repeatedly updating a systematic review or meta-analysis at regular intervals to incorporate new evidence into the summary results. It requires a considerable amount of human time investment in th...

» Human Metapneumovirus Seasonality and Co-Circulation with Respiratory Syncytial Virus - United States, 2014-2024
02/04/25 20:00 from covid-19
Human metapneumovirus (hMPV) infections cause acute respiratory illness and lower respiratory tract disease. Respiratory syncytial virus (RSV) is a closely related virus within the Pneumoviridae family, and hMPV and RSV infections are as...

» COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis
02/04/25 20:00 from covid-19
CONCLUSION: IEI with underlying defects in specific branches of the immune system responding to RNA virus infection experience a higher frequency and mortality of COVID-19 infection. Increasing awareness about these entities and underlyi...

» Rebound Hypoxemia in Mechanically Ventilated Patients With COVID-19 Completing a Standard 10-Day Course of Corticosteroid Therapy
02/04/25 20:00 from covid-19
Background: Rebound hypoxemia may occur after cessation of corticosteroid therapy for COVID-19 pneumonitis. We aimed to determine the incidence of this phenomenon in mechanically ventilated patients with COVID-19 completing corticosteroi...

» Worker Safety in US Meat and Poultry Slaughterhouses, Including Impact of COVID-19
02/04/25 20:00 from coronavirus
From Upton Sinclair's The Jungle published in 1906 to the 2019 Report by Human Rights Watch, When We're Dead and Buried Our Bones Will Keep Hurting, the continuous hazardous working conditions facing workers in meat and poultry slaughter...

» NIH cancels research grants for COVID-19 and future pandemics
02/04/25 20:00 from coronavirus
Scientists reject claim that the work is no longer needed.

» Using artificial intelligence tools to automate data extraction for living evidence syntheses
02/04/25 20:00 from coronavirus
Living evidence synthesis (LES) involves repeatedly updating a systematic review or meta-analysis at regular intervals to incorporate new evidence into the summary results. It requires a considerable amount of human time investment in th...

» COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis
02/04/25 20:00 from coronavirus
CONCLUSION: IEI with underlying defects in specific branches of the immune system responding to RNA virus infection experience a higher frequency and mortality of COVID-19 infection. Increasing awareness about these entities and underlyi...

» Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023
02/04/25 20:00 from coronavirus
CONCLUSIONS: The COVID-19 pandemic has altered the landscape of respiratory viruses causing SVP in children. The presence of underlying health conditions, particularly acute leukemia, other malignancies, and immunodeficiency, significant...

» Assessing the Impact of Haulage Drivers in Uganda's COVID-19 Delta Wave
02/04/25 20:00 from coronavirus
CONCLUSIONS: Our findings suggest that truck drivers were a transient core risk group with limited impact on onward spread. However, uncertainties remain regarding the extent of their role, and interventions like testing and result waiti...

» Emotional and sleep disturbances among patients previously hospitalized due to COVID-19
02/04/25 20:00 from coronavirus
CONCLUSIONS: During follow-up, most patients with COVID-19 suffer from ESDs that are predicted by hemoglobin levels. The ESDs increase the risk of concomitant BFS. The ESDs, particularly sadness, restlessness, insomnia, and excessive day...

» NIH cancels research grants for COVID-19 and future pandemics
02/04/25 20:00 from sars-cov-2
Scientists reject claim that the work is no longer needed.

» Using artificial intelligence tools to automate data extraction for living evidence syntheses
02/04/25 20:00 from sars-cov-2
Living evidence synthesis (LES) involves repeatedly updating a systematic review or meta-analysis at regular intervals to incorporate new evidence into the summary results. It requires a considerable amount of human time investment in th...

» Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
02/04/25 20:00 from coronavirus
CONCLUSIONS: Since coughing is one of the primary forms of transmission for SARS-CoV-2, the observed reduction of coughing might be highly beneficial, particularly for patients living in crowded, poorly ventilated, or confined environments.

» COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis
02/04/25 20:00 from sars-cov-2
CONCLUSION: IEI with underlying defects in specific branches of the immune system responding to RNA virus infection experience a higher frequency and mortality of COVID-19 infection. Increasing awareness about these entities and underlyi...

» Enhanced durability of a Zika virus self-amplifying RNA vaccine through combinatorial OX40 and 4-1BB agonism
02/04/25 20:00 from sars-cov-2
The SARS-CoV-2 pandemic highlighted the potential of mRNA vaccines in rapidly responding to emerging pathogens. However, immunity induced by conventional mRNA vaccines wanes quickly, requiring frequent boosters. Self-amplifying RNA (saRN...

» Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: The COVID-19 pandemic has altered the landscape of respiratory viruses causing SVP in children. The presence of underlying health conditions, particularly acute leukemia, other malignancies, and immunodeficiency, significant...

» Assessing the Impact of Haulage Drivers in Uganda's COVID-19 Delta Wave
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: Our findings suggest that truck drivers were a transient core risk group with limited impact on onward spread. However, uncertainties remain regarding the extent of their role, and interventions like testing and result waiti...

» Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out
02/04/25 20:00 from sars-cov-2
No abstract

» Emotional and sleep disturbances among patients previously hospitalized due to COVID-19
02/04/25 20:00 from sars-cov-2
CONCLUSIONS: During follow-up, most patients with COVID-19 suffer from ESDs that are predicted by hemoglobin levels. The ESDs increase the risk of concomitant BFS. The ESDs, particularly sadness, restlessness, insomnia, and excessive day...

» Incidence, risk factors, and mortality of pulmonary embolism in the Netherlands (2015-22): sex differences and shifts during the coronavirus disease 2019 pandemic
01/04/25 20:00 from coronavirus
CONCLUSIONS: The seemingly favourable pre-pandemic temporal trends in PE epidemiology in the Netherlands reversed during the COVID-19 pandemic but appear to revert to pre-pandemic levels after 2022.

» The role of occupational therapists in return-to-work practice for people with post-COVID condition: A scoping review
01/04/25 20:00 from coronavirus
BackgroundReturn to work has become more valuable today more than ever especially for adult workers who experience post-COVID condition.ObjectiveThis scoping review aims to map the extant literature on the role of occupational therapists...

» Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection
01/04/25 20:00 from sars-cov-2
No abstract

» Thematic trends in fact-checking in Brazil's COVID-19 infodemic: the first year in focus
01/04/25 20:00 from Sars-Cov-2 origins
Fact-checking agencies were pivotal in countering misinformation during the COVID-19 pandemic. We investigated the predominant thematic orientations within Brazilian fact-checking agencies during the pandemic's initial year. Brazil's cas...

» Thematic trends in fact-checking in Brazil's COVID-19 infodemic: the first year in focus
01/04/25 20:00 from Coronavirus origins
Fact-checking agencies were pivotal in countering misinformation during the COVID-19 pandemic. We investigated the predominant thematic orientations within Brazilian fact-checking agencies during the pandemic's initial year. Brazil's cas...

» Assessing stress among community health workers due to COVID-19 related work: A comparative study from Vietnam
01/04/25 20:00 from coronavirus
BackgroundCommunity health workers (CHWs) involved in COVID-19 response might be at increased risk of stress, though evidence remains absent.ObjectiveTo assess the effects of COVID-19 related work on stress and identified factors associa...

» The role of occupational therapists in return-to-work practice for people with post-COVID condition: A scoping review
01/04/25 20:00 from sars-cov-2
BackgroundReturn to work has become more valuable today more than ever especially for adult workers who experience post-COVID condition.ObjectiveThis scoping review aims to map the extant literature on the role of occupational therapists...

» Characterizing HLA-A2-restricted CD8(+) T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients
01/04/25 20:00 from sars-cov-2 spike protein
INTRODUCTION: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies generated by prior infection or vaccination. However, significant knowl...

» Analysis of job stress, depression, and mindfulness among Korean physical therapists during the COVID-19 pandemic
01/04/25 20:00 from coronavirus
BackgroundAlthough there are studies on preventing of COVID-19 infection for physical therapists during the COVID-19 pandemic, few studies have analyzed the job stress, depression, and mindfulness among physical therapists.ObjectiveThis ...

» Back to work again: Survival analysis of factors promoting return after industrial accidents
01/04/25 20:00 from coronavirus
BackgroundsSince 2022, South Korea has enacted the "Serious Accident Punishment Act" to enhance the safety of industrial workers. However, serious industrial accidents have continued to occur since the Act's implementation. The COVID-19 ...

» Assessing stress among community health workers due to COVID-19 related work: A comparative study from Vietnam
01/04/25 20:00 from sars-cov-2
BackgroundCommunity health workers (CHWs) involved in COVID-19 response might be at increased risk of stress, though evidence remains absent.ObjectiveTo assess the effects of COVID-19 related work on stress and identified factors associa...

» Investigation of Chinese medical students' professional quality after COVID-19
01/04/25 20:00 from coronavirus
CONCLUSION: Professional quality education with professional spirit and humanism at its core should be deepened furtherly, and teaching reform should be deepened to promote the all-around development of medical students' professional qua...

» Analysis of job stress, depression, and mindfulness among Korean physical therapists during the COVID-19 pandemic
01/04/25 20:00 from sars-cov-2
BackgroundAlthough there are studies on preventing of COVID-19 infection for physical therapists during the COVID-19 pandemic, few studies have analyzed the job stress, depression, and mindfulness among physical therapists.ObjectiveThis ...

» Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
01/04/25 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infection is still unclear. On the basis of our RNA-Seq data and due to the potential role of sialic acid as a corecepto...

» Incidence, risk factors, and mortality of pulmonary embolism in the Netherlands (2015-22): sex differences and shifts during the coronavirus disease 2019 pandemic
01/04/25 20:00 from covid-19
CONCLUSIONS: The seemingly favourable pre-pandemic temporal trends in PE epidemiology in the Netherlands reversed during the COVID-19 pandemic but appear to revert to pre-pandemic levels after 2022.

» Back to work again: Survival analysis of factors promoting return after industrial accidents
01/04/25 20:00 from sars-cov-2
BackgroundsSince 2022, South Korea has enacted the "Serious Accident Punishment Act" to enhance the safety of industrial workers. However, serious industrial accidents have continued to occur since the Act's implementation. The COVID-19 ...

» Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve
01/04/25 20:00 from coronavirus
The phylodynamic curve (Grenfell et al. 2004 Science 303, 327-332 (doi:10.1126/science.1090727)) conceptualizes how immunity shapes the rate of viral adaptation in a non-monotonic fashion, through its opposing effects on viral abundance ...

» Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil
01/04/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: The incidence of VTE in hospitalized COVID-19 patients was high and correlated with increased mortality. The IMPROVE-DD score effectively identified patients at risk for in-hospital VTE, suggesting it could help to identify ...

» Investigation of Chinese medical students' professional quality after COVID-19
01/04/25 20:00 from sars-cov-2
CONCLUSION: Professional quality education with professional spirit and humanism at its core should be deepened furtherly, and teaching reform should be deepened to promote the all-around development of medical students' professional qua...

» Space-time trends in fetal mortality in Brazil, 1996-2021
01/04/25 20:00 from coronavirus
CONCLUSION: Fetal mortality showed a long-term downward trend at the national and regional levels in Brazil, except in the Central-West region, where the trend was stationary. The covid-19 pandemic slowed down the reduction and increased...

» Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection
01/04/25 20:00 from covid-19
No abstract

» Thematic trends in fact-checking in Brazil's COVID-19 infodemic: the first year in focus
01/04/25 20:00 from Covid-19 origins
Fact-checking agencies were pivotal in countering misinformation during the COVID-19 pandemic. We investigated the predominant thematic orientations within Brazilian fact-checking agencies during the pandemic's initial year. Brazil's cas...

» Machine learning algorithms applied to the diagnosis of COVID-19 based on epidemiological, clinical, and laboratory data
01/04/25 20:00 from coronavirus
CONCLUSIONS: Artificial intelligence techniques represent an efficient strategy to identify patients with high clinical suspicion, particularly in situations in which health care systems face intense strain, such as in the COVID-19 pande...

» Increased Utilization of Overtime and Agency Nurses and Patient Safety
01/04/25 20:00 from covid-19
CONCLUSIONS AND RELEVANCE: These findings suggest that both nurse overtime and nurse agency hours are associated with increased rates of pressure ulcers, a measure that is one of the most sensitive to nursing care. In future research, ho...

» Altered liver hemodynamics in patients with COVID-19: a cross sectional study
01/04/25 20:00 from sars-cov-2
CONCLUSIONS: COVID-19 patients exhibit altered intrahepatic hemodynamics, with hepatic vein waveform abnormalities potentially reflecting liver inflammation and fibrosis. PVV and spleen diameter may serve as non-invasive predictors of re...

» The role of occupational therapists in return-to-work practice for people with post-COVID condition: A scoping review
01/04/25 20:00 from covid-19
BackgroundReturn to work has become more valuable today more than ever especially for adult workers who experience post-COVID condition.ObjectiveThis scoping review aims to map the extant literature on the role of occupational therapists...

» Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil
01/04/25 20:00 from coronavirus
CONCLUSIONS: The incidence of VTE in hospitalized COVID-19 patients was high and correlated with increased mortality. The IMPROVE-DD score effectively identified patients at risk for in-hospital VTE, suggesting it could help to identify ...

» Limitations of point-of-care testing for low SARS CoV-2 loads: Insights for future pandemics
01/04/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: The performance rapid antigen tests was low on samples with low viral load with results markedly different from the manufacturer's reported performance.Contribution: Rapid antigen tests should not be used alone for diagnosis,...

» Assessing stress among community health workers due to COVID-19 related work: A comparative study from Vietnam
01/04/25 20:00 from covid-19
BackgroundCommunity health workers (CHWs) involved in COVID-19 response might be at increased risk of stress, though evidence remains absent.ObjectiveTo assess the effects of COVID-19 related work on stress and identified factors associa...

» Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
01/04/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infection is still unclear. On the basis of our RNA-Seq data and due to the potential role of sialic acid as a corecepto...

» Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve
01/04/25 20:00 from sars-cov-2
The phylodynamic curve (Grenfell et al. 2004 Science 303, 327-332 (doi:10.1126/science.1090727)) conceptualizes how immunity shapes the rate of viral adaptation in a non-monotonic fashion, through its opposing effects on viral abundance ...

» Hearing abilities stimulation program for schools
01/04/25 20:00 from coronavirus
CONCLUSION: The program was incorporated into the curriculum, helping to develop the skills recommended by the Ministry of Education. After auditory stimulation, ASG performed better in auditory figure-ground, temporal resolution, rhyme ...

» Analysis of job stress, depression, and mindfulness among Korean physical therapists during the COVID-19 pandemic
01/04/25 20:00 from covid-19
BackgroundAlthough there are studies on preventing of COVID-19 infection for physical therapists during the COVID-19 pandemic, few studies have analyzed the job stress, depression, and mindfulness among physical therapists.ObjectiveThis ...

» Genomic and spatial epidemiology: lessons learned from SARS-CoV-2 pandemic
01/04/25 20:00 from sars-cov-2
PURPOSE OF REVIEW: The SARS-CoV-2 pandemic presented unprecedented challenges, particularly in understanding its complex spatial transmission patterns. The high transmissibility of the virus led to frequent super-spreading events. These ...

» Social vulnerability and severe COVID-19 in pregnant women: an ecological study in Pernambuco State, Brazil, 2020-2021
01/04/25 20:00 from coronavirus
This study analyzed the association between social vulnerability indicators and the incidence rate of severe COVID-19 in pregnant women in Pernambuco State, Brazil, between 2020 and 2021. It is an ecological study that assessed severe ca...

» Back to work again: Survival analysis of factors promoting return after industrial accidents
01/04/25 20:00 from covid-19
BackgroundsSince 2022, South Korea has enacted the "Serious Accident Punishment Act" to enhance the safety of industrial workers. However, serious industrial accidents have continued to occur since the Act's implementation. The COVID-19 ...

» Chebulinic acid suppresses porcine epidemic diarrhea virus infection by inhibiting viral entry and viral main protease
01/04/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) has resulted in significant economic losses in the global swine industry, making the development of effective therapeutic approaches a pressing need. In this study, we found that chebulinic acid sig...

» Space-time trends in fetal mortality in Brazil, 1996-2021
01/04/25 20:00 from sars-cov-2
CONCLUSION: Fetal mortality showed a long-term downward trend at the national and regional levels in Brazil, except in the Central-West region, where the trend was stationary. The covid-19 pandemic slowed down the reduction and increased...

» Thematic trends in fact-checking in Brazil's COVID-19 infodemic: the first year in focus
01/04/25 20:00 from coronavirus
Fact-checking agencies were pivotal in countering misinformation during the COVID-19 pandemic. We investigated the predominant thematic orientations within Brazilian fact-checking agencies during the pandemic's initial year. Brazil's cas...

» Investigation of Chinese medical students' professional quality after COVID-19
01/04/25 20:00 from covid-19
CONCLUSION: Professional quality education with professional spirit and humanism at its core should be deepened furtherly, and teaching reform should be deepened to promote the all-around development of medical students' professional qua...

» Machine learning algorithms applied to the diagnosis of COVID-19 based on epidemiological, clinical, and laboratory data
01/04/25 20:00 from sars-cov-2
CONCLUSIONS: Artificial intelligence techniques represent an efficient strategy to identify patients with high clinical suspicion, particularly in situations in which health care systems face intense strain, such as in the COVID-19 pande...

» Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19
01/04/25 20:00 from coronavirus
Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role of age-associated dysbiosis on disease outcomes is still elusive. In the current study, we used high-resolution shotgun metagenomics a...

» Altered liver hemodynamics in patients with COVID-19: a cross sectional study
01/04/25 20:00 from covid-19
CONCLUSIONS: COVID-19 patients exhibit altered intrahepatic hemodynamics, with hepatic vein waveform abnormalities potentially reflecting liver inflammation and fibrosis. PVV and spleen diameter may serve as non-invasive predictors of re...

» Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil
01/04/25 20:00 from sars-cov-2
CONCLUSIONS: The incidence of VTE in hospitalized COVID-19 patients was high and correlated with increased mortality. The IMPROVE-DD score effectively identified patients at risk for in-hospital VTE, suggesting it could help to identify ...

» Bilateral Acute Iris Transillumination Following Systemic Moxifloxacin Intake in the Greek Population
01/04/25 20:00 from covid-19
CONCLUSION: Understanding the clinical manifestations of the disease and its geographic spread facilitates a prompt clinical diagnosis, preventing unnecessary diagnostic tests. Although BCVA is typically well preserved in BAIT, persisten...

» Hearing abilities stimulation program for schools
01/04/25 20:00 from sars-cov-2
CONCLUSION: The program was incorporated into the curriculum, helping to develop the skills recommended by the Ministry of Education. After auditory stimulation, ASG performed better in auditory figure-ground, temporal resolution, rhyme ...

» Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
01/04/25 20:00 from covid-19
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infection is still unclear. On the basis of our RNA-Seq data and due to the potential role of sialic acid as a corecepto...

» Social vulnerability and severe COVID-19 in pregnant women: an ecological study in Pernambuco State, Brazil, 2020-2021
01/04/25 20:00 from sars-cov-2
This study analyzed the association between social vulnerability indicators and the incidence rate of severe COVID-19 in pregnant women in Pernambuco State, Brazil, between 2020 and 2021. It is an ecological study that assessed severe ca...

» Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve
01/04/25 20:00 from covid-19
The phylodynamic curve (Grenfell et al. 2004 Science 303, 327-332 (doi:10.1126/science.1090727)) conceptualizes how immunity shapes the rate of viral adaptation in a non-monotonic fashion, through its opposing effects on viral abundance ...

» Thematic trends in fact-checking in Brazil's COVID-19 infodemic: the first year in focus
01/04/25 20:00 from sars-cov-2
Fact-checking agencies were pivotal in countering misinformation during the COVID-19 pandemic. We investigated the predominant thematic orientations within Brazilian fact-checking agencies during the pandemic's initial year. Brazil's cas...

» Cross-validation-based sequential design for stochastic models
01/04/25 20:00 from covid-19
Complex numerical models are increasingly being used in healthcare and epidemiology. To represent the complex features, modellers often make the decision to include stochastic behaviour where repeated runs of the model with identical inp...

» Genomic and spatial epidemiology: lessons learned from SARS-CoV-2 pandemic
01/04/25 20:00 from covid-19
PURPOSE OF REVIEW: The SARS-CoV-2 pandemic presented unprecedented challenges, particularly in understanding its complex spatial transmission patterns. The high transmissibility of the virus led to frequent super-spreading events. These ...

» Effectiveness of mailed versus in-person PAP initiation in VA's TeleSleep program
01/04/25 20:00 from covid-19
CONCLUSIONS: Initiation of PAP therapy via telehealth was non-inferior to in-person set up visits in terms of PAP adherence among Veterans who use VA care.

» Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury
01/04/25 20:00 from coronavirus
CONCLUSION: Heme induced inflammatory cytokine release and cell death in human PCLS, resembling the patterns observed in blood samples from patients with COVID-19 and ARDS. Thus, heme-stimulated PCLS represent a novel ex vivo model for m...

» Burden of non-COVID-19 lower respiratory infections in China (1990-2021): a global burden of disease study analysis
01/04/25 20:00 from coronavirus
CONCLUSIONS: In China, substantial progress has been made in reducing LRI mortality, yet LRIs have remained a threat in China from 1990 to 2021. During the COVID-19 pandemic, the mortality attributable to Influenza and RSV declined. Effe...

» Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals
01/04/25 20:00 from coronavirus
To evaluate the relationship between metformin and the outcome of coronavirus disease 2019 (COVID-19) infection. The study included 413 patients with type 2 diabetes among the 5217 patients enrolled in a COVID-19 study, and analyzed whet...

» Real-world application of molecular docking in drug discovery
01/04/25 20:00 from sars-cov-2 spike protein
Computational drug designing comprising mainly Molecular Docking has surged in popularity due to its efficiency and precision in identifying potential therapeutic candidates, often collectively referred to as virtual screening. This meth...

» Computational exploration of viral cell membrane structures for identifying novel therapeutic target
01/04/25 20:00 from sars-cov-2 spike protein
The membrane proteins of viruses play a critical role, and they shield viruses and takes biochemical mechanisms like sticking to the host cell membrane, merging with them, building new viruses, and breaking free. These steps make sure th...

» A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomised, open-label, superiority trial
01/04/25 20:00 from sars-cov-2 spike protein
BACKGROUND: Chronic lymphocytic leukaemia is the commonest leukaemia and is associated with profound immunosuppression. Bruton tyrosine kinase inhibitors (BTKi) have revolutionised chronic lymphocytic leukaemia management; however, thera...

» Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection
01/04/25 20:00 from covid-19 and viral infections in pigs
CONCLUSION: F.prausnitzii and its OMVs play a critical role in mitigating PEDV infections. These findings provide a promising strategy to ameliorate PEDV infection in piglets. Video Abstract.

» An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters
01/04/25 20:00 from sars-cov-2 spike protein
Newly emerging SARS-CoV-2 variants of concern (VOCs) continue to drive COVID-19 waves and are typically associated with immune escape and increased resistance to current therapeutics including monoclonal antibodies. By contrast, VOCs sti...

» Two opposite abilities of the infectious bronchitis virus helicase Nsp13: separating the duplex and promoting the annealing of single-stranded nucleic acid
31/03/25 20:00 from coronavirus
Genome replication is a key step in the coronavirus life cycle and requires the involvement of a range of virally encoded non-structural proteins. The non-structural protein 13 (Nsp13) of coronaviruses is a highly conserved helicase and ...

» FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry
31/03/25 20:00 from sars-cov-2 spike protein
CONCLUSION AND IMPLICATIONS: We identified four novel FDA-approved candidate drugs for anti-SARS-CoV-2 combination therapy. Our findings contribute to the growing body of evidence supporting drug repurposing as a viable strategy for rapi...

» Demonstration and structural basis of a therapeutic DNA aptamer for SARS-CoV-2 spike protein detection
31/03/25 20:00 from sars-cov-2 spike protein
At the onset of the COVID-19 pandemic, the absence of a rapid and highly specific diagnostic method for the SARS-CoV-2 virus led to significant delays in detection, adversely affecting clinical outcomes. This shortfall highlights the urg...

» FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry
31/03/25 20:00 from coronavirus
CONCLUSION AND IMPLICATIONS: We identified four novel FDA-approved candidate drugs for anti-SARS-CoV-2 combination therapy. Our findings contribute to the growing body of evidence supporting drug repurposing as a viable strategy for rapi...

» Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models
31/03/25 20:00 from sars-cov-2 spike protein
INTRODUCTION: A new generation of mucosal vaccine against the ever-evolving SARS-CoV-2 is of great value to fight COVID-19. In previous studies, our groups developed a viral vector vaccine based on an avirulent Newcastle disease virus (N...

» Effects of the COVID-19 Pandemic on Early Childhood Development and Mental Health: A Systematic Review and Meta-Analysis of Comparative Studies
31/03/25 20:00 from coronavirus
From 2020 to 2023, the coronavirus-19 (COVID-19) pandemic exposed children to a variety of adverse childhood events, including parental loss, abuse, and disruption in services, and it exacerbated societal inequities. Studies evaluating t...

» Enhancing Polyacrylonitrile Nanofibers Antiviral Activity Using Greenly Synthesized Silver Nanoparticles
31/03/25 20:00 from sars-cov-2 spike protein
Developing efficient antiviral protectives is a new approach against respiratory emerging viruses. This study aims to synthesize silver nanoparticles (Ag NPs) via a green technique using crocin to provide a virucidal effect and to enhanc...

» Proteomic Analysis of Endemic Viral Infections in Neurons offers Insights into Neurodegenerative Diseases
31/03/25 20:00 from coronavirus
Endemic viral infections with low pathogenicity are often overlooked due to their mild symptoms, yet they can exert long-term effects on cellular function and contribute to disease pathogenesis. While viral infections have been implicate...

» Rapid Recovery From SARS-CoV-2 Infection Among Immunocompromised Children Despite Limited Neutralizing Antibody Response: A Virologic and Sero-Immunologic Analysis of a Single-Center Cohort
31/03/25 20:00 from sars-cov-2 spike protein
CONCLUSION: IC pediatric patients rapidly recovered from COVID-19 with low viral loads. Antibody response was limited, but cytokine analysis suggested an enhanced IFN-γ- and IL-18-mediated immune response without excessive activation of ...

» Pathogenic built environment? Reflections on modeling spatial determinants of health in urban settings considering the example of COVID-19 studies
31/03/25 20:00 from coronavirus
The triad of host, agent, and environment has become a widely accepted framework for understanding infectious diseases and human health. While modern medicine has traditionally focused on the individual, there is a renewed interest in th...

» Polyunsaturated Fatty Acid Imbalance-A Contributor to SARS CoV-2 Disease Severity
31/03/25 20:00 from sars-cov-2
Overview: SARS CoV-2 infection is accompanied by the development of acute inflammation, resolution of which determines the course of infection and its outcome. If not resolved (brought back to preinjury status), the inflamed state progre...

» Examining Instrumental Factors Influencing the Performance of Data-Independent Acquisition Methods in Hydrogen/Deuterium Exchange Mass Spectrometry
31/03/25 20:00 from sars-cov-2 spike protein
Hydrogen/deuterium exchange mass spectrometry (HX-MS) is a method used to study solution-phase protein structure and dynamics. Despite its many applications, HX-MS is limited in throughput because manual data analysis is still the norm. ...

» Religious affiliation and perceptions of healthcare access during and after COVID-19 in Poland
31/03/25 20:00 from coronavirus
INTRODUCTION: In response to the unprecedented impact of the COVID-19 pandemic on healthcare systems and social life worldwide, this study examines the role of religion in shaping perceptions of healthcare access in Poland during and aft...

» Completeness of Data on Race and Ethnicity and Timeliness of Electronic Case Reports for COVID-19 at 4 Health Care Organizations in Florida, December 2020
31/03/25 20:00 from covid-19
CONCLUSIONS: Advancing implementation of eCR nationwide may provide more complete and timely case data than ELR or manually transmitted documents to guide public health action.

» Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures
31/03/25 20:00 from coronavirus
Research on aged individuals from developed countries show that lifestyle factors such as diet, physical activity, stress, smoking, and sleep quality impact aging. However, other relevant factors may influence aging in less-studied popul...

» Pediatric SARS-CoV-2 infection and development of anxiety and depression
31/03/25 20:00 from sars-cov-2
CONCLUSIONS: Although no association was found between SARS-CoV-2 infection and new diagnoses of anxiety and/or depression, SARS-CoV-2-positive participants were more likely to experience confusion/lack of concentration, abdominal pain, ...

» Non-neutralizing anti-type I interferon autoantibodies could increase thrombotic risk in critical COVID-19 patients
31/03/25 20:00 from coronavirus
During the COVID-19 pandemic, approximately 15% of patients with severe COVID-19 pneumonia were reported to have neutralizing anti-type I interferon (IFN) autoantibodies, which impaired the antiviral response and led to a poorer prognosi...

» An Updated Scoping Review of Disparities in Pediatric Atopic Dermatitis
31/03/25 20:00 from covid-19
CONCLUSION: With an increasing focus on health disparities research, particularly within the context of the COVID-19 pandemic, an update on disparities within pediatric AD is needed. Examining the results of these studies can help point ...

» Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models
31/03/25 20:00 from coronavirus
INTRODUCTION: A new generation of mucosal vaccine against the ever-evolving SARS-CoV-2 is of great value to fight COVID-19. In previous studies, our groups developed a viral vector vaccine based on an avirulent Newcastle disease virus (N...

» The Antiviral Activity of Polyphenols
31/03/25 20:00 from covid-19
Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a wide range of employment, from food pro...