» Smoking cessation among tuberculosis patients during the coronavirus disease-2019 pandemic
23/04/24 20:00 from coronavirus
Smoking has been recognized as a significant risk factor for COVID-19 and mortality. The World Health Organization (WHO) has recommended smoking cessation to reduce the impact of COVID-19. This study aimed to evaluate the smoking cessati...

» Impact of Anti-angiogenic Drugs on Severity of COVID-19 in Patients with Non-Small Cell Lung Cancer
23/04/24 20:00 from coronavirus
Introduction: The 2019 coronavirus disease (COVID-19) pandemic has reshaped oncology practice, but the impact of anti-angiogenic drugs on the severity of COVID-19 in patients with non-small cell lung cancer (NSCLC) remains unclear. Patie...

» Long COVID-19 and mnemonic effects: an integrative literature review
23/04/24 20:00 from coronavirus
No abstract

» Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
23/04/24 20:00 from coronavirus
Although control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and ou...

» Bilateral acute depigmentation of the iris (BADI) and bilateral acute iris transillumination (BAIT): A case series from a center in Brazil
23/04/24 20:00 from coronavirus
Bilateral acute depigmentation of the iris and bilateral acute iris transillumination (BAIT) are similar clinical entities. The former causes acute-onset depigmentation of the iris stroma without transillumination, whereas the latter cau...

» Transition from an in-person to a telemedicine diabetic retinopathy screening program
23/04/24 20:00 from coronavirus
CONCLUSION: The telemedicine approach significantly reduced the waiting time for specialist evaluation in a real-world setting. Employing portable retinal cameras may address the burden of diabetic retinopathy, especially in resource-lim...

» Response to "Analysis of possible risk predictors in patients with coronavirus disease 2019: a retrospective cohort study"
23/04/24 20:00 from coronavirus
No abstract

» Smoking cessation among tuberculosis patients during the coronavirus disease-2019 pandemic
23/04/24 20:00 from covid-19
Smoking has been recognized as a significant risk factor for COVID-19 and mortality. The World Health Organization (WHO) has recommended smoking cessation to reduce the impact of COVID-19. This study aimed to evaluate the smoking cessati...

» Mobile app for pelvic floor muscle training for urinary incontinence during the coronavirus disease 2019 pandemic: clinical trial
23/04/24 20:00 from coronavirus
CONCLUSION: This study revealed notable enhancements in stress urinary incontinence, urinary storage, and overall quality of life subsequent to pelvic floor muscle training guided by a mobile app, particularly during the coronavirus dise...

» Coding-complete genomes of 18 SARS-CoV-2 Omicron JN.1, JN.1.4, and JN.1.11 sub-lineages in Bangladesh
23/04/24 20:00 from sars-cov-2
We report 18 coding-complete genome sequences of emerging SARS-CoV-2 Omicron sub-lineages JN.1, JN.1.4, and JN.1.11 from Bangladesh. Nasopharyngeal swab samples were obtained from individuals with COVID-19 symptoms between December 2023 ...

» Domestic violence patterns in postpartum women who delivered during the COVID-19 pandemic
23/04/24 20:00 from coronavirus
CONCLUSION: Prevalence of DV was considerably high in the postpartum period. DV prevention policies should rely on improving care to women's mental health; preventing food insecurity; and fostering the educational level of young people o...

» Reply to Letter to the Editor: 'Cardiovascular Events After Coronavirus Disease 2019 Vaccinations: Hypersensitivity Myocarditis After Coronavirus Disease 2019 Vaccines, Diagnostic and Long-term Considerations'
23/04/24 20:00 from coronavirus
No abstract

» Genetic diversity of KPC-2-producing Klebsiella pneumoniae complex from aquatic ecosystems
23/04/24 20:00 from covid-19
During the COVID-19 pandemic, the occurrence of carbapenem-resistant Klebsiella pneumoniae increased in human clinical settings worldwide. Impacted by this increase, international high-risk clones harboring carbapenemase-encoding genes h...

» The Impact of Postoperative COVID-19 Infection on 30-day Outcomes of Laparoscopic Cholecystectomy
23/04/24 20:00 from coronavirus
Introduction: Preoperative Coronavirus Disease 2019 (COVID-19) infections are associated with postoperative adverse outcomes. However, there is limited data on the impact of postoperative COVID-19 infection on postoperative outcomes of c...

» Long COVID-19 and mnemonic effects: an integrative literature review
23/04/24 20:00 from sars-cov-2
No abstract

» Rebuttal to the letter "Assessment of COVID-19-related right ventricular morphological and functional alterations and evaluation of their impact on the course of the disease"
23/04/24 20:00 from covid-19
No abstract

» SARS-CoV-2 infection induces thymic atrophy mediated by IFN-γ in hACE2 transgenic mice
23/04/24 20:00 from coronavirus
Pathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immuno...

» Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
23/04/24 20:00 from sars-cov-2
Although control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and ou...

» Adaptation and Implementation of a Volunteer-delivered, Telephone-based, Social Support Program HOW-R-U? during the COVID-19 Pandemic: A Pragmatic Study
23/04/24 20:00 from covid-19
BACKGROUND AND OBJECTIVES: Public health concerns surrounding social isolation and loneliness heightened during the COVID-19 pandemic, as infection prevention measures led to increased feelings of loneliness and depression.Our objective ...

» Revisiting dexamethasone use in the pediatric emergency department
23/04/24 20:00 from coronavirus
PURPOSE OF REVIEW: Dexamethasone is an essential treatment for common pediatric inflammatory, airway, and respiratory conditions. We aim to provide up-to-date recommendations for treatment of anaphylaxis, croup, coronavirus disease, mult...

» Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
23/04/24 20:00 from sars-cov-2
Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) in...

» Bilateral acute depigmentation of the iris (BADI) and bilateral acute iris transillumination (BAIT): A case series from a center in Brazil
23/04/24 20:00 from sars-cov-2
Bilateral acute depigmentation of the iris and bilateral acute iris transillumination (BAIT) are similar clinical entities. The former causes acute-onset depigmentation of the iris stroma without transillumination, whereas the latter cau...

» Transition from an in-person to a telemedicine diabetic retinopathy screening program
23/04/24 20:00 from sars-cov-2
CONCLUSION: The telemedicine approach significantly reduced the waiting time for specialist evaluation in a real-world setting. Employing portable retinal cameras may address the burden of diabetic retinopathy, especially in resource-lim...

» "Maybe if we weren't in the pandemic, I would have reconsidered": Experiences of abortion care-seeking during the COVID-19 pandemic in Maryland
23/04/24 20:00 from coronavirus
CONCLUSIONS: The pandemic changed abortion care-seeking circumstances even in a setting with minimal access barriers. Financial hardship influenced some women to have an abortion for a pregnancy that-while unplanned-they may have preferr...

» Diaphragmatic morphological post-mortem findings in critically ill COVID-19 patients: an observational study
23/04/24 20:00 from covid-19
Our study investigates the post-mortem findings of the diaphragm's muscular structural changes in mechanically ventilated COVID-19 patients. Diaphragm samples of the right side from 42 COVID-19 critically ill patients were analyzed and c...

» Mobile app for pelvic floor muscle training for urinary incontinence during the coronavirus disease 2019 pandemic: clinical trial
23/04/24 20:00 from sars-cov-2
CONCLUSION: This study revealed notable enhancements in stress urinary incontinence, urinary storage, and overall quality of life subsequent to pelvic floor muscle training guided by a mobile app, particularly during the coronavirus dise...

» Domestic violence patterns in postpartum women who delivered during the COVID-19 pandemic
23/04/24 20:00 from sars-cov-2
CONCLUSION: Prevalence of DV was considerably high in the postpartum period. DV prevention policies should rely on improving care to women's mental health; preventing food insecurity; and fostering the educational level of young people o...

» Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine
23/04/24 20:00 from covid-19
CONCLUSIONS: Overall, we demonstrate differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance HD subjects comparable to healthy controls and identify transcriptomic and clinical predictors of an...

» The Padel phenomenon after the COVID-19: an Italian cross-sectional survey of post-lockdown injuries
23/04/24 20:00 from covid-19
The impact of COVID-19 on sport and physical activity has been a subject of considerable interest and concern. Padel satisfies the desire for social interaction and a return to sport after a period of inactivity. The aim of this study is...

» SARS-CoV-2 infection induces thymic atrophy mediated by IFN-gamma in hACE2 transgenic mice
23/04/24 20:00 from sars-cov-2
Pathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immuno...

» Impact of Anti-angiogenic Drugs on Severity of COVID-19 in Patients with Non-Small Cell Lung Cancer
23/04/24 20:00 from covid-19
Introduction: The 2019 coronavirus disease (COVID-19) pandemic has reshaped oncology practice, but the impact of anti-angiogenic drugs on the severity of COVID-19 in patients with non-small cell lung cancer (NSCLC) remains unclear. Patie...

» Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
23/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) in...

» Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis
23/04/24 20:00 from covid-19
The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading infectious killer after COVID-19, with...

» Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics
23/04/24 20:00 from sars-cov-2
Vaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting the SARS-CoV-2 spike ...

» Genomic surveillance of SARS-CoV-2 in North Africa: 4 years of GISAID data sharing
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: This study contributes valuable insights into the genomic landscape of SARS-CoV-2 in North Africa, highlighting the importance of genomic surveillance in understanding viral dynamics and informing public health strategies.

» Optimizing heat inactivation for SARS-CoV-2 at 95 C and its implications: A standardized approach
23/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: The conditions evaluated in the present study could be helpful for laboratories in preparing SARS-CoV-2 EQAP samples.

» What supports and services post COVID-19 do children with disabilities and their parents need and want, now and into the future?
23/04/24 20:00 from sars-cov-2
INTRODUCTION: Children and youth with disabilities and special healthcare needs, and their families, have been uniquely affected by the COVID-19 pandemic. However, the voices of children themselves are still not well represented in the e...

» Coding-complete genomes of 18 SARS-CoV-2 Omicron JN.1, JN.1.4, and JN.1.11 sub-lineages in Bangladesh
23/04/24 20:00 from covid-19
We report 18 coding-complete genome sequences of emerging SARS-CoV-2 Omicron sub-lineages JN.1, JN.1.4, and JN.1.11 from Bangladesh. Nasopharyngeal swab samples were obtained from individuals with COVID-19 symptoms between December 2023 ...

» Quinazolines and thiazolidine-2,4-dions as SARS-CoV-2 inhibitors: repurposing, in silico molecular docking and dynamics simulation
23/04/24 20:00 from sars-cov-2
This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2 inhibitors as potential treatments. The investigation includes an overview of computational methodologies employed in drug repurposing and highlights ...

» Increased Virtual Visits to Physicians During the COVID-19 Pandemic and Estimated Impact on Physician Compensation: The Case of Lung and Colorectal Cancers, Chronic Obstructive Pulmonary Diseases, and Heart Failure in Alberta, Canada
23/04/24 20:00 from covid-19
Introduction: The COVID-19 pandemic started in Alberta in March 2020 and significantly increased telehealth service use and provision reducing the risk of virus transmission. We examined the change in the number and proportion of virtual...

» Optimizing heat inactivation for SARS-CoV-2 at 95 C and its implications: A standardized approach
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: The conditions evaluated in the present study could be helpful for laboratories in preparing SARS-CoV-2 EQAP samples.

» Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial
23/04/24 20:00 from sars-cov-2
CONCLUSION: High-dose Spirulina supplements coupled with the standard treatment of COVID-19 may improve recovery and remarkably reduce mortality in hospitalized patients with COVID-19.

» Effectiveness and Satisfaction with Telemedicine in Geriatric Patients at High Risk of Fragility Fractures
23/04/24 20:00 from covid-19
Background: Telemedicine has increasingly widespread to improve the monitoring of patients with chronic diseases. Secondary prevention of fragility fractures is an urgent matter to be addressed by means of available technology, although ...

» Teleconsultation for Preoperative Anesthesia Evaluation: Identifying Environmental Potentials by Life Cycle Assessment
23/04/24 20:00 from covid-19
Introduction: Teleconsultations for preoperative evaluation in anesthesiology proved to be feasible during the COVID-19 pandemic. However, widespread implementation of teleconsultations has not yet occurred. Besides time savings and econ...

» Post-COVID-19 syndrome, inflammation and insulin resistance: a retrospective cohort study
23/04/24 20:00 from covid-19
CONCLUSIONS: PCS was associated with increased IR, being more evident when the baseline degree of IR was very low. PCS and increased IR were separately associated with inflammation. Acute polysymptomatic COVID-19 and PCS could be clinica...

» Generalizing the application of machine learning predictive models across different populations: does a model to predict the use of renal replacement therapy in critically ill COVID-19 patients apply to general intensive care unit patients?
23/04/24 20:00 from covid-19
No abstract

» A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2
23/04/24 20:00 from coronavirus
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus, is the causative agent responsible for the spread of the COVID19 pandemic across the globe. The global impact of the COVID19 pandemic, the successful ...

» A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2
23/04/24 20:00 from sars-cov-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus, is the causative agent responsible for the spread of the COVID19 pandemic across the globe. The global impact of the COVID19 pandemic, the successful ...

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. Reply
23/04/24 20:00 from coronavirus
No abstract

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from coronavirus
No abstract

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. Reply
23/04/24 20:00 from sars-cov-2
No abstract

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from sars-cov-2
No abstract

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from coronavirus
No abstract

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from sars-cov-2
No abstract

» A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2
23/04/24 20:00 from covid-19
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus, is the causative agent responsible for the spread of the COVID19 pandemic across the globe. The global impact of the COVID19 pandemic, the successful ...

» Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: COVID-19 can cause long-term alterations in the corneal endothelial cells, leading to decreased ECD and HEX. Future research should focus on the long-term implications of COVID-19 on the corneal health and visual outcomes.

» The "Loss Years" of Residency Education: Overcoming COVID-19 Learning Gaps among Trainees
23/04/24 20:00 from coronavirus
No abstract

» The "Loss Years" of Residency Education: Overcoming COVID-19 Learning Gaps among Trainees
23/04/24 20:00 from sars-cov-2
No abstract

» Antibody titers and the risk of infection during the SARS-CoV-2 Omicron phase in Bizen City, Japan
23/04/24 20:00 from coronavirus
CONCLUSIONS: Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future vaccination.

» Oral administration of PEDV-dissolved Alg-CS gel induces high and sustained mucosal immunity in mice
23/04/24 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea (PED) is a serious disease in piglets that leads to high mortality. An effective measure that provides higher IgA levels in the intestine and milk is required to decrease losses. Porcine epidemic diarrhea virus ...

» SARS-CoV-2 RNA and nucleocapsid antigen are blood biomarkers associated with severe disease outcomes that improve in response to remdesivir
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: Reductions in SARS-CoV-2 RNA and antigen levels in blood correlated with clinical benefit from antiviral therapy.

» Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes
23/04/24 20:00 from coronavirus
CONCLUSIONS: Our study is the first national examination of the impact of cardiac comorbidities on COVID outcomes. A higher number of cardiac comorbidities was associated with significantly higher rates of MV and in-hospital mortality, i...

» Antibody titers and the risk of infection during the SARS-CoV-2 Omicron phase in Bizen City, Japan
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future vaccination.

» Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
23/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) in...

» Magnetic Resonance Imaging of Cardiac Involvement in COVID-19
23/04/24 20:00 from sars-cov-2
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated w...

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. Reply
23/04/24 20:00 from covid-19
No abstract

» Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States
23/04/24 20:00 from coronavirus
CONCLUSIONS: Associations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunit...

» Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: Our study is the first national examination of the impact of cardiac comorbidities on COVID outcomes. A higher number of cardiac comorbidities was associated with significantly higher rates of MV and in-hospital mortality, i...

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from covid-19
No abstract

» Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis
23/04/24 20:00 from coronavirus
Elderly patients infected with severe acute respiratory syndrome coronavirus 2 are at higher risk of severe clinical manifestation, extended hospitalization, and increased mortality. Those patients are more likely to experience persisten...

» Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: Associations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunit...

» Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
23/04/24 20:00 from covid-19
No abstract

» Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
23/04/24 20:00 from coronavirus
CONCLUSION: Neuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic.

» An assessment of the perceptual elements of urban streets based on the context of urban tourism - The case of Sheffield
23/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: There is a difference in the indicators chosen by the two groups in the results of the comparison between locals and travelers, and this study is hoped to provide some data support for future urban managers and designers to l...

» Changing epidemiology of COVID-19: potential future impact on vaccines and vaccination strategies
23/04/24 20:00 from sars-cov-2
INTRODUCTION: COVID-19 was an unprecedented challenge worldwide; however, disease epidemiology has evolved, and COVID-19 no longer constitutes a public health emergency of international concern. Nonetheless, COVID-19 remains a global thr...

» Exploring the Prevalence of Tinnitus and Ear-Related Symptoms in China After the COVID-19 Pandemic: Online Cross-Sectional Survey
23/04/24 20:00 from covid-19
CONCLUSIONS: In summary, tinnitus was identified as the most common ear-related symptom during COVID-19 infection. Individuals experiencing tinnitus after COVID-19 infection were found to have poorer cognitive and emotional well-being. D...

» Safety of Ancestral Monovalent BNT162b2, mRNA-1273, and NVX-CoV2373 COVID-19 Vaccines in US Children Aged 6 Months to 17 Years
23/04/24 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this cohort study of pediatric enrollees across 3 commercial health insurance databases, statistical signals detected for myocarditis or pericarditis after BNT162b2 (ages 12-17 years) were consistent with pr...

» Type 1 diabetes in pediatrics during the COVID-19 pandemic: Time from symptom onset and forms of presentation at a referral hospital
23/04/24 20:00 from sars-cov-2
Introduction. The COVID-19 pandemic impacted on the health care of patients with type 1 diabetes mellitus (DM1). An increase in diabetic ketoacidosis (DKA) as a form of diagnosis was reported. Objectives. To assess whether there were cha...

» Cancer Care Supportive Text Messaging Program (Text4Hope) for People Living With Cancer and Their Caregivers During the COVID-19 Pandemic: Longitudinal Observational Study
23/04/24 20:00 from covid-19
CONCLUSIONS: Text4Hope-Cancer Care was well-perceived and effectively addressed anxiety symptoms among people living with cancer and caregivers during the peak of the COVID-19 pandemic. This study provides evidence-based support and insi...

» Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms
23/04/24 20:00 from covid-19
CONCLUSIONS: COVID-19 can cause long-term alterations in the corneal endothelial cells, leading to decreased ECD and HEX. Future research should focus on the long-term implications of COVID-19 on the corneal health and visual outcomes.

» Centrifugo-Pneumatic Reciprocating Flowing Coupled with a Spatial Confinement Strategy for an Ultrafast Multiplexed Immunoassay
23/04/24 20:00 from sars-cov-2
Immunoassays serve as powerful diagnostic tools for early disease screening, process monitoring, and precision treatment. However, the current methods are limited by high costs, prolonged processing times (>2 h), and operational complexi...

» Oral administration of PEDV-dissolved Alg-CS gel induces high and sustained mucosal immunity in mice
23/04/24 20:00 from coronavirus
Porcine epidemic diarrhea (PED) is a serious disease in piglets that leads to high mortality. An effective measure that provides higher IgA levels in the intestine and milk is required to decrease losses. Porcine epidemic diarrhea virus ...

» Avascular necrosis of the hip secondary to long-standing COVID
23/04/24 20:00 from covid-19
Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence of symptoms beyond 12 weeks from...

» Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
23/04/24 20:00 from sars-cov-2
CONCLUSION: Neuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic.

» Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine
23/04/24 20:00 from coronavirus
CONCLUSIONS: Overall, we demonstrate differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance HD subjects comparable to healthy controls and identify transcriptomic and clinical predictors of an...

» COVID-19 Imposed Closure of Rural Co-Housing and Loneliness in Older Adults Living Alone: Longitudinal Evidence From South Korea
23/04/24 20:00 from covid-19
This study aimed to examine the impact of COVID-19 on loneliness among rural older women in senior cohousing in Korea. Using a natural experimental study design, we investigated how the pandemic-induced closure of cohousing affected the ...

» The "Loss Years" of Residency Education: Overcoming COVID-19 Learning Gaps among Trainees
23/04/24 20:00 from covid-19
No abstract

» SARS-CoV-2 RNA and nucleocapsid antigen are blood biomarkers associated with severe disease outcomes that improve in response to remdesivir
23/04/24 20:00 from covid-19
CONCLUSIONS: Reductions in SARS-CoV-2 RNA and antigen levels in blood correlated with clinical benefit from antiviral therapy.

» Antibody titers and the risk of infection during the SARS-CoV-2 Omicron phase in Bizen City, Japan
23/04/24 20:00 from covid-19
CONCLUSIONS: Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future vaccination.

» eXplainable Artificial Intelligence (XAI) for improving organisational regility
23/04/24 20:00 from covid-19
Since the pandemic started, organisations have been actively seeking ways to improve their organisational agility and resilience (regility) and turn to Artificial Intelligence (AI) to gain a deeper understanding and further enhance their...

» Magnetic Resonance Imaging of Cardiac Involvement in COVID-19
23/04/24 20:00 from covid-19
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated w...

» Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes
23/04/24 20:00 from covid-19
CONCLUSIONS: Our study is the first national examination of the impact of cardiac comorbidities on COVID outcomes. A higher number of cardiac comorbidities was associated with significantly higher rates of MV and in-hospital mortality, i...

» A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2
23/04/24 20:00 from sars-cov-2 spike protein
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus, is the causative agent responsible for the spread of the COVID19 pandemic across the globe. The global impact of the COVID19 pandemic, the successful ...

» Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine
23/04/24 20:00 from sars-cov-2 spike protein
CONCLUSIONS: Overall, we demonstrate differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance HD subjects comparable to healthy controls and identify transcriptomic and clinical predictors of an...

» Idiopathic intracranial hypertension associated with SARS-CoV-2 infection in an adult male patient: a case report and review of the literature
23/04/24 20:00 from coronavirus
CONCLUSION: Idiopathic intracranial hypertension (IIH) may occur in association with SARS-CoV-2 infection and should be considered when making a differential diagnosis for headache and blurring of vision. COVID-19 may play a role in the ...

» Acceptability of Tele-mental Health Services Among Users: A Systematic Review and Meta-analysis
23/04/24 20:00 from coronavirus
CONCLUSIONS: The study highlighted a high acceptability of tele-mental health services. These findings suggest a promising outlook for the integration and adoption of tele-mental health services and emphasize the importance of considerin...

» The characteristics of microbiome in the upper respiratory tract of COVID-19 patients
23/04/24 20:00 from coronavirus
CONCLUSION: COVID-19 positive patients demonstrate a notable increase in the abundance of Candida albicans, along with a decrease in the levels of aspartyl proteinases, indicating the alteration of microbiota composition of upper respira...

» Impact of COVID-19 on essential healthcare services at the primary healthcare level in Armenia: a qualitative study
23/04/24 20:00 from coronavirus
CONCLUSIONS: The COVID-19 pandemic has had a profound impact on the delivery and utilization of essential healthcare services at PHC facilities, especially for those with chronic conditions who needed continuous care. Unified national-le...

» Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection
23/04/24 20:00 from Covid-19 origins
The clinical presentation of COVID-19 shows high variability among individuals, which is partly due to genetic factors. The OAS1/2/3 cluster has been found to be strongly associated with COVID-19 severity. We examined this locus in the M...

» Assessment of using Google Trends for real-time monitoring of infectious disease outbreaks: a measles case study
23/04/24 20:00 from coronavirus
Measles remains a significant threat to children worldwide despite the availability of effective vaccines. The COVID-19 pandemic exacerbated the situation by leading to the postponement of supplementary measles immunization activities. A...

» Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection
23/04/24 20:00 from Sars-Cov-2 origins
The clinical presentation of COVID-19 shows high variability among individuals, which is partly due to genetic factors. The OAS1/2/3 cluster has been found to be strongly associated with COVID-19 severity. We examined this locus in the M...

» Post-COVID Trajectory of Pentraxin 3 Plasma Levels Over 6 Months and Their Association with the Risk of Developing Post-Acute Depression and Anxiety
23/04/24 20:00 from coronavirus
CONCLUSIONS: A lower reduction of plasma PTX3 after acute COVID-19 associates with the presence of depression and anxiety, suggesting an involvement of inflammation in post-COVID-19 psychopathology and a potential role of PTX3 as a bioma...

» Construction and validation of machine learning algorithm for predicting depression among home-quarantined individuals during the large-scale COVID-19 outbreak: based on Adaboost model
23/04/24 20:00 from covid-19
CONCLUSIONS: The Adaboost machine learning algorithm developed in this study can be used to construct a depression prediction model for home-quarantined individuals that has better machine learning performance, as well as high effectiven...

» Non-specific effects of the inactivated influenza vaccine. A test-negative study: The inactivated influenza vaccine and SARS-CoV-2 infections
23/04/24 20:00 from coronavirus
CONCLUSIONS: While earlier observational studies suggested a protective non-specific effect of IIV and SARS-CoV-2 infections, this smaller, but well controlled test-negative design study does not suggest an effect, either positive or neg...

» Modeling outbreaks of COVID-19 in China: The impact of vaccination and other control measures on curbing the epidemic
23/04/24 20:00 from coronavirus
This study aims to examine the development trend of COVID-19 in China and propose a model to assess the impacts of various prevention and control measures in combating the COVID-19 pandemic. Using COVID-19 cases reported by the National ...

» Data Resource Profile: Health Insurance Review and Assessment Service Covid-19 Observational Medical Outcomes Partnership (HIRA Covid-19 OMOP) database in South Korea
23/04/24 20:00 from coronavirus
No abstract

» Perspectives of family caregivers and nurses on hospital discharge transitional care for Muslim older adults living with COPD: a qualitative study
23/04/24 20:00 from covid-19
CONCLUSION: Family caregivers require more supportive care to meet the care needs of Muslim older adults living with COPD. Alternative nurse-based transitional care programs for these older adult caregivers should be developed.

» Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: This study successfully demonstrated that C. butyricum and C. sporogenes can produce the two recombinant antigen proteins (NY-ESO-1 and SARS-CoV-2-related Spike_S1 antigens) through genetic manipulations, utilizing the AUU s...

» COVID-19 clinical trial participation and awareness in Texas
23/04/24 20:00 from coronavirus
The COVID-19 pandemic required the rapid development of COVID-19 vaccines and treatments, necessitating quick yet representative clinical trial enrollment to evaluate these preventive measures. However, misinformation around the COVID-19...

» Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial
23/04/24 20:00 from covid-19
CONCLUSIONS: These data, representing the longest follow-up of BCMA-redirected CAR T-cell therapy to date, demonstrate long-term remission and survival with LCAR-B38M for advanced myeloma.

» Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
23/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) in...

» Coordination of COVID-19 platform trials in Europe
23/04/24 20:00 from covid-19
To ensure optimal coordination of the EU-funded COVID-19 platform trials, a double coordination mechanism was established. It included the Trial Coordination Board (TCB) to promote the dialogue between investigators and relevant public h...

» Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
23/04/24 20:00 from covid-19
CONCLUSIONS: This study successfully demonstrated that C. butyricum and C. sporogenes can produce the two recombinant antigen proteins (NY-ESO-1 and SARS-CoV-2-related Spike_S1 antigens) through genetic manipulations, utilizing the AUU s...

» Risk stratification and prognosis prediction using cardiac biomarkers in COVID-19: a single-centre retrospective cohort study
23/04/24 20:00 from coronavirus
CONCLUSIONS: Elevation of cardiac biomarkers was associated with poor prognosis of COVID-19 patients.

» Achalasia Following SARS-CoV-2 Infection: A Case Report and Review of Literature
23/04/24 20:00 from sars-cov-2 spike protein
RATIONALE: The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to health complications beyond respiratory symptoms, revealing multi-organ involvement, including potential gastrointestinal implications.

» Outcome of pregnant women admitted to critical care unit with confirmed severe COVID-19: A center experience
23/04/24 20:00 from coronavirus
CONCLUSION: The results of this study highlight the characteristics of pregnant women admitted to the ICU at a specialized tertiary healthcare center in Saudi Arabia. The APACHI IV scores accurately predicted patient's mortality, duratio...

» Trauma-Informed Healthcare Leadership? Evidence and opportunities from interviews with leaders during COVID-19
23/04/24 20:00 from covid-19
CONCLUSIONS: We propose the Trauma-Informed Healthcare Leadership framework as a useful schema for action and analysis. This approach yields recommendations for healthcare leaders including creating designated spaces for emotional proces...

» INSaFLU-TELEVIR: an open web-based bioinformatics suite for viral metagenomic detection and routine genomic surveillance
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: The accessibility, versatility, and functionality of INSaFLU-TELEVIR are expected to supply public and animal health laboratories and researchers with a user-oriented and pan-viral bioinformatics framework that promotes a st...

» INSaFLU-TELEVIR: an open web-based bioinformatics suite for viral metagenomic detection and routine genomic surveillance
23/04/24 20:00 from covid-19
CONCLUSIONS: The accessibility, versatility, and functionality of INSaFLU-TELEVIR are expected to supply public and animal health laboratories and researchers with a user-oriented and pan-viral bioinformatics framework that promotes a st...

» Effectiveness and safety of rivaroxaban for anticoagulation therapy in COVID-19: A meta-analysis of randomized controlled trials
23/04/24 20:00 from coronavirus
CONCLUSION: Rivaroxaban may reduce thrombotic events in COVID-19 patients, but it does not appear to have an advantage over heparin or LMWH, and it may increase the risk of bleeding.INPLASY Reg. No.: INPLASY 202370097.

» Idiopathic intracranial hypertension associated with SARS-CoV-2 infection in an adult male patient: a case report and review of the literature
23/04/24 20:00 from covid-19
CONCLUSION: Idiopathic intracranial hypertension (IIH) may occur in association with SARS-CoV-2 infection and should be considered when making a differential diagnosis for headache and blurring of vision. COVID-19 may play a role in the ...

» Idiopathic intracranial hypertension associated with SARS-CoV-2 infection in an adult male patient: a case report and review of the literature
23/04/24 20:00 from sars-cov-2
CONCLUSION: Idiopathic intracranial hypertension (IIH) may occur in association with SARS-CoV-2 infection and should be considered when making a differential diagnosis for headache and blurring of vision. COVID-19 may play a role in the ...

» Adults With IDD in Supported Accommodation During COVID-19 Lockdown: The Families' Perspective
23/04/24 20:00 from coronavirus
The present study aims to understand and describe family caregivers' perceptions and experiences regarding contact and relationships with their adult relatives with intellectual and developmental disabilities (IDD) living in supported ac...

» Transcending technology boundaries and maintaining sense of community in virtual mental health peer support: a qualitative study with service providers and users
23/04/24 20:00 from covid-19
CONCLUSIONS: The study contributes to the ongoing efforts to enhance community mental health services and support in the virtual realm. It shows the importance of virtual peer support in situations where in-person support is not accessib...

» Follow-up SARS-CoV-2 serological study of a health care worker cohort following COVID-19 booster vaccination
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: Our findings demonstrate the importance of ongoing COVID-19 booster vaccination strategies in the context of variants such as Omicron and despite hybrid immunity from previous SARS-CoV-2 infections, particularly for at-risk ...

» COMMON LABORATORY ORGANIC SOLVENTS ARE BETTER MEDIUM FOR MOLECULAR DETECTION OF RNA VIRUSES USING PCR
23/04/24 20:00 from coronavirus
CONCLUSION: Methanol was found to be the most promising solvent for increasing the stability of viral RNA thereby enhancing the molecular diagnosis of the concerned pathogen.

» Perceptions on violence against women and its impacts on mental health and response mechanisms among community-based stakeholders: a qualitative study from Nepal
23/04/24 20:00 from covid-19
CONCLUSIONS: Participants reported that verbal and physical violence is often perceived as a normal part of women's lives. Women should be made aware of available support services and empowered and supported to increase access and uptake...

» The characteristics of microbiome in the upper respiratory tract of COVID-19 patients
23/04/24 20:00 from sars-cov-2
CONCLUSION: COVID-19 positive patients demonstrate a notable increase in the abundance of Candida albicans, along with a decrease in the levels of aspartyl proteinases, indicating the alteration of microbiota composition of upper respira...

» Medical specialists' use and opinion of video consultation in Denmark: a survey study
23/04/24 20:00 from covid-19
CONCLUSION: The political aspiration to digitization in healthcare systems should be rooted in professionals' and patients' perceptions and experiences with video consultation which emphasize that it is not a standard tool for all consul...

» Impact of COVID-19 on essential healthcare services at the primary healthcare level in Armenia: a qualitative study
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: The COVID-19 pandemic has had a profound impact on the delivery and utilization of essential healthcare services at PHC facilities, especially for those with chronic conditions who needed continuous care. Unified national-le...

» WHO redefines airborne transmission: what does that mean for future pandemics?
23/04/24 20:00 from sars-cov-2
No abstract

» Resilience and psychological factors among dentistry students who received face-to-face lectures during the COVID-19 pandemic
23/04/24 20:00 from covid-19
CONCLUSIONS: The levels were low compared to other studies in which online teaching was used, which is explained by the fact that the students retained adequate resilience and self-esteem thanks to being able to contact teachers and, abo...

» Assessment of using Google Trends for real-time monitoring of infectious disease outbreaks: a measles case study
23/04/24 20:00 from sars-cov-2
Measles remains a significant threat to children worldwide despite the availability of effective vaccines. The COVID-19 pandemic exacerbated the situation by leading to the postponement of supplementary measles immunization activities. A...

» Association of socioeconomic disadvantage and ethnicity with perinatal neonatal, and infant mortality in Slovakia
23/04/24 20:00 from covid-19
CONCLUSIONS: Life in segregated Roma settlements is connected with the accumulation of socioeconomic disadvantage. Persistent inequities between Roma and the majority population in Slovakia exposed by mortality rates in children point to...

» Long-term monitoring of SARS-CoV-2 seroprevalence and variants in Ethiopia provides prediction for immunity and cross-immunity
23/04/24 20:00 from sars-cov-2
Under-reporting of COVID-19 and the limited information about circulating SARS-CoV-2 variants remain major challenges for many African countries. We analyzed SARS-CoV-2 infection dynamics in Addis Ababa and Jimma, Ethiopia, focusing on r...

» Post-COVID Trajectory of Pentraxin 3 Plasma Levels Over 6 Months and Their Association with the Risk of Developing Post-Acute Depression and Anxiety
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: A lower reduction of plasma PTX3 after acute COVID-19 associates with the presence of depression and anxiety, suggesting an involvement of inflammation in post-COVID-19 psychopathology and a potential role of PTX3 as a bioma...

» Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exertional Malaise: A Best Practice Proposal
23/04/24 20:00 from sars-cov-2
People with long COVID may suffer from a wide range of ongoing symptoms including fatigue, exertional dyspnea, reduced exercise performance, and others. In particular, impaired exercise performance is a condition that can be recovered in...

» Acceptability of Tele-mental Health Services Among Users: A Systematic Review and Meta-analysis
23/04/24 20:00 from covid-19
CONCLUSIONS: The study highlighted a high acceptability of tele-mental health services. These findings suggest a promising outlook for the integration and adoption of tele-mental health services and emphasize the importance of considerin...

» Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection
23/04/24 20:00 from sars-cov-2
The clinical presentation of COVID-19 shows high variability among individuals, which is partly due to genetic factors. The OAS1/2/3 cluster has been found to be strongly associated with COVID-19 severity. We examined this locus in the M...

» COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
23/04/24 20:00 from sars-cov-2
CONCLUSION: This study contributes valuable insights into the prevalence, characteristics, and outcomes of CAPA in the era of Delta and Omicron variants. We report a lower prevalence of CAPA (5.1%) among critically-ill COVID-19 patients ...

» Follow-up SARS-CoV-2 serological study of a health care worker cohort following COVID-19 booster vaccination
23/04/24 20:00 from covid-19
CONCLUSIONS: Our findings demonstrate the importance of ongoing COVID-19 booster vaccination strategies in the context of variants such as Omicron and despite hybrid immunity from previous SARS-CoV-2 infections, particularly for at-risk ...

» Non-specific effects of the inactivated influenza vaccine. A test-negative study: The inactivated influenza vaccine and SARS-CoV-2 infections
23/04/24 20:00 from sars-cov-2
CONCLUSIONS: While earlier observational studies suggested a protective non-specific effect of IIV and SARS-CoV-2 infections, this smaller, but well controlled test-negative design study does not suggest an effect, either positive or neg...

» Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes
23/04/24 20:00 from sars-cov-2
CONCLUSION: This study is the largest case series of CFZ-TMA since its approval in 2012. Patients present with severe AKI and experience frequent sequelae. Complement variants and blockade therapy do not seem to play a role in the pathop...

» Unfolding of maternal-infant bonding amidst the COVID-19 pandemic: Social support as a risk and protective factor
22/04/24 20:00 from covid-19
BACKGROUND: Social, familial, and physiological stressors may put maternal-infant bonding at risk. Therefore, it is plausible that the stressful conditions brought on by COVID-19 could influence maternal-infant bonding. This study aimed ...

» Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
22/04/24 20:00 from coronavirus
CONCLUSIONS: The ELF concentrations of IL-6, IL-8, IL-17A, IL-25, and IL-31 were significantly increased in COVID-19 patients. Although high levels of MIP-1 and MIP-1β were also detected in the blood samples collected simultaneously with...

» Severity of COVID-19 infection in patients with COVID-19 combined with diabetes
22/04/24 20:00 from covid-19
CONCLUSION: Blood glucose control is significantly correlated with the CTSS; the higher the blood glucose is, the more severe the lung manifestation. The CTSS can also be used to evaluate and predict the clinical severity of COVID-19.

» FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection
22/04/24 20:00 from sars-cov-2
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current s...

» A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients
22/04/24 20:00 from covid-19
CONCLUSION: The findings suggest that magnesium supplementation may have beneficial effects on clinical outcomes and arterial oxygen saturation in COVID-19 patients. More investigation is necessary to delve into its potential mechanisms ...

» Toxoplasma gondii suppresses proliferation and migration of breast cancer cells by regulating their transcriptome
22/04/24 20:00 from coronavirus
CONCLUSIONS: T. gondii transcriptionally regulates several signaling pathways by altering the hub genes such as BRCA1, MYC and IL-6, which can inhibit the breast tumor growth and migration, hinting at a potential therapeutic strategy.

» Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
22/04/24 20:00 from covid-19
CONCLUSIONS: The ELF concentrations of IL-6, IL-8, IL-17A, IL-25, and IL-31 were significantly increased in COVID-19 patients. Although high levels of MIP-1 and MIP-1β were also detected in the blood samples collected simultaneously with...

» Toxoplasma gondii suppresses proliferation and migration of breast cancer cells by regulating their transcriptome
22/04/24 20:00 from covid-19
CONCLUSIONS: T. gondii transcriptionally regulates several signaling pathways by altering the hub genes such as BRCA1, MYC and IL-6, which can inhibit the breast tumor growth and migration, hinting at a potential therapeutic strategy.

» Understanding the factors associated with COVID-19 vaccine hesitancy in Venezuela
22/04/24 20:00 from coronavirus
CONCLUSION: Factors such as age, education level, occupation, monthly income, and location were found to be associated with knowledge and attitudes towards COVID-19 vaccine among the surveyed Venezuelans.

» Association between body mass index and mental health among nurses: a cross-sectional study in China
22/04/24 20:00 from covid-19
CONCLUSION: This study found a positive association between BMI and poor mental health among nurses during the COVID-19 pandemic, particularly in those who were overweight or obesity. The findings could assist in developing interventions...

» Exogenous Insulin Antibody Syndrome (EIAS) Presenting in an Elderly, Long-Term Patient with Type 1 Diabetes Mellitus that Resolved with Low-Cost Outpatient Therapy with Mycophenolate Mofetil and Regular Insulin by Pump
22/04/24 20:00 from coronavirus
Exogenous insulin antibody syndrome (EIAS) has until recently been a rarely described complication of exogenous insulin therapy. EIAS results not only in hyperglycemia, but also in hypoglycemia and occasionally in ketoacidosis (DKA). The...

» When one door closes: a qualitative exploration of women's experiences of access to sexual and reproductive health services during the COVID-19 lockdown in Nigeria
22/04/24 20:00 from covid-19
CONCLUSION: COVID-19 negatively impacted access to SRH services and forced women to utilise mostly informal service outlets and home remedies as alternatives to conventional health services. There is a need to ensure the continuity of es...

» Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus
22/04/24 20:00 from coronavirus
Coronaviruses have been identified as pathogens of gastrointestinal and respiratory diseases in humans and various animal species. In recent years, the global spread of new coronaviruses has had profound influences for global public heal...

» Exploring COVID-19 Phobia among International Chinese College Students in South Korea Before Ending COVID-19 Restrictions
22/04/24 20:00 from covid-19
CONCLUSIONS: More authority and proactive communication strategies, such as consultations or education programs, are needed for international students to alleviate their phobias and psychological stress.

» Impact of COVID-19 Nonpharmaceutical Interventions on Respiratory Syncytial Virus Infections in Hospitalized Children
22/04/24 20:00 from sars-cov-2
CONCLUSIONS: The implementation of multilayered NPIs targeted at COVID-19 has affected the activity of RSV. Ongoing monitoring of RSV is warranted as the changing RSV epidemiology can provide valuable insights for future healthcare syste...

» Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: a bioinformatics and early validation study
22/04/24 20:00 from coronavirus
Coronavirus disease (COVID-19) and pulmonary hypertension (PH) are closely correlated. However, the mechanism is still poorly understood. In this article, we analyzed the molecular action network driving the emergence of this event. Two ...

» Understanding the factors associated with COVID-19 vaccine hesitancy in Venezuela
22/04/24 20:00 from covid-19
CONCLUSION: Factors such as age, education level, occupation, monthly income, and location were found to be associated with knowledge and attitudes towards COVID-19 vaccine among the surveyed Venezuelans.

» Does the SARS-CoV-2 mRNA vaccine and its serum IgG levels affect fertility treatments and obstetric outcomes? An observational cohort study
22/04/24 20:00 from sars-cov-2
CONCLUSION: We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.

» The lived experiences of operating room nurses from the surgery on COVID-19 patients: a phenomenological study
22/04/24 20:00 from covid-19
CONCLUSION: The results of this study show that operating room nurses experienced conflicting feelings during surgery on patients with COVID-19. So the feeling of being a hero was a heartwarming experience, but the aggravation of job bur...

» Impact of the 2nd, 3rd and 4th waves of the COVID-19 pandemic on wait times in head and neck cancer: A retrospective study in a French expert center
22/04/24 20:00 from coronavirus
CONCLUSION: Intervals between first consultation and tumor board meeting and between tumor board meeting and treatment did not increase during the 2nd, 3rd and 4th waves of COVID-19 in our center.

» External quality assessments for SARS-CoV-2 genome detection in Austria : A comparison of the first postpandemic round with results from the pandemic era
22/04/24 20:00 from sars-cov-2
CONCLUSION: Overall ratios of true positive results were below the mean of all results during the pandemic but were similar to the first round of the pandemic. A lower post-pandemic true positive ratio was associated with specific labora...

» The anxiety response of patients with severe psychiatric disorders to the recent public health crisis
22/04/24 20:00 from covid-19
CONCLUSION: Anxiety response to health crisis is different in groups with SPDs and control group. The findings of this study suggest that although health anxiety is present in many of these patients during the pandemic, their anxiety res...

» CovEpiAb: a comprehensive database and analysis resource for immune epitopes and antibodies of human coronaviruses
22/04/24 20:00 from coronavirus
Coronaviruses have threatened humans repeatedly, especially COVID-19 caused by SARS-CoV-2, which has posed a substantial threat to global public health. SARS-CoV-2 continuously evolves through random mutation, resulting in a significant ...

» A systematic review and meta-analysis on the effectiveness of bivalent mRNA booster vaccines against Omicron variants
22/04/24 20:00 from sars-cov-2
CONCLUSIONS: The bivalent boosters demonstrated superior protection against severe outcomes than the original monovalent boosters across age groups, highlighting the critical need for improving vaccine coverage, especially among the vuln...

» Personalised exercise rehabilitation in cancer survivorship: the percs triage and referral system study protocol
22/04/24 20:00 from covid-19
BACKGROUND: To effectively embed exercise rehabilitation in cancer survivorship care, a co-ordinated system of acute and community exercise rehabilitation services, forming a stepped model of care, is recommended. Patients can be directe...

» Prevalence and factors associated with depression in healthcare personnel during the SARS-CoV-2 pandemic in the Department of Piura, Peru
22/04/24 20:00 from sars-cov-2
CONCLUSIONS: Approximately 1 in 10 healthcare professionals and technicians developed depression during the COVID-19 pandemic in this study. In addition, having relatives or friends who had died from COVID-19 was negatively associated wi...

» Enhancing pooling levels strengthens the risk resilience of healthcare insurance: a case study of basic medical insurance fund operations data in Gansu, China
22/04/24 20:00 from covid-19
CONCLUSION: From 2020 to 2022, the overall operational performance of basic health insurance in Gansu Province was satisfactory, and enhancing the pooling level is beneficial in addressing the impact of unforeseen events on the health in...

» COVID-19 Australia: Epidemiology Report 85: Reporting period ending 10 March 2024
22/04/24 20:00 from coronavirus
This is the eighty-fifth and final epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 23:59 Australian Eastern Daylight Time [AEST] 10 March 2024. It includes data on COVID-19 cases diagnosed in A...

» The process of hip fracture management before and during the COVID-19 pandemic in Iran
22/04/24 20:00 from covid-19
CONCLUSION: The study suggests that the COVID-19 pandemic did not have a negative impact on hip fracture management in the investigated orthopedic hospital in Iran. further research is needed to explore the effects of the pandemic on oth...

» Impact of the 2nd, 3rd and 4th waves of the COVID-19 pandemic on wait times in head and neck cancer: A retrospective study in a French expert center
22/04/24 20:00 from sars-cov-2
CONCLUSION: Intervals between first consultation and tumor board meeting and between tumor board meeting and treatment did not increase during the 2nd, 3rd and 4th waves of COVID-19 in our center.

» COVID-19 Australia: Epidemiology Report 84: Reporting period ending 11 February 2024
22/04/24 20:00 from coronavirus
This is the eighty-fourth epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 23:59 Australian Eastern Daylight Time [AEST] 11 February 2024. It includes data on COVID-19 cases diagnosed in Australia.

» Author Correction: Exploring the relationship across autonomous motivation, affects, and anxiety among gym practitioners during the second COVID-19 lockdown
22/04/24 20:00 from covid-19
No abstract

» Estimating the incidence of COVID-19, influenza and respiratory syncytial virus infection in three regions of Queensland, Australia, winter 2022: findings from a novel longitudinal testing-based sentinel surveillance programme
22/04/24 20:00 from sars-cov-2
CONCLUSION: This testing-based surveillance programme could estimate disease trends and be a useful tool in settings where testing is less common or accessible. Difficulties with recruitment meant the study was underpowered. The frontlin...

» Detection and differentiation of seven porcine respiratory pathogens using a multiplex ligation-dependent probe amplification assay
22/04/24 20:00 from coronavirus
Respiratory diseases due to viral or bacterial agents, either alone or in combination, cause substantial economic burdens to the swine industry worldwide. Rapid and reliable detection of causal pathogens is crucial for effective epidemio...

» Outer membrane vesicles derived from Bordetella pertussis are potent adjuvant that drive Th1-biased response
22/04/24 20:00 from sars-cov-2 spike protein
For several years, we have been committed to exploring the potential of Bordetella pertussis-derived outer membrane vesicles (OMV(Bp)) as a promising third-generation vaccine against the reemerging pertussis disease. The results of our p...

» Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
22/04/24 20:00 from coronavirus
Approximately 3% of pregnant women have sickle cell disease (SCD). COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a global pandemic in March 2020, resulting in more than 3,500 deaths in Jamaica b...

» CovEpiAb: a comprehensive database and analysis resource for immune epitopes and antibodies of human coronaviruses
22/04/24 20:00 from sars-cov-2
Coronaviruses have threatened humans repeatedly, especially COVID-19 caused by SARS-CoV-2, which has posed a substantial threat to global public health. SARS-CoV-2 continuously evolves through random mutation, resulting in a significant ...

» ISGylation by HERCs facilitates STING activation
22/04/24 20:00 from coronavirus
Optimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function ...

» COVID-19 Australia: Epidemiology Report 85: Reporting period ending 10 March 2024
22/04/24 20:00 from sars-cov-2
This is the eighty-fifth and final epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 23:59 Australian Eastern Daylight Time [AEST] 10 March 2024. It includes data on COVID-19 cases diagnosed in A...

» The Role of Social Media in the Experiences of COVID-19 Among Long-Hauler Women: Qualitative Study
22/04/24 20:00 from coronavirus
CONCLUSIONS: The public health implications of these findings support the development of gender-tailored health promotion interventions that leverage the benefits of social media, while mitigating the negative impacts, for women with lon...

» COVID-19 Australia: Epidemiology Report 84: Reporting period ending 11 February 2024
22/04/24 20:00 from sars-cov-2
This is the eighty-fourth epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 23:59 Australian Eastern Daylight Time [AEST] 11 February 2024. It includes data on COVID-19 cases diagnosed in Australia.

» ORF3a of SARS-CoV-2 modulates PI3K/AKT signaling in human lung epithelial cells via hsa-miR-155-5p
22/04/24 20:00 from sars-cov-2
SARS-CoV-2 infection results in cytokine burst, leading to proinflammatory responses in lungs of COVID-19 patients. SARS-CoV-2 ORF3a triggers the generation of proinflammatory cytokines. However, the underlying mechanism of dysregulation...

» Long-Term Taste and Smell Outcomes After COVID-19
22/04/24 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this study, taste dysfunction as measured objectively was absent 1 year after exposure to COVID-19 while some smell loss remained in nearly one-third of individuals with this exposure, likely explaining tast...

» Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
22/04/24 20:00 from sars-cov-2
SARS-CoV-2 and other sarbecoviruses continue to threaten humanity, highlighting the need to characterize common mechanisms of viral immune evasion for pandemic preparedness. Cytotoxic lymphocytes are vital for antiviral immunity and expr...

» Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
22/04/24 20:00 from sars-cov-2
Approximately 3% of pregnant women have sickle cell disease (SCD). COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a global pandemic in March 2020, resulting in more than 3,500 deaths in Jamaica b...

» Neutralization sensitivity of SARS-CoV-2 Omicron variants FL.1 and GE.1 by therapeutic antibodies and XBB sera
22/04/24 20:00 from sars-cov-2
Two SARS-CoV-2 XBB sub-variants, FL.1 and GE.1, have been increasing in prevalence worldwide, but limited information is available about their ability to evade the immune system. FL.1 and GE.1 are emerging Omicron XBB variants possessing...

» The TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection
22/04/24 20:00 from Cell entry mechanisms of SARS-CoV-2
Angiotensin converting enzyme 2 (ACE2), the host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is differentially expressed in a wide variety of tissues and cell types. The expression of ACE2 is unde...

» Detection and differentiation of seven porcine respiratory pathogens using a multiplex ligation-dependent probe amplification assay
22/04/24 20:00 from covid-19 and viral infections in pigs
Respiratory diseases due to viral or bacterial agents, either alone or in combination, cause substantial economic burdens to the swine industry worldwide. Rapid and reliable detection of causal pathogens is crucial for effective epidemio...

» Current Progress, Challenges and Prospects in the Development of COVID-19 Vaccines
22/04/24 20:00 from covid-19 and viral infections in pigs
The COVID-19 pandemic has resulted in over 772 million confirmed cases, including nearly 7 million deaths, according to the World Health Organization (WHO). Leveraging rapid development, accelerated vaccine approval processes, and large-...

» External quality assessments for SARS-CoV-2 genome detection in Austria : A comparison of the first postpandemic round with results from the pandemic era
22/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Overall ratios of true positive results were below the mean of all results during the pandemic but were similar to the first round of the pandemic. A lower post-pandemic true positive ratio was associated with specific labora...

» Serum and Salivary IgG and IgA Response After COVID-19 Messenger RNA Vaccination
22/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that mRNA vaccination was associated with mucosal immunity in individuals without prior SARS-CoV-2 infection, but at much lower levels than in previously infected indiv...

» Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID-19: A systematic review and meta-analysis
22/04/24 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: The current findings indicate that sotrovimab may be more effective than molnupiravir in reducing the mortality rate in COVID-19 patients. However, no statistical difference was observed between the two treatments for other e...

» Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
22/04/24 20:00 from covid-19
CONCLUSIONS: The ELF concentrations of IL-6, IL-8, IL-17A, IL-25, and IL-31 were significantly increased in COVID-19 patients. Although high levels of MIP-1 and MIP-1β were also detected in the blood samples collected simultaneously with...