» Adverse Events After COVID-19 Vaccination Between Pregnant and Nonpregnant Women
26/06/25 20:00 from covid-19
No abstract

» Successful salvage therapy of ruxolitinib on interstitial pneumonia after long COVID or post-COVID-19 syndrome with follicular lymphoma: two case reports and literature review
26/06/25 20:00 from covid-19
CONCLUSIONS: Ruxolitinib might be a safe and effective alternative salvage therapy for patients with COVID-19 having interstitial inflammation and persistent hypoxemia without high cytokine levels and no response to corticosteroids.

» Responsive population-based cohorts as platforms for characterising pathogen- and population-level infection dynamics for epidemic prevention, preparedness and response
26/06/25 20:00 from covid-19
Establishing population-based cohorts is indispensable for effective epidemic prevention, preparedness and response. Existing passive surveillance systems face limitations in their capacity to promptly provide representative data for est...

» Hospitalisation trends of respiratory syncytial virus (RSV) infection in adults, six European countries, before and during COVID-19, 2016 to 2023
26/06/25 20:00 from covid-19
BACKGROUNDRespiratory syncytial virus (RSV) is a major cause of morbidity in older adults.AIMWe aimed to investigate the epidemiology of RSV in adults in five European countries and one region before and during the COVID-19 era.METHODSWe...

» Real-time monitoring of excess mortality under a new endemic regime
26/06/25 20:00 from covid-19
BACKGROUNDMonitoring of mortality to identify trends and detect deviations from normal levels is an essential part of routine surveillance. In many European countries, disruptions in mortality patterns from the COVID-19 pandemic have req...

» Vaccination behaviour of immigrants and native Icelanders during COVID-19
26/06/25 20:00 from covid-19
CONCLUSION: Greater emphasis should be placed on strengthening trust in vaccination authorities, such as the Directorate of Health and the Chief Epidemiologist. Additionally, economic status and social participation of specific groups sh...

» Cracks in the JD-R model? The failure of strengths use, job crafting, and home-work spillover to support wellbeing during COVID-19
26/06/25 20:00 from covid-19
Drawing from the Job Demands-Resources (JD-R) model, this study examined the relationship between job characteristics, work-home interference, motivation, and psychological wellbeing during the COVID-19 lockdown. Specifically, it explore...

» Unexpected voriconazole toxicity due to nirmatrelvir/ritonavir: a case report on drug-drug interaction and the role of therapeutic drug monitoring
26/06/25 20:00 from covid-19
Voriconazole is a triazole antifungal used for invasive fungal infections, particularly invasive aspergillosis. Its metabolism is primarily mediated by CYP2C19, with CYP3A4 and CYP2C9 also involved. Nirmatrelvir/ritonavir, an oral antivi...

» Management of critically Ill COVID-19 patients: Exploring the potential of morphine and assessing disadvantages of acetaminophen
26/06/25 20:00 from covid-19
No abstract

» Mucormycosis in patients infected with the delta strain of COVID-19 virus, effective of some factors in the prevalence and patient prognosis in Shahid Beheshti Hospital, Kashan, central Iran
26/06/25 20:00 from covid-19
CONCLUSION: Uncontrolled diabetes and hypertension are the two most common risk factors of mucormycosis in COVID patients. High use of glucocorticoid drugs and immune suppression are predisposing causes for opportunistic organisms. Accur...

» Effects of colchicine, interferon beta, IVIG, tocilizumab and corticosteroids on COVID-19 patient survival from all presently available published clinical trials: A narrative review
26/06/25 20:00 from covid-19
One of the deadliest diseases in the world, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing global pandemic known as COVID-19. COVID-19 symptoms range from undetectable to deadly, hyper-inflammato...

» One Health serosurveillance of anti-SARS-CoV-2 antibodies in domestic animals from the metropolitan area of Panama
26/06/25 20:00 from covid-19
CONCLUSION: This study presents the first serological evidence of SARS-CoV-2 exposure in domestic pets in Panama. While low in prevalence, the findings underscore the relevance of community-based animal surveillance and reveal possible s...

» Lost time undermines return behavior
26/06/25 20:00 from covid-19
People commonly experience long gaps of time between getting to do things they love to do. In principle, the longer it has been since people last enjoyed something, the quicker they should jump at the chance to enjoy it again. In practic...

» Prison connectivity and disease transmission to neighboring communities: The role of prison staff
26/06/25 20:00 from covid-19
Using smartphone location data and a novel application of publicly available employment data, we map how California communities are connected to nearby prisons through the movement of prison staff, and we measure the role these connectio...

» Relationship Between Socioeconomic Status and Job Accommodation for Workers with Health Problems in Japan during the COVID-19 Pandemic
26/06/25 20:00 from covid-19
CONCLUSIONS: We found a relationship between SES and the lack of job accommodation for workers with health problems. The lack of job accommodation may further worsen SES and health conditions, reinforcing the importance of accommodating ...

» Ethnic Comparisons of Spike-Specific CD4+ T Cells, Serological Responses, and Neutralizing Antibody Titers Against SARS-CoV-2 Variants
26/06/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Despite a small sample size and potential confounding by natural infections within our long-time-span sampling, our data suggest persistent cellular and humoral immunity 2 years after vaccination across ethnicities, with nota...

» SARS-CoV-2 Variant-Specific Antibodies in Vaccinated Inflammatory Bowel Disease Patients
26/06/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Background/Objectives: Patients suffering from inflammatory bowel diseases (IBDs) undergoing treatment with anti-TNF antibodies mount a diminished humoral immune response to vaccination against SARS-CoV-2 compared to healthy controls. Th...

» Surveillance of Respiratory Pathogens Among Rapid Diagnostic Test-Negative Acute Respiratory Infection Patients in Myanmar in 2023, with a Focus on Rhinovirus and Enterovirus Genotyping
26/06/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
This study explored the distribution and genetic characteristics of respiratory pathogens in outpatients with acute respiratory infections (ARIs) in Yangon, Myanmar, during the 2023 rainy season. Among 267 patients who tested negative fo...

» Successful salvage therapy of ruxolitinib on interstitial pneumonia after long COVID or post-COVID-19 syndrome with follicular lymphoma: two case reports and literature review
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Ruxolitinib might be a safe and effective alternative salvage therapy for patients with COVID-19 having interstitial inflammation and persistent hypoxemia without high cytokine levels and no response to corticosteroids.

» Responsive population-based cohorts as platforms for characterising pathogen- and population-level infection dynamics for epidemic prevention, preparedness and response
26/06/25 20:00 from sars-cov-2
Establishing population-based cohorts is indispensable for effective epidemic prevention, preparedness and response. Existing passive surveillance systems face limitations in their capacity to promptly provide representative data for est...

» Hospitalisation trends of respiratory syncytial virus (RSV) infection in adults, six European countries, before and during COVID-19, 2016 to 2023
26/06/25 20:00 from sars-cov-2
BACKGROUNDRespiratory syncytial virus (RSV) is a major cause of morbidity in older adults.AIMWe aimed to investigate the epidemiology of RSV in adults in five European countries and one region before and during the COVID-19 era.METHODSWe...

» Real-time monitoring of excess mortality under a new endemic regime
26/06/25 20:00 from sars-cov-2
BACKGROUNDMonitoring of mortality to identify trends and detect deviations from normal levels is an essential part of routine surveillance. In many European countries, disruptions in mortality patterns from the COVID-19 pandemic have req...

» Vaccination behaviour of immigrants and native Icelanders during COVID-19
26/06/25 20:00 from sars-cov-2
CONCLUSION: Greater emphasis should be placed on strengthening trust in vaccination authorities, such as the Directorate of Health and the Chief Epidemiologist. Additionally, economic status and social participation of specific groups sh...

» Unexpected voriconazole toxicity due to nirmatrelvir/ritonavir: a case report on drug-drug interaction and the role of therapeutic drug monitoring
26/06/25 20:00 from sars-cov-2
Voriconazole is a triazole antifungal used for invasive fungal infections, particularly invasive aspergillosis. Its metabolism is primarily mediated by CYP2C19, with CYP3A4 and CYP2C9 also involved. Nirmatrelvir/ritonavir, an oral antivi...

» Effects of colchicine, interferon β, IVIG, tocilizumab and corticosteroids on COVID-19 patient survival from all presently available published clinical trials: A narrative review
26/06/25 20:00 from sars-cov-2
One of the deadliest diseases in the world, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing global pandemic known as COVID-19. COVID-19 symptoms range from undetectable to deadly, hyper-inflammato...

» One Health serosurveillance of anti-SARS-CoV-2 antibodies in domestic animals from the metropolitan area of Panama
26/06/25 20:00 from sars-cov-2
CONCLUSION: This study presents the first serological evidence of SARS-CoV-2 exposure in domestic pets in Panama. While low in prevalence, the findings underscore the relevance of community-based animal surveillance and reveal possible s...

» Alpha to JN.1 variants: SARS-CoV-2 genomic analysis unfolding its various lineages/sublineages evolved in Chhattisgarh, India from 2020 to 2024
26/06/25 20:00 from sars-cov-2
CONCLUSION: SARS-CoV-2 from 2020 to 2024 has evolved into 17 lineages/sublineages in Chhattisgarh. The presently circulating JN.1 harbored 40 mutations, especially E554K, A570V, P621S, and P1143 L, capacitating the virus with features of...

» COVID-19 management in patients with comorbid conditions
26/06/25 20:00 from sars-cov-2
The novel coronavirus disease 2019 (COVID-19) causes serious respiratory illness and related disorders. Vulnerable populations, including those with chronic obstructive pulmonary disease, heart disease, diabetes, chronic kidney disease, ...

» Genomic and demographic characterization of SARS-CoV-2 infections within early Omicron cluster, Western Sri Lanka
26/06/25 20:00 from sars-cov-2
CONCLUSION: This study found BA.2 to be the predominant Omicron sub-lineage in the western part of Sri Lanka during the first quarter of 2022, aligning with global trends. Phylogenetic analysis revealed diverse introductions and local tr...

» Risk of COVID-19 infection among frontline healthcare workers during the COVID-19 pandemic
26/06/25 20:00 from sars-cov-2
CONCLUSION: Before vaccination, HCWs in HR areas had a higher risk of infection. Seroprevalence studies suggest that sub-clinical infection was not uncommon.

» Incorporating medical students into an interdisciplinary, population-based study of SARS-CoV-2 infection in asymptomatic individuals in South Texas
26/06/25 20:00 from sars-cov-2
BACKGROUND: Asymptomatic and pre-symptomatic infections may play a significant role in the spread of COVID-19 but determining prevalence of these infections in the general population is labor intensive.

» Epidemiological trends of influenza A and B in one hospital in Chengdu and national surveillance data (2019-2024)
26/06/25 20:00 from sars-cov-2
CONCLUSION: Hospital-based and national influenza surveillance data showed heterogeneity in subtype proportions, seasonal trends, and pandemic-related impacts. These findings underscore the importance of integrating multiple surveillance...

» Post COVID-19 Pulmonary Pseudotumor That Regressed Without Surgery
26/06/25 20:00 from sars-cov-2
A cavitary lung mass discovered after SARS-CoV-2 infection can represent a benign inflammatory pseudotumor that will regress with watchful follow-up, thereby sparing the patient an unnecessary surgical resection.

» Potential therapeutic effects of zinc and copper chlorophyllins in viral respiratory infections: recent developments and future directions
26/06/25 20:00 from Cell entry mechanisms of SARS-CoV-2
Zinc and copper are essential trace elements that regulate immunity and inflammation, with antiviral effects that may help combat respiratory viruses like SARS-CoV-2, the virus responsible for COVID-19. These effects include reducing cyt...

» Prison connectivity and disease transmission to neighboring communities: The role of prison staff
26/06/25 20:00 from Covid-19 origins
Using smartphone location data and a novel application of publicly available employment data, we map how California communities are connected to nearby prisons through the movement of prison staff, and we measure the role these connectio...

» Antibody Kinetics of Immunological Memory in SARS-CoV-2-Vaccinated Healthcare Workers-The ORCHESTRA Project
26/06/25 20:00 from Covid-19 origins
Background/Objectives: This study examines the longitudinal dynamics of anti-nucleocapsid (anti-N) and anti-spike (anti-S) antibody responses to SARS-CoV-2 infection and mRNA vaccination based on 81,878 serum samples from 23,616 healthca...

» A Case of Graves' Disease Exacerbation Triggered by BNT162b2 Vaccination
26/06/25 20:00 from sars-cov-2 spike protein
Graves' disease is an autoimmune thyroid disorder characterized by the production of thyroid-stimulating hormone receptor antibodies and is one of the leading causes of hyperthyroidism. While both genetic and environmental factors are in...

» VITT Pathophysiology: An Update
26/06/25 20:00 from sars-cov-2 spike protein
Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare thrombotic disorder first identified in 2021 as a catastrophic syndrome associated with anti-SARS-CoV-2 adenoviral vector (AdV)-vaccine administration. It is characterized by t...

» SARS-CoV-2 Receptor Binding Domain (RBD) Protein-Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques
26/06/25 20:00 from sars-cov-2 spike protein
Background/Objectives: Rapid development of vaccines against SARS-CoV-2 was pivotal to controlling the COVID-19 pandemic. The emergency also provided a rare opportunity to test novel vaccine platforms such as mRNA in large clinical trial...

» A Poly-Lysine-Based RBD Mucosal Vaccine Induces Potent Antibody Responses in Mice
26/06/25 20:00 from sars-cov-2 spike protein
(1) Background: The COVID-19 pandemic highlights the critical necessity for the development of mucosal vaccines. (2) Objective: In this study, we aimed to develop mucosal vaccines based on the receptor-binding domain (RBD) of the SARS-Co...

» Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease
26/06/25 20:00 from sars-cov-2 spike protein
CONCLUSIONS: Although SARS-CoV-2 antibody responses were attenuated in PIBD patients receiving anti-TNF therapy compared with vedolizumab, this did not impact protection, as seroconversion and breakthrough infection rates were similar, w...

» Humoral and Cellular Immune Responses to SARS-CoV-2 in Participants with Head and Neck Cancer
26/06/25 20:00 from sars-cov-2 spike protein
CONCLUSIONS: This study monitored SARS-CoV-2 humoral/cellular immunity in an HNC cohort relative to non-oncologic participants and demonstrates that SARS-CoV-2-specific B-cells persist beyond 11 months post-immunization. These findings h...

» Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape
26/06/25 20:00 from sars-cov-2 spike protein
In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies-S309, S304, CYFN1006, and VIR-7229. Using integrative com...

» Antibody Kinetics of Immunological Memory in SARS-CoV-2-Vaccinated Healthcare Workers-The ORCHESTRA Project
26/06/25 20:00 from Sars-Cov-2 origins
Background/Objectives: This study examines the longitudinal dynamics of anti-nucleocapsid (anti-N) and anti-spike (anti-S) antibody responses to SARS-CoV-2 infection and mRNA vaccination based on 81,878 serum samples from 23,616 healthca...

» Successful salvage therapy of ruxolitinib on interstitial pneumonia after long COVID or post-COVID-19 syndrome with follicular lymphoma: two case reports and literature review
26/06/25 20:00 from coronavirus
CONCLUSIONS: Ruxolitinib might be a safe and effective alternative salvage therapy for patients with COVID-19 having interstitial inflammation and persistent hypoxemia without high cytokine levels and no response to corticosteroids.

» Responsive population-based cohorts as platforms for characterising pathogen- and population-level infection dynamics for epidemic prevention, preparedness and response
26/06/25 20:00 from coronavirus
Establishing population-based cohorts is indispensable for effective epidemic prevention, preparedness and response. Existing passive surveillance systems face limitations in their capacity to promptly provide representative data for est...

» Hospitalisation trends of respiratory syncytial virus (RSV) infection in adults, six European countries, before and during COVID-19, 2016 to 2023
26/06/25 20:00 from coronavirus
BACKGROUNDRespiratory syncytial virus (RSV) is a major cause of morbidity in older adults.AIMWe aimed to investigate the epidemiology of RSV in adults in five European countries and one region before and during the COVID-19 era.METHODSWe...

» Real-time monitoring of excess mortality under a new endemic regime
26/06/25 20:00 from coronavirus
BACKGROUNDMonitoring of mortality to identify trends and detect deviations from normal levels is an essential part of routine surveillance. In many European countries, disruptions in mortality patterns from the COVID-19 pandemic have req...

» Vaccination behaviour of immigrants and native Icelanders during COVID-19
26/06/25 20:00 from coronavirus
CONCLUSION: Greater emphasis should be placed on strengthening trust in vaccination authorities, such as the Directorate of Health and the Chief Epidemiologist. Additionally, economic status and social participation of specific groups sh...

» Effects of colchicine, interferon β, IVIG, tocilizumab and corticosteroids on COVID-19 patient survival from all presently available published clinical trials: A narrative review
26/06/25 20:00 from coronavirus
One of the deadliest diseases in the world, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing global pandemic known as COVID-19. COVID-19 symptoms range from undetectable to deadly, hyper-inflammato...

» One Health serosurveillance of anti-SARS-CoV-2 antibodies in domestic animals from the metropolitan area of Panama
26/06/25 20:00 from coronavirus
CONCLUSION: This study presents the first serological evidence of SARS-CoV-2 exposure in domestic pets in Panama. While low in prevalence, the findings underscore the relevance of community-based animal surveillance and reveal possible s...

» Alpha to JN.1 variants: SARS-CoV-2 genomic analysis unfolding its various lineages/sublineages evolved in Chhattisgarh, India from 2020 to 2024
26/06/25 20:00 from coronavirus
CONCLUSION: SARS-CoV-2 from 2020 to 2024 has evolved into 17 lineages/sublineages in Chhattisgarh. The presently circulating JN.1 harbored 40 mutations, especially E554K, A570V, P621S, and P1143 L, capacitating the virus with features of...

» COVID-19 management in patients with comorbid conditions
26/06/25 20:00 from coronavirus
The novel coronavirus disease 2019 (COVID-19) causes serious respiratory illness and related disorders. Vulnerable populations, including those with chronic obstructive pulmonary disease, heart disease, diabetes, chronic kidney disease, ...

» Genomic and demographic characterization of SARS-CoV-2 infections within early Omicron cluster, Western Sri Lanka
26/06/25 20:00 from coronavirus
CONCLUSION: This study found BA.2 to be the predominant Omicron sub-lineage in the western part of Sri Lanka during the first quarter of 2022, aligning with global trends. Phylogenetic analysis revealed diverse introductions and local tr...

» Examining rhabdomyolysis-related acute kidney injury in COVID-19 patients and its comparison to other acute kidney injury types
26/06/25 20:00 from coronavirus
Rhabdomyolysis (RM) is characterized by disrupting muscle cells and releasing intracellular components into circulation. Some symptoms associated with RM include muscle weakness, discolored urine, and myalgia. RM can be caused by coronav...

» Risk of COVID-19 infection among frontline healthcare workers during the COVID-19 pandemic
26/06/25 20:00 from coronavirus
CONCLUSION: Before vaccination, HCWs in HR areas had a higher risk of infection. Seroprevalence studies suggest that sub-clinical infection was not uncommon.

» Reliable prediction of protein-protein binding affinity changes upon mutations with Pythia-PPI
26/06/25 20:00 from coronavirus
Protein-protein interactions (PPIs) are essential for numerous biological functions and predicting binding affinity changes caused by mutations is crucial for understanding the impact of genetic variation and advancing protein engineerin...

» The relationship between women's empowerment and fatalism and self-care behaviors in COVID-19 virus
26/06/25 20:00 from coronavirus
CONCLUSION: According to the results of the present study, empowerment of women as one of the effective members of the family and society and also paying attention to the beliefs of individuals can play a decisive role in improving self-...

» Epidemiological trends of influenza A and B in one hospital in Chengdu and national surveillance data (2019-2024)
26/06/25 20:00 from coronavirus
CONCLUSION: Hospital-based and national influenza surveillance data showed heterogeneity in subtype proportions, seasonal trends, and pandemic-related impacts. These findings underscore the importance of integrating multiple surveillance...

» B cells are not drivers of stromal cell activation during acute CNS infection
26/06/25 20:00 from coronavirus
CONCLUSIONS: Neither B cell-derived LTβ or B cells are primary drivers of stromal cell activation networks in the CNS following mCoV infection. Although supplementary agonist mediated LTβR engagement confirmed a role for LTβ in enhancing...

» Pharmacokinetic Simulation of Optimal Lopinavir and Ritonavir Dose Combination for COVID-19: Boosting Lopinavir With Ritonavir
26/06/25 20:00 from coronavirus
CONCLUSION: These findings provide a basis to quantify the booster effect of ritonavir on LPV in COVID-19 treatment and calculate the optimal LPV and ritonavir dose combination.

» Synchronous HPV-related Tonsillar Squamous Cell Carcinoma and Type AB Thymoma: Successful Cancer Treatment Complicated by Fatal COVID-19 Infection
26/06/25 20:00 from coronavirus
CONCLUSION: To the best of our knowledge, this is the first documented case with synchronous tonsillar SCC and mediastinal thymoma. This case underscores the complexity of treating synchronous malignancies and illustrates how multidiscip...

» ViruSeg: Harnessing the Power of Large Language-Image Model for Enhanced Virus Image Segmentation
26/06/25 20:00 from sars-cov-2
The emergence of novel viral diseases, with SARS-CoV-2 as a stark example, poses increasing threats to public health, causing significant global morbidity and mortality. Accurate identification and segmentation of viral imaging are cruci...

» Women's Health Care, Prevention in Practice, and Common Medical Illnesses
26/06/25 20:00 from coronavirus
This issue is informative on common family medicine concerns. There are several articles on women's health issues (family physicians providing obstetric care, COVID-19 and cervical cancer screening, the availability of in vitro fertiliza...

» Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine
26/06/25 20:00 from sars-cov-2 spike protein
Low- and middle-income countries face substantial challenges in immunizing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including high costs, limited access, and insufficient local manufacturing. To address these...

» Potential protective advantage of the protein-subunit SARS-CoV-2 vaccines, MVC-CoV1901 and NVX-CoV2373, in patients with rituximab-treated immune-mediated inflammatory diseases: Real-world evidence
26/06/25 20:00 from sars-cov-2
Since the COVID-19 pandemic, patients with immune-mediated inflammatory diseases (IMID) are recommended to receive SARS-CoV-2 vaccinations to reduce complications following COVID-19 infection. We conducted a case-control study and case a...

» National Trends of Telehealth Use in Medicare Annual Wellness Visits
26/06/25 20:00 from coronavirus
INTRODUCTION: In response to COVID-19, Medicare began reimbursing for Annual Wellness Visits (AWVs) via telehealth in March 2020. Little is known about nationwide utilization of telehealth AWVs as a preventive care service among Medicare...

» Neurological and psychiatric aspects of long COVID among vaccinated healthcare workers: An assessment of prevalence and reporting biases
26/06/25 20:00 from sars-cov-2
CONCLUSION: The study highlighted potential biases in symptom reporting that may inflate long COVID prevalence estimates. While the robust methodology shed light on diverse health profiles among HCWs, future research should focus on long...

» Inference of differential kinase interaction networks with KINference
26/06/25 20:00 from sars-cov-2
MOTIVATION: Differential kinase interaction networks (DKINs) are networks containing kinase-substrate links that are differentially active between two conditions. Existing methods are either able to predict condition-agnostic kinase-subs...

» The Impact of COVID-19 on Cervical Cancer Screening in Primary Care
26/06/25 20:00 from coronavirus
CONCLUSIONS: CC screening rates remained below prepandemic levels throughout the 2 years of the pandemic. Policy makers and health care professionals should strategize approaches to enhance CC screening rates, including the exploration o...

» Pharmacokinetic Simulation of Optimal Lopinavir and Ritonavir Dose Combination for COVID-19: Boosting Lopinavir With Ritonavir
26/06/25 20:00 from sars-cov-2
CONCLUSION: These findings provide a basis to quantify the booster effect of ritonavir on LPV in COVID-19 treatment and calculate the optimal LPV and ritonavir dose combination.

» Synchronous HPV-related Tonsillar Squamous Cell Carcinoma and Type AB Thymoma: Successful Cancer Treatment Complicated by Fatal COVID-19 Infection
26/06/25 20:00 from sars-cov-2
CONCLUSION: To the best of our knowledge, this is the first documented case with synchronous tonsillar SCC and mediastinal thymoma. This case underscores the complexity of treating synchronous malignancies and illustrates how multidiscip...

» Background rates of medical events of interest before and during the COVID-19 pandemic: a longitudinal cohort study using claims data
26/06/25 20:00 from coronavirus
CONCLUSIONS: Substantial variability was observed in IRs of MEI by study cohort, year, data source and follow-up duration. When generating background rates for contextualising safety signals from COVID-19 interventions, careful considera...

» Women's Health Care, Prevention in Practice, and Common Medical Illnesses
26/06/25 20:00 from sars-cov-2
This issue is informative on common family medicine concerns. There are several articles on women's health issues (family physicians providing obstetric care, COVID-19 and cervical cancer screening, the availability of in vitro fertiliza...

» Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China
26/06/25 20:00 from coronavirus
CONCLUSIONS: Among COVID-19 patients with pre-existing hypertension, the effectiveness of azvudine is not inferior to Paxlovid in reducing all-cause death and composite disease progression, with fewer adverse events.

» National Trends of Telehealth Use in Medicare Annual Wellness Visits
26/06/25 20:00 from sars-cov-2
INTRODUCTION: In response to COVID-19, Medicare began reimbursing for Annual Wellness Visits (AWVs) via telehealth in March 2020. Little is known about nationwide utilization of telehealth AWVs as a preventive care service among Medicare...

» How did staffing strategies change amid COVID-19 and post pandemic? A qualitative study
26/06/25 20:00 from coronavirus
CONCLUSIONS: Our study elucidates the staffing strategies that were employed during the COVID-19 pandemic that included creating new and adapting existing roles and teams; redeploying healthcare professionals; and enhancing coverage. Stu...

» Nonthermal plasma jet mitigates viral replication and inflammation in human coronavirus 229E-infected lung cells by targeting the NF-kappaB and MAPK pathways
26/06/25 20:00 from coronavirus
SARS-CoV-2 is a pressing global health issue, largely driven by uncontrolled viral replication and severe proinflammatory responses. Despite significant technological progress made by humanity, medical science has frequently found itself...

» Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine
26/06/25 20:00 from coronavirus
Low- and middle-income countries face substantial challenges in immunizing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including high costs, limited access, and insufficient local manufacturing. To address these...

» Depression, anxiety and change in eating habits during the COVID-19 pandemic in Brazilian university students
26/06/25 20:00 from coronavirus
This cross-sectional study aims to evaluate the association between anxiety and depression with changes in the consumption of hyperpalatable foods and meal patterns in a sample of 771 Brazilian university students during the social isola...

» The Impact of COVID-19 on Cervical Cancer Screening in Primary Care
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: CC screening rates remained below prepandemic levels throughout the 2 years of the pandemic. Policy makers and health care professionals should strategize approaches to enhance CC screening rates, including the exploration o...

» Towards new forms of communication and surveillance: a mixed methods study of rapid respiratory virus assessment in general practice during the SARS-CoV-2 pandemic
26/06/25 20:00 from coronavirus
Introduction Improvements in diagnostic test accuracy across multiple pathogens have resulted in multi-viral point-of-care testing (POCT) via a rapid antigen test (RAT). Aim This study aimed to describe general practice practitioners' re...

» Background rates of medical events of interest before and during the COVID-19 pandemic: a longitudinal cohort study using claims data
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Substantial variability was observed in IRs of MEI by study cohort, year, data source and follow-up duration. When generating background rates for contextualising safety signals from COVID-19 interventions, careful considera...

» Prediction of mortality in severe ischemic stroke during COVID-19 in patients with multiorgan dysfunction
26/06/25 20:00 from coronavirus
CONCLUSION: MOD is a key mortality-associated indicator in patients with severe IS and concomitant COVID-19. The mortality risk is significantly higher in patients with cardioembolic IS subtype.

» Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Among COVID-19 patients with pre-existing hypertension, the effectiveness of azvudine is not inferior to Paxlovid in reducing all-cause death and composite disease progression, with fewer adverse events.

» How did staffing strategies change amid COVID-19 and post pandemic? A qualitative study
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Our study elucidates the staffing strategies that were employed during the COVID-19 pandemic that included creating new and adapting existing roles and teams; redeploying healthcare professionals; and enhancing coverage. Stu...

» Single-molecule imaging prefusion intermediate conformations of MERS-CoV spike trimers in membrane during entry
26/06/25 20:00 from coronavirus
Middle East respiratory syndrome coronavirus (MERS-CoV) entry into host cells is mediated by the spike (S) glycoprotein trimer. The S2 domain of spike promotes membrane fusion for MERS entry, but its mechanism of action is currently elus...

» Nonthermal plasma jet mitigates viral replication and inflammation in human coronavirus 229E-infected lung cells by targeting the NF-κB and MAPK pathways
26/06/25 20:00 from sars-cov-2
SARS-CoV-2 is a pressing global health issue, largely driven by uncontrolled viral replication and severe proinflammatory responses. Despite significant technological progress made by humanity, medical science has frequently found itself...

» Neurological and psychiatric aspects of long COVID among vaccinated healthcare workers: An assessment of prevalence and reporting biases
26/06/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: The study highlighted potential biases in symptom reporting that may inflate long COVID prevalence estimates. While the robust methodology shed light on diverse health profiles among HCWs, future research should focus on long...

» Epstein-Barr virus (EBV) reactivation in post COVID-19
26/06/25 20:00 from sars-cov-2
CONCLUSION: EBV reactivation plays a role in Long-COVID syndrome following COVID-19 infection supporting the usage of EBV inhibitors for long-term COVID-19 treatment.

» NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis
26/06/25 20:00 from sars-cov-2
NSP7 (Non-Structural Protein 7) of SARS-CoV-2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine-48-...

» B cells are not drivers of stromal cell activation during acute CNS infection
26/06/25 20:00 from covid-19
CONCLUSIONS: Neither B cell-derived LTβ or B cells are primary drivers of stromal cell activation networks in the CNS following mCoV infection. Although supplementary agonist mediated LTβR engagement confirmed a role for LTβ in enhancing...

» Global Maternal Child Health Initiatives and Programs 1974 to 2023
26/06/25 20:00 from covid-19
CONCLUSION: Four trends were noted across these five decades: (1) MCH Mortality decreased but unacceptable inequities persist with COVID-19, ongoing conflicts and climate change threatening these gains. (2) Implementation of primary heal...

» ViruSeg: Harnessing the Power of Large Language-Image Model for Enhanced Virus Image Segmentation
26/06/25 20:00 from covid-19
The emergence of novel viral diseases, with SARS-CoV-2 as a stark example, poses increasing threats to public health, causing significant global morbidity and mortality. Accurate identification and segmentation of viral imaging are cruci...

» The English-Only Nature of Vaccine Deservedness and Harms of Racialized Administrative Burdens
26/06/25 20:00 from covid-19
Despite extensive efforts to facilitate COVID-19 vaccine access and achieve a 70% vaccination rate, race-based disparities and barriers to vaccine access continue to persist in the United States. To investigate discrimination among Limit...

» Understanding the effectiveness of psychosocial services for older adults' mental health in China: a systematic review and meta-analysis
26/06/25 20:00 from covid-19
CONCLUSIONS: Psychosocial services could significantly benefit Chinese older adults' mental health. The moderator and subgroup analysis suggests that the most effective interventions involve mental health professionals and utilize multif...

» Potential protective advantage of the protein-subunit SARS-CoV-2 vaccines, MVC-CoV1901 and NVX-CoV2373, in patients with rituximab-treated immune-mediated inflammatory diseases: Real-world evidence
26/06/25 20:00 from covid-19
Since the COVID-19 pandemic, patients with immune-mediated inflammatory diseases (IMID) are recommended to receive SARS-CoV-2 vaccinations to reduce complications following COVID-19 infection. We conducted a case-control study and case a...

» Neurological and psychiatric aspects of long COVID among vaccinated healthcare workers: An assessment of prevalence and reporting biases
26/06/25 20:00 from covid-19
CONCLUSION: The study highlighted potential biases in symptom reporting that may inflate long COVID prevalence estimates. While the robust methodology shed light on diverse health profiles among HCWs, future research should focus on long...

» Inference of differential kinase interaction networks with KINference
26/06/25 20:00 from covid-19
MOTIVATION: Differential kinase interaction networks (DKINs) are networks containing kinase-substrate links that are differentially active between two conditions. Existing methods are either able to predict condition-agnostic kinase-subs...

» Turning the Tide: Unraveling Aortic Dynamics and Patent Foramen Ovale in Platypnea-Orthodeoxia Syndrome
26/06/25 20:00 from covid-19
BACKGROUND: Platypnea-orthodeoxia syndrome (POS) is a rare disorder characterized by positional dyspnea and hypoxemia due to right-to-left shunting, often through a patent foramen ovale (PFO). It requires both an anatomical substrate and...

» Sodium-Glucose Cotransporter Inhibition Preserves Apolipoprotein M During Acute Inflammation in Mice and Humans
26/06/25 20:00 from covid-19
CONCLUSIONS: SGLT2i maintains Lrp2 levels, preserving ApoM and promoting endothelial barrier integrity in acute inflammation, indicating a novel protective mechanism of SGLT2i through ApoM preservation.

» Pharmacokinetic Simulation of Optimal Lopinavir and Ritonavir Dose Combination for COVID-19: Boosting Lopinavir With Ritonavir
26/06/25 20:00 from covid-19
CONCLUSION: These findings provide a basis to quantify the booster effect of ritonavir on LPV in COVID-19 treatment and calculate the optimal LPV and ritonavir dose combination.

» Synchronous HPV-related Tonsillar Squamous Cell Carcinoma and Type AB Thymoma: Successful Cancer Treatment Complicated by Fatal COVID-19 Infection
26/06/25 20:00 from covid-19
CONCLUSION: To the best of our knowledge, this is the first documented case with synchronous tonsillar SCC and mediastinal thymoma. This case underscores the complexity of treating synchronous malignancies and illustrates how multidiscip...

» Women's Health Care, Prevention in Practice, and Common Medical Illnesses
26/06/25 20:00 from covid-19
This issue is informative on common family medicine concerns. There are several articles on women's health issues (family physicians providing obstetric care, COVID-19 and cervical cancer screening, the availability of in vitro fertiliza...

» National Trends of Telehealth Use in Medicare Annual Wellness Visits
26/06/25 20:00 from covid-19
INTRODUCTION: In response to COVID-19, Medicare began reimbursing for Annual Wellness Visits (AWVs) via telehealth in March 2020. Little is known about nationwide utilization of telehealth AWVs as a preventive care service among Medicare...

» Intervention to Improve Psychosocial Care for People with Type 2 Diabetes
26/06/25 20:00 from covid-19
CONCLUSIONS: Given the growing number of people with type 2 diabetes and the importance of psychosocial care for these patients, INTEGRATE-D warrants further pilot-testing with a larger sample of clinics and patients, and under condition...

» Potential protective advantage of the protein-subunit SARS-CoV-2 vaccines, MVC-CoV1901 and NVX-CoV2373, in patients with rituximab-treated immune-mediated inflammatory diseases: Real-world evidence
26/06/25 20:00 from covid-19
Since the COVID-19 pandemic, patients with immune-mediated inflammatory diseases (IMID) are recommended to receive SARS-CoV-2 vaccinations to reduce complications following COVID-19 infection. We conducted a case-control study and case a...

» Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Among COVID-19 patients with pre-existing hypertension, the effectiveness of azvudine is not inferior to Paxlovid in reducing all-cause death and composite disease progression, with fewer adverse events.

» Potential protective advantage of the protein-subunit SARS-CoV-2 vaccines, MVC-CoV1901 and NVX-CoV2373, in patients with rituximab-treated immune-mediated inflammatory diseases: Real-world evidence
26/06/25 20:00 from covid-19
Since the COVID-19 pandemic, patients with immune-mediated inflammatory diseases (IMID) are recommended to receive SARS-CoV-2 vaccinations to reduce complications following COVID-19 infection. We conducted a case-control study and case a...

» Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China
26/06/25 20:00 from sars-cov-2
CONCLUSIONS: Among COVID-19 patients with pre-existing hypertension, the effectiveness of azvudine is not inferior to Paxlovid in reducing all-cause death and composite disease progression, with fewer adverse events.