» Hospital resource use and in-hospital mortality before and during the COVID-19 pandemic: a nationwide cohort study
15/10/25 20:00 from coronavirus
CONCLUSION: In this study, we observed an association between the COVID-19 pandemic and hospital resource use in COVID-19 patients only, resulting in higher in-hospital mortality, longer lengths of hospital stay and more frequent facilit...

» Effect of Mobile Stroke Unit Dispatch on Process Parameters and Functional Outcomes in Patients With Acute Stroke: The B_PROUD-2.0 Study
15/10/25 20:00 from coronavirus
BACKGROUND AND OBJECTIVES: Prehospital stroke management on mobile stroke units (MSUs) shortens time to IV thrombolysis (IVT) and improves functional outcomes. Because IVT effects are time-dependent, optimizing workflows and dispatch-rel...

» Psychosocial Impacts of COVID-19 and Racial Injustice on Undergraduate Research Trainees
15/10/25 20:00 from coronavirus
Undergraduate research programs (URPs) play an important role in preparing the next cohort of professionals in the health research workforce. URPs also provide continuity and structure during times of stress and uncertainty, like the COV...

» Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
15/10/25 20:00 from coronavirus
SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans. Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed tha...

» Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic
15/10/25 20:00 from coronavirus
The COVID-19 pandemic had profound effects on developing adolescents that, to date, remain incompletely understood. Youth with preexisting mental health problems and associated brain alterations were at increased risk for higher stress a...

» Trends and outcomes of cardiac arrest and extracorporeal membrane oxygenation during the COVID-19 pandemic in the United States
15/10/25 20:00 from coronavirus
CONCLUSION: CA incidence and mortality increased during the COVID-19 Pandemic, while ECMO use declined, emphasizing the need to improve care of CA and ECMO patients. COVID-19 patients with CA had dismal outcomes, suggesting no role for E...

» Spatiotemporal structure of SARS-CoV-2 mutational frequencies in wastewater samples from Ontario
15/10/25 20:00 from coronavirus
Starting October 2021, the Ontario wastewater surveillance initiative has used next-generation sequencing (NGS) to monitor SARS-CoV-2 RNA in wastewater samples. The fragmented and heterogeneous nature of these data precludes using compar...

» Healthcare employees' perspectives on organizational communication about preventive mental health interventions: A focus group study
15/10/25 20:00 from coronavirus
The COVID-19 pandemic exposed healthcare employees to stressful situations with possible long-term mental health consequences, stressing the need for supportive interventions. However, in practice healthcare employees' use of preventive ...

» SARS-CoV-2 sequencing artifacts associated with targeted PCR enrichment and read mapping
15/10/25 20:00 from coronavirus
Protocols and pipelines for SARS-CoV-2 genome sequencing were rapidly established when the COVID-19 outbreak was declared a pandemic. The most widely used approach for sequencing SARS-CoV-2 includes targeted enrichment by PCR, followed b...

» Acute Toxicity of Commercial Ethanol and Sodium Hypochlorite on Freshwater Species: Potential Implications of the COVID-19 Pandemic Disinfection Measures
15/10/25 20:00 from coronavirus
The global response to the SARS-CoV-2 pandemic involved intensified disinfection of public spaces, predominantly using 70% ethanol (EtOH) and bleach (sodium hypochlorite). However, the extensive application of these agents has raised con...

» Evaluating the 4Ms of Age-Friendly Nursing Homes During COVID-19
15/10/25 20:00 from coronavirus
CONCLUSION: Strengthening nursing homes' ability to sustain the 4Ms during a public health crisis is essential for providing quality care.

» Vitamin D may influence disease course in PIMS-TS/MIS-C: An observational cohort study
15/10/25 20:00 from coronavirus
CONCLUSIONS: Methylprednisolone suppressed CRP early and without evidence of coronary aneurysm in this cohort. We demonstrate a relationship between vitamin D, SARS-CoV-2 anti-nucleocapsid antibody production, inflammatory biomarkers, an...

» School infection control strategy during and after the COVID-19 pandemic: Nationwide trends (2022-2024)
15/10/25 20:00 from coronavirus
CONCLUSIONS: This study provides nationwide insights into how Japanese schools adjusted their infection control strategies across three academic years. These findings highlight the need for evidence-informed decision-making and closer pa...

» Classification and regulatory interactions of key transcription factors in COVID-19
15/10/25 20:00 from coronavirus
SARS-CoV-2, the virus responsible for COVID-19, interferes with the host's transcriptional control systems, triggering widespread disruption of immune regulation and metabolic stability. Key transcription factors (TFs), including AHR, NR...

» Editorial: Advances in understanding mucosal immunity in coronaviruses: from mechanisms to vaccines
15/10/25 20:00 from coronavirus
No abstract

» Temporal Trends in Cervical Human Papillomavirus Prevalence Among Females in Xiamen, China (2016-2023): Cross-Sectional Study
15/10/25 20:00 from covid-19
CONCLUSIONS: Cervical HPV infection, particularly non-vaccine-targeted genotypes, remains a substantial public health burden in Xiamen, highlighting the urgency to develop broader spectrum vaccines, to enhance cervical cancer screening p...

» Hospital resource use and in-hospital mortality before and during the COVID-19 pandemic: a nationwide cohort study
15/10/25 20:00 from sars-cov-2
CONCLUSION: In this study, we observed an association between the COVID-19 pandemic and hospital resource use in COVID-19 patients only, resulting in higher in-hospital mortality, longer lengths of hospital stay and more frequent facilit...

» Psychosocial Impacts of COVID-19 and Racial Injustice on Undergraduate Research Trainees
15/10/25 20:00 from sars-cov-2
Undergraduate research programs (URPs) play an important role in preparing the next cohort of professionals in the health research workforce. URPs also provide continuity and structure during times of stress and uncertainty, like the COV...

» Hospital resource use and in-hospital mortality before and during the COVID-19 pandemic: a nationwide cohort study
15/10/25 20:00 from covid-19
CONCLUSION: In this study, we observed an association between the COVID-19 pandemic and hospital resource use in COVID-19 patients only, resulting in higher in-hospital mortality, longer lengths of hospital stay and more frequent facilit...

» Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
15/10/25 20:00 from sars-cov-2
SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans. Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed tha...

» COVID-19 Structural Transformation and Program Adaptation in Emergency Domestic Violence Shelters
15/10/25 20:00 from covid-19
The COVID-19 pandemic dramatically increased domestic violence (DV) rates and structurally changed how social services like emergency DV shelters could be provided. We surveyed employees at 103 U.S. DV shelter providers about how their o...

» Effect of Mobile Stroke Unit Dispatch on Process Parameters and Functional Outcomes in Patients With Acute Stroke: The B_PROUD-2.0 Study
15/10/25 20:00 from covid-19
BACKGROUND AND OBJECTIVES: Prehospital stroke management on mobile stroke units (MSUs) shortens time to IV thrombolysis (IVT) and improves functional outcomes. Because IVT effects are time-dependent, optimizing workflows and dispatch-rel...

» Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic
15/10/25 20:00 from sars-cov-2
The COVID-19 pandemic had profound effects on developing adolescents that, to date, remain incompletely understood. Youth with preexisting mental health problems and associated brain alterations were at increased risk for higher stress a...

» Universal Genetic Testing for Pancreatic Cancer: Closing the Gap on a Missed Opportunity
15/10/25 20:00 from covid-19
Approximately 10%-15% of pancreatic ductal adenocarcinomas (PDACs) are caused by pathogenic germline variants (PGVs). Universal genetic testing (UGT) for PDAC, regardless of family history, was first recommended in 2018. Successful PDAC ...

» Trends and outcomes of cardiac arrest and extracorporeal membrane oxygenation during the COVID-19 pandemic in the United States
15/10/25 20:00 from sars-cov-2
CONCLUSION: CA incidence and mortality increased during the COVID-19 Pandemic, while ECMO use declined, emphasizing the need to improve care of CA and ECMO patients. COVID-19 patients with CA had dismal outcomes, suggesting no role for E...

» Psychosocial Impacts of COVID-19 and Racial Injustice on Undergraduate Research Trainees
15/10/25 20:00 from covid-19
Undergraduate research programs (URPs) play an important role in preparing the next cohort of professionals in the health research workforce. URPs also provide continuity and structure during times of stress and uncertainty, like the COV...

» Spatiotemporal structure of SARS-CoV-2 mutational frequencies in wastewater samples from Ontario
15/10/25 20:00 from sars-cov-2
Starting October 2021, the Ontario wastewater surveillance initiative has used next-generation sequencing (NGS) to monitor SARS-CoV-2 RNA in wastewater samples. The fragmented and heterogeneous nature of these data precludes using compar...

» Healthcare employees' perspectives on organizational communication about preventive mental health interventions: A focus group study
15/10/25 20:00 from sars-cov-2
The COVID-19 pandemic exposed healthcare employees to stressful situations with possible long-term mental health consequences, stressing the need for supportive interventions. However, in practice healthcare employees' use of preventive ...

» Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
15/10/25 20:00 from covid-19
SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans. Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed tha...

» Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic
15/10/25 20:00 from covid-19
The COVID-19 pandemic had profound effects on developing adolescents that, to date, remain incompletely understood. Youth with preexisting mental health problems and associated brain alterations were at increased risk for higher stress a...

» SARS-CoV-2 sequencing artifacts associated with targeted PCR enrichment and read mapping
15/10/25 20:00 from sars-cov-2
Protocols and pipelines for SARS-CoV-2 genome sequencing were rapidly established when the COVID-19 outbreak was declared a pandemic. The most widely used approach for sequencing SARS-CoV-2 includes targeted enrichment by PCR, followed b...

» Trends and outcomes of cardiac arrest and extracorporeal membrane oxygenation during the COVID-19 pandemic in the United States
15/10/25 20:00 from covid-19
CONCLUSION: CA incidence and mortality increased during the COVID-19 Pandemic, while ECMO use declined, emphasizing the need to improve care of CA and ECMO patients. COVID-19 patients with CA had dismal outcomes, suggesting no role for E...

» Acute Toxicity of Commercial Ethanol and Sodium Hypochlorite on Freshwater Species: Potential Implications of the COVID-19 Pandemic Disinfection Measures
15/10/25 20:00 from sars-cov-2
The global response to the SARS-CoV-2 pandemic involved intensified disinfection of public spaces, predominantly using 70% ethanol (EtOH) and bleach (sodium hypochlorite). However, the extensive application of these agents has raised con...

» Impact of Covid-19 control strategies on health and GDP growth outcomes in 193 sovereign jurisdictions
15/10/25 20:00 from covid-19
The Covid-19 pandemic caused approximately 27.3 million excess deaths globally as of June 2024. Despite growing research on pandemic response factors, the effectiveness of different strategic approaches to Covid-19 control remains insuff...

» Vitamin D may influence disease course in PIMS-TS/MIS-C: An observational cohort study
15/10/25 20:00 from sars-cov-2
CONCLUSIONS: Methylprednisolone suppressed CRP early and without evidence of coronary aneurysm in this cohort. We demonstrate a relationship between vitamin D, SARS-CoV-2 anti-nucleocapsid antibody production, inflammatory biomarkers, an...

» School infection control strategy during and after the COVID-19 pandemic: Nationwide trends (2022-2024)
15/10/25 20:00 from sars-cov-2
CONCLUSIONS: This study provides nationwide insights into how Japanese schools adjusted their infection control strategies across three academic years. These findings highlight the need for evidence-informed decision-making and closer pa...

» Spatiotemporal structure of SARS-CoV-2 mutational frequencies in wastewater samples from Ontario
15/10/25 20:00 from covid-19
Starting October 2021, the Ontario wastewater surveillance initiative has used next-generation sequencing (NGS) to monitor SARS-CoV-2 RNA in wastewater samples. The fragmented and heterogeneous nature of these data precludes using compar...

» Utility, comfort and feasibility of SARS-CoV-2 antigen rapid diagnostic testing integration into routine care: a cross-sectional survey assessing healthcare workers' perspectives in Kenya and Cameroon
15/10/25 20:00 from sars-cov-2
CONCLUSIONS: HCWs found the integration of SARS-CoV-2 Ag-RDT useful; most felt comfortable providing counselling but had concerns regarding the safety of testing, particularly sample collection. Patient refusal due to discomfort, time co...

» Healthcare employees' perspectives on organizational communication about preventive mental health interventions: A focus group study
15/10/25 20:00 from covid-19
The COVID-19 pandemic exposed healthcare employees to stressful situations with possible long-term mental health consequences, stressing the need for supportive interventions. However, in practice healthcare employees' use of preventive ...

» Classification and regulatory interactions of key transcription factors in COVID-19
15/10/25 20:00 from sars-cov-2
SARS-CoV-2, the virus responsible for COVID-19, interferes with the host's transcriptional control systems, triggering widespread disruption of immune regulation and metabolic stability. Key transcription factors (TFs), including AHR, NR...

» Evaluation of disparities in the incidence, presentation, and treatment of pediatric differentiated thyroid cancer in the United States (2000-2022)
15/10/25 20:00 from covid-19
CONCLUSION: Declines in reported pediatric thyroid cancer incidence, particularly among the smallest tumor sizes, after 2018 may be attributable to application of thyroid cancer management guidelines. However, the continued increase amon...

» SARS-CoV-2 sequencing artifacts associated with targeted PCR enrichment and read mapping
15/10/25 20:00 from covid-19
Protocols and pipelines for SARS-CoV-2 genome sequencing were rapidly established when the COVID-19 outbreak was declared a pandemic. The most widely used approach for sequencing SARS-CoV-2 includes targeted enrichment by PCR, followed b...

» Identification of antigen-specific functional CD8⁺ T cells using an optofluidic system independent of epitope information
15/10/25 20:00 from sars-cov-2
Most studies detect and isolate antigen-specific CD8^(+) T cells solely by measuring T cell receptor (TCR) binding affinity to peptide-major histocompatibility complexes (p-MHCs) without considering T cell function. Here, we present a fu...

» Interparental processes mitigating risk for psychological aggression during the COVID-19 pandemic
15/10/25 20:00 from covid-19
The onset of the COVID-19 pandemic posed significant challenges for families, particularly those with young children, due to rapid shifts in routines and increased responsibilities. Corresponding increases in psychological aggression wer...

» Personalized prediction of SARS-CoV-2 vaccine-induced immunity after boost: a longitudinal analysis using joint modeling
15/10/25 20:00 from sars-cov-2
INTRODUCTION: The SARS-CoV-2 pandemic has revealed substantial inter-individual variability in immune responses, particularly following widespread primary vaccination and booster campaigns. These differences affect the durability of prot...

» Impact of CMV latency on T-cell responses to COVID-19 vaccination among predominantly antibody-deficient patients
15/10/25 20:00 from sars-cov-2 spike protein
CONCLUSION: CMV latency negatively impacted the CD4^(+) TEM population's functionality regarding COVID-19 vaccination in patients with CVID. Our results in patients with IEI and previous similar findings in healthy populations highlight ...

» The Predictive Power of Barotrauma from the Macklin Effect in the ARDS Population: A Comparison of COVID-19 and Non-COVID-19 ARDS-Could the Macklin Effect Serve as a Helpful Tool for Evaluating Transfer to ARDS Reference Centers?
15/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Background: The Macklin effect recently demonstrated a high positive predictive value for barotrauma in the COVID-19 ARDS population. However, there was less evidence available regarding the ARDS population without SARS-CoV-2 infection. ...

» Understanding sex and gender disparities in COVID-19 mortality: a narrative review beyond biology
15/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Sex-related biological factors may have influenced COVID-19 outcomes, but they do not adequately account for the observed differences in mortality between women and men. Approaching the study of health inequities through a ge...

» Socio-demographic and behavioural risk factors of SARS- CoV-2 seropositivity in rural tribal population of Tripura: A population based cross-sectional study
14/10/25 20:00 from sars-cov-2
CONCLUSIONS: Further investigations are needed to establish an association of COVID-19 seropositivity with smoking.

» Digital health: current applications, challenges, and future directions for enhancing healthcare quality and safety
14/10/25 20:00 from sars-cov-2
Digital Health Technologies (DHTs) have become a cornerstone of modern healthcare, significantly improving quality and safety across clinical practice, public health, and medical research. Originating in the mid-to-late 20th century, DHT...

» Tomatine as a versatile adjuvant boosts mRNA vaccine responses
14/10/25 20:00 from sars-cov-2
The potent adaptive immune response of mRNA vaccines requires that sufficient antigens translated from mRNA cargos and highly efficient activation of innate immunity. However, it remains unclear if simple introduction of an adjuvant can ...

» Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity
14/10/25 20:00 from sars-cov-2
CONCLUSION: Our study fills a critical gap by addressing the lack of research on genetic factors of ChAdOx1 nCoV-19 vaccine responses in Asian population, providing valuable insights into the genetic basis of DNA-based vaccine responses....

» Advances in molecular adjuvants for nucleic acid vaccines
14/10/25 20:00 from sars-cov-2
As nucleic acid vaccine technology continues to advance, modern adjuvants are being engineered to quantitatively and qualitatively shape immune responses. Since their development in the early 1990's, nucleic acid approaches have garnered...

» Impact of recent COVID-19 infection on liver and kidney transplantation - a worldwide meta-analysis and systematic review
14/10/25 20:00 from sars-cov-2
INTRODUCTION: The shortage of suitable donor organs represents an ongoing global challenge for organ transplantation. During the COVID-19 pandemic, the number of transplantable organs was especially limited. To date, the impact of recent...

» Impact of COVID-19 Pneumonia on Chest Computed Tomography Scan and Spirometry During Six Months
14/10/25 20:00 from sars-cov-2
CONCLUSION: In summary, our study indicated that abnormal spirometry in the post-COVID-19 recovery phase is associated with a higher risk of long-term parenchymal lung disease, characterized by fibrotic-like changes in chest CT scans and...

» D2Screen: Embedding Pretrained Representation Learning Model and Molecular Docking for Virtual Screening
14/10/25 20:00 from sars-cov-2
Virtual screening and molecular docking are widely used computational strategies for drug discovery. Recently, deep learning has emerged as a powerful approach that leverages known pharmacological data to identify compounds with similar ...

» Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV-2 NSP14
14/10/25 20:00 from sars-cov-2
Non-structural protein 14 (NSP14) is a key two-domain protein responsible for maintaining coronavirus replication fidelity, and in its absence reproduction is severely impacted. With the goal of identifying new inhibitors of SARS-CoV-2 N...

» Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2
14/10/25 20:00 from sars-cov-2
Peptide-based inhibitors exhibit considerable potential as antiviral agents targeting SARS-CoV-2. In this study, we designed analogs (TLP-1, TLP-2, and TLP-3) of Temporin L (TL) peptide with the specific objective of selectively interact...

» Identification and Exploration of a Series of SARS-Cov-2 M(Pro) Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group
14/10/25 20:00 from sars-cov-2
Starting from a simple scaffold hopping exercise based on our previous exploration of cysteine protease inhibitors against legumain, compound 6a was identified as a starting point for the development of a SARS-CoV-2 main protease (M^(Pro...

» Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and Long COVID: current state and future direction
14/10/25 20:00 from sars-cov-2
Postural orthostatic tachycardia syndrome (POTS), neurocardiogenic syncope, and orthostatic hypotension are the most common autonomic disorders encountered in clinical practice. The autoimmune etiology and association of these conditions...

» Correction: Vaccine Effectiveness in SARS-CoV-2-Infected Pregnant Women with Gestational Diabetes Mellitus: Results from a Multicenter Registry-Based Prospective Cohort Study in Germany
14/10/25 20:00 from sars-cov-2
[This corrects the article DOI: 10.1055/a-2576-6293.].

» Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction
14/10/25 20:00 from sars-cov-2
CONCLUSION: In the study period of 2022, infection with SARS-CoV-2, in most cases with the Omicron variant, during or up to six months prior to a pregnancy following assisted reproduction did not significantly affect the risk of maternal...

» Vaccine Effectiveness in SARS-CoV-2-Infected Pregnant Women with Gestational Diabetes Mellitus: Results from a Multicenter Registry-Based Prospective Cohort Study in Germany
14/10/25 20:00 from sars-cov-2
Introduction COVID-19 in pregnancy is associated with increased maternal and neonatal morbidity and mortality. The aim of our study was to investigate the effectiveness of COVID-19 vaccination in SARS-CoV-2-infected pregnant women with f...

» Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis
14/10/25 20:00 from covid-19
Orphan genes, which encode species-specific proteins, are common but are rarely investigated. The SARS-CoV-2 orphan gene, ORF10, has been understudied; in vitro work suggests it may modulate innate immunity. Whether ORF10 influences COVI...

» The impact of the timing of PRRSV and swine enteric coronaviruses introduction on wean-to-market productivity
14/10/25 20:00 from coronavirus
PRRSV and SeCoV can significantly decrease the productivity of growing pigs by increasing mortality rates and decreasing growth, resulting in economic losses for swine producers. A better understanding of how infection patterns of these ...

» Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active haematological diseases undergoing combined antiviral treatments
14/10/25 20:00 from covid-19
CONCLUSIONS: Combination regimens for SARS-CoV-2 did not affect the time to restart haematological therapy, whereas the occurrence of pneumonia was associated with delayed resumption of chemotherapy. The real benefit of COVID-19 combinat...

» The population-level impact of COVID-19 on maternal healthcare utilization: evidence from the 2022 Kenya Demographic and Health Survey
14/10/25 20:00 from covid-19
CONCLUSIONS: The findings underscore a need for targeted policy/program strategies to mitigate adverse consequences of public health emergencies among disproportionately impacted population subgroups.

» Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis
14/10/25 20:00 from coronavirus
Orphan genes, which encode species-specific proteins, are common but are rarely investigated. The SARS-CoV-2 orphan gene, ORF10, has been understudied; in vitro work suggests it may modulate innate immunity. Whether ORF10 influences COVI...

» Design of a lateral flow assay targeting the conserved NIID_2019-nCoV_N gene region for molecular viral diagnosis
14/10/25 20:00 from covid-19
SARS-CoV-2, the causative agent of the COVID-19 pandemic, remains a significant threat to global public health. Therefore, rapid and accurate detection of the virus continues to be of critical importance. Among the specific gene regions ...

» The population-level impact of COVID-19 on maternal healthcare utilization: evidence from the 2022 Kenya Demographic and Health Survey
14/10/25 20:00 from coronavirus
CONCLUSIONS: The findings underscore a need for targeted policy/program strategies to mitigate adverse consequences of public health emergencies among disproportionately impacted population subgroups.

» COVID-19 Vaccine Effectiveness in Patients with Hematologic Malignancies: a Nationwide Cohort Study
14/10/25 20:00 from covid-19
CONCLUSIONS: COVID-19 vaccination lowered the risk of severe COVID-19 in SARS-CoV-2-infected patients with hematologic malignancies, although these patients remained at elevated risk compared to others. Determinants of severe COVID-19 in...

» Digital health: current applications, challenges, and future directions for enhancing healthcare quality and safety
14/10/25 20:00 from Sars-Cov-2 origins
Digital Health Technologies (DHTs) have become a cornerstone of modern healthcare, significantly improving quality and safety across clinical practice, public health, and medical research. Originating in the mid-to-late 20th century, DHT...

» Design of a lateral flow assay targeting the conserved NIID_2019-nCoV_N gene region for molecular viral diagnosis
14/10/25 20:00 from coronavirus
SARS-CoV-2, the causative agent of the COVID-19 pandemic, remains a significant threat to global public health. Therefore, rapid and accurate detection of the virus continues to be of critical importance. Among the specific gene regions ...

» Factors associated with nursing workload in patients undergoing extracorporeal membrane oxygenation: a retrospective cohort study
14/10/25 20:00 from covid-19
Nursing workload is high with patients undergoing extracorporeal membrane oxygenation. The initial 24 hours of extracorporeal membrane oxygenation have the highest workload, quantified using the Nursing Activities Score. Presence of COVI...

» Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
14/10/25 20:00 from covid-19
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have...

» Factors associated with nursing workload in patients undergoing extracorporeal membrane oxygenation: a retrospective cohort study
14/10/25 20:00 from coronavirus
Nursing workload is high with patients undergoing extracorporeal membrane oxygenation. The initial 24 hours of extracorporeal membrane oxygenation have the highest workload, quantified using the Nursing Activities Score. Presence of COVI...

» Identification of COVID-19 susceptibility genes by Mendelian randomization
14/10/25 20:00 from covid-19
ObjectiveWe applied Mendelian Randomization (MR) to investigate potential genetic targets involved in the pathogenesis of COVID-19, aiming to identify causal factors that may contribute to disease susceptibility and severity.MethodsWe ag...

» Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
14/10/25 20:00 from coronavirus
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have...

» Topology across scales on heterogeneous cell data
14/10/25 20:00 from covid-19
Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides...

» Impact of the COVID-19 pandemic on computational biology early career researchers: A global retrospective study
14/10/25 20:00 from covid-19
The COVID-19 pandemic led to devastating physical, psychological, and financial impacts on millions of people across the world. Amidst a rapidly evolving research landscape, the global scientific community was forced to swiftly adapt to ...

» Identification of COVID-19 susceptibility genes by Mendelian randomization
14/10/25 20:00 from coronavirus
ObjectiveWe applied Mendelian Randomization (MR) to investigate potential genetic targets involved in the pathogenesis of COVID-19, aiming to identify causal factors that may contribute to disease susceptibility and severity.MethodsWe ag...

» A multi-disciplinary approach to identify spillover interfaces of bat coronaviruses to pig farms in Italy
14/10/25 20:00 from covid-19
Bats are recognized reservoirs of diverse coronaviruses (CoVs), but little is known about the pathways enabling their spillover into livestock. This study applied a multidisciplinary approach, combining bioacoustic surveys, landscape ana...

» Topology across scales on heterogeneous cell data
14/10/25 20:00 from coronavirus
Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides...

» Leaving the health workforce during the COVID-19 pandemic: A cross-sectional study among Filipino healthcare workers
14/10/25 20:00 from covid-19
The COVID-19 pandemic exacerbated the shortage of healthcare workers (HCWs), particularly in low- and middle-income countries. This cross-sectional descriptive study aimed to examine why hospital-based HCWs in the Philippines quit from t...

» Return-to-work for people living with long COVID: A scoping review of interventions and recommendations
14/10/25 20:00 from covid-19
CONCLUSION: Many uncertainties remain regarding which RTW interventions are effective or the optimal characteristics of these interventions.

» Impact of the COVID-19 pandemic on computational biology early career researchers: A global retrospective study
14/10/25 20:00 from coronavirus
The COVID-19 pandemic led to devastating physical, psychological, and financial impacts on millions of people across the world. Amidst a rapidly evolving research landscape, the global scientific community was forced to swiftly adapt to ...

» A multi-disciplinary approach to identify spillover interfaces of bat coronaviruses to pig farms in Italy
14/10/25 20:00 from coronavirus
Bats are recognized reservoirs of diverse coronaviruses (CoVs), but little is known about the pathways enabling their spillover into livestock. This study applied a multidisciplinary approach, combining bioacoustic surveys, landscape ana...

» Who gets sicker and why? Parents' perceptions of COVID-19 disparities and how they would explain them to their children
14/10/25 20:00 from covid-19
The COVID-19 pandemic revealed substantial health disparities, disproportionately impacting Black individuals, individuals of lower socioeconomic status, and older adults in the US. Little is known as to whether and how adults discuss th...

» Return-to-work for people living with long COVID: A scoping review of interventions and recommendations
14/10/25 20:00 from coronavirus
CONCLUSION: Many uncertainties remain regarding which RTW interventions are effective or the optimal characteristics of these interventions.

» Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
14/10/25 20:00 from covid-19
SARS-CoV-2 continues to evolve, causing waves of infections. It is critical to understand the features of the virus that explain its growth advantages. Recently, SARS-CoV-2 Omicron JN.1 subvariants KP.3.1.1 and XEC were outcompeted by LP...

» Who gets sicker and why? Parents' perceptions of COVID-19 disparities and how they would explain them to their children
14/10/25 20:00 from coronavirus
The COVID-19 pandemic revealed substantial health disparities, disproportionately impacting Black individuals, individuals of lower socioeconomic status, and older adults in the US. Little is known as to whether and how adults discuss th...

» COVID-19 Booster Vaccine Messaging in Emergency Departments: A Cluster Randomized Clinical Trial
14/10/25 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial of adult ED patients, tailored messaging and simple inquiry alone did not significantly increase 30-day updated COVID-19 vaccine uptake among patients. The slight incre...

» Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions
14/10/25 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this cross-sectional study, there was a significant reduction in serum antibodies to S pyogenes and RSV in children aged 3 to 4 years after introduction of NPIs. Equivalent to approximately a 1-year delay in...

» First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies
14/10/25 20:00 from coronavirus
CONCLUSIONS AND RELEVANCE: In this cohort study of pregnancies exposed to mRNA COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any MCMs, overall, by organ group, or by individual MCM, suppo...

» The impact of the timing of PRRSV and swine enteric coronaviruses introduction on wean-to-market productivity
14/10/25 20:00 from Coronavirus origins
PRRSV and SeCoV can significantly decrease the productivity of growing pigs by increasing mortality rates and decreasing growth, resulting in economic losses for swine producers. A better understanding of how infection patterns of these ...

» Digital health: current applications, challenges, and future directions for enhancing healthcare quality and safety
14/10/25 20:00 from Coronavirus origins
Digital Health Technologies (DHTs) have become a cornerstone of modern healthcare, significantly improving quality and safety across clinical practice, public health, and medical research. Originating in the mid-to-late 20th century, DHT...

» Immunological Mechanisms Underlying Allergy Predisposition After SARS-CoV-2 Infection in Children
14/10/25 20:00 from Cell entry mechanisms of SARS-CoV-2
As the pediatric COVID-19 landscape evolves, it is essential to evaluate whether SARS-CoV-2 infection predisposes children to allergic disorders. This narrative review synthesizes current epidemiological and immunological evidence linkin...

» First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS AND RELEVANCE: In this cohort study of pregnancies exposed to mRNA COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any MCMs, overall, by organ group, or by individual MCM, suppo...

» Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: In the study period of 2022, infection with SARS-CoV-2, in most cases with the Omicron variant, during or up to six months prior to a pregnancy following assisted reproduction did not significantly affect the risk of maternal...

» Does Prenatal SARS-CoV-2 Infection Exacerbate Postpartum Lower Urinary Tract Symptoms? A Multicenter Retrospective Cohort Study
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Prenatal SARS-CoV-2 infection was not significantly associated with an increased risk of postpartum LUTS but independently altered pelvic floor muscle electromyographic activity, suggesting potential neuromuscular effects.

» Impact of the COVID-19 pandemic on fasting blood glucose and HbA1c levels in Lebanon: An observational analysis by age and gender
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The impact of COVID-19 pandemic on diabetes management and control is controversial and has never been studied in Middle Eastern countries. The aim of this study is to assess recent trends in HbA1c and fasting blood glucose (FBG) in Leba...

» A multi-disciplinary approach to identify spillover interfaces of bat coronaviruses to pig farms in Italy
14/10/25 20:00 from covid-19 and viral infections in pigs
Bats are recognized reservoirs of diverse coronaviruses (CoVs), but little is known about the pathways enabling their spillover into livestock. This study applied a multidisciplinary approach, combining bioacoustic surveys, landscape ana...

» Comparison of clinical characteristics and analysis of prognostic factors in patients with severe pneumonia infected with influenza A and COVID-19: A single-center case-control study
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The objective was to study the clinical characteristics and prognostic factors of patients with severe pneumonia combined with COVID-19 and influenza A (IFV-A). We retrospectively collected the diagnostic and treatment data of 170 patien...

» Triazolo pyrimidine derivatives of coumarin and benzocoumarin: green synthesis, biological activity screening study with in silico evaluation
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
In the current study, triazolo pyrimidine coumarin and benzocoumarin derivatives were prepared using green methods as a fast and cost-efficient strategy in comparison with the traditional method in terms of reaction time and yield. Combi...

» Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
14/10/25 20:00 from sars-cov-2 spike protein
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have...

» Digital health: current applications, challenges, and future directions for enhancing healthcare quality and safety
14/10/25 20:00 from Covid-19 origins
Digital Health Technologies (DHTs) have become a cornerstone of modern healthcare, significantly improving quality and safety across clinical practice, public health, and medical research. Originating in the mid-to-late 20th century, DHT...

» Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis
14/10/25 20:00 from sars-cov-2
Orphan genes, which encode species-specific proteins, are common but are rarely investigated. The SARS-CoV-2 orphan gene, ORF10, has been understudied; in vitro work suggests it may modulate innate immunity. Whether ORF10 influences COVI...

» Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active haematological diseases undergoing combined antiviral treatments
14/10/25 20:00 from sars-cov-2
CONCLUSIONS: Combination regimens for SARS-CoV-2 did not affect the time to restart haematological therapy, whereas the occurrence of pneumonia was associated with delayed resumption of chemotherapy. The real benefit of COVID-19 combinat...

» Machine Learning Models for Differentiating Causes of Dyspnea in Emergency Department Patients: A Retrospective Study
14/10/25 20:00 from Covid-19 origins
CONCLUSION: ML algorithms show promise in supporting triage by distinguishing broad etiological categories of dyspnea, such as respiratory versus cardiac origins. While the models demonstrate useful classification performance, their limi...

» Design of a lateral flow assay targeting the conserved NIID_2019-nCoV_N gene region for molecular viral diagnosis
14/10/25 20:00 from sars-cov-2
SARS-CoV-2, the causative agent of the COVID-19 pandemic, remains a significant threat to global public health. Therefore, rapid and accurate detection of the virus continues to be of critical importance. Among the specific gene regions ...

» COVID-19 Vaccine Effectiveness in Patients with Hematologic Malignancies: a Nationwide Cohort Study
14/10/25 20:00 from sars-cov-2
CONCLUSIONS: COVID-19 vaccination lowered the risk of severe COVID-19 in SARS-CoV-2-infected patients with hematologic malignancies, although these patients remained at elevated risk compared to others. Determinants of severe COVID-19 in...

» Factors associated with nursing workload in patients undergoing extracorporeal membrane oxygenation: a retrospective cohort study
14/10/25 20:00 from sars-cov-2
Nursing workload is high with patients undergoing extracorporeal membrane oxygenation. The initial 24 hours of extracorporeal membrane oxygenation have the highest workload, quantified using the Nursing Activities Score. Presence of COVI...

» Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
14/10/25 20:00 from sars-cov-2
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have...

» Identification of COVID-19 susceptibility genes by Mendelian randomization
14/10/25 20:00 from sars-cov-2
ObjectiveWe applied Mendelian Randomization (MR) to investigate potential genetic targets involved in the pathogenesis of COVID-19, aiming to identify causal factors that may contribute to disease susceptibility and severity.MethodsWe ag...

» Topology across scales on heterogeneous cell data
14/10/25 20:00 from sars-cov-2
Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides...

» Impact of the COVID-19 pandemic on computational biology early career researchers: A global retrospective study
14/10/25 20:00 from sars-cov-2
The COVID-19 pandemic led to devastating physical, psychological, and financial impacts on millions of people across the world. Amidst a rapidly evolving research landscape, the global scientific community was forced to swiftly adapt to ...

» Return-to-work for people living with long COVID: A scoping review of interventions and recommendations
14/10/25 20:00 from sars-cov-2
CONCLUSION: Many uncertainties remain regarding which RTW interventions are effective or the optimal characteristics of these interventions.

» Who gets sicker and why? Parents' perceptions of COVID-19 disparities and how they would explain them to their children
14/10/25 20:00 from sars-cov-2
The COVID-19 pandemic revealed substantial health disparities, disproportionately impacting Black individuals, individuals of lower socioeconomic status, and older adults in the US. Little is known as to whether and how adults discuss th...

» Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
14/10/25 20:00 from sars-cov-2
SARS-CoV-2 continues to evolve, causing waves of infections. It is critical to understand the features of the virus that explain its growth advantages. Recently, SARS-CoV-2 Omicron JN.1 subvariants KP.3.1.1 and XEC were outcompeted by LP...

» Nanostructured Biosensors with Ultra-Low Detection Limit and High Selectivity for Real-Time and Continuous Sewage Monitoring
14/10/25 20:00 from sars-cov-2
Wastewater-Based Epidemiology (WBE) has emerged as a powerful tool for rapid monitoring and forecasting community health trends. However, conventional WBE relies on real-time polymerase chain reaction (RT-PCR) techniques, which are relia...

» COVID-19 Booster Vaccine Messaging in Emergency Departments: A Cluster Randomized Clinical Trial
14/10/25 20:00 from sars-cov-2
CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial of adult ED patients, tailored messaging and simple inquiry alone did not significantly increase 30-day updated COVID-19 vaccine uptake among patients. The slight incre...

» Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions
14/10/25 20:00 from sars-cov-2
CONCLUSIONS AND RELEVANCE: In this cross-sectional study, there was a significant reduction in serum antibodies to S pyogenes and RSV in children aged 3 to 4 years after introduction of NPIs. Equivalent to approximately a 1-year delay in...

» The establishment of a universal standard for both viral antigen and nucleid acid detection based on digital PCR
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: We established and validated a BPL-inactivated universal national standard specifically designed to overcome the difficulties in quantifying antigen and enabling direct sensitivity comparison between SARS-CoV-2 Ag-RDTs and NA...

» Alterations of the amygdala in post-COVID olfactory dysfunction
14/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Olfactory dysfunction (OD) as a symptom of COVID-19 has received significant attention in research due to its high prevalence. While it is transient in the majority of individuals, post-COVID OD persists in a notable subset of patients e...

» Explainable Machine Learning Framework for Dynamic Monitoring of Disease Prognostic Risk: Retrospective Cohort Study
13/10/25 20:00 from coronavirus
CONCLUSIONS: Integrating static admission triage with daily, explainable RSF predictions enables early identification of patients with COVID-19 at high risk of deterioration. By surfacing phase-specific, actionable predictors, the framew...

» Determination of Potential Inhibitors against Mycobacterium tuberculosis, Staphylococcus aureus, and Helicobacter pylori Shikimate Dehydrogenase by using Virtual Screening
13/10/25 20:00 from coronavirus
Drug development is expensive and time-consuming, and current efforts to lower the process's financial and temporal costs rely increasingly on computational methodologies. Specifically, during emergencies such as the coronavirus 2019 pan...

» Boswellic acid derived molecules as SARS-CoV-2 spike protein inhibitors: A comprehensive virtual screening, triplicate molecular dynamic simulation and biochemical validation
13/10/25 20:00 from coronavirus
CONCLUSION: The current findings suggest that compounds C3 and C6 effectively disrupt the function of RBD of SARS-CoV-2 spike protein and can serve as potential drug candidates for spike protein.

» Mental health symptoms and associated factors for general population at the stable, recurrence, and end-of-emergency stages of the COVID-19 pandemic: a repeated national cross-sectional study
13/10/25 20:00 from coronavirus
CONCLUSIONS: Mental health symptoms increased when pandemic recurred, and could remain after end-of-emergency, requiring prolonged interventions. Several key factors associated with mental symptoms and their variations were identified at...

» Sensitivity to change of the COVID-19 anxiety syndrome scale among Canadian dentists
13/10/25 20:00 from coronavirus
CONCLUSION: The C-19ASS is sensitive to change over time and with external anxiety stimuli. COVID-19 related anxiety among dentists was associated with age, sex and practice type.

» Traffic-driven spatio-temporal prediction for fine-scale epidemic outbreaks in China
13/10/25 20:00 from coronavirus
CONCLUSIONS: Our proposed approach integrates transportation patterns and human mobility into edge weight calculations to enhance spatial connectivity. This post-lockdown simulation across cities in China offers a fine-grained analytical...

» SARS-CoV-2 vaccination and plasma levels of psychotropic agents: a prospective cohort study
13/10/25 20:00 from coronavirus
CONCLUSION: SARS-CoV-2 vaccination was not associated with essential alterations of psychotropic drugs levels. Observed CRP increases did not reach concentrations that may be associated with elevated drug levels. Nevertheless, monitoring...

» Wastewater-Based Tracking SARS-CoV-2 RNA and Estimating Infected Population in Industrial Setting After Songkran Festival-Thailand Traditional New Year in 2023
13/10/25 20:00 from coronavirus
Monitoring SARS-CoV-2 RNA in industrial wastewater has emerged as a potential approach to indirectly identify infected individuals within workplace populations. However, wastewater-based surveillance of SARS-CoV-2 in industrial settings ...

» Scaled-up non-thermal plasma-generating device Plasmatico enables effective and harmless disinfection of personal protective equipment
13/10/25 20:00 from coronavirus
The COVID-19 pandemic highlighted the urgent need to find effective methods for disinfecting items such as personal protective equipment (PPE) in case a similar situation occurs in the future. To address this problem, we selected FFP2 ma...

» Risk of Stroke in COVID-19 Survivors With Asthma: A Nationwide, Population-Based Cohort Study
13/10/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: This study highlights a significant association between severe COVID-19 and stroke occurrence in adults with asthma, emphasizing the need for ongoing stroke monitoring to improve long-term asthma outcomes during the COVID-19 ...

» The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities
13/10/25 20:00 from sars-cov-2 spike protein
Angiotensin-converting enzyme 2 (ACE2), a key regulator of the renin-angiotensin system (RAS), maintains central nervous system (CNS) homeostasis by metabolizing neuroinflammatory peptides like angiotensin II (Ang II) and apelin-13, ther...

» Immune antibodies recognizing the stem region of SARS-CoV-2 spike protein: Molecular modeling and in vitro study of synthetic peptides presentation to the antibodies
13/10/25 20:00 from sars-cov-2 spike protein
Antibodies to peptide 1147 (amino acids 1147-61) of the SARS-CoV-2 S protein are highly diagnostic. Peptide 1147, although located in a region that is partly spatially hidden in the intact protein, is not subject to mutations, suggesting...

» Boswellic acid derived molecules as SARS-CoV-2 spike protein inhibitors: A comprehensive virtual screening, triplicate molecular dynamic simulation and biochemical validation
13/10/25 20:00 from sars-cov-2 spike protein
CONCLUSION: The current findings suggest that compounds C3 and C6 effectively disrupt the function of RBD of SARS-CoV-2 spike protein and can serve as potential drug candidates for spike protein.

» A comprehensive strategy for pandemic preparedness with neutralizing monoclonal antibodies
12/10/25 20:00 from sars-cov-2
The success of nucleic acid-based vaccines during the COVID-19 pandemic positioned these technologies at the forefront of global preparedness. A retrospective analysis, however, demonstrates that while vaccines play a central role, they ...

» Can past variants of SARS-CoV-2 predict the impact of future variants? Machine learning for early warning of US counties at risk
12/10/25 20:00 from sars-cov-2
In this paper, we determine whether machine learning (ML) models created using data from the novel SARS-CoV-2 Alpha variant can prospectively predict county-level incidence of emerging variants, validated using data of the Omicron varian...

» From infection to intervention: post-acute sequelae of SARS-CoV-2 infection and cardiovascular risk
12/10/25 20:00 from sars-cov-2
COVID is now a worldwide epidemic of non-communicable diseases. The symptoms, which impact several organs, might last for hours, weeks, or even months after the SARS-CoV-2 infection has ended. Electrocardiogram abnormalities (ECG), postu...

» Shifts in epidemic patterns and age dynamics of RSV, IFV, and SARS-CoV-2 in Chinese children following COVID-19 non-pharmaceutical intervention relaxation, 2017 - 2024
12/10/25 20:00 from sars-cov-2
CONCLUSIONS: The post-NPI era in China brought profound shifts in pediatric respiratory virus epidemiology, characterized by altered seasonality and age distribution for RSV and IFV, and a distinct sequential pattern for SARS-CoV-2. Thes...

» Impacts of adipokines in the development and consequence of COVID-19-associated mucormycosis
12/10/25 20:00 from sars-cov-2
Adipokines play fundamental roles in regulating inflammatory responses. Patients with COVID-19 and mucormycosis suffer from inflammatory responses leading to immune dysregulation. This study therefore focused on clarifying whether visfat...

» Multiplex and Spatiotemporal Detection of Single-Cell Antibody Secretions Using Protein-Patterned Microwells
12/10/25 20:00 from sars-cov-2
Antibodies (Abs) are pivotal components in a myriad of applications including therapeutics and diagnostics. To discover novel target-specific Abs, screening and isolating Ab-expressing cells have proven to be an interesting route. Nevert...

» Reaching Consensus on Long COVID Symptoms and Patient-Reported Outcomes Across the Veterans Health Administration Using a Modified Hybrid Nominal Group-Delphi Approach
12/10/25 20:00 from sars-cov-2
CONCLUSIONS: A structured, rapid consensus process was used to identify a battery of symptom instruments to standardize Long COVID symptom assessment across VHA clinics.

» Retraction: Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assays
12/10/25 20:00 from sars-cov-2
Retraction of 'Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assays' by Shannon L. Faley et al., Lab Ch...

» Treatment of Shoulder Pain After COVID Vaccination - How it is Done Under Ultrasound Guidance!
12/10/25 20:00 from covid-19
No abstract

» Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants
12/10/25 20:00 from sars-cov-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains a threat to human health, particularly among immunocompromised and elderly individuals, given their heightened vulnerability to coronavirus disease 2019 (COVI...

» Shifts in epidemic patterns and age dynamics of RSV, IFV, and SARS-CoV-2 in Chinese children following COVID-19 non-pharmaceutical intervention relaxation, 2017 - 2024
12/10/25 20:00 from coronavirus
CONCLUSIONS: The post-NPI era in China brought profound shifts in pediatric respiratory virus epidemiology, characterized by altered seasonality and age distribution for RSV and IFV, and a distinct sequential pattern for SARS-CoV-2. Thes...

» Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants
12/10/25 20:00 from sars-cov-2
SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here, we use pseudovirus-based deep mutational scanning to measure how mutations to th...

» Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID-19 Mucosal Vaccine
12/10/25 20:00 from sars-cov-2
The COVID-19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically comp...

» Impacts of adipokines in the development and consequence of COVID-19-associated mucormycosis
12/10/25 20:00 from coronavirus
Adipokines play fundamental roles in regulating inflammatory responses. Patients with COVID-19 and mucormycosis suffer from inflammatory responses leading to immune dysregulation. This study therefore focused on clarifying whether visfat...

» A comprehensive strategy for pandemic preparedness with neutralizing monoclonal antibodies
12/10/25 20:00 from covid-19
The success of nucleic acid-based vaccines during the COVID-19 pandemic positioned these technologies at the forefront of global preparedness. A retrospective analysis, however, demonstrates that while vaccines play a central role, they ...

» Vaccine-Induced and Hybrid Immunity Against SARS-CoV-2 Variants of Concern in Two Cohorts in Queensland, Australia (2021-2022)
12/10/25 20:00 from sars-cov-2
The spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for vaccine development, as antibodies generated against the spike protein are the most immunodominant and neutralizing against the...

» Reaching Consensus on Long COVID Symptoms and Patient-Reported Outcomes Across the Veterans Health Administration Using a Modified Hybrid Nominal Group-Delphi Approach
12/10/25 20:00 from coronavirus
CONCLUSIONS: A structured, rapid consensus process was used to identify a battery of symptom instruments to standardize Long COVID symptom assessment across VHA clinics.

» Insights Into School-Based Physical Activity Implementation Strategies During the COVID-19 Pandemic: A Thematic Analysis
12/10/25 20:00 from covid-19
CONCLUSION: These findings provide insight into how schools created PA opportunities for students amid COVID-19 pandemic restrictions. Emergency preparedness plans may incorporate flexible PA programming and further develop infrastructur...

» Physicochemical Tuning of Bispecific Antibody Fragment Immobilization for Robust Digital SERS Biosensing
12/10/25 20:00 from sars-cov-2
Surface-enhanced Raman scattering (SERS) biosensing platforms offer exceptional sensitivity and multiplexing capabilities for biomarker detection, but their performance is often limited by uncontrolled ligand orientation on nanotags. To ...

» Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants
12/10/25 20:00 from coronavirus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains a threat to human health, particularly among immunocompromised and elderly individuals, given their heightened vulnerability to coronavirus disease 2019 (COVI...

» Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID-19 Mucosal Vaccine
12/10/25 20:00 from coronavirus
The COVID-19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically comp...

» Can past variants of SARS-CoV-2 predict the impact of future variants? Machine learning for early warning of US counties at risk
12/10/25 20:00 from covid-19
In this paper, we determine whether machine learning (ML) models created using data from the novel SARS-CoV-2 Alpha variant can prospectively predict county-level incidence of emerging variants, validated using data of the Omicron varian...

» Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library
12/10/25 20:00 from sars-cov-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten global health. This underpins the need for novel therapeutics against this virus. Nonstructural protein 1 (Nsp1) of SARS-CoV-2 is a multifunctional protei...

» Vaccine-Induced and Hybrid Immunity Against SARS-CoV-2 Variants of Concern in Two Cohorts in Queensland, Australia (2021-2022)
12/10/25 20:00 from coronavirus
The spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for vaccine development, as antibodies generated against the spike protein are the most immunodominant and neutralizing against the...

» Causal networks guiding large language models: application to COVID-19
12/10/25 20:00 from covid-19
In the context of diagnosis of COVID-19, this paper shows how to convert a Causal Network to a Large Language Model (LLM). The Causal Network was converted to the language model using prompts and completions. Prompts were composed from t...

» Burden of chronic diseases in migrant workers (MW) in Singapore and impact on COVID-19: A large single-centre cohort study during the peak MW 2020 outbreak
12/10/25 20:00 from Covid-19 origins
CONCLUSIONS: Although MWs had favourable COVID-19 medical outcomes during their acute illness, our study demonstrates a considerable burden of undiagnosed chronic diseases predisposing to cardiovascular disease and highlights health disp...

» Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library
12/10/25 20:00 from coronavirus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten global health. This underpins the need for novel therapeutics against this virus. Nonstructural protein 1 (Nsp1) of SARS-CoV-2 is a multifunctional protei...

» The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies
12/10/25 20:00 from sars-cov-2
CONCLUSIONS: The overall mean liver parameter values were not altered compared to physiological values, except for GGTP, lactate dehydrogenase activity, and INR values. In the case of AST, ALT and albumin levels, mean point estimates wer...

» Glucose-6-phosphatase catalytic subunit 3 enhances host resistance to porcine epidemic diarrhea virus through regulating glycolysis/gluconeogenesis
12/10/25 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) causes a highly contagious disease in pigs, and the intricacies of its host-pathogen interactions require further elucidation. Chinese Min piglets, known for their superior resistance to stress and ...

» From infection to intervention: post-acute sequelae of SARS-CoV-2 infection and cardiovascular risk
12/10/25 20:00 from covid-19
COVID is now a worldwide epidemic of non-communicable diseases. The symptoms, which impact several organs, might last for hours, weeks, or even months after the SARS-CoV-2 infection has ended. Electrocardiogram abnormalities (ECG), postu...

» Exploring Spatially Varying Associations of COVID-19 Rates with Contextual Socioeconomic, Health, and Environmental Factors under Partial Population Coverage of Vaccination: A Retrospective Ecological Study in Georgia, USA
12/10/25 20:00 from covid-19
A good understanding of the associations of COVID-19 infection and mortality with contextual factors when vaccines were not widely available is necessary for human societies to be better prepared for future outbreaks of infectious diseas...

» Guided sparse decomposition with anisotropic fusion for medical image enhancement
12/10/25 20:00 from coronavirus
CONCLUSIONS: The proposed GSDAF effectively enhances medical images while preserving critical structural details. GSDAF addresses the limitations of traditional enhancement techniques. Our findings suggest that this approach can signific...

» The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies
12/10/25 20:00 from coronavirus
CONCLUSIONS: The overall mean liver parameter values were not altered compared to physiological values, except for GGTP, lactate dehydrogenase activity, and INR values. In the case of AST, ALT and albumin levels, mean point estimates wer...

» Social Skills as a Predictor of Mental Health Trajectories among Autistic Youth and Youth with ADHD during the COVID-19 Pandemic
12/10/25 20:00 from covid-19
Neurodiverse youth face increased mental health risks, which may make them particularly vulnerable to the effects of the pandemic. Given high rates of co-occurrence between autism and attention-deficit/hyperactivity disorder (ADHD), it i...

» Longitudinal associations between the COVID-19 pandemic and sleep characteristics in children and parents
12/10/25 20:00 from coronavirus
INTRODUCTION: The COVID-19 pandemic and associated preventive measures influenced family health and behavior, leading to diverse effects on sleep.

» Neurological Adverse Events from COVID-19 Vaccination and It's Associated Factors in Burkina Faso: Analysis of Spontaneous Reports from the National Database of Pharmacovigilance from 2021 to 2023
12/10/25 20:00 from covid-19
CONCLUSION: Neurological adverse events after COVID-19 immunisation were frequent and benign among spontaneous notifications. Headache was the most common neurological adverse effect of COVID-19 vaccines. Serious side effects were more f...

» Prevalence of post COVID-19 condition and associations with risk factors among U.S. adults: 2023 Behavioral Risk Factor Surveillance System
12/10/25 20:00 from coronavirus
INTRODUCTION: During the COVID-19 pandemic, between 12 and 20% of US adults were identified as having post-COVID-19 condition, commonly referred to as 'Long COVID'. These individuals maintained symptoms of COVID-19 for 3 months or longer...

» Automated quantitative chest CT for mortality prediction in COVID-19 patients in a resource-limited emergency setting in Gaza: a retrospective study using LungCTAnalyzer
12/10/25 20:00 from covid-19
CONCLUSION: Automated quantitative chest CT provides objective, reproducible metrics for early mortality risk stratification in COVID-19 pneumonia. The use of open-source tools like LungCTAnalyzer may assist emergency radiologists in pri...

» The Impact of the COVID-19 Pandemic on a Nuclear Medicine Department in Riyadh, Saudi Arabia
12/10/25 20:00 from coronavirus
INTRODUCTION: The Coronavirus disease (COVID-19) pandemic which is an infectious disease caused by the SARS-CoV-2 virus had a profound impact on healthcare services worldwide, including the field of nuclear medicine. Understanding these ...

» Shifts in epidemic patterns and age dynamics of RSV, IFV, and SARS-CoV-2 in Chinese children following COVID-19 non-pharmaceutical intervention relaxation, 2017 - 2024
12/10/25 20:00 from covid-19
CONCLUSIONS: The post-NPI era in China brought profound shifts in pediatric respiratory virus epidemiology, characterized by altered seasonality and age distribution for RSV and IFV, and a distinct sequential pattern for SARS-CoV-2. Thes...

» Adapted Physical Activity Protocol Improves Health-Related Quality of Life and Psychological Outcomes in Long COVID: A Prospective Longitudinal Study
12/10/25 20:00 from coronavirus
CONCLUSION: The APA protocol showed significant short- and medium-term improvements in HRQOL and psychological outcomes in long COVID patients. Benefits were more pronounced for physical symptoms and anxiety than for depression. These fi...

» Increasing Retention in a Large-Scale Decentralized Clinical Trial: Learnings From the COVID-RED Trial
12/10/25 20:00 from coronavirus
CONCLUSION: This study describes how innovative and targeted data-driven retention strategies can be applied in a large decentralized clinical trial and presents the implemented retention strategies and discontinuation rates. Results can...

» Impacts of adipokines in the development and consequence of COVID-19-associated mucormycosis
12/10/25 20:00 from covid-19
Adipokines play fundamental roles in regulating inflammatory responses. Patients with COVID-19 and mucormycosis suffer from inflammatory responses leading to immune dysregulation. This study therefore focused on clarifying whether visfat...

» Post-Pandemic Prevalence of Urinary Incontinence Among Women in the United States and Associated Risk Factors
12/10/25 20:00 from covid-19
CONCLUSION: Urinary incontinence remains prevalent and symptomatically burdensome among US women. Age-specific risk profiles underscore the importance of tailored screening and management. Addressing functional and mental health, as well...

» Multiplex and Spatiotemporal Detection of Single-Cell Antibody Secretions Using Protein-Patterned Microwells
12/10/25 20:00 from covid-19
Antibodies (Abs) are pivotal components in a myriad of applications including therapeutics and diagnostics. To discover novel target-specific Abs, screening and isolating Ab-expressing cells have proven to be an interesting route. Nevert...

» Reaching Consensus on Long COVID Symptoms and Patient-Reported Outcomes Across the Veterans Health Administration Using a Modified Hybrid Nominal Group-Delphi Approach
12/10/25 20:00 from covid-19
CONCLUSIONS: A structured, rapid consensus process was used to identify a battery of symptom instruments to standardize Long COVID symptom assessment across VHA clinics.

» Vaccine-Induced and Hybrid Immunity Against SARS-CoV-2 Variants of Concern in Two Cohorts in Queensland, Australia (2021-2022)
12/10/25 20:00 from sars-cov-2 spike protein
The spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for vaccine development, as antibodies generated against the spike protein are the most immunodominant and neutralizing against the...

» Impact of chemotherapy on humoral and cellular immune responses to COVID-19 vaccination in patients with solid tumors
12/10/25 20:00 from sars-cov-2 spike protein
INTRODUCTION: Despite SARS-CoV-2 pandemic has subsided, vaccine response profiling in patients with cancer remains critical.

» Patient and donor antibody profiles in early COVID-19 convalescent plasma therapy in the COnV-ert trial
12/10/25 20:00 from sars-cov-2 spike protein
INTRODUCTION: The negative efficacy results of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) as early treatment in the COnV-ert trial have been attributed to the use of methylene blue (MB). We characterized immune respons...

» How the Universal MSA52 Aptamer Recognizes the SARS-CoV-2 Spike Protein
12/10/25 20:00 from sars-cov-2 spike protein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the COVID-19 pandemic. The prominent characteristic of SARS-CoV-2 is the use of a trimeric spike (S) glycoprotein to invade the host cell; there...

» Glucose-6-phosphatase catalytic subunit 3 enhances host resistance to porcine epidemic diarrhea virus through regulating glycolysis/gluconeogenesis
12/10/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) causes a highly contagious disease in pigs, and the intricacies of its host-pathogen interactions require further elucidation. Chinese Min piglets, known for their superior resistance to stress and ...

» Immunogenicity of single-chain antibodies: germlining of a VHH lowers T-cell activation from epitopes in FR2 and CDR regions
12/10/25 20:00 from sars-cov-2 spike protein
Single-chain antibodies (scAbs), derived from camelid antibodies, have gained attention as therapeutic candidates due to their small size and perceived low immunogenicity, but recent studies have reported immune responses to several scAb...

» Mechanism by which porcine transmissible gastroenteritis virus disrupts host innate immunity
12/10/25 20:00 from covid-19 and viral infections in pigs
Innate immune evasion is a critical aspect of viral infections, as it disrupts the host's defense mechanisms.The innate immune system, as the primary defense against pathogens, detects pathogen-associated molecular patterns (PAMPs) via p...

» Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study
12/10/25 20:00 from sars-cov-2
AimAcute respiratory infections caused by viral pathogens are the most common reason for hospitalization of children. Annually, 150 million infants worldwide are diagnosed with bronchiolitis, and 2-3% of them are hospitalized. This study...

» Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study
12/10/25 20:00 from coronavirus
AimAcute respiratory infections caused by viral pathogens are the most common reason for hospitalization of children. Annually, 150 million infants worldwide are diagnosed with bronchiolitis, and 2-3% of them are hospitalized. This study...

» EFFECTIVENESS OF INCENTIVES ON STI TESTING UPTAKE: A TRIAL AMONG ABORIGINAL AND TORRES STRAIT ISLANDER YOUNG PEOPLE IN REMOTE CENTRAL AUSTRALIA (2015-2020)
12/10/25 20:00 from covid-19
CONCLUSIONS: The limited impact of incentives could be explained by low coverage, or that the incentive was not motivating enough to overcome STI testing barriers. Future studies should investigate alternative methods of increasing STI t...

» The unreliability of estimated release dates in hospital drug shortage management: A case study of hospital pharmacy operations during the COVID-19 pandemic
12/10/25 20:00 from coronavirus
Drug shortages are prominent, persistent operational challenges that hospital pharmacies have been facing for years. During a drug shortage, hospital pharmacists must solve the problem of how best to invest resources to mitigate the effe...

» Enhancing antibody-antigen interaction prediction with atomic flexibility
12/10/25 20:00 from sars-cov-2
Antibodies are indispensable components of the immune system, known for their specific binding to antigens. Beyond their natural immunological functions, they are fundamental in developing vaccines and therapeutic interventions for infec...

» Immunogenicity and safety of DS-5670d, an omicron XBB.1.5-targeting COVID-19 mRNA vaccine: A phase 3, randomized, active-controlled study
12/10/25 20:00 from coronavirus
CONCLUSIONS: A single dose of DS-5670d was immunogenically non-inferior to BNT162b2 and acceptably safe in persons with or without a history of prior infection and/or vaccination. Trial registration Japan Registry of Clinical Trials (jRC...

» The unreliability of estimated release dates in hospital drug shortage management: A case study of hospital pharmacy operations during the COVID-19 pandemic
12/10/25 20:00 from sars-cov-2
Drug shortages are prominent, persistent operational challenges that hospital pharmacies have been facing for years. During a drug shortage, hospital pharmacists must solve the problem of how best to invest resources to mitigate the effe...

» Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
12/10/25 20:00 from coronavirus
A pharmacophore defines the spatial arrangement of molecular features required for optimal interactions between a compound and its biological target. These models can be derived by analyzing the intermolecular interactions between a targ...

» Immunogenicity and safety of DS-5670d, an omicron XBB.1.5-targeting COVID-19 mRNA vaccine: A phase 3, randomized, active-controlled study
12/10/25 20:00 from sars-cov-2
CONCLUSIONS: A single dose of DS-5670d was immunogenically non-inferior to BNT162b2 and acceptably safe in persons with or without a history of prior infection and/or vaccination. Trial registration Japan Registry of Clinical Trials (jRC...

» Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study
12/10/25 20:00 from covid-19
AimAcute respiratory infections caused by viral pathogens are the most common reason for hospitalization of children. Annually, 150 million infants worldwide are diagnosed with bronchiolitis, and 2-3% of them are hospitalized. This study...

» Safe autopsy procedures for COVID-19: Experience of one research center
12/10/25 20:00 from coronavirus
In the early days of the 2019 coronavirus disease (COVID-19) pandemic, there were few published guidelines for safely performing autopsies of infected individuals. To limit the risk to autopsy personnel, major changes to our autopsy prot...

» A comprehensive strategy for pandemic preparedness with neutralizing monoclonal antibodies
12/10/25 20:00 from coronavirus
The success of nucleic acid-based vaccines during the COVID-19 pandemic positioned these technologies at the forefront of global preparedness. A retrospective analysis, however, demonstrates that while vaccines play a central role, they ...

» Hepatic Arterial Infusion Pump Chemotherapy in Patients With Unresectable Intrahepatic Cholangiocarcinoma-PUMP-2 Trial
12/10/25 20:00 from covid-19
CONCLUSION: Combining HAIP chemotherapy with floxuridine and systemic gem-cis in patients with unresectable liver-confined iCCA had a 1- and 3-year OS superior to gem-cis alone in historical cohorts.

» Insights Into School-Based Physical Activity Implementation Strategies During the COVID-19 Pandemic: A Thematic Analysis
12/10/25 20:00 from coronavirus
CONCLUSION: These findings provide insight into how schools created PA opportunities for students amid COVID-19 pandemic restrictions. Emergency preparedness plans may incorporate flexible PA programming and further develop infrastructur...

» Healthcare renunciation among Italian older adults during the COVID-19 pandemic: insights from the PASSI d'Argento surveillance system
12/10/25 20:00 from covid-19
During the COVID-19 pandemic, a noticeable decrease in medical care utilization occurred which may contribute to increased morbidity and mortality rates associated with treatable conditions. In Italy, severely impacted by the pandemic, a...

» Enhancing antibody-antigen interaction prediction with atomic flexibility
12/10/25 20:00 from covid-19
Antibodies are indispensable components of the immune system, known for their specific binding to antigens. Beyond their natural immunological functions, they are fundamental in developing vaccines and therapeutic interventions for infec...

» Shifts in epidemic patterns and age dynamics of RSV, IFV, and SARS-CoV-2 in Chinese children following COVID-19 non-pharmaceutical intervention relaxation, 2017 - 2024
12/10/25 20:00 from coronavirus
CONCLUSIONS: The post-NPI era in China brought profound shifts in pediatric respiratory virus epidemiology, characterized by altered seasonality and age distribution for RSV and IFV, and a distinct sequential pattern for SARS-CoV-2. Thes...

» The unreliability of estimated release dates in hospital drug shortage management: A case study of hospital pharmacy operations during the COVID-19 pandemic
12/10/25 20:00 from covid-19
Drug shortages are prominent, persistent operational challenges that hospital pharmacies have been facing for years. During a drug shortage, hospital pharmacists must solve the problem of how best to invest resources to mitigate the effe...

» Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
12/10/25 20:00 from sars-cov-2
A pharmacophore defines the spatial arrangement of molecular features required for optimal interactions between a compound and its biological target. These models can be derived by analyzing the intermolecular interactions between a targ...

» Beyond alarmism: what Australia's influenza season really tells us about Italy
12/10/25 20:00 from sars-cov-2
The seasonality of influenza still poses a significant challenge to public health today, with different dynamics between the southern and northern hemispheres. In Europe and Italy, the arrival of winter is often accompanied by alarmist m...

» Safe autopsy procedures for COVID-19: Experience of one research center
12/10/25 20:00 from sars-cov-2
In the early days of the 2019 coronavirus disease (COVID-19) pandemic, there were few published guidelines for safely performing autopsies of infected individuals. To limit the risk to autopsy personnel, major changes to our autopsy prot...

» Glucose-6-phosphatase catalytic subunit 3 enhances host resistance to porcine epidemic diarrhea virus through regulating glycolysis/gluconeogenesis
12/10/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) causes a highly contagious disease in pigs, and the intricacies of its host-pathogen interactions require further elucidation. Chinese Min piglets, known for their superior resistance to stress and ...

» Insights Into School-Based Physical Activity Implementation Strategies During the COVID-19 Pandemic: A Thematic Analysis
12/10/25 20:00 from sars-cov-2
CONCLUSION: These findings provide insight into how schools created PA opportunities for students amid COVID-19 pandemic restrictions. Emergency preparedness plans may incorporate flexible PA programming and further develop infrastructur...

» Healthcare waste management practices and associated factors among healthcare workers in Sub-Saharan Africa: A systematic review and meta-analysis
12/10/25 20:00 from covid-19
CONCLUSIONS: This review showed that only half of the healthcare workers practiced good healthcare waste management practices. Sex of the healthcare workers, training status, use of working manuals/guidelines, knowledge towards healthcar...

» Reaching Consensus on Long COVID Symptoms and Patient-Reported Outcomes Across the Veterans Health Administration Using a Modified Hybrid Nominal Group-Delphi Approach
12/10/25 20:00 from coronavirus
CONCLUSIONS: A structured, rapid consensus process was used to identify a battery of symptom instruments to standardize Long COVID symptom assessment across VHA clinics.

» Immunogenicity and safety of DS-5670d, an omicron XBB.1.5-targeting COVID-19 mRNA vaccine: A phase 3, randomized, active-controlled study
12/10/25 20:00 from covid-19
CONCLUSIONS: A single dose of DS-5670d was immunogenically non-inferior to BNT162b2 and acceptably safe in persons with or without a history of prior infection and/or vaccination. Trial registration Japan Registry of Clinical Trials (jRC...

» Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
12/10/25 20:00 from covid-19
A pharmacophore defines the spatial arrangement of molecular features required for optimal interactions between a compound and its biological target. These models can be derived by analyzing the intermolecular interactions between a targ...