» Polyphosphate, Zn2+ and high molecular weight kininogen modulate individual reactions of the contact pathway of blood clotting
18/09/19 10:24 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» Ehlers-Danlos syndromes
18/09/19 08:45 from Latest headlines from BMJ
What you need to knowEhlers-Danlos syndromes (EDS) are inherited connective tissue disorders with variable severity; features include skin fragility, joint hypermobility, and rupture of blood vessels...

» Helen Salisbury: A hostile environment in the NHS
17/09/19 10:26 from Latest headlines from BMJ
A temporary resident recently attended our practice after coughing up blood. The likely cause was pneumonia, but tuberculosis and malignancy were on the list of differential diagnoses. My colleague...

» Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease
13/09/19 11:43 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Volume 0, Issue ja, -Not available-.

» Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL
12/09/19 16:00 from Blood current issue
Zanubrutinib is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK). In this first-in-human, open-label, multicenter, phase 1 study, patients in part 1 (3 + 3 dose escalation) had relapsed/refractory B-cell malignanci...

» Genomic landscape of neutrophilic leukemias of ambiguous diagnosis
12/09/19 16:00 from Blood current issue
Chronic neutrophilic leukemia (CNL), atypical chronic myeloid leukemia (aCML), and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are a group of rare and heterogeneous myeloid disorders. There is strong morpholo...

» Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients
12/09/19 16:00 from Blood current issue
Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability in hemophilia A patients. Although previous studies have determined that age, body mass index, von Willebrand factor antigen (VWF:Ag) levels, and ABO ...

» Posttransplant cyclophosphamide vs antithymocyte globulin in HLA-mismatched unrelated donor transplantation
12/09/19 16:00 from Blood current issue
The use of anti-thymocyte globulin (ATG) has represented the standard of care in graft-versus-host disease (GVHD) prophylaxis in patients undergoing a mismatched unrelated donor (MMUD) transplant. The safety and feasibility of posttransp...

» Martin P, Bartlett NL, Blum KA, et al. A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma. Blood. 2019;133(11):1201-1204.
12/09/19 16:00 from Blood current issue

» P2X1 ion channel deficiency causes massive bleeding in inflamed intestine and increases thrombosis
10/09/19 18:27 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding
10/09/19 16:40 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain
08/09/19 19:00 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» International Society on Thrombosis and Haemostasis core curriculum project: Core competencies in laboratory thrombosis and hemostasis
05/09/19 09:19 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» A non‐circulating pool of factor XI associated with glycosaminoglycans in mice
03/09/19 15:34 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Volume 17, Issue 9, Page 1449-1460, September 2019.

» Cell surface expression of HLA I molecules as a marker of young platelets
03/09/19 15:34 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Volume 17, Issue 9, Page 1511-1521, September 2019.

» Variability of von Willebrand factor‐related parameters in endothelial colony forming cells
03/09/19 15:34 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Volume 17, Issue 9, Page 1544-1554, September 2019.

» Sex matters: Practice 5P's when treating young women with venous thromboembolism
03/09/19 15:34 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Volume 17, Issue 9, Page 1417-1429, September 2019.

» A single‐domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor
03/09/19 08:44 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis
03/09/19 08:25 from Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, EarlyView.

» CD45 expression discriminates waves of embryonic megakaryocytes in the mouse
31/08/19 22:05 from Haematologica current issue
Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10...

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