Movie baddies | Wordsearch | Naming tumours | Halloween I’m an Arab/British screenwriter, and although I wholeheartedly agree with Ana Schnabl’s article ( Hollywood’s villains were once Russian or Chinese. Now they’re us – people from...
The addition of veliparib to adjuvant temozolomide failed to improve OS for patients with newly diagnosed, MGMT-hypermethylated glioblastoma, according to randomized phase 2/phase3 study results. Patients assigned the investigative...
We thank Paul de Boissieu and Sylvie Chevret for their comments on our Article.1 As mentioned by de Boissieu and Chevret and in our Article title,1 we reported an exploratory analysis of a randomised study that started enrolment more...
Randomised controlled trials need to be analysed based on the intention-to-treat (ITT) principle by analysing all participants in the groups to which they were originally assigned, regardless of whether they completed the treatment,...
We congratulate Pierre Vera and colleagues on their publication of the RTEP7-IFCT-1402 trial investigating radiotherapy dose-escalation in patients with stage III non-small-cell lung cancer, according to mid-treatment...
We thank Sarah Bowen Jones and colleagues and Xiaoling Xu and colleagues for their interesting comments on our RTEP7-IFCT-1402 trial investigating radiotherapy dose-escalation in patients with stage III non-small-cell lung cancer.1
Iliopoulos O, Iversen AB, Narayan V, et al. Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study. Lancet Oncol 2024; 25: 1325–36—In this...
Provencio M, Nadal E, Insa A, et al. Perioperative chemotherapy and nivolumab in non-small-cell lung cancer (NADIM): 5-year clinical outcomes from a multicentre, single-arm, phase 2 trial. Lancet Oncol 2024; 25: 1453–64—In figure 3 of...
Camizestrant at 75 and 150 mg showed a significant benefit in progression-free survival versus fulvestrant. These results support further development of camizestrant for the treatment of oestrogen receptor-positive, HER2-negative breast...
Our findings do not support a clinically relevant ischaemic cardiotoxic potential of AIT in patients with early breast cancer and do not support avoiding AIT prescription in patients with early breast cancer.
The development, application, and benchmarking of artificial intelligence (AI) tools to improve diagnosis, prognostication, and therapy in neuro-oncology are increasing at a rapid pace. This Policy Review provides an overview and...
Technological advancements have enabled the extended investigation, development, and application of computational approaches in various domains, including health care. A burgeoning number of diagnostic, predictive, prognostic, and...
The impact of a cancer diagnosis, and the resulting treatment, adverse events, financial burden, and fear of recurrence can cause substantial distress and anxiety, not just to the patient themselves but also to their caregivers. Most...
Medications targeting the oestrogen receptor are foundational therapies for patients with oestrogen receptor-positive metastatic breast cancer, but, despite the efficacy of these agents used alone or in combination with a targeted...
We read with great interest the study by Yaacov R Lawrence and colleagues1 who reported results of a phase 2, multicentre, non-randomised trial of celiac plexus stereotactic radiosurgery for pain management. The trial successfully met...
We thank Ertugrul Senturk and Serap Catli Dinc for their interest in our study1 and their erudite comments. The question of whether it is optimal to include the adjacent tumour within the treatment volumes for celiac plexus radiosurgery...
The Article by Xin Liu and colleagues1 published in The Lancet Oncology is the first randomised trial showing a benefit of site-specific therapy over empirical chemotherapy among patients with previously untreated cancer of unknown...
We appreciate Ryan Huey and Kanwal Raghav's interest in our Article.1 The putative primary tumour of cancer of unknown primary (CUP) has been investigated using genomic tools, with gene-expression profiling (eg, the 90-gene assay) being...
I read with great interest the Article in The Lancet Oncology by Madeleine J Karpinski and colleagues.1 The authors are to be commended for their comprehensive analysis of prostate-specific membrane antigen (PSMA)-PET results and...
I read with interest the Article in The Lancet Oncology by Madeleine J Karpinski and colleagues,1 and although the authors offer substantial advancements in use of prostate-specific membrane antigen (PSMA)-PET for staging of prostate...
We thank Hantong Hu and Dan Shan for their correspondence regarding our Article.1 Our study included patients who underwent prostate-specific membrane antigen (PSMA)-PET between 2014 and 2021, a timeframe that begins before the...
The recent publication of the AtTEnd trial by Nicoletta Colombo and colleagues in The Lancet Oncology presents a crucial advance in the treatment of advanced or recurrent endometrial carcinoma. However, we would like to highlight some...
We read with interest the recent Article by Nicoletta Colombo and colleagues.1 This study provides compelling evidence for the efficacy of adding atezolizumab to standard chemotherapy in patients with advanced or recurrent endometrial...
We appreciate the interest of Queran Lin and colleagues and Ze Xiang and Jian Wu in our Article on the AtTEnd trial results.1 For the letter by Queran Lin and colleagues, we would like to underline some points. Firstly, as no strong...
Whether individuals with chronic diseases should or should not receive continuous therapy is a question of interest (eg, for statins1 and psychotropics2). In patients with cancer, this is a new but crucial question that has arisen with...
PHILADELPHIA — Patients with a false-positive Shield test result did not appear to be at increased risk for non-colorectal cancer malignancies at 1 year compared with those with a true-negative result, according to a presenter here....
Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective. An international research team has developed a novel...
ORLANDO — Certain Mohs surgery repair types raised the risk for healing complications following adjuvant radiation therapy, according to a presentation at the American Society for Dermatologic Surgery Annual Meeting. “As we know,...
The addition of inavolisib to palbociclib and fulvestrant more than doubled PFS for certain patients with advanced breast cancer, according to results of a randomized phase 3 trial. The regimen also improved OS and response for adults...
Dave Rowntree speaks out about his ex-wife’s choice to take her life at Dignitas in Switzerland The Blur drummer, Dave Rowntree, has attacked the UK law on assisted dying as “psychopathic” as he spoke out for the first time about the...
Lack of health insurance contributes to a high percentage of racial and ethnic disparities in advanced-stage diagnoses for several cancer types, according to results of a mediation analysis. This trend persisted among Black, Hispanic and...
New research is exploring low-cost, non-invasive ways to diagnose Barrett's esophagus, a condition associated with deadly esophageal cancer, to find effective strategies to identify patients with this condition.
Researchers have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study used a cutting-edge spatial genomics technology...
A new, large study found that lack of health insurance coverage accounts for a significant proportion of racial and ethnic disparities in advanced-stage diagnosis of multiple cancers.
A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how...
New research into the long-term dynamics of transplanted stem cells in a patient's body explains how age affects stem cell survival and immune diversity, offering insights that could make transplants safer and more successful.
Cell division is a pivotal moment in the life cycle of a cell: when things go wrong, the cell typically triggers growth arrest or its own self-destruction. Researchers have now discovered a previously unknown process that initiates...
Researchers reported beneficial effects of a supervised exercise intervention on breast cancer outcomes, according to preliminary findings from the OptiTrain trial presented at ESMO Congress. Previously, the study showed that patients...
Breast cancer survivors who participated in a remote personalized exercise program experienced modest improvements in quality of life, according to results from the eMouvoir trial presented at ESMO Congress. Patients experienced the most...
Another battle after Boris is beaten | A Marxist pledge from Robert Jenrick? | Working people | Starmer’s mixed metaphors | A dog’s body clock When I had oesophageal cancer, you were kind enough to publish my letter ( 29 May 2022 ) about...
A telephone-based weight loss intervention significantly increased moderate or vigorous physical activity in patients with breast cancer with overweight/obesity, according to a breast cancer weight loss trial presented at ESMO Congress....
Sara M. Tolaney, MD, MPH, breast medical oncologist from Dana-Farber Cancer Institute, discussed the long-term follow-up data of 4-year outcomes from the NATALEE trial. The data, presented at ESMO Congress, showed the benefit seen after...
Trastuzumab deruxtecan, or T-DXd, showed clinical activity in a large population of metastatic HER2-positive breast cancer patients with brain metastases, according to “really impressive” data from DESTINYBreast-12 presented at ESMO...
Sara M. Tolaney, MD, MPH, breast medical oncologist from Dana-Farber Cancer Institute, talked about survival data from KEYNOTE-522 that have been awaited with “a lot of anticipation.” KEYNOTE-522 has previously shown the benefit of...
Daylight saving time has been a source of contention and debate since its introduction in 1918. For some, the practice of advancing clocks to allow for more use of daylight hours in the summer — which a congressional act standardized...
The FDA has expanded the approval of an oral liquid methotrexate solution to include children and adolescents with polyarticular juvenile idiopathic arthritis and acute lymphoblastic leukemia, according to a press release. The FDA’s...
New studies released by NCI’s Human Tumor Atlas Network explore the role of the tumor microenvironment and the immune system in promoting the spread of cancer and its resistance to treatment. The studies appear across several Nature...