MIRV did not seem to impair or improve patient quality of life compared with investigator's choice of chemotherapy. The similar quality-of-life outcomes in the two treatment groups, combined with the previously reported higher efficacy...
Over the past few decades, breakthroughs in cancer biology at the molecular level have revolutionised cancer treatment. Enhanced precision in radiotherapy has not only reduced patient side-effects, but also enabled the delivery of...
Neurological complications are an important concern in patients undergoing chimeric antigen receptor (CAR) T-cell therapy. Consensus guidelines inform the management of immune effector cell-associated neurotoxicity syndrome (ICANS)....
Realising the potentially substantial benefits of chimeric antigen receptor (CAR) T-cell therapy for children with cancer is hindered by non-scientific barriers that are also relevant for other rare diseases. A solely commercial...
The National Cancer Audit Collaborating Centre (NATCAN) was launched on Oct 1, 2022, and is delivering ten national cancer audits to assess and assure the quality of National Health Service (NHS) cancer care in England and Wales. These...
Armed conflict causes huge challenges to health systems, particularly in low-income and middle-income countries (LMICs).1,2 Conflict leads to interruptions in supply chains, closure of facilities, harm to medical staff, food insecurity,...
Talazoparib plus enzalutamide prolonged time to definitive deterioration in GHS/QoL versus placebo plus enzalutamide. Together with clinical efficacy and safety data, these results inform the risk-benefit assessment of talazoparib plus...
The demonstrated delays in definitive deterioration in GHS/QoL, urinary symptoms, and other functioning and symptom scales with talazoparib plus enzalutamide compared with placebo plus enzalutamide in patients with HRR-deficient...
We appreciate Shearwood McClelland 3rd and colleagues’ Correspondence on our recent publication regarding the preplanned interim analysis of the EUROPA trial.1 Their thoughtful insights into the financial implications of radiotherapy and...
We are writing to express our interest in the recently published Editorial on prioritising oral health in cancer care.1 As dental practitioners in comprehensive cancer centres and hospitals in Europe, we urge the integration of oral...
We read with great interest the Article by Lincoln Nadauld and colleagues describing the patient-reported outcomes of the PATHFINDER study.1 The study provides valuable insights into the psychosocial effects of multicancer early...
Rodriguez-Otero P, Usmani S, Cohen AD, et al. International Myeloma Working Group immunotherapy committee consensus guidelines and recommendations for optimal use of T-cell-engaging bispecific antibodies in multiple myeloma. Lancet Oncol...
Zdenkowski N, Kuper-Hommel MJJ, Niman SM, et al. Timing of nivolumab with neoadjuvant carboplatin and paclitaxel for early triple-negative breast cancer (BCT1902/IBCSG 61–20; Neo-N): a non-comparative, open-label, randomised, phase 2...
As the options available to manage castration-resistant prostate cancer increase, and as treatments gradually move earlier in the patient journey, it is ever more essential that management decisions maximise quality of life as well as...
Communication between health-care professionals and individuals with cancer regarding the effects of treatment on sexual health and fertility has historically been limited. Contemporary studies have revealed that most oncologists agree...
The WHO Classification of Tumours (WCT) was initiated following a resolution adopted by the World Health Assembly in 1956.1,2 Fundamentally, it forms the basis for the diagnosis, clinical management, and preventative measures of...
The far-reaching implications of Icro Meattini and colleagues’ EUROPA trial1 represent the importance of tangibly assessing the utility of each component of widely accepted adjuvant therapy for breast cancer. Having built on the...
On Feb 25, 2025, the UK Government announced that the overseas aid budget will be cut in 2027 from 0·5% to 0·3% of the UK's gross national income—a cut of about £6 billion—to pay for increased defence spending. This cut is in addition to...
As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called...
A new study on the genetic causes of the PTEN Hamartoma Tumour Syndrome (PHTS) has found that inhibitors of the PI3ka pathway, commonly used as anticancer drugs, are also effective against this disease, reducing the extent of vascular...
Seven-year follow-up data of a multicenter, randomized phase 2 study evaluating the treatment of melanoma brain metastases shows ipilimumab plus nivolumab is an effective long-term care option. First published in 2018, results from the...
Due to the destructive nature of COPD on patients’ lungs and well-being, timely diagnosis is key, and integrating spirometry at the time of lung cancer screening could help identify this disease early in an at-risk population. “COPD...
The addition of nivolumab to neoadjuvant chemotherapy significantly increased pathologic complete response among certain patients with breast cancer, according to findings published in Nature Medicine. The randomized phase 3 CheckMate...
Physician enthusiasm about the role of AI in health care continues to increase, according to an AMA survey. However, a majority of Americans do not have faith in health systems to utilize AI responsibly, a separate study showed. AMA...
Exclusive: Ministers halt money for radiotherapy auto-contouring that would reduce waiting times and address staff shortages Ministers have cut millions of pounds of funding for potentially life saving AI cancer technology in England,...
I’m with Lauren Laverne: surviving the disease can lead to a newfound resilience and love of simply being alive Lauren Laverne says she loves her life more now that she’s had cancer. I know exactly what she means. Imagine you’re...
CHICAGO — For patients with cancer requiring extended anticoagulant therapy, a strategy of reduced-dose apixaban was noninferior to full-dose apixaban for prevention of cancer-associated recurrent venous thromboembolism. Reduced-dose...
Investigators have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key...
The FDA approved a radioligand therapy for earlier use prior to chemotherapy in patients with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer, according to a Novartis-issued press release....
The FDA approved fitusiran (Qfitlia, Sanofi) for routine prophylaxis for prevention or reduction in bleeding episodes in patients with hemophilia A or hemophilia B who are above 12 years old, according to a press release. Fitusiran...
Terminally ill journalist and assisted dying supporter no longer healthy enough to travel to Dignitas The life-preserving cancer drugs that Dame Esther Rantzen was placed on last year are no longer working, her daughter has said. The...
Leveraging the power of AI and machine learning technologies, researchers developed a more effective model for predicting how patients with muscle-invasive bladder cancer will respond to chemotherapy. The model harnesses whole-slide...
Researchers at Cleveland Clinic have developed a model to predict the risk for colorectal cancer in adults aged younger than 45 years. The CDC and American Cancer Society recommend screening for CRC at age 45 years, but the rates of...
Approximately 80% of individuals who receive immune checkpoint inhibitors for advanced cancer do not respond to therapy, according to results of a cross-sectional analysis. The number of FDA-approved immune checkpoint inhibitors (ICIs)...
Chronic parental alcohol use causes changes in mitochondrial activity and immune function in their offspring, potentially predisposing them to cancer, according to study findings. Researchers at Texas A&M College of Veterinary Medicine...
HHS announced a massive restructuring today to comply with an executive order to implement the controversial Department of Government Efficiency’s initiative for workforce optimization. There are several key elements to the...
A greater intake of sugar-sweetened beverages was tied to a higher risk for oral cavity cancer, or OCC, in women, a longitudinal study in JAMA Otolaryngology-Head & Neck Surgery showed. Such findings were significant regardless of...
In the latest installment of Healio’s video series with ASGE, Fiyinfoluwa O. Abraham, MD, discusses ethnic and racial disparities observed in the incidence of pancreatic cancer, demonstrating the need for “reducing barriers” to care....
Patients showed a preference for messages created by AI over those by clinicians, an analysis in JAMA Network Open showed. Patients were less enthused when they were told AI was involved, but the results were still “reassuring,” Anand...
The Senate voted Tuesday to confirm the heads of two major federal health agencies. Jay Bhattacharya, MD, PhD, will become the NIH director, and Martin Makary, MD, MPH, will become the FDA commissioner. Both Bhattacharya and Makary will...
Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer.
The body's cells respond to stress -- toxins, mutations, starvation or other assaults -- by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses. If the stress is manageable, cells...
The first-line combination of amivantamab-vmjw plus lazertinib extended OS compared with osimertinib for patients with EGFR-mutated advanced non-small cell lung cancer, according to data from the randomized phase 3 MARIPOSA trial....
The United States Senate Committee on Finance voted to advance the nomination of Mehmet Oz, MD, MBA, to be the next administrator of CMS. Healio previously reported on Oz’s committee hearing, where he was grilled by senators on reigning...
High adherence to the Mediterranean diet appeared linked to a slight reduction in risk for obesity-related cancer, according to data published in JAMA Network Open. “The findings were largely in line with our expectations, as previous...