Scientists created four cannabis-derived CBN analogs (chemical look-a-likes) with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer's, Parkinson's, and traumatic brain...
Investigators have discovered how brain cells responsible for working memory -- the type required to remember a phone number long enough to dial it -- coordinate intentional focus and short-term storage of information.
New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.
Neuroscientists have identified a genetic mutation that fends off Alzheimer's disease in people at high risk and could lead to a new way to protect people from the disease.
Researchers use network analysis to study whether it can reveal the subtle changes associated with subjective cognitive decline that cannot otherwise be detected through standard test analyses. By running a statistical analysis of data...
Scientists discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from Alzheimer's disease.
A traumatic brain injury (TBI) can quadruple your risk for developing dementia and increase your chances of developing neurodegenerative diseases such as ALS. In a new study scientists use lab-grown human brain structures known as...
A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain....
Scientists have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer's disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean...
Cell damage from oxidative stress is a major underlying cause of age-related cognitive and muscle strength decline. Antioxidants can reduce oxidative stress and prevent age-related health decline. A new study has found that mice...
Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson's disease.
A smartphone app could enable greater participation in clinical trials for people with frontotemporal dementia (FTD), a devastating neurological disorder that often manifests in midlife.
A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The method, which can be easily replicated by other labs, will enable researchers to more...
Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the...
Just as you can't make an omelet without breaking eggs, scientists have found that you can't make long-term memories without DNA damage and brain inflammation.
Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.
Dedicated memory tests on smartphones enable the detection of 'mild cognitive impairment', a condition that may indicate Alzheimer's disease, with high accuracy.
Researchers have identified a new potential target for the treatment of Alzheimer's disease -- PDE4B. The researchers observed that AD mice showed memory deficits in maze tests, but memory was unimpaired in AD mice with genetically...
Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study. In the study, almost one in ten of over 50-year-olds were found to have tissue markers of Lewy body disease in the brain.
The International Brain pH Project Consortium unveils groundbreaking findings in a large-scale animal model study, indicating altered brain pH and lactate levels as a transdiagnostic endophenotype in neuropsychiatric disorders with...
The health impacts of a complex protein that plays a major role in the development of Alzheimer's disease and heart conditions can be lessened by three kinds of drug inhibitors, according to scientists.
Single-cell gene expression patterns in the brain motor and frontal cortex, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.
A new study has identified 17 genetic variants that may influence Alzheimer's disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention.
A 3D-printed 'brain phantom' has been developed, which is modeled on the structure of brain fibers and can be imaged using a special variant of magnetic resonance imaging (dMRI). The scientific team has now shown in a study, these brain...
Using novel genetic and genomic tools, researchers have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases. The study represents a...
A study of nearly 95,000 Washington state residents found that people living outside of urban areas as well as Native American and Hispanic people face longer travel distances to be seen by neurologists. The researchers said these...
The middle-aged brain could provide a window into future cognitive health. A team reviewed evidence from human and animal studies suggesting that middle age -- commonly considered as the period between 40 and 60 or 65 years of age --...
A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging....
U.S. veterans of the wars in Afghanistan and Iraq who suffered mild traumatic brain injury from exposure to explosive blasts were found to have changes in cerebrospinal fluid proteins that are typically seen in people who develop...
A largescale new study has found that some people whose genetics are linked to the common iron overload condition haemochromatosis have substantially greater levels of liver, musculoskeletal and brain disease than previously reported,...
Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). It is this complex vascular network...
Gait impairments often are prevalent in the early stages of cognitive decline. Researchers quantitatively compared straight walking and curved walking -- a more natural yet complex activity -- in healthy older adults and adults with mild...
Early stages of neurodegenerative disorders are characterized by the accumulation of proteins in discrete populations of brain cells and degeneration of these cells. For most diseases, this selective vulnerability pattern is unexplained,...
A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer's disease, report researchers studying a mouse model of the disease. Furthermore, the increased protein activity leads to the seizures...
A noninvasive treatment may help to counter 'chemo brain' impairment often seen in chemotherapy patients: Exposure to light and sound with a frequency of 40 hertz protected brain cells from chemotherapy-induced damage in mice,...
A link between abnormal blood levels of amyloid -- a protein associated with Alzheimer's disease -- and subtle changes in brain microstructures on a type of MRI could lead to a new way to detect Alzheimer's earlier in people with no...
Language-processing difficulties are more of an indicator than memory loss of amnestic mild cognitive impairment (aMCI), a risk factor for dementia due to Alzheimer's disease, according to a new study.