Using an AI tool, researchers have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated...
Researchers have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in a subset of people. It is believed most humans are exposed to this virus -- called...
Phase I clinical trial of a drug was successfully completed, with promise to treat Alzheimer's and other neurodegenerative diseases. The compound, named VU319, is the first end-to-end drug discovery effort related to memory loss,...
To identify and follow blood vessel-related changes in the brain that contribute to cognitive impairment and dementia, researchers and clinicians typically rely on MRI to evaluate 'downstream' biological markers -- those at the end of a...
Engineers have modified lipid nanoparticles (LNPs) -- the revolutionary technology behind the COVID-19 mRNA vaccines -- to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This...
A new study raises the possibility that jobs that require frequent spatial processing -- such as figuring out a taxi route or the best way to navigate to a hospital -- could lead to lower rates of death from Alzheimer's disease....
Just as a conductor coordinates different instruments in an orchestra to produce a symphony, breathing coordinates hippocampal brain waves to strengthen memory while we sleep, reports a new study. This is the first time breathing rhythms...
Older adults whose blood pressure fluctuates over time may be more likely to have problems with thinking and memory skills, according to a new study. The association was found in Black participants but not in white participants in the...
A new study is helping solve the mystery as to why the brain shrinks in a unique pattern, known as atrophy, in chronic traumatic encephalopathy (CTE). This research provides novel evidence that cumulative repetitive head impacts are...
Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real-world patient data to identify...
A new way of mapping activity and connections between different regions of the brain has revealed fresh insights into how higher order functions like language, thought and attention, are organized.
New research has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone...
A new study provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear. This discovery could point to new...
New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the presence and impact of glyphosate's...
Researchers have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including Alzheimer's disease (AD). This innovative tool analyzes biomarkers that can induce 3D...
What do spiders and Alzheimer's disease have in common? A team of researchers may have just uncovered the answer. Researchers from have made a groundbreaking connection between brain 'waste canals' and Alzheimer's disease -- a discovery...
Patients with frontotemporal dementia often lack the ability to empathize. A study has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is...
Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers...
Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain. Scientists, working in mouse models of Alzheimer's disease...
Beta-blocker drugs -- commonly used to treat heart and blood pressure issues -- may slow the progression of Huntington's disease (HD), according to a new study.
A new study represents a significant step forward in scientists' understanding of Alzheimer's disease. A team of investigators has examined the role of two proteins found in the brain and suggest the stability of their relationship to...
A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as 'Alzheimer's in a dish,' the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain...
Scientists used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying...
Healing the gut may be the key to improving long-term recovery in stroke patients, scientists have found. The latest of multiple studies highlights the potential of this novel avenue of treatment, which takes advantage of the link...
Research found that wildfire smoke is especially hazardous to people's memory health. An analysis of the health care records of 1.2 million Southern California residents found that higher long-term smoke exposure was associated with a...
Researchers developed an innovative approach -- demonstrated in mouse models and isolated human brain tissue -- to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of...
A loss of brain volume associated with new immunotherapies for Alzheimer's disease may be caused by the removal of amyloid plaques, rather than the loss of neurons or brain tissue, finds a new study.
A new study analyzed data from participants who have been followed for over 50 years, starting before their births. Researchers found that maternal immune activity during a critical period of sex-dependent brain development in pregnancy...
Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a new study. The study compared the differences in years of education based on variations in state...
People with Alzheimer's exhibit a loss of motor control along with cognitive decline, and one of the earliest signs of this decay can be spotted in involuntary eye movements known as saccades. These quick twitches of the eyes in...
A study by researchers presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia. While the condition remains incurable, there are a number of common risk factors that, if...
People diagnosed with type 2 diabetes at a younger age are at a higher risk for developing dementia than those diagnosed later in life, according to a new study. The findings show that the increased risk is especially pronounced among...
A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.
A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon make Alzheimer's testing much more accessible worldwide.
Researchers have linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression. The proteins were gathered from cerebrospinal fluid and are a good proxy for activity...
Researchers have revealed how two neural circuits located in the brain's retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer's...
New research highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process have been linked to neurodegenerative disorders like...
Researchers have developed a simple model system that can be used to break down fibrils -- the cause of numerous disorders including Alzheimer's and Parkinson's disease -- into their constituent single units or liquid droplets.
Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called...