A massive international brain study has revealed that memory decline with age isn’t driven by a single brain region or gene, but by widespread structural changes across the brain that build up over time. Analyzing thousands of MRI scans...
Researchers have discovered a brain activity pattern that can predict which people with mild cognitive impairment are likely to develop Alzheimer’s disease. Using a noninvasive brain scanning technique and a custom analysis tool, they...
Your daily rhythm may matter more for brain health than previously thought. Older adults with weaker, more disrupted activity patterns were far more likely to develop dementia than those with steady routines. A later daily energy peak...
Researchers discovered that clogged brain “drains” show up early in people at risk of Alzheimer’s disease. These blockages, easily seen on standard MRI scans, are tied to toxic protein buildup linked to memory loss and cognitive decline....
Cannabis products with higher THC levels may slightly reduce chronic pain, particularly nerve pain, according to a review of multiple clinical trials. The improvement was small and short-lived, while side effects were more common....
New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation...
Eating full-fat cheese and cream may be associated with a lower risk of dementia, according to a large study that tracked people for more than 25 years. Those who consumed higher amounts of these foods developed dementia less often than...
Obesity accelerates the rise of Alzheimer’s-related blood biomarkers far more rapidly than previously recognized. Long-term imaging and plasma data show that obese individuals experience much faster increases in proteins linked to...
Researchers discovered that a tiny structural feature of the enzyme GPX4 helps keep neurons safe. A rare mutation removes this protection, allowing harmful molecules to damage cell membranes and trigger early dementia. Mouse and cell...
A unique vaccine rollout in Wales gave researchers an accidental natural experiment that revealed a striking reduction in dementia among seniors who received the shingles vaccine. The protective effect held steady across multiple...
Scientists have uncovered a stepwise system that guides how the brain sorts and stabilizes lasting memories. By tracking brain activity during virtual reality learning tasks, researchers identified molecules that influence how long...
Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more...
Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light...
Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive...
Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and...
Scientists have developed a new molecule that breaks down beta-amyloid plaques by binding to excess copper in the brain. The treatment restored memory and reduced inflammation in rats, while also proving non-toxic and able to cross the...
Japanese researchers found that lecanemab, an amyloid-clearing drug for Alzheimer’s, does not improve the brain’s waste clearance system in the short term. This implies that nerve damage and impaired clearance occur early and are...
Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and neuronal damage in mice. The findings...
Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a...
Walking a few thousand steps daily may help hold off Alzheimer’s for years, a Mass General Brigham study found. Even moderate physical activity slowed both cognitive decline and the buildup of harmful tau proteins in the brain. The...
Disrupted sleep patterns in Alzheimer’s disease may be more than a symptom—they could be a driving force. Researchers at Washington University found that the brain’s circadian rhythms are thrown off in key cell types, changing when...
Researchers used supramolecular nanoparticles to repair the brain’s vascular system and reverse Alzheimer’s in mice. Instead of carrying drugs, the nanoparticles themselves triggered natural clearance of amyloid-β proteins. This restored...
Scientists have uncovered a toxic alliance between Aβ and fibrinogen that may explain how Alzheimer’s disease begins. The two proteins together create stubborn clots that damage blood vessels and spark inflammation in the brain. These...
SuperAgers defy normal aging by keeping sharp memories and healthy brains well into their 80s. Northwestern scientists discovered that these individuals either resist the buildup of harmful brain proteins or remain unaffected by them....
Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis....
A massive new study combining observational and genetic data overturns the long-held belief that light drinking protects the brain. Researchers found that dementia risk rises in direct proportion to alcohol consumption, with no safe...
New research from Houston Methodist reveals how obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate...
Researchers in Japan discovered that Parkinson’s patients diagnosed in their 80s are far more likely to show signs of amyloid buildup, a hallmark of Alzheimer’s, even without dementia symptoms. The study compared younger and older...
For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with...
Chronic insomnia may do more than leave you groggy, it could speed up brain aging. A large Mayo Clinic study found that people with long-term sleep troubles were 40% more likely to develop dementia or cognitive impairment, with brain...
Scientists discovered that certain blood proteins linked to brain injury and inflammation strongly correlate with early signs of memory and cognitive decline, especially in Hispanic and Latino adults. This breakthrough points to a future...
Scientists at the University of Bath have developed a simple three-minute brainwave test called Fastball EEG that can detect memory problems years before Alzheimer’s is typically diagnosed. Unlike traditional memory tests, it passively...
A sweeping review of nearly 100 studies has raised concerns about the mental health impacts of high-potency cannabis products. Researchers found strong links to psychosis, schizophrenia, and cannabis use disorder, while results for...
Harvard scientists have uncovered that lithium, a naturally occurring element in the brain, may be the missing piece in understanding Alzheimer’s. Their decade-long research shows that lithium depletion—caused by amyloid plaques binding...
Using cannabis to self-medicate comes with hidden dangers—new research shows these users face higher paranoia and consume more THC. Childhood trauma further amplifies the risks, especially emotional abuse, which strongly predicts paranoia.
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness...
THC levels in cannabis have soared in recent years, raising the risk of psychosis—especially in young, frequent users. Studies reveal a strong connection between cannabis-induced psychosis and schizophrenia, making early cessation and...
Scientists have discovered a direct cause-and-effect link between faulty mitochondria and the memory loss seen in neurodegenerative diseases. By creating a novel tool to boost mitochondrial activity in mouse models, researchers restored...
Many people with dementia endure long delays often over 3 years before receiving a diagnosis, with even longer waits for younger patients. A global review of over 30,000 cases reveals that age, dementia type, and systemic healthcare...
Scientists at UCSF have uncovered how certain immune cells in the brain, called microglia, can effectively digest toxic amyloid beta plaques that cause Alzheimer’s. They identified a key receptor, ADGRG1, that enables this protective...
USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron...
A new way of thinking about Alzheimer's disease has yielded a discovery that could be the key to stopping the cognitive decline seen in Alzheimer's and other neurodegenerative diseases, including ALS and Parkinson's.
While Alzheimer's disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body. Working with the laboratory fruit fly, researchers provide a new understanding...
In many neurodegenerative diseases, proteins misfold and clump together in brain tissue. Scientists developed a new therapy made of peptides and a sugar that naturally occurs in plants. The therapeutic molecules self-assemble into...