Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research has found. The findings provide new hope in the battle against this devastating disorder.
Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. The study...
Scientists have come up with a drug that is a potential candidate for tackling memory deficits in the early stages of the disease in rodents. Research shows that the drug activates the cannabinoid neurotransmitter system (which protects...
Mild cognitive impairment is linked to blood vessel dysfunction in the brain's temporal lobes -- the seat of memory -- according to a new study. The findings, seen in people with and without signs of amyloid buildup in the brain, suggest...
Researchers have uncovered novel insights into how brain function disruptions related to cerebrovascular disease (CeVD) interact with Alzheimer's disease (AD) pathology to impact neurodegeneration and cognition in older adults.
A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.
Cognitive profiles for early diagnosis of Dementia with Lewy bodies (DLB) have been outlined in a new study. Although DLB is the second most common neurodegenerative dementia following Alzheimer's Disease, it is usually misdiagnosed,...
Older people wait an average of just over a month to see a neurologist for specialty care after being referred by their primary care physician or another physician, according to a new study. The study, which looked at people who have...
Declining blood levels of two molecules that occur naturally in the body track closely with worsening Alzheimer's disease, particularly in women. Levels were found to drop gradually, from women with no signs of memory, disorientation,...
A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain...
A research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal...
A study has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in...
Researchers have uncovered mechanisms that may link head injuries and concussions to the emergence of neurodegenerative disease, pointing to latent viruses lurking in most of our brains that may be activated by the jolt, leading to...
Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and cell culture models to show that a...
A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers report.
Researchers have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD). The study highlights microglia, the brain's primary immune cells, as central players in both the...
Using an AI tool, researchers have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated...
Researchers have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in a subset of people. It is believed most humans are exposed to this virus -- called...
Phase I clinical trial of a drug was successfully completed, with promise to treat Alzheimer's and other neurodegenerative diseases. The compound, named VU319, is the first end-to-end drug discovery effort related to memory loss,...
To identify and follow blood vessel-related changes in the brain that contribute to cognitive impairment and dementia, researchers and clinicians typically rely on MRI to evaluate 'downstream' biological markers -- those at the end of a...
Engineers have modified lipid nanoparticles (LNPs) -- the revolutionary technology behind the COVID-19 mRNA vaccines -- to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This...
A new study raises the possibility that jobs that require frequent spatial processing -- such as figuring out a taxi route or the best way to navigate to a hospital -- could lead to lower rates of death from Alzheimer's disease....
Just as a conductor coordinates different instruments in an orchestra to produce a symphony, breathing coordinates hippocampal brain waves to strengthen memory while we sleep, reports a new study. This is the first time breathing rhythms...
Older adults whose blood pressure fluctuates over time may be more likely to have problems with thinking and memory skills, according to a new study. The association was found in Black participants but not in white participants in the...
A new study is helping solve the mystery as to why the brain shrinks in a unique pattern, known as atrophy, in chronic traumatic encephalopathy (CTE). This research provides novel evidence that cumulative repetitive head impacts are...
Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real-world patient data to identify...
A new way of mapping activity and connections between different regions of the brain has revealed fresh insights into how higher order functions like language, thought and attention, are organized.
New research has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone...
A new study provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear. This discovery could point to new...
New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the presence and impact of glyphosate's...
Researchers have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including Alzheimer's disease (AD). This innovative tool analyzes biomarkers that can induce 3D...
What do spiders and Alzheimer's disease have in common? A team of researchers may have just uncovered the answer. Researchers from have made a groundbreaking connection between brain 'waste canals' and Alzheimer's disease -- a discovery...
Patients with frontotemporal dementia often lack the ability to empathize. A study has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is...
Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers...
Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain. Scientists, working in mouse models of Alzheimer's disease...
Beta-blocker drugs -- commonly used to treat heart and blood pressure issues -- may slow the progression of Huntington's disease (HD), according to a new study.
A new study represents a significant step forward in scientists' understanding of Alzheimer's disease. A team of investigators has examined the role of two proteins found in the brain and suggest the stability of their relationship to...
A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as 'Alzheimer's in a dish,' the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain...
Scientists used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying...
Healing the gut may be the key to improving long-term recovery in stroke patients, scientists have found. The latest of multiple studies highlights the potential of this novel avenue of treatment, which takes advantage of the link...
Research found that wildfire smoke is especially hazardous to people's memory health. An analysis of the health care records of 1.2 million Southern California residents found that higher long-term smoke exposure was associated with a...