People diagnosed with type 2 diabetes at a younger age are at a higher risk for developing dementia than those diagnosed later in life, according to a new study. The findings show that the increased risk is especially pronounced among...
A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.
A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon make Alzheimer's testing much more accessible worldwide.
Researchers have linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression. The proteins were gathered from cerebrospinal fluid and are a good proxy for activity...
Researchers have revealed how two neural circuits located in the brain's retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer's...
New research highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process have been linked to neurodegenerative disorders like...
Researchers have developed a simple model system that can be used to break down fibrils -- the cause of numerous disorders including Alzheimer's and Parkinson's disease -- into their constituent single units or liquid droplets.
Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called...
One of the first studies to investigate the prevalence of unrecognized cognitive impairment among patients seen at Federally Qualified Health Centers, has found that it is ubiquitous, especially among minoritized older adults. These...
By examining RNA in hundreds of thousands of individual brain cells, scientists further support that alcohol use disorder could accelerate Alzheimer's disease progression, paving the way for future targeted treatments.
A new study involving 8,500 children from across the United States has revealed that a form of air pollution, largely the product of agricultural emissions, is linked to poor learning and memory performance in 9- and 10-year-olds. The...
A team of researchers has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease. The team, led by Professor Norifumi Shioda and Associate...
Research has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other neurodegenerative diseases.
A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer's disease.
Sleep apnea, a common yet underdiagnosed sleep disorder, contributes to the development of dementia among adults -- particularly women, a new study suggests. At every age level, women with known or suspected sleep apnea were more likely...
Researchers published a study examining symptoms, health outcomes, and physical function over time in older adults with and without Alzheimer's disease and related dementias and polypharmacy.
Researchers have joined forces to give a boost to spatial memory by creating a unique experimental setup that combines non-invasive deep-brain stimulation, virtual reality training, and fMRI imaging. The study demonstrates that targeted,...
Researchers reveal a link between olfactory loss and inflammation in 139 medical conditions. The researchers say loss of smell is an early sign of numerous neurological and bodily diseases.
In dementia diseases such as Alzheimer's, incorrectly folded proteins accumulate in the brain. Researchers have now resolved a particularly active species of protein fibrils with unprecedented precision. The formation of potentially...
In a study, researchers use neuroimaging methods to examine brain resilience in regions of the brain linked to language and aging. They found that the hippocampus in bilinguals with Alzheimer's disease was noticeably larger than those...
New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous system.
New research quantified the association between loneliness and dementia by analyzing data from more than 600,000 people around the world. The meta-analysis of 21 longitudinal studies showed that experiencing feelings of loneliness...
Symptoms and disease progression of Rett syndrome are different in females than males. A new study shows why it is important to understand these differences to develop better treatments.
Neuroscientists have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells. The research offers exciting potential for advancing our understanding and...
Researchers used mouse models and human post-mortem brain tissue to study the molecular underpinnings that may increase the risk of Alzheimer's after traumatic brain injury (TBI).
Alzheimer's disease may damage the brain in two distinct phases, based on new research using sophisticated brain mapping tools. According to researchers who discovered this new view, the first, early phase happens slowly and silently --...
Higher levels of HDL-C -- known as the 'good cholesterol' -- have been shown to correlate with heightened risk for Alzheimer's disease. A new study might explain why.
A new American Heart Association scientific statement suggests addressing cardiovascular health earlier in life may reduce the risk of stroke and help preserve thinking and memory later in life.
A new computer simulation of how our brains develop and grow neurons has been built. Along with improving our understanding of how the brain works, researchers hope that the models will contribute to neurodegenerative disease research...
A new study definitively reveals the existence of a system that had been theorized to clear metabolic wastes in the human brain. The study uses imaging in neurosurgery patients to show how brain's glymphatic system clears waste;...
Dementia doesn't just erode memory -- it also changes behavior and mental health. A study shows the brain's salience network and tau protein may be involved.
Researchers have identified individuals with increased risk for dementia using mobility data, recorded during a smartphone-based way-finding task on the university campus. The findings show the potential of smartphone data, collected in...
An international team of researchers have made a promising breakthrough in the development of drugs to treat Alzheimer's Disease. For the first time, scientists have developed a drug that works on both major aggregation-promoting...
Researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana's main ingredient, THC, reduces agitation in patients with Alzheimer's by an average of 30%.
A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is...
Using a sophisticated brain-imaging system, neuroscientists say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.
Investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.