Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to new findings. This is significant because of emerging data in human studies showing an...
Researchers used mice with nine different genetic backgrounds to identify factors influencing eye aging, paving the way for eye-based diagnostics for neurodegenerative diseases.
Researchers have devised a way to communicate the effects of taking the new Alzheimer's medications in language that is accessible and understandable to patients and their families. Using data on the natural history of the disease and...
Neurogeneticists have discovered a novel genetic mutation and associated buildup of toxic proteins in the brain -- a type of buildup distinct from amyloid or tau, proteins that have long been the focus of Alzheimer's research.
Researchers have discovered a new type of neuron that plays a fundamental role in recognition memory -- how the brain registers the difference between new and familiar objects and forms long-term memories. The new cell type, called ovoid...
A study reveals that traumatic brain injury alters the small vessels in the brain, resulting in an accumulation of amyloid beta -- a hallmark of Alzheimer's disease. The findings suggest that vascular dysfunction could be an early driver...
A complementary drug to combat Alzheimer's disease could target a specific part of the nerve cell protein tau. This is the finding of new research which also offers a better way to measure the effect of treatment among patients.
Researchers discovered that nearly 70 per cent of suspected frontotemporal dementia patients ultimately did not have the disease in a study aimed at identifying factors that contribute to misdiagnosis of this notoriously difficult to...
Years before tau tangles show up in brain scans of patients with Alzheimer's disease, a biomarker test can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal...
Living in a disadvantaged community may decrease the length of time a person can survive with amyotrophic lateral sclerosis, or ALS, by over 30%, a study suggests. Similar studies have shown that living in resource-deprived areas is...
A research team has discovered that the two key pathological hallmarks of Alzheimer's -- tau protein and beta-amyloid -- affect brain circuits in distinct yet synergistic ways, particularly those linked to memory and emotions. The study,...
New research has shown that diet could influence the risk of both depression and Alzheimer's disease (AD). Evidence suggests that depressive symptoms are both a risk factor for AD and a reaction to early memory problems.
A new study has found that certain bacteria were associated with better memory and attention, while others were linked to an increased risk of Alzheimer's disease.
A paradigm-shifting study shows an experimental drug, GL-II-73, has the potential to restore memory and cognitive function in a mouse model of Alzheimer's disease. The study demonstrates that the drug improves memory deficits and...
Scientists provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease. Their findings, based on studies in cell culture, mice and tissue samples from patients, may contribute...
An international research team has identified key genetic factors that confer protective effects against Alzheimer's disease (AD) through a comprehensive genetic analysis of East Asian populations, including Chinese and Japanese, as well...
Research has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer's disease contribute to the neurodegeneration. Researchers found that the median respiration rate was...
Key cells in the brain, neurons, form networks by exchanging signals, enabling the brain to learn and adapt at incredible speed. Researchers have now developed a 3D-printed 'brain-like environment' where neurons grow similarly to a real...
Older adults whose cholesterol changes over time may be more likely to develop dementia than people whose cholesterol is stable, regardless of the actual cholesterol level, according to a new study.
Research comparing different approaches to dementia care for people with Alzheimer's disease and other dementias found no significant differences in patient behavioral symptoms or caregiver strain, whether delivered through a health...
Researchers have successfully applied advanced artificial intelligence (AI) genetics models to Parkinson's disease. Researchers identified genetic factors in progression and FDA-approved drugs that can potentially be repurposed for PD...
Scientists have shown that specialized cells involved in how the body responds to insulin are activated in the brain after exercise, suggesting that physical activity may directly improve brain function.
New guidelines will help doctors identify patients with a common memory-loss syndrome that is often misdiagnosed as Alzheimer's disease in older adults. The diagnostic criteria for limbic-predominant age-related TDP-43 encephalopathy...
Researchers demonstrated that individuals who had childhood epilepsy have an increased accumulation of brain amyloid later in life, potentially predisposing them to late-onset brain amyloid disorders, such as Alzheimer's disease.
A breakthrough study sheds new light on how brain cells relay critical information from their extremities to their nucleus, leading to the activation of genes essential for learning and memory.
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.
Researchers find that microglia function differently in males versus females, potentially having broad implications for how neurological diseases are studied.
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's disease, finds a new study.
Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live cells with unprecedented detail. By combining computer simulations with live-cell imaging, researchers have...
Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research has found. The findings provide new hope in the battle against this devastating disorder.
Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. The study...
Scientists have come up with a drug that is a potential candidate for tackling memory deficits in the early stages of the disease in rodents. Research shows that the drug activates the cannabinoid neurotransmitter system (which protects...
Mild cognitive impairment is linked to blood vessel dysfunction in the brain's temporal lobes -- the seat of memory -- according to a new study. The findings, seen in people with and without signs of amyloid buildup in the brain, suggest...
Researchers have uncovered novel insights into how brain function disruptions related to cerebrovascular disease (CeVD) interact with Alzheimer's disease (AD) pathology to impact neurodegeneration and cognition in older adults.
A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.
Cognitive profiles for early diagnosis of Dementia with Lewy bodies (DLB) have been outlined in a new study. Although DLB is the second most common neurodegenerative dementia following Alzheimer's Disease, it is usually misdiagnosed,...
Older people wait an average of just over a month to see a neurologist for specialty care after being referred by their primary care physician or another physician, according to a new study. The study, which looked at people who have...
Declining blood levels of two molecules that occur naturally in the body track closely with worsening Alzheimer's disease, particularly in women. Levels were found to drop gradually, from women with no signs of memory, disorientation,...
A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain...
A research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal...
A study has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in...
Researchers have uncovered mechanisms that may link head injuries and concussions to the emergence of neurodegenerative disease, pointing to latent viruses lurking in most of our brains that may be activated by the jolt, leading to...