Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin (AAT) within hepatocytes, which limits its access to the circulation and exposes...
The effect of tenofovir amibufenamide (TMF) on blood lipid profiles in patients with chronic hepatitis B (CHB) remains unclear. This study aimed to explore whether TMF affects blood lipids during 48 weeks in patients with CHB.
Ipsen announced today that the National Institute for Health and Care Excellence (NICE) has recommended elafibranor 80mg tablets for the treatment of PBC in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate...
Data regarding risk factors and long-term outcomes of U.S. patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD) are limited.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated steatohepatitis, have emerged as the most prevalent liver diseases worldwide.
An international team of researchers has found that an antibiotic commonly prescribed for patients with liver disease, called rifaximin, has led to the global emergence of an almost untreatable form of the antimicrobial resistant...
A new mouse model mimicking the liver symptoms of myotonic dystrophy type 1 -- the most prevalent form of adult-onset muscular dystrophy -- provides insight into why patients develop fatty liver disease and display hypersensitivity to...
Ultra-processed food consumption in obese adolescents is linked to insulin resistance and liver disease, stressing the need for improved dietary interventions.
A new discovery about how the liver flushes cholesterol from the body could lead to more effective treatments for cardiovascular disease – the leading cause of death worldwide.
Currently, there are a few available treatment options for liver cancer, including a combination of immunotherapies and a class of drugs known as tyrosine kinase inhibitors (TKIs), but their long-term effects are limited.
People with an often-fatal liver condition are being prioritised for liver transplants for the first time thanks … The post World-first liver transplant priority offers “genuine hope” for patients with acute on chronic liver...
The Love Your Liver roadshow visited Stormont in September, the seat of the Northern Ireland Assembly on … The post Love Your Liver roadshow welcomed to Stormont by Northern Ireland’s MLAs appeared first on British Liver Trust .
New data presented today at the British Association for the Study of the Liver Annual Meeting in … The post Latest data reinforces calls for extension of opt-out hepatitis B testing and highlights need to resolve inequalities...
As winter approaches, so does the circulation of respiratory viruses, increasing the risk to liver patients of … The post Campaign urges people at risk to get their flu and COVID-19 vaccinations appeared first on British Liver Trust .
October marks Liver Cancer Awareness Month, a time to shed light on a disease that often goes … The post Belinda’s story: Raising awareness of liver health and liver cancer in Liver Cancer Awareness Month appeared first on British...
A research team analyzed how diabetes mellitus and obesity factor into recurrence and survival after surgery for hepatocellular carcinoma, a type of liver cancer.
A study reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease). This...
Study reviews cardiovascular side effects linked to antiviral therapies for COVID-19, highlighting the need for careful consideration when prescribing these drugs to high-risk patients.
Members of the public in Belfast, Enniskillen and Derry/Londonderry are being encouraged to get their liver checked … The post Roadshow comes to Northern Ireland to find those ‘unaware’ they have liver damage appeared...
The British Liver Trust met with Neil Gray MSP, the Scottish Minister for Health and Social Care, … The post Cabinet Secretary meets with Less Survivable Cancers Taskforce appeared first on British Liver Trust .
On Wednesday, August 21st, our Chief Executive, Pamela Healy OBE, had the privilege of officially opening the … The post British Liver Trust at the opening of South West’s first liver specific ward appeared first on British Liver...
Researchers revealed how certain liver cells contribute to inflammatory responses underlying chronic hepatitis. Using mouse and cell culture models, they observed increased levels of inflammatory genes, including signaling molecules...
Millions of people around the world have now had COVID-19 vaccines. When they were first available, COVID-19 … The post Update for people with liver disease on the Covid-19 vaccine appeared first on British Liver Trust .
Faecal Microbiota Transplantation (FMT) to reduce susceptibility to infections resulting in hospitalisation for patients with liver disease. … The post The PROMISE study appeared first on British Liver Trust .
The white blood cells' typical role is to promote inflammation and stimulate the immune response, but researchers say some actually appear to temper inflammatory conditions and improve healing.
In this interview, we explore global and local efforts to combat viral hepatitis with Lindsey Hiebert, Deputy Director of the Coalition for Global Hepatitis Elimination (CGHE), and James Amugsi, a Mandela Washington Fellow and Physician...
Routine childhood vaccinations among children born between 1994 and 2023 have prevented millions of illnesses and deaths in the U.S., saving $540 billion in direct costs and $2.7 trillion in societal costs.
A study followed patients whose colorectal cancer was under control, but who had liver tumors that could not be surgically removed. All patients were eligible for liver transplantation, but some opted for other classical therapies, like...
Researchers uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to...
A new study brings researchers closer to better understanding the pathology of the fatty liver disease MASH, which stands for metabolic dysfunction-associated steatohepatitis. MASH is a consequence of poor diet and obesity and results in...
Research paper reviews the efficacy of the first licensed malaria vaccines, RTS,S and R21, highlighting their potential to significantly reduce childhood mortality and discussing future vaccine development strategies.
High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein...
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and one of the leading causes of cancer-related deaths worldwide. Early detection and accurate diagnosis are crucial for effective management and improved survival rates.
Nearly 40% of cancer cases and 44% of cancer deaths in 2019 were due to modifiable risk factors, with cigarette smoking as the leading cause. This study highlights the potential to significantly reduce cancer burden through lifestyle...
A new study led by researchers at the American Cancer Society (ACS) finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States (or 713,340 cancer cases and 262,120 cancer...
A new study has found a startling disparity in the frequency of liver disease for transgender individuals and highlights the need for more specialized care.
In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus infected cells but are inactive. Researchers have discovered that cells blood vessels in the liver start a 'sleep timer' that switches off...
While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure. A research team now might have found a way to turn back time and...
Early diagnosis of hepatocellular carcinoma (HCC) -- one of the most fatal malignancies -- is crucial to improve patient survival. In a breakthrough study investigators report on the development of a serum fusion-gene machine-learning...
Fatty liver disease (steatotic liver disease, SLD for short) is increasingly causing failure of the liver as a vital organ. A team led by researchers has now discovered that a saturated fatty acid in blood vessels leads to the production...
Early detection has the potential to transform treatment and outcomes in cancer care, especially for cancers like liver cancer, which is typically diagnosed at a late stage with limited options for cure. A new study suggests that...
What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a...
Researchers discovered liver resident macrophages' pivotal role in defending against gut bacteria and related substances entering via the portal vein, particularly under compromised intestinal barrier conditions. Identified as 'sentinel...
As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths. While the treatment options for this aggressive type of cancer remain limited, the incidence is increasing. A...