Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a...
Perjeta (chemical name: pertuzumab) used in combination with Herceptin (chemical name: trastuzumab), another targeted therapy medicine, and Taxotere (chemical name: docetaxel), a type of chemotherapy, to treat HER2-positive, metastatic...
Herceptin (chemical name: trastuzumab) can be used to treat HER2-positive breast cancer that is either early-stage or advanced-stage/metastatic. Herceptin is currently approved by the U.S. Food and Drug Administration: to treat...
Kadcyla (chemical name: T-DM1 or ado-trastuzumab emtansine) is a targeted therapy approved by the U.S. Food and Drug Administration (FDA) to treat: HER2-positive metastatic breast cancer that has previously been treated with Herceptin...
On Feb. 28, 2019, the U.S. Food and Drug Administration (FDA) approved an injectable form of Herceptin (chemical name: trastuzumab) called Herceptin Hylecta (chemical name: trastuzumab and hyaluronidase-oysk) to treat people diagnosed...
In a new study by Yale Cancer Center, researchers have demonstrated that in states with expanded Medicaid coverage through the Affordable Care Act a higher percentage of women with breast cancer had their disease diagnosed at an early...
The Prosigna Breast Cancer Prognostic Gene Signature Assay (formerly called the PAM50 test), made by NanoString, is a genomic test that analyzes the activity of certain genes in early-stage, hormone-receptor-positive breast cancer....
The Oncotype DX test is a genomic test that analyzes the activity of a group of genes that can affect how a cancer is likely to behave and respond to treatment. The Oncotype DX is used in two ways: to help doctors figure out a woman’s...
The MammaPrint test, made by Agendia, is a genomic test that analyzes the activity of certain genes in early-stage breast cancer. Research suggests the MammaPrint test may eventually be widely used to help make treatment decisions based...
The EndoPredict Test, offered by Myriad Genetics, Inc., is a genomic test for people newly diagnosed with early-stage, estrogen-receptor-positive, HER2-negative breast cancer. Research suggests the EndoPredict test may be widely used to...
The Breast Cancer Index test, made by Biotheranostics, analyzes the activity of seven genes to help predict the risk of node-negative, hormone-receptor-positive breast cancer coming back 5 to 10 years after diagnosis. The test can help...
Three American Cancer Society researchers will receive the Real-World Data Impact Award to advance patient-centric research, the ACS and Flatiron Health announced today.
In molecular biology, chaperones are a class of proteins that help regulate how other proteins fold. Folding is an important step in the manufacturing process for proteins. When they don't fold the way they're supposed to, it can lead to...
The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold...
"Clean margins" are a goal of cancer excision surgery. If even a small piece of cancerous tissue is left behind, it increases the likelihood of a local recurrence and spread of the disease, possibly reducing overall survival time.
The Breastcancer.org team is a passionate group of people committed to making every effort to provide you with balanced, responsible, encouraging, and thorough breast cancer information. The Breastcancer.org team consists of business...
Most people who have been diagnosed with cancer think they eat a healthy diet, but a study found that their diets were generally poor. The research was published in the June 2020 issue of the European Journal of Clinical Nutrition . Read...
When a solid cancer is surgically removed, any small piece that is left behind increases the chance of a local recurrence or spread. In a pilot study of dogs with mammary tumors, a disease very similar to human breast cancer, a team...
On June 29, 2020, the U.S. Food and Drug Administration (FDA) approved the fixed-dose combination of Herceptin (chemical name: trastuzumab), Perjeta (chemical name: pertuzumab), and hyaluronidase-zzxf to treat all stages of HER2-positive...
Reports show that cancer is the second-highest leading cause of death globally. A recent study by scientists provides new evidence supporting the presence of a key mechanism behind progression and relapse in cancer. The study discusses...
Studies on tumor-secreted microRNAs point to a functional role of these in cellular communication and reprogramming of the tumor microenvironment. Uptake of tumor-secreted microRNAs by neighboring cells may re...
Prof. TIAN Chao's group from the Department of Precision Machinery and Instrumentation, University of Science and Technology of China of the Chinese Academy of Sciences has made progress on the photoacoustic imaging for medical science.
Protein kinase C theta, (PRKCQ/PKCθ) is a serine/threonine kinase that is highly expressed in a subset of triple-negative breast cancers (TNBC) and promotes their growth, anoikis resistance, epithelial-mesench...
Three of the most well-known genes that can mutate and raise the risk of breast and/or ovarian cancer are BRCA1 , BRCA2 , and PALB2 . Women who inherit a mutation, or abnormal change, in any of these genes — from their mothers or their...
Russian scientists from Far Eastern Federal University, G. B. Elyakov Pacific Institute of Bioorganic Chemistry, and A.V. Zhirmunsky National Scientific Center for Marine Biology have discovered four new steroid substances which target...
Xue and colleagues analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005-2014 on 2,361 cancer survivors and 23,114 participants who had not had cancer as a comparison group.
Breast cancer is the most common malignancy to spread to the orbit and periorbit, and the invasive lobular carcinoma (ILC) histologic subtype of breast cancer has been reported to form these ophthalmic metasta...
A study suggests that women who talk to other people online shortly after being diagnosed with breast cancer may be more satisfied with their treatment decisions. The research was published online on July 28, 2016 by the journal JAMA...
Many, but not all, women who have mastectomy to treat breast cancer go on to have one or both breasts reconstructed. There are many ways to reconstruct a breast. Tissue from the back, belly, buttocks, or other part of the body can be...
C-reactive protein (CRP) is a protein in the blood. CRP levels are a marker for inflammation; your body makes more CRP when there is inflammation or infection. Many doctors use CRP levels to estimate overall heart health and help figure...
About 5% to 10% of breast cancers are thought to be hereditary, caused by mutated genes passed from parent to child. Genes are short segments of DNA (deoxyribonucleic acid) found in chromosomes. DNA contains the instructions for building...
Women of Ashkenazi Jewish descent who know they have a mutation in the BRCA1 or BRCA2 gene, but decided not to have preventive mastectomy, have better outcomes if they’re diagnosed with breast cancer compared to Ashkenazi Jewish women...
Women with a BRCA genetic mutation who have their ovaries and fallopian tubes removed preventively — called prophylactic bilateral salpingo-oophorectomy — are likely to have lower bone density after surgery, especially if a woman is...
In the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account for different immunohistochemistry assays, different cell types and different cutoff valu...
Scientists have identified and developed two potent small molecules that appear to suppress tumor growth in multiple cancers even when other treatments cease to work, possibly due to the development of drug resistance. Called CS1 and...
A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment...
With treatment altered or surgery postponed, more cancer patients are seeking help for mental wellbeing from charities struggling to fund it Coronavirus – latest updates See all our coronavirus coverage As the UK resigned itself to life...
Breast cancer survivors in romantic relationships who feel happy and satisfied with their partners may be at lower risk for a host of health problems, new research suggests.
New research finds that a protein called TiPARP acts as a terminator for several cancer-causing transcription factors, including HIF-1, which is implicated in many cancers, including breast cancer. The research demonstrates that TiPARP,...
Researchers have identified a gene that causes an aggressive form of breast cancer to rapidly grow. More importantly, they have also discovered a way to ''turn it off'' and inhibit cancer from occurring. The animal study results have...
How do tumors change their behavior and resist anticancer therapies? Cancer biologists have documented genetic signals that promote the conversion of cancer cells into those that resist therapy.
An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer.
The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer, according to preclinical studies. The promising preclinical results for this 'triple therapy' have underpinned a...
Breast cancer researchers have discovered a new type of immune cell that helps to keep breast tissue healthy by regulating a vital process within mammary ducts - the sites where milk is produced and transported, but also where most...
Trying to understand why dormant breast cancer cells survive despite being starved of estrogen to prevent growth, researchers found that breakdown of fat to produce energy supports cancer cell survival. This type of fat metabolism is...