Age has made me a more fully realized version of myself – I didn’t recognize that until returning to the Philippines Last month, it was my paternal grandmother’s 105th birthday. It’s unlikely that we’ll have many more chances to visit...
Am I just too fussy or too old? Either way I’m not cut out for a life in the wilderness I don’t really want to run away from everything. But I’m disappointed to realise I’m no longer able to do so anyway. We all have the instinct for...
Researchers have discovered a new way that neurons act in neurodegeneration by using human neural organoids -- also known as 'mini-brain' models -- from patients with frontotemporal lobar degeneration (FTLD). Understanding this new...
With the global prevalence of obesity on the rise, it is crucial to explore the neural mechanisms linked to obesity and its influence on brain and cognitive health. However, the impact of obesity on the brain is complex and multilevel.
Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its role in the brain was unknown until now. Researchers used preclinical models to uncover Tim-3's...
A federal judge in Texas blocked a Biden administration rule to boost staffing at nursing homes. The decision comes even though many homes lack enough workers to maintain residents’ care.
Researchers discovered the blood vessels at the back of the eye -- called retinal microvasculature -- can show early signs someone is at risk of developing dementia.
Calcium transport into and out of mitochondria -- the powerhouses of cells -- is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, cells rely on a protein known as the...
When the world’s oldest woman passed away at 117, much was made of her three yoghurts a day diet. But what role does yoghurt actually play in longevity? Get our weekend culture and lifestyle email Supercentenarians – humans who live...
Which moisturiser is worth buying? What’s the deal with retinol vs retinal? And do I need an eye cream? (Answer: no.) Our beauty columnist shares her secrets to glowy, firm skin Anti-ageing – I know, I know. It’s a gross and futile term....
Damage to the mitochondria, the 'power plants' of the cells, contributes to many diseases. Researchers now describe how cells with defective mitochondria activate a special recycling system to eliminate damaged genetic material.
Families, nursing facilities, and home health agencies rely on foreign-born workers to fill health care jobs that are demanding and do not attract enough American citizens. The Trump administration’s anti-immigration policies threaten to...
Los estadounidenses dependen de muchos trabajadores nacidos en el extranjero para cuidar a sus familiares mayores, lesionados o discapacitados que no pueden valerse por sí mismos.
In a new extensive systematic review, researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any one of them can reduce your risk of all three conditions. The findings...
From halting diversity programs that benefit disabled workers to making federal staffing cuts, the Trump administration has taken a slew of actions that harm people with disabilities.
Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer's disease, finds a new study.
Researchers have demonstrated how specific biomarkers in the blood can predict the development of dementia up to ten years before diagnosis, among older adults living independently in the community.
Older adults experience less muscle soreness following exercise according to research which overturns the widespread belief that aging muscles are less resilient. Younger adults were categorized as between 18 to 25 and older adults more...
A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% -- more than any other known intervention.
Why is the moral panic only ever about younger generations? It’s time we heard what confuses or worries them about us Every generation looks at the next generation, and the one after that, with bafflement and concern. There’s probably a...
Despite social media hype, there is little evidence that the therapies, marketed as pills, shots and IV infusions, have any effects on ageing The fountain of youth is an enduring legend. Different iterations of the fabled spring – which...
A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.
New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.
More than a quarter of adults over 65 fall annually. Fortunately, it’s avoidable, and when it happens you can recover The National Institute on Aging reports that more than one in four adults 65 and older fall annually. Fortunately, it’s...
Didier Eribon’s guilt and shame fuels an angry and eloquent meditation on our attitudes towards the elderly and the end of life “My mother,” writes Didier Eribon, “was unhappy her whole life.” Abandoned as a child, she started work at 14...
Thank you, Guardian | Grudges | Couples therapy | Meat-free Feast | Labour membership John Crace’s mention of his late mother, Rosemary, carrying the Guardian around her care home moved me to tears ( Digested week, 21 March ). My...
People living in more disadvantaged neighborhoods may be more likely to develop dementia than people living in neighborhoods with fewer disadvantages, according to a new study. The study does not prove that neighborhood factors cause...
People who have early signs of heart problems may also have changes in brain health that can be early signs of dementia, such as loss of brain volume, according to a meta-analysis. The meta-analysis does not prove that early heart...
A study finds that factors beyond a person's control, like socioeconomic status and whether their mom smoked or was obese, can influence whether they are overweight or obese as teenagers or adults.
Stroke survivors who have attended some level of higher education may face even steeper mental declines, according to a study. The findings suggest that attending higher education may enable people to retain greater cognitive ability...
For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer's disease and other chronic diseases. But these cells are...
An adult brain affected by attention deficit disorder with or without hyperactivity (ADHD) presents modifications similar to those observed in individuals suffering from dementia. These are the findings of a study which shows that,...
Maintaining a healthy diet rich in plant-based foods, with low to moderate intake of healthy animal-based foods and lower intake of ultra-processed foods, was linked to a higher likelihood of healthy aging -- defined as reaching age 70...
An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study. The findings suggest -- for the first time in a...
For women in their 80s, experiencing increasing sleepiness during the day over a five-year period is associated with double the risk of developing dementia during that time, according to a new study. The study does not prove that daytime...
Motoring figures | The power of music | Art appreciation | Friends’ joint accounts | Drummer jokes “Fresh incentives to boost a flatlining electric car market are urgently needed, according to the UK automotive industry,” you report ( 13...
Dining out | Sourdough don’ts | Is this art? | Organ recital | Online safety I take no notice of the reviews posted by restaurant customers ( ‘The customer isn’t always right’: top chef loses appetite for difficult diners, 15 March )....
Losing a licence can be a blow to older people’s independence, but keeping it too long can be fatal Get our weekend culture and lifestyle email Our octogenarian dad had been driving for almost 65 years and he wasn’t about to willingly...
Older men get a surprisingly large benefit from volunteering opportunities that they find meaningful. "Grandpas United" brings them into schools for life lessons that benefit both generations.
Researchers have revealed a new scientific clue that could unlock the key cellular pathway leading to devastating neurodegenerative diseases like Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
A research team has developed a new system to estimate a person's biological age -- a measure of how well their body has aged, rather than just counting the years since birth. Using just five drops of blood, this new method analyzes 22...
A person's 'bioenergetic age' -- or how youthfully their cells generate energy -- might be a key indicator of whether they're at risk of developing Alzheimer's disease, new research shows. The study suggests healthy living can turn back...
Researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery. In a major breakthrough, they have been able to see the human PINK1 protein and how it is switched on for the first time....
Sarah Sorensen says we should be hanging up on surveillance capitalism The Guardian has published quite a lot of articles recently expressing some concern over the use of smartphones. Emma Beddington’s piece ( My phone knows what I...
Everyday afflictions | New moons | Art appreciation | Cinema ads | End of the peer show Regarding Adrian Chiles’s article ( I twanged my achilles playing pickleball. Here’s what it taught me about tendons – and human nature, 12 March ),...