University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.
A test using genetics to predict who is at the highest risk of developing type 1 diabetes could one day be applied to large-scale health studies, to identify adults who could benefit from new drugs, new research shows.
A rare genetic disorder discovered by UT Southwestern Medical Center researchers and their colleagues can cause brain damage from dangerously low blood sugar levels and liver damage in infants, along with variable body fat loss...
Scientists discovered a small protein region that determines whether plants reject or welcome nitrogen-fixing bacteria. By tweaking only two amino acids, they converted a defensive receptor into one that supports symbiosis. Early success...
Researchers at the University of Pittsburgh and UPMC Children's Hospital of Pittsburgh discovered a promising new biomarker of "complicated" mild to severe pediatric traumatic brain injury, or TBI. Unlike a concussion—which usually...
A new study has developed a powerful computational method that can detect how genes interact with each other to influence complex traits in humans at a scale previously impossible. The new method was applied to massive datasets that pair...
A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to...
When it comes to brain function, neurons get a lot of the glory. But healthy brains depend on the cooperation of many kinds of cells. The most abundant of the brain's non-neuronal cells are astrocytes, star-shaped cells with a lot of...
A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with the same leukemia-causing gene mutation can have dramatically different outcomes: It depends on when in development the mutation first...
A single-dose gene replacement therapy is found to improve movement ability in children over 2 years of age and teenagers with spinal muscular atrophy, according to research published in Nature Medicine. The results of this phase 3...
Even as they develop at their primary site, pancreatic cancer cells are already expressing the genes that will determine where they will metastasize, according to new findings from Columbia researchers. The work, published in Nature...
A new study published in Nature Communications reveals the specific genetic factors linked to the presence of reticular pseudodrusen—deposits that drive vision loss and are found on the retina of up to 60% of people with advanced...
Researchers revealed that the microbial metabolite TMA can directly block the immune protein IRAK4, reducing inflammation and improving insulin sensitivity. The molecule counteracts damage caused by high-fat diets and even protects mice...
High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact within these droplet-like structures. The findings connect molecular architecture to the broader behaviors of...
Tuberculosis (TB) is one of the oldest and deadliest infectious diseases we know. It commonly impacts the lungs, but can also affect other areas of the body like the spine, brain or kidneys.
Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services. That's what happens inside cells when the 3D structure of DNA collapses.
Scientists have developed algorithms that give predictive scores for a host of physical and mental traits UK IVF couples use legal loophole to rank embryos based on potential IQ, height and health The Guardian has learned that couples...
British fertility clinics raise scientific and ethical objections over patients sending embryos’ genetic data abroad for analysis What is polygenic embryo screening in IVF and does it work? Couples undergoing IVF in the UK are exploiting...
Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable bacterial product causes mutations in DNA that have been linked to colorectal cancer. Because it breaks down...
A gene that turns on very early in embryonic development could be key to the formation of the placenta, which provides the developing fetus with what it needs to thrive during gestation.
A genetic variant is likely putting some children suffering with myocarditis—inflammation of the heart muscle—at higher risk of developing heart failure, which can be fatal, according to a study published in Circulation Heart Failure.
A new study shows that children born preterm who are later diagnosed with autism often present with more extensive support needs and a higher number of co-occurring conditions than autistic children born at full term. Surprisingly,...
A team from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labeled affinity-purified mass spectrometry plus sequencing) that, for the first...
A Northwestern Medicine study published in the Journal of Clinical Investigation has uncovered a connection between a well-known cancer-related protein and a major RNA modification process, which may inform new treatment strategies...
New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in cancer and identified cancer-driving mutations in an underexplored part of the genome.
A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common present-day chemicals could explain why some women are more likely to develop endometriosis.
In an Australian-first, researchers have been able to map inflammatory pathways and genetic signatures in Australian veterans who have been diagnosed with Gulf War Illness (GWI).
Researchers at The University of Texas MD Anderson Cancer Center have identified a specific protein, RASH3D19, that is responsible for activation of RAS signaling pathways involved in aggressive tumor growth and resistance to KRAS...
The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both sides of the DNA helix are cut at once. Healthy cells can normally fix these breaks using highly precise repair...
Understanding the shape or morphology of neurons and mapping the tree-like branches via which they receive signals from other cells (i.e., dendrites) is a long-standing objective of neuroscience research. Ultimately, this can help to...
Researchers have identified a molecular mechanism that helps explain why growing up in a stimulating environment enhances memory. In contrast, a lack of stimulation can impair it. The team from the Institute for Neurosciences (IN), a...
Cancer is a leading cause of death worldwide, and among all cancers, colorectal cancer ranks second in mortality, responsible for more than 900,000 deaths in 2020.
Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of standardization and consistency. To address...
Cedars-Sinai scientists have developed an experimental drug that repairs DNA and serves as a prototype for a new class of medications that fix tissue damage caused by heart attack, inflammatory disease or other conditions.
Researchers recreated conditions from billions of years ago and found that Earth’s young atmosphere could make key molecules linked to life. These sulfur-rich compounds, including certain amino acids, may have formed naturally in the...
Ant pupae that are fatally sick don’t hide their condition; instead, they release a special scent that warns the rest of the colony. This signal prompts worker ants to open the pupae’s cocoons and disinfect them with formic acid,...
Scientists found that adult bristleworm eyes grow continuously thanks to a rim of neural stem cells similar to those in vertebrate eyes. This growth is surprisingly regulated by environmental light via a vertebrate-like c-opsin. The...
Dolichospermum, a type of cyanobacteria thriving in Lake Erie’s warming waters, has been identified as the surprising culprit behind the lake’s dangerous saxitoxins—some of the most potent natural neurotoxins known. Using advanced genome...
Researchers studying thousands of canine genomes discovered that wolf DNA is still present in most dog breeds. This ancient genetic influence shows up in traits like body size, behavior, and environmental resilience. Even dogs bred far...
Scientists decoded DNA from millennia-old lentils preserved in volcanic rock silos on Gran Canaria. The findings show that today’s Canary Island lentils largely descend from varieties brought from North Africa around the 200s. These...
Ribosomes don’t just make proteins—they can sense when something’s wrong. When they collide, they send out stress signals that activate a molecule called ZAK. Researchers uncovered how ZAK recognizes these collisions and turns them into...
Moss spores survived an extended stay on the outside of the ISS and remained capable of germinating once back on Earth. Their resilience to vacuum, extreme temperatures, and UV radiation surprised the researchers who expected them to...
Oliver Chu from California first person to have the one-off treatment for Hunter syndrome Doctors are cautiously optimistic about a groundbreaking gene therapy for children affected by a devastating inherited disorder after seeing...
UC Davis researchers engineered wheat that encourages soil bacteria to convert atmospheric nitrogen into plant-usable fertilizer. By boosting a natural compound in the plant, the wheat triggers bacteria to form biofilms that enable...
The prehistoric birch tar found in Estonia contained traces of saliva that were analysed by genetics experts A piece of stone age “gum” chewed by a teenage girl 10,500 years ago has been discovered by archaeologists in Estonia. The...
Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at different points, researchers can now...
Scientists used CRISPR to boost the efficiency and digestibility of a fungus already known for its meatlike qualities. The modified strain grows protein far more quickly and with much less sugar while producing substantially fewer...
Scientists are turning venom, radioisotopes, engineered proteins, and AI into powerful new tools against cancer. From Amazonian scorpions yielding molecules that kill breast cancer cells as effectively as chemotherapy, to improved fibrin...
Researchers have sequenced the oldest RNA ever recovered, taken from a woolly mammoth frozen for nearly 40,000 years. The RNA reveals which genes were active in its tissues, offering a rare glimpse into its biology and final moments....