A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized fluorescence technology, a valuable...
A clinical research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), and international genetic researchers led a global research study using multi-omics analysis and identified a novel gene, DDX39B, for a rare...
Blood proteins serve as crucial indicators of health and disease risk throughout development. Now, researchers at the University of Copenhagen and the Max Planck Institute of Biochemistry have revealed how these proteins are regulated...
Doctors in London have become the first in the world to cure blindness in children born with a rare genetic condition using gene therapy. The children had leber congenital amaurosis (LCA), a form of retinal dystrophy that causes vision...
Four children can now see shapes, find toys, recognise their parents’ faces and some can read and write Doctors in London have become the first in the world to cure blindness in children born with a rare genetic condition using a...
Researchers from the Mitochondrial Medicine Program at Children's Hospital of Philadelphia (CHOP) have better characterized a spectrum of what were classically considered discrete mitochondrial DNA deletion disease syndromes. The...
Rett syndrome is a rare genetic disease affecting 1 in 10,000 newborn girls, characterized by sudden regression around 1 year of age, with loss of acquired language and motor skills and leading to profound cognitive impairment. Its main...
A gene called high mobility group A1 (HMGA1) may be the key that opens the door to the development of colon cancer, according to research led by investigators from the Johns Hopkins Kimmel Cancer Center, Johns Hopkins Department of...
Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with regulatory processes to prevent this chaos. One such mechanism involves a protein called p53. Often dubbed the...
Highly valued economically, ecologically and culturally, the white oak (Quercus alba) is a keystone forest species and is one of the most abundant trees across much of eastern North America. It also faces declining seedling recruitment...
Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.
Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, researchers have identified a vulnerability that opens the door to new treatments.
Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, the most common genetically-caused...
Scientists at the Icahn School of Medicine at Mount Sinai and collaborators have identified novel genetic interactions that may contribute to congenital heart disease (CHD), a common birth defect.
Genetic testing should be used to help doctors spot high-risk cases of myeloma and enable targeted treatments, say researchers from the University of Leeds and The Institute of Cancer Research.
New research shows almost 90% of people in England would agree to genetic testing to get the most effective medication and reduce the risk of side effects. The study is published in the QJM: An International Journal of Medicine.
Cardiac arrhythmias affect millions across the world and are responsible for a fifth of all deaths in the Netherlands. Currently there are multiple treatment options, ranging from life-long medication to invasive surgical procedures....
Science editor Ian Sample joins co-host Madeleine Finlay to discuss some of the most intriguing science stories of the week. From a concerning rise in hospital diagnoses of constipation in children, to research suggesting that the...
A strong perception of experiencing discrimination correlates with differences in human gene expression by race and sex. Interestingly, some of the affected genes are involved in conditions, such as certain cancers, that are associated...
A team of researchers at NYU Abu Dhabi has uncovered how genetic and lifestyle factors influence immune responses to malaria in children from two large West African ethnic groups. The study found that children from the Fulani group have...
Researchers have found a compound in ginger, called furanodienone (FDN), that selectively binds to and regulates a nuclear receptor involved in inflammatory bowel disease (IBD). While researchers have been aware of FDN for decades, they...
An international team of researchers has, for the first time, created a detailed map of the location and identity of individual cells in the adult lung, both from healthy lungs and in lungs from people affected by chronic lung disease.
A research team led by Prof. Jiang Yanyi from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has uncovered an important mechanism that enables squamous cell carcinoma (SCC) to resist ferroptosis, a form of...
A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University...
Researchers from the Huntington's Disease Center, UCL Queen Square Institute of Neurology, and UK DRI at UCL have taken major steps forward in advancing MSH3-targeting therapies for Huntington's disease (HD). Their study is published in...
Analysis of UK BioBank data shows importance of factors including living conditions and smoking, say experts The environment is about 10 times more important than genes in explaining why some people have a higher risk of an early death...
Researchers used mice with nine different genetic backgrounds to identify factors influencing eye aging, paving the way for eye-based diagnostics for neurodegenerative diseases.
Vision changes are an inevitable part of aging, but why are some more susceptible to age-related eye diseases and why do some individuals experience more severe decline than others? New research from The Jackson Laboratory (JAX) reveals...
Researchers at Tel Aviv University, led by Prof. Illana Gozes, examined the effects of different mutations in the ADNP protein, which is essential for normal brain development and aging, on the brain cells of mice—distinguishing between...
A groundbreaking study has revealed a surprising biochemical connection between plant immune responses and human neurological health. Researchers have discovered that the metabolic pathways regulating vitamin B6 homeostasis -- critical...
A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and inhibit liver fibrosis.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle weakness and eventually death. While significant strides have been made in...
A new international study led by scientists from Ben-Gurion University of the Negev has characterized the populations of fat cells in various fat tissues in the human body. Using innovative technology, the researchers were able to...
Biologists converted gut bacteria into miniature protein factories that manufacture and release a sustained flow of targeted proteins inside the lower intestines. This technique solves one of the longstanding problems surrounding...
The effectiveness of a common drug to quit smoking could be down to people's genes, according to a study from the University of Leicester (United Kingdom).
Past research studies have consistently found that there are disparities in the health outcomes of people from different socio-economic backgrounds. More recently, some findings hinted at the possibility that genetics also play a role in...
Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch. Previous studies from the Gastrointestinal Genetics team at CIC bioGUNE—BRTA and LUM University...
Thousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of developing cancer. But until now, it's not been clear which are directly responsible for the uncontrolled...
Max Planck Institute for Biological Intelligence researchers have identified over 60 transcriptomic neuron types in the zebrafish optic tectum with nearly identical gene-expression profiles yet very different functions and shapes,...
The TV reporter’s struggles with depression and the suicide of his father, whose own father killed himself, prompt this incisive, highly personal investigation J ames Longman is an English broadcast journalist who was the BBC’s man in...
Scientists discovered years ago that the hypothalamus -- which helps to manage body temperature, hunger, sex drive, sleep and more -- includes neurons that express the protein opsin 3 (OPN3). Far less clear, however, was what this...
The clownfish-anemone living arrangement is one of the most widely recognized examples of symbiosis. Researchers have made a breakthrough in understanding how anemonefish can live safely among sea anemones without being stung by their...
Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause of the currently incurable...
Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.
A research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating Charcot-Marie-Tooth disease.
A guardian molecule ensures that liver cells do not lose their identity. The discovery is of great interest for cancer medicine because a change of identity of cells has come into focus as a fundamental principle of carcinogenesis for...