An international research collaboration, including Professor Iijima Kazumoto et al. (of the Department of Pediatrics, Kobe University Graduate School of Medicine) has revealed that NPHS1 is a disease-susceptibility gene for...
The pandemic has forced health care providers to find new ways to connect with patients through screens. For genetic specialists, who provide patients and families with genetic testing for conditions linked to DNA, connecting with...
Scientists at Johns Hopkins Medicine have found types of cells in the brain that are most susceptible to inherited genetic variants linked to schizophrenia. As a result, their work reveals a shortlist of the variants that most likely...
For the first time, scientists have shown that the bacterium that causes the tick-borne disease anaplasmosis interferes with tick gene expression for its survival inside cells and to spread to a new vertebrate host.
Almost all land plants employ an army of molecular editors who correct errors in their genetic information. Researchers have now transferred one of these proofreaders from the moss Physcomitrium patens (previously known as Physcomitrella...
Researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination.
The immune system is supposed to protect from external microbial invaders, but sometimes it turns its efforts inward, potentially resulting in autoimmune diseases. In a new study, researchers from Osaka University have discovered how...
The Editor-in-Chief of Human Gene Therapy, the first journal devoted to the field of gene therapy, and one of the world's leading experts on gene therapy have co-authored a new editorial, Moving Forward After Two Deaths in a Gene Therapy...
Flashback to mid-March: the novel coronavirus had reached San Diego, California. Few people could get tested, and even less was known about how the virus mutated as it spread from person to person.
New technologies capable of sequencing single molecules in fine detail will help scientists better understand the mechanisms of rare nucleotides thought to play an important role in the progression of some diseases.
Cyanobacteria hardly need any nutrients and use the energy of sunlight. Bathers are familiar with these microorganisms as they often occur in waters. A group of researchers has discovered that the multicellular species Phormidium lacuna...
Evaluating the genetic correlations across our phenotypes is of essential importance for understanding disease etiology and other potential causality. A new method—published in the journal Nature Genetics—vastly improves estimates of...
Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a...
Researchers analyzed the epigenetic and transcriptional regulation in structural cells. They found widespread activity of immune genes, suggesting that structural cells are deeply involved in the body's response to pathogens. Moreover,...
Researchers mapped the signaling network in plants and discovered novel insights about how plants process information about their environment. This gives new potential to strategies to protect crops and help them thrive in the time of...
(HealthDay)—Different genetic test interpretations have been identified for genetic variants, and some of these can impact patient management, according to a research letter published online June 30 in the Annals of Internal Medicine.
Melbourne researchers have developed a fast, new test for infections and infectious diseases that could transform Australia's ability to provide targeted clinical care and respond to pandemics and biosecurity threats.
An international team of scientists from Switzerland Spain, has studied the genetic basis of aromatase deficiency, a rare metabolic disorder that prevents the production of estrogens in humans, according to new research in JCEM (Journal...
After several years of experimentation, scientists have engineered thale cress, or Arabidopsis thaliana, to behave like a succulent, improving water-use efficiency, salinity tolerance and reducing the effects of drought. The tissue...
For the nascent brain of a human embryo to develop into the complex organ that controls human consciousness, a finely tuned sequence of genetic events has to take place; hundreds of genes are activated and deactivated in a precise...
Many rheumatic conditions develop slowly and initially have inflammatory arthritis as the first sign that something is amiss. The trouble with such close similarity is the difficulty that clinicians have differentiating one condition...
By sequencing entire genomes for DNA modifications, and analyzing both cancer tissues and healthy ones, Hackensack Meridian Health researchers and doctors have found what could be a key to risks for cancer and other diseases: specific...
Researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease called familial Mediterranean fever because of evolutionary pressure to survive the bubonic plague epidemics.
Scientists have found a way to control different plant processes -- such as when they grow -- using nothing but colored light. The development reveals how colored light can be used to control biological processes in plants by switching...
Researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague. The study, carried out by scientists at the National Human...
Cancers arise when the genetic code of normal cells is altered, causing excessive growth. Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have discovered a protein...
Chemically engineered peptides could prove valuable in the battle against some of the most persistent human health challenges. New findings demonstrate how researchers can engineer peptides capable of selectively and specifically binding...
Researchers have identified a novel protein complex that regulates Aurora B localization to ensure that chromosomes are correctly separated during cell division. The complex, NWC, is made up of three proteins: NOL11, WDR43, and Cirhin....
Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's...
The most common congenital disorders of all, especially in baby boys, are differences in a newborn's sexual anatomy that is not standard female or male. In boys, they include undescended testicles, misplaced urethras, and improperly...
This nuanced study argues that far from being an unwelcome threat to global stability, migration and mixing are essential to human survival “A wild exodus has begun,” writes Sonia Shah early on in The Next Great Migration . “It is...
Researchers have performed the first room temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. It marks an important first step in the ultimate goal of building a comprehensive...
Scientists at deCODE genetics, a subsidiary of Amgen, and their collaborators from the Icelandic healthcare system, University of Iceland and the Karolinska Institute in Sweden, have published a study in Nature comparing over 30,000...
Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of the drugs actinomycin and streptomycin and are known to harbor other...
In recent months, even as our attention has been focused on the coronavirus outbreak, there have been a slew of scientific breakthroughs in treating diseases that cause blindness.
We all know that there are ''good'' and ''bad'' bacteria, but scientists have little insight into how bacteria become ''bad'' or ''pathogenic'' and cause disease. Now, a team of scientists has described how mutations resulting in the...
Researchers develop an artificial cell that brings to light the dynamics that govern each cell's internal symmetry. Two coexisting actomyosin networks with opposing functions exists in cells: a ring-like centripetal actomyosin that...
The ability to sequence the genome of a tumor has revolutionized cancer treatment over the last 15 years by identifying drivers of cancer at the molecular level. But understanding the genetic diversity of individual cells within a tumor...
A new study of childhood epilepsy has identified the world's first environmental risk factor for the disease—maternal smoking in pregnancy, and discovered a new genetic association with the condition, pointing to potential new treatments...
Genes located in 'copy number variants' (CNVs) -- parts of chromosomes that are missing in some individuals and duplicated in others -- that are associated with neurodevelopmental disorders affect more than just brain development,...
Scientists at St. Jude Children's Research Hospital alongside global partners are studying a common TP53-R337H variant found among people of Brazilian descent. The researchers found that a variant in the tumor suppressor gene XAF1...
Genes located in 'copy number variants' (CNVs)—parts of chromosomes that are missing in some individuals and duplicated in others—that are associated with neurodevelopmental disorders affect more than just brain development, according to...
DNA testing companies like Ancestry.com and 23andMe are using their expertise in the fight against COVID-19. Ancestry.com's study is available only to its members, but 23andMe is asking past and present COVID-19 patients (customers or...
Life depends on an intricate game of hide-and-seek taking place inside the cell. New research sheds light on the mechanisms with which DNA-binding proteins search the genome for their specific binding sites.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Radboud University Medical Center in the Netherlands have identified mutations in a gene called CNOT1 that affect brain development and impair memory and learning. The...
A research program pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease. Whole genome sequencing is the technology used by the 100,000 Genomes Project, a...
A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. The study found that these pre-clinical mutations were...
An arthritis drug is to be trialed as a treatment for children with a fatal metabolic disorder which causes neurological deterioration thanks to University of Manchester researchers.