Researchers have discovered genes linked to obesity in both Labradors and humans. They say the effects can be over-ridden with a strict diet and exercise regime.
Researchers studying British Labrador retrievers have identified multiple genes associated with canine obesity and shown that these genes are also associated with obesity in humans. The results are published in the journal Science.
Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition...
Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and...
A study conducted by researchers at the University of Tartu showed a nearly five-fold enrichment of hereditary cancer variants in infertile men compared to fertile men.
At a time when US scientists are under attack from their own government, the illiteracy around these elephantine fantasies is dangerous You will never ever see a living woolly mammoth. While this is an obvious truth to most geneticists,...
UCSF researchers may have discovered how the female brain remains resilient in aging, answering an age-old question of how most women outlive men and retain their cognitive abilities longer.
Some bacteria deploy tiny spearguns to retaliate against rival attacks. Researchers mimicked attacks by poking bacteria with an ultra-sharp tip. Using this approach, they have uncovered that bacteria assemble their nanoweapons in...
A genetic mutation in mice affects cells required for sexual reproduction and holds clues about male infertility that could pave the way for new treatments and male contraceptives, a Rutgers University–New Brunswick researcher and...
The way in which blood stem cells evolve over a lifespan differs greatly between humans and mice, new research reveals. The findings provide a new understanding of the critical factors that influence tissue aging.
Johns Hopkins Medicine laboratory scientists say they have developed a potential new way to treat a variety of rare genetic diseases marked by too low levels of specific cellular proteins. To boost those proteins, they've created...
Bigger, tastier tomatoes and eggplants could soon grace our dinner plates thanks to scientists who have discovered genes that control how large the fruits will grow.
The latest research led from Manchester could revolutionize the diagnosis of Perrault syndrome, a rare genetic condition that results in hearing loss. In women, it also leads to early menopause or infertility. Perrault syndrome can be...
A new study has uncovered that a gene variant common in Oceanian communities was misclassified as a potential cause of heart disease, highlighting the risk of the current diversity gap in genomics research which can pose a greater risk...
A new drug that works against the main types of primary bone cancer has been developed by researchers at the University of East Anglia and University of Sheffield.
RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at Baylor College of Medicine's Medical...
A vivid new image is taking shape in the world of cell biology: Imagine bacteria adhering to the surface of a cell, perhaps at the site of an injury or wound. In response, a white blood cell arrives at the scene. This cell encircles the...
Creation of a comprehensive genetic representation for more than 2.5 billion people across the Middle East and South Asia could make a major contribution towards advancing precision medicine, a publication in Nature Medicine reveals.
Researchers have discovered that what was previously thought to be a unique seaweed species of bladderwrack for the Baltic Sea is in fact a giant clone of common bladderwrack, perhaps the world's largest clone overall. The discovery has...
A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a 'ball-and-chain' channel-plugging mechanism. The findings boost the understanding of ion channel biology and...
The pioneering research of UC Santa Cruz's Upasna Sharma to determine how a father's life experiences and environment can influence the health and well-being of his children moves forward with the recent discovery of four genes required...
For the first time, large-scale DNA sequence data on three U.K. long-term birth cohorts has been released, creating a unique resource to explore the relationship between genetic and environmental factors in child health and development.
Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants A plan to revive the mammoth is on track, scientists have said after creating a new species: the woolly mouse. Scientists at the US...
Scientists from UCLA, the University of Toronto and the University of Melbourne have uncovered new genetic clues that explain why some prostate cancers remain slow-growing while others become life-threatening.
Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become a cancerous one. Among those genes, TP53 (encoding the p53 protein) has been identified as the most frequently...
DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these proteins -- called polymerase theta...
A research team has uncovered how a naturally occurring biological mechanism found in mammals is able to prevent sperm cells from interacting with an egg, preventing fertilization. The discovery, identified in rodent models, offers a new...
DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these proteins—called polymerase theta...
Researchers have shown how a low carbohydrate diet can worsen the DNA-damaging effects of some gut microbes to cause colorectal cancer. The study compared the effects of three different diets in combination with specific gut bacteria on...
New genetic links have been discovered between genetically predicted height and an individual's likelihood of developing a range of diseases and conditions. These new data could help improve early diagnosis and risk monitoring for patients.
E-cigarette use, including vaping, is often seen as a safer and trendier alternative to traditional tobacco products. However, a new study from researchers at the University of Rochester Medical Center published in Scientific Reports...
Despite advances in cancer treatment in recent years, five-year survival rates for acute myeloid leukemia (AML) remain low at just 30% on average, according to the National Cancer Institute. Factors in the development of AML are diverse...
Advances in generative artificial intelligence and machine learning, trained on large-scale datasets across multiple institutions, have the potential to revolutionize medicine. However, data is hard to gather. It is siloed in individual...
The KRAS G12C mutation is found in approximately 3% of all colorectal cancer cases and 1% to 2% of pancreatic adenocarcinoma cases, according to Hao Xie, MD, PhD, a medical oncologist at Mayo Clinic Comprehensive Cancer Center.
Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10–15%. However, this effect was only...
New research has looked into a comprehensive and structured approach to genetic testing, matching children and young people with cancer to targeted treatments. The study aimed to advance precision medicine in the UK to help young cancer...
The malaria parasite is still killing almost half a million people every year. A project has now identified a gene that holds out the prospect of a safe, effective live vaccine. The study is published in PLOS One.
A study led by UMass Chan Medical School researchers has demonstrated that a gene therapy to correct a mutation that causes maple syrup urine disease (MSUD) prevented newborn death, normalized growth, restored coordinated expression of...
Rare diseases (RD) are more common than you might think. For every 20 people you know, one is likely affected by a rare disease. Of the 7,000 known RD conditions, 80% have a genetic origin, yet over 95% remain incurable. Preventive...
Researchers have succeeded in generating high-quality feline embryonic stem cells using sperm and eggs from testes and ovaries discarded during sterilization surgery.
New research highlights the unique dilemma faced by Sydney's koala population. Populations in south-western Sydney are among the very few in New South Wales still free of chlamydia, a highly contagious disease causing infertility that...
A new study has identified a genetic circuit in plants that controls individual leaf growth and allows the plants to adapt to their environment. The findings could help the development of more drought-resistant crops.
The corn earworm causes the loss of more than 76 million bushels of corn in the United States annually, and there is mounting evidence that increasingly extreme weather events and temperatures will exacerbate the damage done to...
Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity. A new study details the unexpected...
Cells attach to each other through carefully arranged molecules. A research team has now found that the way they organize to find their proper places is similar to how grease drops self-organize in soup.
A comprehensive encyclopedia of the known functions of all protein-coding human genes has just been completed and released. Researchers used large-scale evolutionary modeling to integrate data on human genes with genetic data collected...