An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019. NAFLD is characterized by the accumulation of fat in at...
University of Toronto researchers have identified two genes that play a critical role in tumor growth in the pancreas—findings that have significant implications for understanding and treating pancreatic cancer.
When we form a new memory, the brain undergoes physical and functional changes known collectively as a "memory trace." A memory trace represents the specific patterns of activity and structural modifications of neurons that occur when a...
Women treated for ovarian cancer caused by an inherited faulty gene have a lower risk of developing breast cancer following that treatment, new research from Manchester University NHS Foundation Trust (MFT) and The University of...
Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method...
Millions of adults have atrial fibrillation—an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death. Many genetic mutations in the developing fetus can lead to adult atrial...
Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne...
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania revealed the most extensive single cell atlas of the human kidney, capturing the complexity of healthy and...
Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.
New research led by UCLA Health has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing insights useful to doctors developing targeted therapies.
Scientists have uncovered that "gene misbehavior"—where genes are active when they were expected to be switched off—is a surprisingly common phenomenon in the healthy human population.
Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other...
Researchers at Simon Fraser University, in collaboration with a group from Baylor College of Medicine in Texas, have identified a gene that appears to reverse Parkinson's disease symptoms in fruit flies.
A new and freely available Human Gut Microbiome Atlas could help researchers and health care professionals around the world better understand how microorganisms in the gut impact disease, leading to more effective treatment.
As a species, humans like to think that we are fully in control of our decisions and behavior. But just below the surface, forces beyond our conscious control influence how we think and behave: our genes.
New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the...
Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe...
As part of a breast cancer diagnosis, pathologists take cells from a biopsy and check them under a microscope. Most cancerous cells form roundish clumps, known as no special type, or invasive ductal carcinoma (IDC). In fewer patients,...
A new study by scientists at deCODE Genetics shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and other human traits.
Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular processes and has been implicated in...
Chronological age reveals the number of years an individual has lived since birth. By contrast, biological age varies between individuals of the same chronological age at a rate reflective of physiological decline.
Colorectal cancer (CRC) remains a significant global health concern, being the third most diagnosed cancer and the second leading cause of cancer-related deaths worldwide. In 2020 alone, CRC accounted for 1.9 million new cases and nearly...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that arises from the malignant transformation of T-cell progenitors. This disease is most commonly diagnosed in children, where it accounts for a significant...
A team of researchers at NYU Abu Dhabi, led by Professor Sehamuddin Galadari, has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cell death called ferroptosis in human...
A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.
The protein tau is essential to the function of cells in the brain and central nervous system, but when over-produced under certain conditions, it forms tangles that clog the cells' internal structures. These tangles have also been found...
Cancer is caused by genetic changes that occur in our cells over time. There are two main types of changes, namely somatic mutations, which are alterations in the DNA sequence, and copy number alterations, which are changes in the number...
Despite rapid advances in genetic testing in recent decades, more than half of people worldwide with suspected Mendelian genetic disorders do not have an accurate molecular diagnosis. Others endure more than six years of tests before a...
A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.
Parkinson's disease is the world's fastest growing neurological condition. Currently there are no drugs or therapies that slow or stop the progression of the disease.
Scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of...
Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for...
A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even though they are non-toxic,...
A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days...
In Huntington's disease, the mutant huntingtin gene (HTT) mRNA is retained in the nucleus and forms insoluble clusters. A new study shows that short interfering RNA (siRNA), an oligonucleotide therapeutic strategy that reduces levels of...
The Association for Molecular Pathology (AMP) has published consensus recommendations to aid in the design and validation of clinical DPYD genotyping assays, promote standardization of testing across different laboratories, and improve...
Don’t put your faith in the 10,000-hour rule – some athletes are born with talents the rest of us will never have Stefan Holm was told he was too short to be a high jumper. But by the time he won Sweden a gold medal in the 2004 Olympics,...
Researchers call on the government to settle dispute, which they say is impeding groundbreaking research Researchers have called on the government to step in to settle a dispute preventing them from fully exploiting the world’s largest...
Recent research on Lotus japonicus, a model leguminous plant, has unveiled that the interaction between legume roots and rhizobia is characterized by periodic gene expression with a six-hour rhythm. This rhythmic gene expression...
A group of small, freshwater animals (bdelloid rotifers) protect themselves from infections using antibiotic recipes 'stolen' from bacteria, according to new research. This raises the potential that rotifers are producing novel...
New research is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena.
The human genome is filled with flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago. Scientists used to think they were harmless, but new research shows that, when reawakened, they help...
The discovery of a hybrid population of poplar trees in western Wyoming has provided insight into how natural hybridization informs the evolution of many plant species, according to researchers. They also said their discovery suggests...
High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein...