• Saliva analysis could reveal risk of developing cancer, heart disease or Parkinson's using molecular markers
    Thursday, June 26, 2025 from Medical Xpress - Genetics News
    A research team led by the University of the Basque Country has identified hundreds of molecular markers in saliva that could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and...
  • UK scientists to synthesise human genome to learn more about how DNA works
    Thursday, June 26, 2025 from Genetics | The Guardian
    Five-year SynHG project aims to pave way for next generation of medical therapies and treatment of diseases Researchers are embarking on an ambitious project to construct human genetic material from scratch to learn more about how DNA...
  • ‘Huge advances in cancer and rare diseases’: 25 years of the human genome – podcast
    Thursday, June 26, 2025 from Genetics | The Guardian
    It has been 25 years since Bill Clinton announced one of humanity’s most important scientific achievements: the first draft of the human genome. At the time, there was a great deal of excitement about the benefits that this new knowledge...
  • Protein split reveals dual roles in childhood ciliopathies and cell signaling
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    New research by Sumeda Nandadasa, Ph.D., reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, Joubert syndrome and other ciliopathies is cut in half to perform two separate functions, both of which are...
  • Early biomarkers of brain damage progression in Alzheimer's disease revealed
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    A new study led by scientists from BGI Genomics' Institute of Intelligent Medical Research (IIMR) has identified early biomarkers and disease neurons associated with Alzheimer's Disease (AD) pathology.
  • Spatial mapping reveals network of cells and genes involved in Crohn's disease complication
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    Up to half of patients with Crohn's disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these...
  • New study reveals genetic link between brain criticality and human cognition
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    A new study has revealed compelling evidence that brain criticality—a dynamic balance between neural excitation and inhibition—has a strong genetic foundation and is associated with cognitive performance. The research was published on...
  • Aggressive blood cancer: A key protein could pave the way for targeted therapies
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    Acute myeloid leukemia (AML) is an aggressive cancer affecting the blood and bone marrow that progresses rapidly, making immediate treatment essential. While chemotherapy and targeted drugs have improved outcomes for some patients, many...
  • Gene therapy may slow loss of motor function in ALS
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    Researchers have developed a gene therapy that significantly slowed motor function loss in preclinical models of amyotrophic lateral sclerosis (ALS), offering new hope for treating the devastating neurodegenerative disease.
  • How old are you really? Are the latest 'biological age' tests all they're cracked up to be?
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    We all like to imagine we're aging well. Now a simple blood or saliva test promises to tell us by measuring our "biological age." And then, as many have done, we can share how "young" we really are on social media, along with our secrets...
  • Just how identical are identical twins?
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    From Romulus and Remus—the myth of the twin brothers who founded the city of Rome—to the synchronized speech of Australia's "Twinnies" Paula and Brigette Powers, identical siblings have long inspired our fascination and imagination.
  • One scientist's bold vision to make on-demand treatments routine for life-threatening rare genetic diseases
    Wednesday, June 25, 2025 from Medical Xpress - Genetics News
    In May 2025, researchers announced that K.J. Muldoon, a baby boy born without the ability to process dietary protein properly, had become the first person to be treated with a customized gene-editing therapy. Based on a technology...
  • Scientists reprogram ant behavior using brain molecules
    Wednesday, June 25, 2025 from ScienceDaily: Genetics News
    Leafcutter ants live in highly organized colonies where every ant has a job, and now researchers can flip those jobs like a switch. By manipulating just two neuropeptides, scientists can turn defenders into nurses or gardeners into leaf...
  • Researchers find that genetic ancestry influences how gene mutations impact cancer prognosis
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    Investigators have unveiled for the first time that changes in certain genes affect an aggressive cancer, T-cell acute lymphoblastic leukemia (T-ALL), differently depending on genetic ancestry.
  • Novel study uncovers the critical role of ADAM10 protein in the development of retinal disorders
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina, which can cause vision loss or impairment.
  • Best practice recommendations for clinical homologous recombination deficiency testing published
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD) testing. The manuscript, titled...
  • First-of-its-kind dataset illuminates gene activity in African populations
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    The newly launched South African Blood Regulatory (SABR) dataset reveals how genetic variation influences blood traits and gene activity in African populations, providing crucial insights into diseases like diabetes and heart disease.
  • Insulin on edge: Study identifies stress-triggered gene behind diabetes
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    Researchers from Osaka Metropolitan University have identified a gene that, when activated by metabolic stress, damages pancreatic β-cells—the cells responsible for insulin production and blood sugar control—pushing them toward...
  • Two proteins that could lead to less toxic cancer treatments identified
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated. When this fails, the wrong parts of the genome can be activated,...
  • Gene mutation could be target for 'ultrapersonalized' therapies in colon cancer
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene—a gene that can cause cancer—that may play an important role in colon cancer. Researchers also showed how this mutation could be targeted therapeutically.
  • Gene editing treats smooth muscle disease in preclinical model
    Tuesday, June 24, 2025 from Medical Xpress - Genetics News
    Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center blocked the symptoms of a rare smooth muscle disease before they developed. Their findings, published in Circulation, could eventually lead to gene...
  • These frozen wolf cubs ate a woolly rhino—and changed what we know about dogs
    Tuesday, June 24, 2025 from ScienceDaily: Genetics News
    Two Ice Age wolf pups once thought to be early dogs have been identified as wild wolves, thanks to detailed DNA and chemical analysis. Surprisingly, their last meals included woolly rhinoceros meat—an unusually large prey item—hinting...
  • A new genetic target could shape the future of liver cancer treatment
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    Hepatocellular carcinoma (HCC), the most common type of liver cancer and the third-leading cause of cancer-related deaths worldwide, is extremely challenging to treat. However, the future of HCC patient care looks brighter thanks to...
  • How inflammation drives prostate tumor formation
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death in men worldwide. However, the mechanisms controlling the early stages of prostate cancer formation are poorly understood.
  • Common drug shows promise in halting rare blood cancer by restoring tumor suppressor
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    Northwestern Medicine scientists have uncovered key details about a group of rare but serious blood disorders, which may help inform potential treatments, according to a study published in the Journal of Clinical Investigation.
  • Genetic cause for rare childhood brain developmental disorder found
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    University of Otago–Ōtākou Whakaihu Waka has led international research uncovering a new genetic cause for a rare developmental disorder that profoundly impacts brain growth and function in children.
  • Genomic test uses chromosomal instability to predict which patients will not respond to cancer chemotherapy
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    Chemotherapy seeks to destroy tumor cells and has been a standard treatment for cancer for decades. However, it doesn't always work. "Chemotherapy is good for some patients, but it's not effective in all cases. Between 20 and 50% of...
  • Sex-specific pathway driving melanoma metastasis discovered, with implications across female cancer treatments
    Monday, June 23, 2025 from Medical Xpress - Genetics News
    Institut Curie researchers have identified a sex-specific molecular pathway connecting E-cadherin loss, estrogen receptor-α (ERα), and GRPR, contributing significantly to increased melanoma metastasis in women.
  • From cursed tomb fungus to cancer cure: Aspergillus flavus yields potent new drug
    Monday, June 23, 2025 from ScienceDaily: Genetics News
    In a remarkable twist of science, researchers have transformed a fungus long associated with death into a potential weapon against cancer. Found in tombs like that of King Tut, Aspergillus flavus was once feared for its deadly spores....
  • Mismatch repair germline pathogenic variants could predispose to uveal melanoma
    Saturday, June 21, 2025 from Medical Xpress - Genetics News
    Mismatch repair (MMR) germline alterations are enriched among patients with uveal melanoma (UM), according to a study published online June 18 in JAMA Ophthalmology.
  • Computational tool exposes hidden cancer DNA changes that may drive treatment resistance
    Saturday, June 21, 2025 from Medical Xpress - Genetics News
    Some of the most harmful genetic changes in cancer are also the hardest to see. These structural alterations, deep within a tumor's DNA, can fuel aggressive growth and evade standard testing, especially when tissue samples are small or...
  • Genetics of cardiomyopathy risk in childhood cancer survivors differ by age of onset, study shows
    Saturday, June 21, 2025 from Medical Xpress - Genetics News
    The relationship between genetic variants and the risk of late-onset cardiomyopathy remains poorly understood in survivors of childhood cancer despite being otherwise well established. Scientists from St. Jude Children's Research...
  • All babies in England to get DNA test to assess risk of diseases within 10 years
    Friday, June 20, 2025 from Genetics | The Guardian
    Newborns will have whole genome sequencing to enable personalised healthcare that predicts and prevents illness Every baby in England is to have a DNA screening to avoid fatal diseases and receive personalised healthcare as part of the...
  • David Hopkinson obituary
    Friday, June 20, 2025 from Genetics | The Guardian
    My friend and former colleague David Hopkinson, who has died aged 89, was director of the Medical Research Council’s human biochemical genetics unit at University College London from 1976 until its closure in 2000. Hoppy, as he was...
  • Hidden cases of rare disease uncovered by rapid genetic testing method
    Friday, June 20, 2025 from Medical Xpress - Genetics News
    A new laboratory method developed by researchers at Columbia University Vagelos College of Physicians and Surgeons may now help physicians more quickly diagnose patients with suspected genetic disorders of the immune system, many who...
  • Frozen in time: Transparent worms keep genes in sync for 20 million years
    Friday, June 20, 2025 from ScienceDaily: Genetics News
    Even after 20 million years of evolutionary separation, two tiny worm species show astonishingly similar patterns in how they turn genes on and off. Scientists mapped every cell s activity during development and found that genes...
  • Novel gene linked to neurodevelopmental disorders and epilepsy could improve diagnosis
    Thursday, June 19, 2025 from Medical Xpress - Genetics News
    Researchers from Children's Hospital of Philadelphia (CHOP) have identified a novel gene associated with neurodevelopmental disorders and epilepsy. The study, published in the American Journal of Human Genetics, leveraged large data...
  • Aging's roll of the dice: How molecular randomness may drive differences in lifespan
    Thursday, June 19, 2025 from Medical Xpress - Genetics News
    "Biological stochasticity"—random events at the molecular and cellular level—might be one of the biggest, most overlooked drivers of differences in how we age, says Ryo Sanabria.
  • How life endured the Snowball Earth: Evidence from Antarctic meltwater ponds
    Thursday, June 19, 2025 from ScienceDaily: Genetics News
    During Earth's ancient Snowball periods, when the entire planet was wrapped in ice, life may have endured in tiny meltwater ponds on the surface of equatorial glaciers. MIT researchers discovered that these watery refuges could have...
  • Defying Darwin: Scientists discover worms rewrote their DNA to survive on land
    Wednesday, June 18, 2025 from ScienceDaily: Genetics News
    New research is shaking up our understanding of evolution by revealing that some species may not evolve gradually at all. Instead, scientists discovered that certain marine worms experienced an explosive genetic makeover when they...
  • DNA testing firm 23andMe fined £2.3m by UK regulator for 2023 data hack
    Tuesday, June 17, 2025 from Genetics | The Guardian
    Information stolen from US company included details of 150,000 British residents including family trees The genetic testing company 23andMe has been fined more than £2.3m for failing to protect the personal information of more than...
  • 23andMe’s founder wins bid to regain control of bankrupt DNA testing firm
    Monday, June 16, 2025 from Genetics | The Guardian
    Anne Wojcicki made $305m bid for firm, which has lost customers since declaring bankruptcy, with backing of Fortune 500 company 23andMe’s former CEO is set to regain control of the genetic testing company after a $305m bid from a...
  • 600-million-year-old body blueprint found in sea anemones
    Monday, June 16, 2025 from ScienceDaily: Genetics News
    Sea anemones may hold the key to the ancient origins of body symmetry. A study from the University of Vienna shows they use a molecular mechanism known as BMP shuttling, once thought unique to bilaterally symmetrical animals like humans,...
  • Tiny wasp’s shocking reproductive trick may transform global agriculture
    Sunday, June 15, 2025 from ScienceDaily: Genetics News
    Aphid-hunting wasps can reproduce with or without sex, challenging previous assumptions. This unique flexibility could boost sustainable pest control if its hidden drawbacks can be managed.
  • Koalas on the brink: Precision DNA test offers a lifeline to Australia’s icons
    Saturday, June 14, 2025 from ScienceDaily: Genetics News
    A University of Queensland-led project has developed a tool to standardise genetic testing of koala populations, providing a significant boost to conservation and recovery efforts.
  • Pincer plot twist: How female earwigs evolved deadly claws for love and war
    Thursday, June 12, 2025 from ScienceDaily: Genetics News
    Female earwigs may be evolving exaggerated weaponry just like males. A study from Toho University found that female forceps, once assumed to be passive tools, show the same kind of outsized growth linked to sexual selection as the male's...
  • Scientists discover natural cancer-fighting sugar in sea cucumbers
    Wednesday, June 11, 2025 from ScienceDaily: Genetics News
    Sea cucumbers, long known for cleaning the ocean floor, may also harbor a powerful cancer-fighting secret. Scientists discovered a unique sugar in these marine creatures that can block Sulf-2, an enzyme that cancer cells use to spread....
  • Scientists find immune molecule that supercharges plant growth
    Friday, June 6, 2025 from ScienceDaily: Genetics News
    Scientists have discovered that a molecule known for defending animal immune systems called itaconate also plays a powerful role in plants. Researchers showed that itaconate not only exists in plant cells but actively stimulates growth,...
  • Scientists uncover 230 giant ocean viruses that hijack photosynthesis
    Friday, June 6, 2025 from ScienceDaily: Genetics News
    Scientists have uncovered over 200 new giant viruses lurking in ocean waters that not only help shape marine ecosystems but also manipulate photosynthesis in algae. These massive viruses once nearly invisible to science are now being...
  • 23andMe back on the auction block after former CEO makes 11th-hour bid
    Thursday, June 5, 2025 from Genetics | The Guardian
    Anne Wojcicki, ex-CEO of the DNA testing firm, put in a $305m bid, upending Regeneron’s $256m agreement The DNA testing company 23andMe is back up for sale, throwing a purchase agreement reached last month into chaos, court filings show....
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