Researchers found that 21 million children missed measles vaccination in 2022, far exceeding those missing other vaccines, and 96% were in low- and middle-income countries. The study urges adding measles vaccination rates to global...
Two-dose measles vaccination coverage has fallen by 3.7% globally since 2019, leaving most WHO regions off track to meet Immunization Agenda 2030 targets. The study highlights a worrying rise in zero-dose children, especially in Africa,...
Researchers racing to develop bird flu vaccines for humans have turned to a cutting-edge technology that enabled the rapid development of lifesaving covid shots.
An ambitious project led by Vanderbilt University Medical Center investigators aims to use artificial intelligence technologies to generate antibody therapies against any antigen target of interest.
Recent outbreaks of highly pathogenic avian influenza (also known as bird flu) have created a need for rapid and sensitive detection methods to mitigate its spread. Now, researchers have developed a prototype sensor that detects a type...
Panelists at a covid conference last fall were asked to voice their regrets — policies they had supported during the pandemic but had come to see as misguided. Covid contact tracing, one said. Closing schools, another said. Vaccine...
Can the Trump administration refuse to spend money appropriated through Congress by firing federal workers and canceling existing contracts? And if the courts say it cannot, will the administration obey those directives? That key...
The microbiome shapes development of insulin-producing cells in infancy, leading to long-term changes in metabolism and diabetes risk, new research in mice has found. The results could ultimately help doctors reduce the risk of type 1...
A new study suggests a promising alternative to previous attempts to remove the sticky, toxic amyloid beta plaques from brains with Alzheimer's Disease: enhancing the brain's own immune cells to clear these plaques more effectively. The...
Researchers have discovered how antibodies help to protect against contagious bacterial infections caused by Strep A, including strep throat. And the findings are already contributing to efforts to accelerate the development of a Strep A...
For more than three decades, scientists have been racing to stop Alzheimer's disease by removing amyloid beta plaques - sticky clumps of toxic protein that accumulate in the brain.
Scientists at The University of Texas at Austin, in collaboration with researchers from the University of North Carolina at Chapel Hill and the National Institutes of Health, have discovered a strategy to fight back against norovirus, a...
Scientists have discovered a strategy to fight back against norovirus, a leading cause of gastroenteritis worldwide. Their new study identifies powerful antibodies capable of neutralizing a wide range of norovirus strains. The finding...
The body's internal clock doesn't just dictate when we sleep -- it also determines how quickly our muscles heal. A new study in mice suggests that muscle injuries heal faster when they occur during the body's natural waking hours.
Scientists have uncovered the mechanism behind how aspirin could reduce the metastasis of some cancers by stimulating the immune system. The scientists say that discovering the mechanism will support ongoing clinical trials, and could...
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting around 250,000 people in Austria. While previous treatment approaches have mainly focused on inhibiting pro-inflammatory immune cells, a study shows that...
Scientists have a new target to prevent cold sores -- and genital herpes flare-ups caused by the same virus -- after researchers discovered an unexpected way the herpes virus re-activates in the body.
Scientists have discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth.
Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing. For many years, scientists assumed that blood production...
Using an animal model of multiple sclerosis (MS), researchers have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings provide a window into the early disease state and...
Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis.
A new study suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury (TBI). By studying the effects of the nasal anti-CD3 in a mouse model of TBI, researchers found...
Researchers observed a rise in adult central nervous system (CNS) infections, primarily aseptic meningitis caused by the varicella zoster virus (VZV), post-2019. The researchers highlighted the potential of zoster vaccination to reduce...
Research reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice. This discovery could pave the way for a new class of drugs to treat rheumatoid...
Pre-existing immunity against seasonal H1N1 flu might help explain why most reported human cases of H5N1 bird flu in the U.S. have not resulted in lethal outcomes.
New findings could help make immunotherapies for brain cancer more effective. The team analyzed almost 200,000 individual immune cells in tumor samples taken from patients with glioma, the most common and aggressive type of primary brain...
Immune cells that eat bacteria in the body don't stash them in specialized compartments as once thought, but turn them into critical nutrients that build proteins, create energy and keep the cells alive, according to a new study.
The new research reveals how a protein in brain cells may drive Parkinson's onset -- and offers a possible explanation for why Parkinson's is much more common in men.
Working toward more effective tuberculosis (TB) vaccines, researchers have developed two strains of mycobacteria with 'kill switches' that can be triggered to stop the bacteria after they activate an immune response.
Researchers have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors. According to preclinical results, the approach combined the benefits of more well-known antibody-drug...
Researchers have shown that a particular type of immune cell acts more flexibly than previously thought -- with potential for new therapeutic approaches.
Researchers have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause diarrhea. Their findings show that these cells greatly increase in number when exposed to...
Receptors on B and T cells hint at what the immune system is targeting. An AI approach called Mal-ID developed increases diagnostic accuracy, particularly for autoimmune diseases.
Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study. The new approach, which requires further development and testing,...
A discovery offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists have pinpointed proteins in immune cells that, when blocked, could...
Scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood -- known as the tertiary lymphoid structure -- where they become frustratingly dysfunctional when in close contact...
Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.
A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave researchers a look at how primary progressive multiple sclerosis, the...
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique.
When a tumour develops, it creates a structure around itself called the tumour stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis, i.e. the development of lymphatic...
A fungal infection has been shown to trigger a fruit fly's own immune system to destroy brain cells leading to signs of neurodegeneration, a new study has found.