A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published today in Nature Microbiology.
Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells-white blood cells that can destroy harmful pathogens-can completely prevent viral infection, to an extent previously thought only...
A study shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer. Investigators examined how molecular dynamics at the immune synapse -- where CAR T cells bind to cancer cells --...
A look at cancer cells: Thanks to an innovative method of super-resolution microscopy, researchers observed with molecular resolution in 3D how therapeutic antibodies attack and alter B cells, thereby inducing their destruction. Their...
Scientists have discovered that T cells -- white blood cells that can destroy harmful pathogens -- can completely prevent viral infection, to an extent previously thought only possible due to neutralizing antibodies. Their findings...
Researchers at the University of Gothenburg, Sweden, in collaboration with colleagues in China, have discovered an antibody-like molecule that can protect mice from various influenza viruses.
An international team of UK and US scientists discovered that the activity of macrophages -- a type of white blood cell that engulf pathogens and cancer cells -- can be used to predict whether or not a melanoma patient will respond to...
Results from the malaria vaccine trial indicate that GA2 immunization provides significant protection, paving the way for more effective vaccination strategies.
A new study shows that one or two doses of the HPV vaccine can be as effective against severe cervical changes as three doses for girls and young women.
Severe pneumonia caused by human metapneumovirus in an immunocompetent adult highlights diagnostic challenges and underscores the need for rapid molecular diagnostics to improve outcomes.
Researchers in India discovered novel hMPV lineages A2.2.1 and A2.2.2, emphasizing their role in pediatric respiratory infections and potential public health implications.
Researchers review decades of progress in human cytomegalovirus (HCMV) vaccine development, emphasizing challenges, innovative platforms, and the critical need for effective prevention strategies.
Leading clinical researcher Professor Alison Elliott has been honoured with an OBE in the King's New Year Honours for services to medicine and global health.
Much of our knowledge of the protein PD-1, a leading cancer treatment target, comes from studies in mice. In a comprehensive assessment of PD-1, researchers have found that PD-1 in mice is significantly weaker than the human version,...
Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria.
A novel class of antibodies that binds to a previously untargeted portion of the malaria parasite could lead to new prevention methods, according to a study from researchers at the National Institutes of Health (NIH) published today in...
Highly pathogenic H5N1 avian influenza A virus (HPAI H5N1) remains a low risk to the general public, and public health experts in the United States believe that available treatments and vaccines, as well as those in development, are...
A recent study reveals the pivotal role of tristetraprolin (TTP), an RNA-binding protein, in regulating inflammatory responses in basophils, immune cells central to allergic reactions. The research shows that TTP controls the stability...
A new study uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific components of the adaptive immune system, particularly CD4+...
Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.
Researchers have shown that people 60 years or older with weakened immunity do not respond as strongly to vaccines against the respiratory syncytial virus (RSV) as people in the same age group with normal immune function.
A year after becoming available, vaccines to protect against RSV in newborns and older adults are being more widely accepted by the American public, according to a new health survey.
A team has discovered a new communication pathway between the gut and lung. Their findings highlight how a little-known member of the gut microbiome reshapes the lung immune environment to have both beneficial and detrimental effects on...
A new role has been uncovered for a cell's own RNA in fending off attacks by RNA viruses. Some of the cell's RNA molecules, researchers found, help regulate antiviral signaling. These signals are part of the intricate coordination of...
New research shows that the lockdowns during the COVID-19 pandemic had a significant impact on people's immune response to microorganisms. During the lockdown, inflammation level in the body was low, but afterwards, the immune system...
Researchers are closer to understanding what drives the autoimmune disorder Sj gren's disease, thanks to new discoveries about the role of calcium signaling, regulatory T cells, and interferon. Their latest study finds that impaired...
A new study shows how one kind of bacteria, Vibrio cholerae, triggers painful intestinal contractions by activating the immune system. The research also finds a more general explanation for how the gut rids itself of unwanted intruders,...
New research has explained how the body's internal clock influences the inflammatory process of the immune system. The findings describe how immune cells, called macrophages, work differently at various times of the day and could pave...
Despite national medical guidelines supporting the use of antiviral medications in young children diagnosed with influenza, a recent study reports an underuse of the treatment.
Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative pharmacological therapy requires an in-depth...
Food allergies affect millions of people worldwide, and flavonoids are promising natural compounds to help modulate the immune response and treat inflammation caused by these allergies. In a recent study, researchers have identified that...
After dozens of clinical trials, there are still no effective vaccines against Staphylococcus aureus. In two new studies, scientists report that the pathogen turns on the protein interleukin 10, shutting down the protective vaccine...
Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells. Typically, several molecules restrain the ability of T cells to target cancer cells and developing...
Researchers have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses. A better understanding of its structure may help optimize designs for the platform, which can be used to develop cancer...
Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.
A new study found that tumors grew 2.5 times larger in female fruit flies than males. With fruit flies sharing many genetic similarities and signaling pathways with humans, the finding could lead to better understanding of cancer...
A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination.
New research provides valuable insights into the brain-body immune connection identifying key communication hubs in the dural sinuses and skull bone marrow at the back of the head.
Research revealed that foetuses are not as defenceless as once thought; they can actually fight infections from within the womb. This new understanding could significantly change the way doctors protect foetuses from infections that lead...
Researchers found that transmission of rotavirus vaccine strains in a neonatal intensive care unit (NICU) is rare and without clinical consequences, strongly suggesting that giving the rotavirus vaccine to eligible infants during their...
A research team has uncovered a molecular strategy employed by worm parasites (helminths) to evade host immune defenses. This discovery opens new avenues for the development of innovative vaccines and therapies. The study offers...