As critical responders, macrophages can perceive helpful biotechnology as threats. If not created with the right materials or mechanical forces, these devices can trigger an immune response that can cause inflammation, scar tissue or...
The study uncovers gene expression signatures that predict neonatal sepsis, highlighting the potential for early intervention to reduce mortality in infants.
VALANX Biotech (VALANX), a biotech company developing novel technology for site-specific protein conjugation in drug and diagnostics discovery, and Fina Biosolutions LLC (FinaBio), experts in conjugate vaccine development and conjugate...
Researchers have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study used a cutting-edge spatial genomics technology...
A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how...
Researchers have found a process by which the brain guards against attack by the immune system. In mice with multiple sclerosis, such 'guardian' proteins that train the immune system were drastically depleted, and replenishing them...
A new study sheds light on how the blood-borne parasite that causes African sleeping sickness in humans and related diseases in cattle and other animals establishes long-term infections in hosts. Using a mouse model, the researchers...
The World Health Organization (WHO) today published a new report on tuberculosis revealing that approximately 8.2 million people were newly diagnosed with TB in 2023 – the highest number recorded since WHO began global TB monitoring in...
Infection with HPV16, a high-risk human papillomavirus (HPV), can cause cervical cancer in humans. These infections carry a high risk of morbidity and mortality globally in females.
As Africa grapples with multiple outbreaks of mpox, public health leaders say locally produced vaccines are vital to end donation dependence and secure the continent's health.
Doctors detail what we learned after the first season following the approval of RSV vaccines. The vaccine effectively prevented severe illness in older, but only 24 percent of eligible US adults received the vaccine, compared to 50...
Medical scientists involved in a large international study have identified new signs of kidney transplant rejection that could lead to more precise diagnosis and treatment for transplant recipients. The research examined more than 16,000...
Researchers have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity. The pre-clinical findings highlight the potential to activate these cells to fight tumors more...
Throughout the Covid pandemic, media widely reported that Black patients were more likely than White patients to refuse vaccines, including the influenza and Covid vaccines.
The innate immune system is the body's first line of defence against pathogens like bacteria or viruses. TRIM25 is a protein that is important in the innate immune response against RNA viruses, such as influenza viruses, coronaviruses,...
During the COVID pandemic, many of us have received multiple mRNA vaccines. New work by researchers at the VIB-UGent Center for Inflammation Research, Ghent University, and University Hospital Ghent, among others, has found that such...
What keeps some immune systems youthful and effective in warding off age-related diseases? In new research done on mice, scientists point the finger at a small subset of blood stem cells, which make an outsized contribution to...
Maternal antibodies passed across the placenta can interfere with the response to the malaria vaccine, which would explain its lower efficacy in infants under five months of age, according to new research. The findings suggest that...
Researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack -- blocking the energy supply T cells depend on. The work points toward a promising new immunotherapy approach for ovarian...
Researchers have discovered that GPR31, found in certain immune cells in the human gut, plays a key role in responding to bacterial metabolites and activating immune responses. Specifically, in the presence of metabolite pyruvate, these...
SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may point the way to the development of...
A team has re-engineered immune cells with a light-activated switch that modulates protein function and cellular behavior. When exposed to blue light, the cells change shape, infiltrating solid tumors grown in the lab and killing them.
Researchers have discovered a family of enzymes that work to reduce IgG-mediated pathologies in diseases like MG. The findings, involving mouse models, show that a specific enzyme (an endoglycosidase called CU43) was particularly...
The protein factories of our cells are much more diverse than we thought they were. Scientists have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system.
This multi-state study is a real world data analyses of the effectiveness of the RSV -- short for respiratory syncytial virus -- vaccine. VISION Network researchers report that across the board these vaccines were highly effective in...
Black men with advanced prostate cancer have a greater chance of survival after immunotherapy treatment, at least in part, because of ancestral gene variants in immune responses.
With viral outbreaks spreading more quickly, faster responses and quicker development of new vaccines has become crucial. However, production of the mRNA used in vaccines is hindered by its production, which involves both chemical...
A new vaccine provides hope for treating and even preventing the highly contagious and difficult-to-treat Clostridioides difficile infection, more commonly known as C. difficile or C. diff. In animal models, this first mRNA-LNP C....
It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study.
A clinical trial of an mpox vaccine in adolescents found it was safe and generated an antibody response equivalent to that seen in adults, according to a planned interim analysis of study data. Adolescents are among the population groups...
A new study has provided a detailed analysis of how mRNA vaccines circulate and break down in the human bloodstream. The research aimed to help improve the safety and effectiveness of these vaccines, including reducing the side effects...
Researchers have engineered bacteria as personalized cancer vaccines that activate the immune system to specifically seek out and destroy cancer cells.
Scientists have discovered a new process in our immune systems that leads to the production of an important family of anti-viral proteins called interferons. They hope the discovery will now lead to new, effective therapies for people...
Distinct immune 'signatures' in patients who develop adverse events while taking immunotherapy for cancer may help oncologists identify patients at risk and treat them early to prevent serious side effects, suggests a new study.
Researchers have developed a new method to recreate a robust and functional human immune system in mice using mononuclear cells from the cord blood. This new kind of mice, that count with most of the human immune cell types with lower...
Scientists discover how innate immunity envelops bacteria. The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat,...
Analyzing the genetics of patients that responded well to checkpoint blockade revealed mutations in the gene Asxl1 in immune T cells. Disrupting the Asxl1 gene in T cells enhanced response to immune checkpoint blockade and improved...
Inflammation of the arteries is a primary precursor and driver of cardiovascular disease -- the No. 1 killer of people in the United States. This inflammation is associated with the buildup of dangerous plaque inside the arteries....
A human cell culture model of the lung's most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein.
Researchers have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the...
Scientists have recreated the growth of Lewy bodies in human neurons and followed their formation to gain important insight into why and how they form. Critically, they find that immune challenge is important for this process,...
In the fight against cancer, chimeric antigen receptor (CAR) T cell therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors. A study demonstrates that a different...
Over the past decade, decreasing vaccination rates now threaten the huge beneficial impacts of vaccinations in the U.S. and globally. Researchers discuss the multifactorial barriers including increasing vaccine hesitancy and new clinical...