» Neurological complications of the central nervous system after allogeneic stem cell transplantation: the role of TA-TMA as a potential underreported cause
19/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSION: CNS-NC are associated with poor prognosis after allo-HSCT with TAC emerging as a potential yet insufficiently characterized predisposing factor.

» Neck muscle spasticity in patients with disorder of consciousness: a pilot study
18/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: Spasticity of neck muscles frequently develops in patients with DOC and is more severe in those after TBI. UWV and MCS have different spasticity profiles as regards risk factors and neurological and functional outcome. Sever...

» TRAUMATIC BRAIN INJURY AND ITS IMPLICATIONS FOR BEHAVIORAL HEALTH FACTORS
18/03/24 17:00 from pubmed: tbi diagnosis
The constant increase in the level of traumatic brain injuries in recent years, the frequent cases of disability and mortality associated with them require in-depth comprehensive research to study the problem on the ground, its medical, ...

» Hsa_circ_0018401 and miR-127-5p Expressions are Diagnostic and Prognostic Markers for Traumatic Brain Injury (TBI) in Trauma Patients
15/03/24 17:00 from pubmed: tbi diagnosis
This study investigated the potentials of hsa_circ_0018401 and miR-127-5p in traumatic brain injury (TBI) diagnosis, stratification and outcome prediction. A retrospective analysis of clinical data and blood samples of n= 109 TBI patient...

» From degraded to deciphered: ATAC-seq's application potential in forensic diagnosis
15/03/24 17:00 from pubmed: tbi diagnosis
In recent years, molecular biology-based diagnostic techniques have made remarkable strides and are now extensively utilized in clinical practice, providing invaluable insights for disease diagnosis and treatment. However, forensic medic...

» Clinical characteristics associated with pediatric traumatic intracranial hemorrhage
14/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSION: These factors might aid clinicians in making an appropriate decision regarding the use of brain CT in pediatric TBI cases.

» Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias
14/03/24 17:00 from pubmed: tbi diagnosis
BACKGROUND AND OBJECTIVES: Cavum septum pellucidum (CSP) is a common but nonspecific MRI finding in individuals with prior head trauma. The type and extent of head trauma related to CSP, CSP features specific to head trauma, and the impa...

» Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study
14/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: In this multi-institutional cohort study, raw rSO(2)was found to contain no significant prognostic information. However, rSO(2)-based indices of CVR, COx and COx_a, were found to have a uniform grand mean threshold of 0.2 an...

» Traumatic Brain Injury, Psychological Trauma Exposure, and Anxious and Depressive Symptoms in a Clinical Population
13/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: Individuals with prior TBI experienced psychological trauma, particularly childhood trauma, at a significantly higher rate than those without TBI. Psychological trauma exposure and TBI independently predicted anxious and dep...

» Symptoms and Functional Outcomes Among Traumatic Brain Injury Patients 3- to 12-Months Post-Injury
13/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSION: Cognitive symptoms should be integrated into the clinical care of rehabilitating TBI patients. Nurses should monitor for physical, affective, and cognitive symptoms during the recovery phase of TBI.

» Identifying the Cerebral Physiologic Response to Aerobic Exercise Following Concussion: A Scoping Review
13/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: There are currently too few studies investigating the cerebral physiologic response to aerobic exercise following concussion or mild TBI to draw definitive conclusions. Further research on this topic is necessary since under...

» Patterns of concomitant traumatic brain injury and ocular trauma in US service members
13/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: A practical approach using temporal proximity of diagnostic data was developed to identify concomitant cases of TBI and OT which presented with more severe injury types than non-concomitant cases. These results indicate OT p...

» Efficacy of a virtual reality-based cognitive interactive training program for children with traumatic brain injuries: study protocol for a parallel-group randomized controlled trial
13/03/24 17:00 from pubmed: tbi diagnosis
BACKGROUND: Traumatic brain injury (TBI) is a leading cause of disability in children. Cognitive rehabilitation for this population is critical for their long-term health outcomes. This trial aims to evaluate the efficacy of a virtual re...

» Predictive value of the Trauma Rating Index in Age, Glasgow Coma Scale, Respiratory rate and Systolic blood pressure score (TRIAGES) for the short-term mortality of older patients with isolated traumatic brain injury: a retrospective cohort study
12/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: The TRIAGES system is a promising tool for predicting 24-hour in-hospital mortality in older patients with TBI, demonstrating comparable or slightly superior efficacy to the GCS. Further multicentre studies are recommended f...

» Tuberculosis infection and hypertension: prevalence estimates from the US National Health and Nutrition Examination Survey
12/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: More than half of adults with TBI in the USA had hypertension. Importantly, we observed a relationship between TBI and hypertension among those without established CVD risk factors.

» Effect of prior anticoagulation therapy on outcomes of traumatic brain injury: A systematic review and meta‑analysis
12/03/24 17:00 from pubmed: tbi diagnosis
Anticoagulants are commonly prescribed for multiple conditions. However, their influence on traumatic brain injury (TBI) outcomes, especially mortality, is not clear. The present study aimed to explore the effect of prior anticoagulation...

» Remnant cholesterol, iron status and diabetes mellitus: a dose-response relationship and mediation analysis
12/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSIONS: RC has a dose-response relationship with iron status. The association between RC and DM was mediated in part by iron status. Future studies are needed to confirm these findings and further clarify the underlying mechanism.

» Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients
12/03/24 17:00 from pubmed: tbi diagnosis
Traumatic brain injury (TBI) is defined as an injury to the brain by external forces which can lead to cellular damage and the disruption of normal central nervous system functions. The recently approved blood-based biomarkers GFAP and U...

» Imaging predictors of hemorrhagic progression of a contusion after traumatic brain injury: a systematic review and meta-analysis
12/03/24 17:00 from pubmed: tbi diagnosis
The hemorrhagic progression of a contusion (HPC) after Traumatic brain injury (TBI) is one of the important causes of death in trauma patients. The purpose of this meta-analysis was to evaluate the predictive effect of imaging features o...

» Effectiveness of aerobic exercise on cognition in individuals with traumatic brain injury: A systematic review
11/03/24 17:00 from pubmed: tbi diagnosis
Cognitive deficits are among the most common impairments in individuals with traumatic brain injury (TBI). Aerobic exercise is a repetitive and structured physical activity that influences structural and functional brain alterations diff...

» Accuracy of maximal acceleration time of pedal arteries to diagnose critical limb ischemia
11/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSION: AT^(max) is a reliable diagnostic tool to diagnose low TP and could be a new easily performed hemodynamic criterion for diagnosis of CLTI.

» CD4+ CD11b+ T cells infiltrate and aggravate the traumatic brain injury depending on brain-to-cervical lymph node signaling
11/03/24 17:00 from pubmed: tbi diagnosis
CONCLUSION: The infiltration of CD4^(+) CD11b^(+) T cells exacerbates secondary brain damage in TBI, and this process is modulated by brain-to-CLN signaling.

» A narrative review of risk factors and predictors for poor outcome and prolonged recovery after a mild traumatic brain injury
10/03/24 17:00 from pubmed: tbi diagnosis
Mild traumatic brain injuries (mTBI) are often caused by a blow to the head or a sudden jolt resulting in a wide range of physical, cognitive, and emotional temporary symptoms. Mild TBI diagnosis can be challenging and most commonly foll...

» Assessing Patients Perception: Analyzing the Quality, Reliability, Comprehensibility and the Mentioned Medical Concepts of Traumatic Brain Injury Videos on YouTube
07/03/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: Results suggest the requirement for higher quality and reliability in YouTube content about TBI. Emphasis should be placed on clear and accurate language to promote comprehensibility. Continued research, guidelines, educatio...

» Influence of affective instability on suicidal ideation beyond traumatic brain injury and posttraumatic stress disorder in veterans
07/03/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: Severe Affective instability appears to be a key factor in suicidal ideation among Veterans beyond TBI or PTSD history. PTSD was more strongly associated with suicidality at lower and moderate levels of affective instability...

» Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis
07/03/24 16:00 from pubmed: tbi diagnosis
CONCLUSION: The administration of TXA is significantly associated with reduced mortality and hemorrhage growth in patients suffering from TBI, while the need of neurosurgery, seizures, and incidence of pulmonary embolism remains comparab...

» Management of Head Trauma
06/03/24 16:00 from pubmed: tbi diagnosis
Traumatic brain injury (TBI) represents a heterogenous spectrum of disease. It is essential to rapidly assess a patient's neurologic status and implement measures to prevent secondary brain injury. Intracranial hypertension, a common seq...

» Neuroinflammation and acquired traumatic CNS injury: a mini review
06/03/24 16:00 from pubmed: tbi diagnosis
Acquired traumatic central nervous system (CNS) injuries, including traumatic brain injury (TBI) and spinal cord injury (SCI), are devastating conditions with limited treatment options. Neuroinflammation plays a pivotal role in secondary...

» State of art of the detection of M. tuberculosis during TB infection by blood tests using the phage technology
05/03/24 16:00 from pubmed: tbi diagnosis
Tuberculosis (TB), an aerosol transmitted infection caused by Mycobacterium tuberculosis (Mtb), remains the commonest cause of death globally, from an infectious bacterial disease. Nine years on from the launch of the WHO's END-TB strate...

» Lack of association of informant-reported traumatic brain injury and chronic traumatic encephalopathy
05/03/24 16:00 from pubmed: tbi diagnosis
Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear if a history of traumatic brain injury (TBI) is sufficient to precipitate CTE neuropat...

» Anesthetic Challenges for a Pediatric Leukemia Patient Undergoing Total Body Irradiation (TBI): A Case Report
05/03/24 16:00 from pubmed: tbi diagnosis
Radiotherapy of the whole body is called total body irradiation (TBI). It is a well-established component of conditioning regimens before stem cell transplantation in juvenile leukemia. The patient was a three-year-old child with a diagn...

» Exercise and Recovery Following Mild-to-Moderate Traumatic Brain Injury in the Community Setting
03/03/24 16:00 from pubmed: tbi diagnosis
Introduction The recommendations on return to exercise post-traumatic brain injury (TBI) remain debatable. As recent as 10 years ago, the conventional recovery modality for a mild TBI was to reduce neurostimulating activity and encourage...

» International classification of functioning, disability and health with long-term consequences of cranio-brain injury
02/03/24 16:00 from pubmed: tbi diagnosis
CONCLUSION: Conclusions: Patients of all groups identified the family and close relatives, healthcare service and social welfare services, as the most frequent relieving factors of life activity. The use of the ICF Brief Core Set for ass...

» Patterns and predictors of ten-year mortality after discharge from community-based post-acute care for acquired brain injury: A retrospective cohort study (ABI-RESTaRT), Western Australia, 1991-2017
29/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: Individuals with ABI have an elevated risk of mortality years post-injury. Comorbidity management, continuity of care, and rehabilitation are important to reduce long-term mortality risk.

» iDISCO Tissue Clearing Whole-Brain and Light Sheet Microscopy for High-Throughput Imaging in a Mouse Model of Traumatic Brain Injury
29/02/24 16:00 from pubmed: tbi diagnosis
Immunolabeling-enabled imaging of solvent-cleared organs (iDISCO) (Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M, Cell 159:896-910, 2014) aims to match the refractive index (RI) of tissue to the surrounding medium, thereby...

» Weight-Drop Method for Inducing Closed Head Diffuse Traumatic Brain Injury
29/02/24 16:00 from pubmed: tbi diagnosis
Traumatic brain injury (TBI) is one of the foremost causes of disability and death globally. Prerequisites for successful therapy of disabilities associated with TBI involved improved knowledge of the neurobiology of TBI, measurement of ...

» Symptoms and Disability after Mild Traumatic Brain Injury: A Five-Year Follow-up
28/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: Five years after suffering mTBI, patients reported high rates of symptoms and disabilities. Our findings suggest that tailored rehabilitation interventions should be designed to identify mTBI patients in need of early rehabi...

» Toe brachial index and not ankle brachial index is appropriate in initial evaluation of peripheral arterial disease in type 2 diabetes
26/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSION: ABI 9.0 including the normal of ABI (0.9-1.3) can be confirmed with TBI, which correlated strongly with CTA. TBI is also non-inferior for PAD detection, when ABI < 0.9. TBI and not ABI can be utilized for initial assessment o...

» Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience
26/02/24 16:00 from pubmed: tbi diagnosis
In patients affected by traumatic brain injury (TBI), hypofibrinogenemia within the initial hours of trauma can be expected due to vascular and inflammatory changes. In this study, we aimed to evaluate the effect of hypofibrinogenemia on...

» Outcomes of patients with traumatic brain injury after stress ulcer prophylaxis: a retrospective multicenter study
26/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: This study highlights the low incidence of CSGIBs in neurocritical trauma patients and suggests potential benefits of SUP, particularly for those with severe neurological impairment. Nevertheless, the increased risk of pneum...

» Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease
26/02/24 16:00 from pubmed: tbi diagnosis
Graft-versus-host disease (GVHD) is a common complication in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is characterized as either acute or chronic based on symptomatology and histopathological fin...

» A pilot clinical study to estimate intracranial pressure utilising cerebral photoplethysmograms in traumatic brain injury patients
25/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSION: The clinical evaluation of this innovative optical nICP sensor revealed its ability to estimate ICP non-invasively with acceptable and clinically useful accuracy. This breakthrough opens the door to further technological refi...

» Association of mild traumatic brain injury, post-traumatic stress disorder, and other comorbidities on photosensitivity
25/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSIONS: Repetitive mild traumatic brain injury, post-traumatic stress disorder, anxiety, and sleep disturbances were all found to significantly impact photosensitivity severity and are therefore important clinical factors that eye c...

» Current practice of intracranial pressure monitoring in children with severe traumatic brain injury-a nationwide prospective surveillance study in Germany
25/02/24 16:00 from pubmed: tbi diagnosis
CONCLUSION: In children <10 years with sTBI, the present clinical management regarding ICP monitoring deviates from the current German national and international guidelines. The reasons remain unclear, with the low level of evidence in t...

» Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad
23/02/24 16:00 from pubmed: tbi diagnosis
Exposure to ionizing radiation (IR) presents a formidable clinical challenge. Total-body or significant partial-body exposure at a high dose and dose rate leads to acute radiation syndrome (ARS), the complex pathologic effects that arise...

» Scrutinizing Clinical Biomarkers in a Large Cohort of Patients with Lyme Disease and Other Tick-Borne Infections
23/02/24 16:00 from pubmed: tbi diagnosis
Standard clinical markers can improve tick-borne infection (TBI) diagnoses. We investigated immune and other clinical biomarkers in 110 patients clinically diagnosed with TBIs before (T0) and after antibiotic treatment (T2). At T0, both ...

» Delirium and Its Associations with Critical Care Utilizations and Outcomes at the Time of Hospital Discharge in Patients with Acute Brain Injury
23/02/24 16:00 from pubmed: tbi diagnosis
Background and Objectives: We analyzed delirium testing, delirium prevalence, critical care associations outcomes at the time of hospital discharge in patients with acute brain injury (ABI) due to acute ischemic stroke (AIS), non-traumat...

» Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview
23/02/24 16:00 from pubmed: tbi diagnosis
This paper presents an in-depth exploration of Post-Traumatic Epilepsy (PTE), a complex neurological disorder following traumatic brain injury (TBI), characterized by recurrent, unprovoked seizures. With TBI being a global health concern...

» A Systematic Review and Meta-Analysis of the Inflammatory Biomarkers in Mild Traumatic Brain Injury
23/02/24 16:00 from pubmed: tbi diagnosis
Mild traumatic brain injury (mTBI) accounts for most TBI cases, the leading cause of morbidity and mortality worldwide. Despite its high incidence, mTBI pathophysiology remains largely unknown. Recent studies have shown that the inflamma...

» Blood-Derived Metabolic Signatures as Biomarkers of Injury Severity in Traumatic Brain Injury: A Pilot Study
22/02/24 16:00 from pubmed: tbi diagnosis
Metabolomic biomarkers hold promise in aiding the diagnosis and prognostication of traumatic brain injury. In Canada, over 165,000 individuals annually suffer from a traumatic brain injury (TBI), making it one of the most prevalent neuro...

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