A new study led by researchers at the UCLA Health Jonsson Comprehensive Cancer Center has found that many cases of high-risk nonmetastatic hormone-sensitive prostate cancer may be more advanced than previously thought.
Scientists mapped how aging alters gene expression across brain cell types in mice, revealing immune activation, neuronal decline, and hypothalamus-specific changes that may impact aging and neurodegeneration.
People across diverse countries experienced greater happiness by spending on others, experiences, and personal growth, with cultural and economic contexts shaping the emotional impact of spending choices.
Imagine the deep frustration of countless men who long to become fathers, only to face infertility due to a genetic condition they can't control. For those with Klinefelter syndrome, this painful reality is a constant struggle.
Researchers reveal insulin resistance may be driven by insulin degradation during transit in the bloodstream, challenging the belief that cell defects are the primary cause.
Gozetotide is a drug for diagnostic application in adults with prostate cancer. It is currently the only diagnostic agent that recognizes PSMA-positive prostate cancer and can therefore identify patients for whom PSMA-targeted therapy...
Frequent but moderate egg consumption, coupled with proper cooking methods, does not increase obesity risk and may even support healthy lipid metabolism.
There are several strategies for the early detection of prostate cancer. The first step is often a blood test for prostate-specific antigen (PSA). If PSA levels exceed a certain threshold, the next step typically involves taking a tissue...
Research has uncovered a vulnerability in prostate cancer animal models that starves prostate tumors of critical nutrients and stunts their growth, which could lead to the development of new treatments for the deadly disease.
Researchers identified nicotinamide (NAM) and pyridoxine (PN) as safe, synergistic nutrients that restore muscle stem cell function, reversing age-related muscle degeneration in mice and humans.
Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers...
A new study offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention. Men...
Improvements in cancer prevention and screening have averted more deaths from five cancer types combined over the past 45 years than treatment advances, according to a modeling study. The study looked at deaths from breast, cervical,...
A special protein can play a key role in the fight against certain types of prostate cancer. Until now, treatments have involved blocking the protein in question that builds a so-called signalling pathway, but now the researchers show...
An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study. The results could potentially lead to new therapies for patients with limited options and...
Researchers have developed a three-dimensional mathematical model of prostate cancer. The model depicts various processes, including tumour growth, genetic evolution and tumour cell competition.
After a comprehensive two-year follow-up, researchers found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and...
A research team has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.
Scientists uncover functionality of a genetic variant in the prostate specific antigen (PSA) gene to improve the current diagnostic test to help distinguish aggressive from non-aggressive prostate cancers.
Increasing percentages of some older U.S. men with intermediate-risk and high-risk prostate cancers are undergoing treatments that carry risks of side effects that can significantly reduce the quality of life without extending life,...
Prostate cancer is the second most common cancer in men worldwide. Researchers have investigated a new strategy for the development of treatment options that not only slow tumor growth, but also stimulate the immune system to combat...
Prostate cancer is the second most common cancer in men, and almost 300,000 individuals are diagnosed with it each year in the U.S. To develop a consistent method of estimating prostate cancer size, which can help clinicians more...
Black men with advanced prostate cancer have a greater chance of survival after immunotherapy treatment, at least in part, because of ancestral gene variants in immune responses.
A team tests the protective effect of a fermented black garlic extract against inflammation and the progression of prostate cancer in a study conducted on human prostate cancer cell models in the laboratory.
A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest. It can help providers decide which patients should receive standard...
Researchers describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy tumors.
A new study sheds light on testosterone recovery following androgen deprivation therapy (ADT) in men undergoing radiotherapy for prostate cancer, providing key insights for optimizing patient care.
A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given researchers a deeper insight into how prostate cancer spreads or metastasizes.
There is a challenge related to prostate and many other cancers that cancer cells form resistance to treatments as the disease progresses. However, these resistance mechanisms are not yet fully understood. A new study found that...
A multi-institutional clinical trial showed that a newer technique for collecting prostate biopsy samples reduced the risk of infection compared with traditional biopsy approaches.
By tracking the changes in prostate cancer cells over time, researchers have found that activation of the MYC gene -- a well-known cancer-causing gene -- sets off a cascade of events that leads to both initiation and progression of the...
New research has shown that immunotherapy can be effective in treating prostate cancer in men who are selected based on the genetic characteristics of their tumors. In a recent study, it was found that for some men with a particular...
West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods, according to a new study. The findings suggest that...
Researchers have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When...
A treatment paradox has recently come to light in prostate cancer: blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced....
Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle. Now, researchers have developed a new molecule with a neopentyl glycol...
The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial...
Men with metastatic castration-resistant prostate cancer should be treated primarily with second-generation hormone drugs, which offer better treatment response and longer life expectancy than chemotherapy. However, the effect depends on...
Keeping your hands clean is the most important method to avoid getting sick and spreading germs to other people in the household. Many diseases are spread by not washing hands with soap and clean water. We cover the five most important...
The Stockholm3 blood test is equally effective at detecting prostate cancer in different ethnic groups, a new paper reports. The test produces significantly better results than the current PSA standard.
A recent study examined data from more than 10,000 patients with 'Biopsy Gleason Grade Group (GGG) 1,' a diagnosis considered to be the lowest grade cancer. Researchers found that even among patients diagnosed using the most modern...
Transgender women are still at risk for prostate cancer. A new study concludes that current screening guidelines could miss early-stage prostate cancer in transgender women on hormone therapy.
AI detects prostate cancer more often than radiologists. Additionally, AI triggers false alarms half as often. This was a large-scale study where an international team transparently evaluated and compared AI with radiologist assessments...
By using AI to assist with cancer contouring, the researchers found predicting the cancer size was 45 times more accurate and consistent than when physicians used only conventional clinical imaging and blood tests to predict the cancer...
As prostate cancer progresses, it becomes increasingly aggressive and can metastasize. In this form, the tumor is difficult to treat, which is reflected in high mortality rates: Worldwide, the malignant disease of the prostate is the...
A recent study suggests that the SIX2 protein may be a possible factor underlying increased plasticity of prostate cancer cells and treatment resistance.