Study estimates the global lifetime risk and benefits of modifying cardiovascular risk factors like hypertension, smoking, and obesity by age 50, showing significant improvements in both life expectancy and quality of life. It highlights...
Researchers developed a machine-learning algorithm to accurately predict free sugar content in packaged foods globally. The model enables large-scale assessment of carbohydrate quality based on fiber and sugar content.
Caffeine combined with beetroot juice significantly improves both initial and repeated 1000-meter running performance in non-athlete men. Body fat percentage, sleep duration, and nutrition emerge as key factors influencing endurance...
Eating four or more servings of ultra-processed food daily increases the risk of depression by 10% in older adults and modestly reduces their mental health-related quality of life.
A 12-week feasibility trial tested the MIND diet in midlife adults, showing improved diet quality, mood, and physical quality of life but no significant cognitive gains.
A global study finds that low milk intake is linked to increased colorectal cancer burden, especially in older adults. Prostate cancer rates showed negative trends, though the findings may reflect model limitations rather than protective...
Lower iodine levels and use of non-iodized salt are linked to a higher risk of frailty in people with type 2 diabetes. This association is strongest in those with thyroid dysfunction, underscoring the importance of adequate iodine intake.
Researchers have discovered a new mechanism that is used by a male sex hormone essential for muscle and bone function. The findings could lead to the development of new drugs with fewer side effects, for use in applications such as...
The incidence of advanced prostate cancer in California rose markedly in the decade since doctors stopped routinely screening all men for the disease, according to a new study.
Men undergoing radiation therapy for prostate cancer who experience side effects early in treatment may face a higher risk of developing more serious long-term urinary and bowel health issues, according to a new study.
The inherited mutated gene WNT9B, which functions normally in embryonic prostate development, increases risk of adult prostate cancer, according to a new study.
In April 2021, a provision in the 21st Century Cures act took effect which required that all medical test results be released to a patient's electronic medical record as soon as they become available. As a result of this newer law, many...
There are several strategies for the early detection of prostate cancer. The first step is often a blood test for prostate-specific antigen (PSA). If PSA levels exceed a certain threshold, the next step typically involves taking a tissue...
Research has uncovered a vulnerability in prostate cancer animal models that starves prostate tumors of critical nutrients and stunts their growth, which could lead to the development of new treatments for the deadly disease.
Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers...
A new study offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention. Men...
Improvements in cancer prevention and screening have averted more deaths from five cancer types combined over the past 45 years than treatment advances, according to a modeling study. The study looked at deaths from breast, cervical,...
A special protein can play a key role in the fight against certain types of prostate cancer. Until now, treatments have involved blocking the protein in question that builds a so-called signalling pathway, but now the researchers show...
An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study. The results could potentially lead to new therapies for patients with limited options and...
Researchers have developed a three-dimensional mathematical model of prostate cancer. The model depicts various processes, including tumour growth, genetic evolution and tumour cell competition.
After a comprehensive two-year follow-up, researchers found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and...
A research team has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.
Scientists uncover functionality of a genetic variant in the prostate specific antigen (PSA) gene to improve the current diagnostic test to help distinguish aggressive from non-aggressive prostate cancers.
Increasing percentages of some older U.S. men with intermediate-risk and high-risk prostate cancers are undergoing treatments that carry risks of side effects that can significantly reduce the quality of life without extending life,...
Prostate cancer is the second most common cancer in men worldwide. Researchers have investigated a new strategy for the development of treatment options that not only slow tumor growth, but also stimulate the immune system to combat...
Prostate cancer is the second most common cancer in men, and almost 300,000 individuals are diagnosed with it each year in the U.S. To develop a consistent method of estimating prostate cancer size, which can help clinicians more...
Black men with advanced prostate cancer have a greater chance of survival after immunotherapy treatment, at least in part, because of ancestral gene variants in immune responses.
A team tests the protective effect of a fermented black garlic extract against inflammation and the progression of prostate cancer in a study conducted on human prostate cancer cell models in the laboratory.
A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest. It can help providers decide which patients should receive standard...
Researchers describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy tumors.
A new study sheds light on testosterone recovery following androgen deprivation therapy (ADT) in men undergoing radiotherapy for prostate cancer, providing key insights for optimizing patient care.
A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given researchers a deeper insight into how prostate cancer spreads or metastasizes.
There is a challenge related to prostate and many other cancers that cancer cells form resistance to treatments as the disease progresses. However, these resistance mechanisms are not yet fully understood. A new study found that...
A multi-institutional clinical trial showed that a newer technique for collecting prostate biopsy samples reduced the risk of infection compared with traditional biopsy approaches.
By tracking the changes in prostate cancer cells over time, researchers have found that activation of the MYC gene -- a well-known cancer-causing gene -- sets off a cascade of events that leads to both initiation and progression of the...
New research has shown that immunotherapy can be effective in treating prostate cancer in men who are selected based on the genetic characteristics of their tumors. In a recent study, it was found that for some men with a particular...
West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods, according to a new study. The findings suggest that...
Researchers have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When...
A treatment paradox has recently come to light in prostate cancer: blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced....
Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle. Now, researchers have developed a new molecule with a neopentyl glycol...
The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial...