Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons. The average life span after diagnosis of this incurable disease is two to five years.
Researchers at the Warren Center for Neuroscience Drug Discovery, a clinical stage biotech within the Vanderbilt University School of Medicine Basic Sciences, have detailed the successful drug discovery of a phase I single ascending dose...
As 2024 is set to end as Earth's hottest year on record – breaking the previous record set in 2023– a UCLA Health researcher says people living with neurodegenerative diseases will be uniquely vulnerable to worsening heat waves because...
Dancing lowers the depression associated with Parkinson's disease, and the benefits can be seen in multiple ways, according to a study involving York University researchers published in the Journal of Medical Internet Research.
A joint research team from the University of Canberra and Kuwait College of Science and Technology has achieved groundbreaking detection of Parkinson's disease with near-perfect accuracy, simply by analyzing brain responses to emotional...
A joint research team from the University of Canberra and Kuwait College of Science and Technology has achieved groundbreaking detection of Parkinson's disease with near-perfect accuracy, simply by analyzing brain responses to emotional...
A team of researchers at The Keck School of Medicine of USC have received a $3.4 million federal grant to advance research on an innovative approach to slowing age-related cognitive decline.
Wearable sensor data combined with machine learning predicts fall risk in Parkinson's patients, enhancing preventive care and clinical outcomes over five years.
Traumatic brain injury (TBI) is a leading cause of death and disability among young people in the United States and is the most devastating survivable injury in modern warfare, according to the University of Cincinnati's Ishita Basu.
Neurological disorders are now the leading cause of disability worldwide. Parkinson's disease is the second most common neurodegenerative disorder, and case numbers are growing quickly.
Researchers from the Structural Biology Brussels group at Vrije Universiteit Brussel (VUB) have uncovered a significant mechanism that may contribute to amyotrophic lateral sclerosis (ALS), a disease that causes muscle weakness and...
University of Southern California-led researchers have discovered the structural details of a brain receptor called GPR6, which could lead to new treatments for Parkinson's disease.
A new study from the University of Oxford demonstrates how clinicians could use data to predict the risk of falls in people with Parkinson's disease (PD) to help improve effective longer term care planning.
Immune cells have a surprising and critical role in controlling movement and bridging neural activity with metabolic demands, concludes a groundbreaking study published in Nature by researchers at the University of Copenhagen and...
The University of Colorado Anschutz Medical Campus will receive up to $46 million from the Advanced Research Projects Agency for Health (ARPA-H) Transplantation of Human Eye Allografts (THEA) program to advance pioneering research aimed...
The use of PD Neurotechnology's pioneering telemonitoring device to assess Parkinson's Disease (PD) symptoms and inform medication adjustments led to the majority of patients exhibiting improved or stable symptom manifestation, according...
Investigators led by Tanya Simuni, MD, the Arthur C. Nielsen, Jr., Research Professor of Parkinson's Disease and Movement Disorders, have defined new biologic and clinical biomarkers for better identifying patients with different stages...
Scientists at La Trobe University have created a world-first method to investigate "disordered" proteins in living cells, in research that could change how we understand and treat Parkinson's disease.
Neurodegenerative diseases, such as Parkinson's disease, can be thought of as arising from malfunctions in the network of neuronal agglomerates in the brain. It is therefore often useful to apply insights from a branch of mathematics...
A new study has revealed that the widely prescribed Parkinson's disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.
Algorithms that can detect subtle changes in a person's voice are emerging as a potential new diagnostic tool for Parkinson's disease, according to researchers from Iraq and Australia.
Deep brain stimulation has revealed that a specific type of brain wave activity is associated with levels of anxiety in people living with Parkinson's disease, according to research led by scientists at City St George's and University of...
In the United States, there are currently more adults living with cerebral palsy than children. Despite this, the Centers for Disease Control and Prevention still label cerebral palsy as "the most common motor disability in childhood."
A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.
A recently published study by researchers at the University of Arizona Health Sciences found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of...
Researchers from the Champalimaud Foundation have shed light on the puzzling relationship between dopamine and rest tremor in Parkinson's disease, finding that preserved dopamine in certain brain regions may actually contribute to tremor...
Researchers have linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression. The proteins were gathered from cerebrospinal fluid and are a good proxy for activity...
University of Wisconsin–Madison researchers targeting a group of hereditary neurodegenerative diseases have found success using a gene therapy treatment in an animal model. The approach, which uses CRISPR-Cas9 genome editing technology,...
Researchers at Tel Aviv University (TAU) discovered a new factor in the pathology of Parkinson's disease, which in the future may serve as a target for developing new treatments for this terrible ailment, affecting close to 10 million...
Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called...
A team of researchers from the University of Barcelona and the Bellvitge Biomedical Research Institute (IDIBELL) has identified a potential biomarker of Parkinson's disease progression. According to the study, published in npj...
Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.
Scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington's disease, an incurable, debilitating illness that causes nerve cells to break down in the brain.
A team of researchers has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease. The team, led by Professor Norifumi Shioda and Associate...
Brain disorders like Parkinson's disease (PD) or Alzheimer's disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their...
A team of researchers at Kumamoto University has uncovered a mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's disease.
Using sequencing techniques, researchers associated 51 mutations in mitochondrial DNA with amyotrophic lateral sclerosis (ALS), an incurable degenerative neurological disorder that leads to muscle atrophy and paralysis. Thirteen of the...
A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer's disease.
Rapid side-to-side eye movements can help stabilize posture, avoid falls and maintain balance for people with Parkinson's disease, just as they can for healthy people. This seemingly counterintuitive conclusion was reached by researchers...
The amount of money people pay out-of-pocket for branded drugs to treat neurological diseases like multiple sclerosis (MS), Alzheimer's, and Parkinson's disease continues to rise, especially for MS drugs, according to a new study. The...
Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington's disease. This discovery opens up the possibility of studying the disease before its clinical onset and...
A new mouse model mimicking the liver symptoms of myotonic dystrophy type 1—the most prevalent form of adult-onset muscular dystrophy—provides insight into why patients develop fatty liver disease and display hypersensitivity to...
Neuroscientists have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells. The research offers exciting potential for advancing our understanding and...
A new technology enables the control of specific brain circuits non-invasively with magnetic fields, according to a preclinical study. The technology holds promise as a powerful tool for studying the brain and as the basis for future...
Scientists have recreated the growth of Lewy bodies in human neurons and followed their formation to gain important insight into why and how they form. Critically, they find that immune challenge is important for this process,...
A research team has revealed that a molecule in the brain -- ophthalmic acid -- unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's and other...