Although there are still some aspects pending confirmation for its use in the clinical setting, and its resolution needs to be improved slightly, a study has shown that a method routinely used to carry out ophthalmological tests can also...
Although there are still some aspects pending confirmation for its use in the clinical setting, and its resolution needs to be improved slightly, a study by the UPV/EHU and Biobizkaia has shown that a method routinely used to carry out...
A novel approach to gene therapy is improving lives in ways once thought impossible. Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a new platform to deliver the gene therapy...
One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer's or Parkinson's, yet treatment options remain sparse for this population.
Scientists created four cannabis-derived CBN analogs (chemical look-a-likes) with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer's, Parkinson's, and traumatic brain...
Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments. The researchers designed and used an AI-based strategy to identify compounds that block the clumping, or...
A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias.
A new study offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias. The findings reveal that brain cells with Lewy...
A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias.
Prasinezumab, a monoclonal antibody, is shown to reduce signs of motor deterioration in individuals with Parkinson's disease (PD) who have rapidly progressing disease, as reported in an exploratory analysis of data from a large phase 2...
Findings from a recent study in the Journal of Neuromuscular Diseases demonstrate the effectiveness of disease-modifying treatments (DMTs) in infants with spinal muscular atrophy (SMA). The study's results add further support for gene...
Researchers at the University of Turku and Turku University Hospital in Finland have shown that bodily sensations related to emotions are altered by the neurological disorder Parkinson's disease.
Researchers at the University of Iowa in a new study have linked a region in the brain to how humans redirect thoughts and attention when distracted. The connection is important because it offers insights into cognitive and behavioral...
Subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) increases on time without troublesome dyskinesia among patients with Parkinson disease, according to a study published online March 15 in The Lancet Neurology.
Low-cost, wearable sensors could increase access to care for patients with Parkinson's disease. New machine-learning approaches and a baseline of data from healthy older adults improve the accuracy of the results from such sensors,...
Multiple sclerosis is a disease mainly associated with the slowing down of information processing and a lack of motor coordination. It is an incurable disease that leads to degeneration of the central nervous system, manifesting as motor...
Over the last decade, researchers at the University of Michigan have continued to find that exposure to environmental toxins—from pesticides used in agriculture to volatile organic compounds in the manufacturing industry—is linked to the...
New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.
Parkinson's disease is a neurodegenerative movement disorder that progresses relentlessly. It gradually impairs a person's ability to function until they ultimately become immobile and often develop dementia. In the U.S. alone, over a...
The nose or the gut? For the past two decades, the scientific community has debated the wellspring of the toxic proteins at the source of Parkinson's disease. In 2003, a German pathologist, Heiko Braak, MD, first proposed that the...
Researchers have for the first time identified critical targets in the molecular signature of Parkinson's disease across different stages of the disease's progression.
Study investigates the gut microbiome's role in Parkinson's disease patients with mild cognitive impairments, revealing no distinct microbiome signatures associated with MCI in PD compared to cognitively normal PD patients or controls.
Parkinson's disease (PD) is a common neurodegenerative disease that affects millions worldwide. Now, a groundbreaking clinical study conducted by researchers at Ghent University Hospital, VIB, and Ghent University has demonstrated the...
A drug used to treat diabetes slowed the progression of motor issues associated with Parkinson's disease, a study published in the New England Journal of Medicine said Wednesday.
Study reviews the advancements in pharmacological treatments for neuropsychiatric syndromes in neurodegenerative disorders, discussing the complexities of managing symptoms such as depression, disinhibition, apathy, psychosis, and...
Alzheimer's disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline.
Delphia Brown (left) exercises at the Stephen A. Orthwein Center, a wheelchair-accessible gym in St. Louis operated by Paraquad, an organization that helps people with disabilities achieve independence.
Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson's disease.
Although Parkinson's disease has been recognized for more than 100 years, no treatments can slow or halt the disease's progress, let alone cure it. One of the major factors underlying this lack of progress is our relatively poor...
Research investigates the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD), revealing that IBS is not linked to an increased overall risk of PD. Subgroup analyses suggest that certain IBS populations may...
Scientists from the University of Aberdeen in collaboration with the University of Edinburgh and international partners, have identified a new way to detect signs of motor neuron disease (MND) in brain tissue that can pick up indicators...
Imagine being middle aged and starting to feel that you are off balance a lot and that you are having a hard time coordinating your movements. Those are among the symptoms of Spinocerebellar ataxia type 6, known as SCA6, a rare...
Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study by the University of Helsinki and the University of Tampere. In the study, almost 1 in 10 of over-50-year-olds were found to...
Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study. In the study, almost one in ten of over 50-year-olds were found to have tissue markers of Lewy body disease in the brain.
The survival of neurons, unlike most other cells in the body, depends largely on the energy provided by mitochondria, intracellular organelles that contain their DNA to function properly.
On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very...
Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome. The causes of ALS are currently unknown, and there is...
Motor neurons are the cells the brain uses to command muscles to act. Scientists typically thought of them as simple connections, much like the cables that link computers with their accessories. Now, in fly studies, researchers at...
In a paper published in the Journal of the American Medical Association (JAMA), neurologists at Beth Israel Deaconess Medical Center (BIDMC) showed that a simple skin biopsy test detects an abnormal form of alpha-synuclein, the...
Neuroscientists at the University of Galway have made an exciting discovery that could revolutionize stem cell-based brain repair therapy for Parkinson's disease.
New research supported by the Knight Initiative for Brain Resilience at Stanford's Wu Tsai Neurosciences Institute highlights significant strides researchers have made in developing biomarkers for the early detection and monitoring of...
A research team led by Professor Chaogu Zheng from the School of Biological Sciences at The University of Hong Kong (HKU) recently discovered that propionate, a short-chain fatty acid (SCFA), strongly suppressed neurodegeneration in...
Researchers uncovered the mechanistic details behind how several proteins interact to help cells recognize and remove damaged mitochondria. Optineurin (OPTN) and its interactions are needed to provide a contact site for another protein,...
Pesticides and herbicides used in farming have been linked to Parkinson's disease in the Rocky Mountain and Great Plains region of the country, according to a preliminary study.
A new study demonstrated the use of deep brain stimulation (DBS) to map a 'human dysfunctome' -- a collection of dysfunctional brain circuits associated with different disorders.
Researchers have discovered a network of neurons in the brain of mice that help them make right and left turns. In the future, the discovery may be used in treatment for Parkinson's disease.