telesante_strategique

Development and validation of the mHealth Apps Rating Inventory (mARI): A comprehensive tool for assessing the quality of mobile health applications.

Thu, 01 Jan 2026 05:00:00 +0000

International Journal of Medical Informatics; 01/01/2026
(AN 188685752); ISSN: 13865056
CINAHL Complete

Telerehabilitation for visual field defects with a multisensory training: a feasibility study.

Mon, 01 Dec 2025 05:00:00 +0000

Journal of NeuroEngineering & Rehabilitation (JNER); 12/01/2025
(AN 183265607); ISSN: 17430003
CINAHL Complete

A real-time web-based telemedicine framework based on AI and IoMT for emergency triage and initial diagnostics: the TeleMedQuick solution.

Mon, 01 Dec 2025 05:00:00 +0000

International Journal of Medical Informatics; 12/01/2025
(AN 187749862); ISSN: 13865056
CINAHL Complete

Digital divide and health professional shortages: telehealth access for chronic disease management in rural Florida.

Mon, 01 Dec 2025 05:00:00 +0000

International Journal of Medical Informatics; 12/01/2025
(AN 187749853); ISSN: 13865056
CINAHL Complete

Investigating the role of physician communication behaviors on the use of telehealth visits by older Black Americans with chronic conditions.

Mon, 01 Dec 2025 05:00:00 +0000

Patient Education & Counseling; 12/01/2025
(AN 188677889); ISSN: 07383991
CINAHL Complete

Subsequent suicide acts of 1830 suicidal crisis hotline callers: A one-month follow-up study.

Sat, 01 Nov 2025 04:00:00 +0000

Journal of Affective Disorders; 11/01/2025
(AN 186643092); ISSN: 01650327
CINAHL Complete

Insights from high and low clinical users of telemedicine: a mixed-methods study of clinician workflows, sentiments, and user experiences.

Sat, 01 Nov 2025 04:00:00 +0000

International Journal of Medical Informatics; 11/01/2025
(AN 187069209); ISSN: 13865056
CINAHL Complete

The role of trust as the facilitator and contingency factor in the adoption of digital healthcare services: A telemedicine context.

Sat, 01 Nov 2025 04:00:00 +0000

Computers in Human Behavior; 11/01/2025
This article revisits the role of trust in digital healthcare services, specifically telemedicine, as a context of heightened privacy risks. It posits that trust in a telemedicine service provider causes potential users of the telemedicine service to have confidence in the service provider, and empowers them to take responsibility for their own service adoption decision. Drawing on both the unified theory of acceptance and use of the technology and the contingency theory, this article conceptualizes trust as a contingency factor (i.e., moderator) that alters the influence of the determinants of adoption decisions that have not been examined previously in the extant literature. Based on survey data from 483 consumers, the results suggest that trust in the service provider has a positive effect on the user's intention to use a digital healthcare service (i.e., telemedicine). Moreover, it positively moderates (i.e., strengthens) the influence of performance expectancy, effort expectancy, social influence, and online privacy concerns, but negatively moderates (i.e., weakens) the effect of the facilitating conditions on this intention. [Display omitted] • Trust in the service provider positively affects the user's adoption intention. • Trust amplifies the effect of performance expectancy on adoption intention. • Trust amplifies the effect of effort expectancy on adoption intention. • Trust amplifies the effect of social influence on adoption intention. • Trust attenuates the effect of the facilitating conditions on adoption intention.
(AN 187528299); ISSN: 07475632
CINAHL Complete

Relationships between genetic counseling students' screensharing, nonverbal and verbal communication, and satisfaction in simulated telehealth visits.

Sat, 01 Nov 2025 04:00:00 +0000

Patient Education & Counseling; 11/01/2025
(AN 187792176); ISSN: 07383991
CINAHL Complete

Evaluating telehealth and text-based interventions for at-risk drinkers: A pilot study of feasibility and efficacy.

Sat, 01 Nov 2025 04:00:00 +0000

Journal of Substance Use & Addiction Treatment; 11/01/2025
(AN 187995553); ISSN: 29498767
CINAHL Complete

Building Resilience and Improving Neurocognition (BRAIN): Feasibility and acceptability of a novel, multimodal telehealth cognitive rehabilitation intervention.

Sat, 01 Nov 2025 04:00:00 +0000

Applied Neuropsychology: Adult; 11/01/2025
(AN 188316405); ISSN: 23279095
CINAHL Complete

Addressing tech-health equity with a rural public library telehealth model.

Sat, 01 Nov 2025 04:00:00 +0000

Social Work in Mental Health; 11/01/2025
Mental health workforce shortages are one challenge rural communities experience when addressing residents' mental health needs. Telepractice has been a recommended solution for workforce shortages, however its effectiveness relies on a robust broadband infrastructure and community members' digital literacy. Libraries show significant potential as a hub for community resources to address broadband accessibility and digital literacy through an emerging collaboration with schools of social work. This article describes the development and implementation of a social work school-based telepractice program with graduate social work student practitioners. The program partnered with rural libraries to offer free tele-mental health services to rural residents.
(AN 188444912); ISSN: 15332985
CINAHL Complete

"Voice of Concern" for Rural Veterans With PTSD: Care Managers' Role Engaging Rural Veterans in Evidence-Based Therapies via Telemedicine.

Sat, 01 Nov 2025 04:00:00 +0000

Psychological Trauma: Theory, Research, Practice & Policy; 11/01/2025
Objective: In a Department of Veterans Affairs collaborative care implementation trial, care managers (CMs) focused on engaging rural Veterans diagnosed with posttraumatic stress disorder in trauma-focused psychotherapies, specifically cognitive processing therapy and prolonged exposure therapy, delivered over telehealth. As part of a summative evaluation, we interviewed Veterans about their experience, especially their interactions with their CM. Because relatively few Veterans initiated a trauma-focused psychotherapy, we specifically asked them about their conversations with CMs to better understand what worked and what did not work with regard to treatment engagement. Method: We conducted phone interviews with a purposive sample of 43 unique Veterans between 2017 and 2019. We purposively sampled Veterans who reported changes in satisfaction with Veterans Affairs posttraumatic stress disorder services and had experiences with different care modalities and patients who declined to initiate a trauma-focused psychotherapy. Data were analyzed using deductive–inductive content analysis. Results: Overall, Veterans perceived CMs as helpful in three ways: (a) for care coordination—especially with therapists; (b) as a "voice of concern"—for Veterans' health and daily life; and (c) as a "side counselor"—helping prepare Veterans for appointments and following up after their trauma-focused psychotherapy sessions. Conclusions: Veterans appreciated many qualities about their CM unrelated to trauma-focused psychotherapy. For those engaging in trauma-focused psychotherapy, CMs played the role of "side counselor" helping them stay engaged in care. Understanding patient perspectives about CMs' roles can help other types of providers understand how to best engage patients in trauma-focused psychotherapies. Clinical Impact Statement: Veterans reported that their care managers coordinated care, created a genuine sense of caring and trust, and encouraged them to stay engaged in treatment. Understanding how the care managers were effective from the patients' perspectives could be a blueprint for other providers who support patients with posttraumatic stress disorder but do not deliver the evidence-based therapies themselves—like primary care providers, psychiatrists, social workers, or case managers.
(AN 188519026); ISSN: 19429681
CINAHL Complete

Evaluating PREPaRe (Promoting Readiness and Engagement in Pain Rehabilitation): A Randomized Controlled Trial of a Telehealth Motivational Interviewing Intervention for Youth and Families With Chronic Pain.

Sat, 01 Nov 2025 04:00:00 +0000

Clinical Journal of Pain; 11/01/2025
(AN 188621779); ISSN: 07498047
CINAHL Complete

Quantification of Heterogeneous Semi-Structured Patient-Reported Physical Activities Derived from a Diabetes Telehealth Service.

Sat, 01 Nov 2025 04:00:00 +0000

Studies in Health Technology & Informatics; 11/01/2025
Telehealth systems have shown to facilitate lifestyle changes like an increase in physical activity. Therefore, an easily quantifiable measure of physical activity levels for both assessing a patient's status quo and tracking physical activity development is needed. The aim of this work was to map semi-structured activities reported as type-intensity-duration triplets in the DiabMemory telehealth system to Metabolic Equivalents of Task (METs). The activity data of 947 telehealth patients were analyzed to create a mapping table between type-intensity pairs and MET values from a preexisting compendium. Additionally, the distribution of activity types and resulting MET scores was evaluated. Combining the MET scores with the duration resulted in the quantified activity measure (MET-minutes). A significant difference in the MET-minutes per activity type (p<0.0001) was identified. In the future, our method of mapping semi-structured data to METs will serve as a support the evaluation of the effectiveness of DiabMemory.
(AN 188615465); ISSN: 09269630
CINAHL Complete

Efficacy of a Self-Monitoring Traffic Light for Weight Control in Patients with Heart Failure in a Telerehabilitation Program.

Sat, 01 Nov 2025 04:00:00 +0000

Studies in Health Technology & Informatics; 11/01/2025
Heart Failure (HF), a life-threatening condition, poses a significant global health challenge. Monitoring patients' symptoms and weight is essential, as key HF symptoms tend to cause weight gain and indicate decompensation. The aim of this study is to evaluate the effect of a traffic light algorithm on home monitoring of weight in HF patients. In the project 'Future Patient - Telerehabilitation of Patients with HF II', HF patients monitored their weight, blood pressure, pulse, steps, and sleep at home. Data has been transmitted to the web portal HeartPortal. Each measurement in the weight overview was color-coded using a traffic light algorithm that would indicate whether the patient's weight changes were within the acceptable range. The patients' monitoring data, along with their questionnaire responses, were then analyzed and interpreted. The analysis of the data suggests that the traffic light was effective in alerting patients to weight changes according to clinical guidelines. Most of the patients noticed the traffic light and understood the significance of the colors. The study demonstrates that the traffic light is an effective tool for alerting HF patients to weight fluctuations. The traffic light provides early warnings, enabling timely interventions, and encouraging patient engagement in understanding the causes behind weight changes.
(AN 188615501); ISSN: 09269630
CINAHL Complete

Quantification of Heterogeneous Semi-Structured Patient-Reported Physical Activities Derived from a Diabetes Telehealth Service...Quantification of Heterogeneous Semi-Structured Patient-Reported Physical Activities Derived from a Diabetes Telehealth Servi

Sat, 01 Nov 2025 04:00:00 +0000

Efficacy of a Self-Monitoring Traffic Light for Weight Control in Patients with Heart Failure in a Telerehabilitation Program...24th Special Topic Conference (STC 2025) of the European Federation for Medical Informatics (EFMI), October 20-22, 2025, Osnabr

Sat, 01 Nov 2025 04:00:00 +0000

Development of a Mobile App (iCANSleep) to Treat Insomnia in Cancer Survivors: User-Centered Design Study

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Garland S.N.,Kutana S.,Piedalue K.-A.,Lee R.,Rash J.,Cerallo G.

Database Source: Embase Weekly Updates

Journal Title: JMIR Cancer

Article Title: Development of a Mobile App (iCANSleep) to Treat Insomnia in Cancer Survivors: User-Centered Design Study

Year: 2025

Issue:

Volume: 11

Abstract: Background: Insomnia affects the quality of life and health outcomes of cancer survivors. Cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment for insomnia among cancer survivors, but it is not readily accessible due to the limited number of trained providers and the difficulties in providing care across wide geographical areas. Mobile health (mHealth) technologies represent a promising solution; however, these technologies are not tailored to the unique needs of cancer survivors. Objective(s): This study aimed to understand the needs and preferences of cancer survivors and test the usability of an evidence-based CBT-I smartphone app called iCANSleep that will be tailored and accessible to cancer survivors. Method(s): A user-centered design (UCD) approach was applied, and cancer survivors were actively engaged in the app's design, usability testing, and prototype refinement. In phase 1, semistructured interviews were conducted with a purposive sample of cancer survivors (n=20) to inform the design of the app and its content. In phase 2, iterative low- (n=8) and high-fidelity (n=7) usability testing was conducted with participants until no further recommendations for change were suggested. Result(s): Users suggested several defining characteristics, features, and desired functionalities, including a user-friendly and evidence-based design. They saw increased accessibility and simplicity as advantages of a mobile app but expressed some concerns about data security and losing the accountability that comes with in-person treatment. User testing highlighted the preference for images of real people and diverse stories over graphics and animated videos, and offered suggestions for enhanced navigation. The first iteration of the app was developed using the information gained during the needs assessment and usability testing. Feedback was integrated into the final prototype of the iCANSleep app, which will be tested for feasibility, acceptability, and efficacy. Conclusion(s): Cancer survivors desire an insomnia treatment app that is simple, user-friendly, evidence-based, convenient, and secure. The iCANSleep app represents the merging of mHealth principles and best practices with evidence-based insomnia care, allowing for an intervention with minimal access barriers related to cost, geography, and provider availability. Feasibility, acceptability, and efficacy of the intervention will be maximized by following a UCD framework involving the engagement of end users at every design stage. Copyright © Sheila N Garland, Samlau Kutana, Katherine-Ann Piedalue, Rachel Lee, Joshua Rash, Gregory Cerallo.

Dynamic effects of technological innovations, research and development expenditure, and effective governance on carbon emission: New insights for environmental policy formulation in BRI region

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Xia Y.,Cao D.,Wang L.

Database Source: Embase Weekly Updates

Journal Title: Journal of Environmental Management

Article Title: Dynamic effects of technological innovations, research and development expenditure, and effective governance on carbon emission: New insights for environmental policy formulation in BRI region

Year: 2025

Issue:

Volume: 394

Abstract: Expenditure on research and development, technological innovations, and the commitment of government and state institutions are essential elements in the fight for environmental sustainability. Upon recognizing the effects of these elements, this study examined how Technological Innovations (TI), Government Effective (GE), Institutional Quality (IQ), and R&D influence CO<inf>2</inf> emissions and environmental sustainability in the BRI region. The study employed Generalized Method of Moments (GMM) and Moments of Quantile Regression (MMQ) models to unravel the intricate relationships between these factors. While the GMM estimates showed that GE and TI each reduce CO<inf>2</inf> emissions by 8.10% and 8.40% respectively, institutional quality and R&D decrease CO<inf>2</inf> emissions by 6.20% and 5.80%, respectively. The MMQ findings displayed similar patterns across lower, middle, and upper quantiles, with effects ranging from 4.01% to 8.60%. The negative effect of both GE and IQ is substantially stronger at the highest quantile (0.9). R&D demonstrates modestly negative at low quantiles but becomes extremely large and negative at the 0.3 (-4.224) and 0.7 (-2.222) quantiles. The implication of these results is that rapidly industrializing countries with moderate governance scores could face rising emissions levels, which may offset the gains from other factors. These findings highlight the importance of strong governance, high-quality institutions, increased investments in R&D, and technological innovations for global environmental sustainability efforts. Therefore, governments should be encouraged to foster institutional collaborations in order to boost investments in R&D and technological innovation. This can help countries in the BRI region to meet their environmetal policy targets and sustainable development goals. Copyright © 2025 Elsevier Ltd

Transforming doctor-patient communication: Internet and telemedicine in simulation-based medical training

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Csongor A.,Egyed C.,Fekete J.,Hambuch A.,Nagy R.

Database Source: Embase Weekly Updates

Journal Title: Communication & medicine

Article Title: Transforming doctor-patient communication: Internet and telemedicine in simulation-based medical training

Year: 2025

Issue: 1

Volume: 20

Abstract: At present, doctor-patient communication is undergoing significant transformation due to digital technologies. The rise of the internet, social media, and digital tools that support medical purposes requires that doctors have new skills. This study presents the experiences of a new course for undergraduate medical students at the University of Pecs Medical School in Hungary. The course endeavors to demonstrate the internet's impact on the doctor-patient relationship by giving medical students the opportunity to practice communication strategies with 'Google patients' and e-patients, and use telemedicine in simulation-based training. We also explain how simulated patient consultations and feedback are incorporated into the curriculum and the methods used to prepare the students for these interactions. We explored the students' evaluations with the help of a course feedback questionnaire and written reflective essays. Based on the responses, students were satisfied with the training content and found the course innovative and relevant in the post-pandemic period. They highlighted the novel combination of theoretical teaching with simulation training and emphasized the need for practice in the field.

Exploration of "out of hours" calls to the Child and Adolescent Sexual Assault Treatment Service in Galway over a one-year period to quantify need for continued extended hours service

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Lahoud E.,Nelson J.,Bergin C.

Database Source: Embase Weekly Updates

Journal Title: Journal of Forensic and Legal Medicine

Article Title: Exploration of "out of hours" calls to the Child and Adolescent Sexual Assault Treatment Service in Galway over a one-year period to quantify need for continued extended hours service

Year: 2025

Issue:

Volume: 116

Abstract: Introduction: The Galway Child and Adolescent Sexual Assault Treatment Service (CASATS) operates within a Barnahus model on site on weekdays from 08.00 to 16.00 h with 24/7/365 out of hours on call availability. The service is localised to West and Mid-West Ireland for "in hours" examinations but covers the whole of Southern Ireland for "out of hours" examinations. Whilst CASATS supports children under 18 years of age, "out of hours" forensic medical examinations (FME) are predominantly children under 14 years of age as the adult sexual assault treatment units (SATU) in Ireland offer acute FME to patients from 14 years up. The overlapping 14-18 age group between adult SATU and CASATS makes commissioning challenging. Service specifications in Ireland recommend working towards provision of a 12/7 (08.00-20.00 h) service for paediatric FME, but do not detail recommendations for "out of hours" care for children under 14 years after 20.00 h. This review sought to quantify the number of "out of hours" telephone queries from professionals exploring the need for a paediatric FME for suspected sexual harm and the number of children subsequently examined "out of hours" by Galway CASATS in 2024 to determine the need for a continued extended hours service. "Out of hours" included Saturdays, Sundays, bank or public holidays and between 16.00 and 08.00 on weekdays. Method(s): Data were collected anonymously through retrospective review of medical notes and from records of telephone queries received from January 01, 2024 to December 31, 2024. Inclusion criteria were (a) All telephone queries to Galway CASATS ("in" and "out of hours") relating to the need for FME in children (<18 years) where sexual harm had been disclosed, witnessed or strongly suspected (b) All "in" and "out of hours" FMEs undertaken in Galway CASATS for children (<18 years) including those where agreement had been reached that FME would be beneficial, following discussion ("in hours") at Barnahus West Interagency planning meetings. Exclusion criteria were (i) Children for whom FME was not indicated, following "in hours" interagency Barnahus discussion (ii) The 41 Children 14-18 years in 2024 supported through the adult sexual assault treatment units, all eligible for Barnahus support. Result(s): The number of telephone queries and requests for FME arising from Barnahus West in 2024 related to 126 children. Thirty-eight telephone queries concerning 42 children were received outside of Galway CASATS' normal workday of 08.00-16.00 h. Seventeen calls concerning 20 children were received outside the 08.00-20.00 h 12/7 paediatric FME service specifications for Ireland. Of the 93 children who attended for FME in Galway CASATS in 2024, 19 (19/93 = 20 %) required urgent "out of hours" examination (outside of 08:00-16:00 Monday to Friday workweek) of whom 5 (5/93 = 5 %) required examination outside of 08.00-20.00 h 12/7 paediatric FME service specifications for Ireland. All 19 children who required urgent "out of hours" FME in Galway CASATS in 2024 were under the age of 14 years. Conclusion(s): This review supports the need for continued 24/7/365 on call services for FME for sexual assault in children under 14 years of age. There will be no immediate change to the current Galway CASATS service and the findings of this review will be presented to national committees to support ongoing extended hours service provision. Copyright © 2025 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Implementation and Evaluation of a Remote, Questionnaire-Based Model for Monitoring Patients Following Hip or Knee Replacement Surgery

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Gill S.D.,Gillies H.,Beattie S.,Porter K.,Gentle A.,Wilkinson A.,Jaysuriya J.,Page R.

Database Source: Embase Weekly Updates

Journal Title: CiOS Clinics in Orthopedic Surgery

Article Title: Implementation and Evaluation of a Remote, Questionnaire-Based Model for Monitoring Patients Following Hip or Knee Replacement Surgery

Year: 2025

Issue: 5

Volume: 17

Abstract: Background: The benefits of long-term follow-up of patients following hip and knee joint replacement surgery are currently debated. This study evaluated a questionnaire-based model for remotely monitoring patients. Primary outcomes included response rates, acceptability to patients, and whether remote review identified patients requiring reoperation. Method(s): Data were collected over a 7-year period from a large regional teaching hospital in Australia. Hard-copy questionnaires were sent to patients at 1, 5, and 8 years after joint replacement and biennially thereafter. The questionnaire assessed whether patients had pain or concerns regarding their joint replacement and whether orthopedic review was requested. Response rate was determined as the proportion of patients who returned the questionnaire and was considered acceptable if it was not significantly lower than the proportion of patients who attended a 1-year in-person appointment in the 3 years prior to introducing remote-review. Patient preferences for remote versus in-person review were collected from a subgroup of patients (n = 488) using an investigator-designed questionnaire. All reoperations during the study period were examined to determine if they were first identified via the remote-review questionnaire. Result(s): The response rate at 1 year was 69.3% (2,266 responses from 3,268 questionnaires sent), which was significantly lower than historical in-person outpatient attendance rates (82.7%, p < 0.001). A majority of patients (62.1%) preferred remote follow-up to in-person review. Of the 116 reoperations that occurred during the study period, remote review identified 5 patients, representing 0.1% of questionnaire responses. Most complications requiring reoperation were first identified via emergency departments (56.9%) or general practice (31.9%). Conclusion(s): While remote review following joint replacement surgery was consistent with most patients' preferences for follow-up care, response rates were lower than historical attendance rates for in-person outpatient appointments. Routine remote review was an inefficient mechanism for identifying complications requiring reoperation, most of which were first identified via emergency departments and general practice. Copyright © 2025 by The Korean Orthopaedic Association.

Promoting cervical cancer screening via a mailed HPV self-collection kit: Reactions from screeners and non-screeners

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Tiro J.A.,Metcalfe S.,Muthukrishnan M.,Jose A.,Hansen K.,Lin J.,Dorsey C.N.,Gao H.,Lacey C.,Anderson M.L.,Meenan R.T.,Green B.B.,Buist D.S.M.,Sparks A.,Winer R.L.

Database Source: Embase Weekly Updates

Journal Title: Patient Education and Counseling

Article Title: Promoting cervical cancer screening via a mailed HPV self-collection kit: Reactions from screeners and non-screeners

Year: 2026

Issue:

Volume: 142

Abstract: Objective: Mailed human papillomavirus self-collection (HPV-SC) kits improve cervical cancer screening adherence; however, not all respond to kit invitations. This qualitative study sought to understand reactions to HPV-SC kit invitation among screeners and non-screeners in the STEP trial, a pragmatic trial offering kits. Method(s): Kaiser Permanente Washington patients randomized to the STEP trial's kit intervention arms, received educational materials and were notified they would receive a kit in one week (direct mail) or given information on how to request a kit (opt-in). Materials highlighted cancer risk, screening importance, test differences (Pap, HPV), and what to expect with abnormal results. Based on their screening status 6 months post-randomization, two categories of patients were invited for focus groups: 1) screeners with negative kit results or clinician-performed test; 2) non-screeners. We oversampled non-white patients. Six online focus groups were conducted from May to June 2022 with 40 patients (29 screeners, 11 non-screeners). A facilitator asked about HPV and cervical cancer knowledge, reaction to the kit and educational materials, and screening preference (self- vs. clinician-collected). Field notes and transcripts were analyzed by five coders using iterative content analysis. Result(s): Participants desired more flexibility during the invitation process, preferring multiple methods (mail, patient portal, text, in-clinic distribution) and support services (website, nurse-staffed phone). Educational resources acknowledging different learning styles (print, diagrams, audio-visual) and for specific populations (LGBTQ, monogamous) were suggested. Participants recommended clinicians reinforce kit efficacy to encourage use. Trust in the kit and in the health care system were key to ensure comfort with self-collection. Conclusion(s): Multiple, diverse outreach strategies are needed to engage patients in screening with this new modality. Practice implications: Flexible engagement by the healthcare system with comprehensive educational materials inclusive of diverse populations, and provider encouragement are needed to build patients' trust in, comfort with, and use of HPV-SC tests. Trial registration: ClinicalTrials.gov Identifier: NCT04679675 Copyright © 2025

A novel ANK1 frameshift mutation associated with neonatal hereditary spherocytosis: a case report

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Qing X.,Zhu J.,Zhu X.,Zhang Y.,Deng J.,Tang B.

Database Source: Embase Weekly Updates

Journal Title: Frontiers in Pediatrics

Article Title: A novel ANK1 frameshift mutation associated with neonatal hereditary spherocytosis: a case report

Year: 2025

Issue:

Volume: 13

Abstract: Background: Hereditary spherocytosis (HS) is a genetically inherited hemolytic anemia resulting from erythrocyte membrane defects, predominantly associated with genetic mutations in membrane protein genes such as ANK1 and SPTB. The disease exhibits considerable heterogeneity in both clinical manifestations and age of onset, presenting substantial diagnostic challenges for clinicians, particularly in pediatric cases. Case presentation: The patient was a 29-day-old boy who had experienced persistent anemia and a medical history of neonatal hyperbilirubinemia since birth. Upon admission, the infant lacked typical HS manifestations such as splenomegaly, jaundice, and spherocytosis on the peripheral blood smear. Whole-exome sequencing identified a novel frameshift mutation c.3556delG (EX30, NM_000037.4), resulting in an amino acid alteration p.Glu1186Lysfs*3. Subsequent Sanger sequencing-based family segregation analysis confirmed that this mutation originated from the paternal allele. Based on the characteristic clinical manifestations and genetic findings, a definitive diagnosis of HS was established. Conclusion(s): In neonates presenting with unexplained recurrent anemia, particularly those with a history of neonatal hyperbilirubinemia, HS should be suspected. Due to the atypical manifestations, genetic analysis serves as a pivotal tool in the early diagnosis of HS, and novel genetic mutations may be identified, which can subsequently be added to the genetic database. Copyright 2025 Qing, Zhu, Zhu, Zhang, Deng and Tang.

Advancements and challenges in multiple sclerosis care in Uruguay: A comprehensive overview

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Rocha V.,Sorondo N.

Database Source: Embase Weekly Updates

Journal Title: Journal of Clinical Neuroscience

Article Title: Advancements and challenges in multiple sclerosis care in Uruguay: A comprehensive overview

Year: 2025

Issue:

Volume: 142

Abstract: Multiple sclerosis (MS) is a chronic neurological disorder that can lead to significant disability if untreated. Over the past years, Uruguay has made notable progress in MS care, including improved epidemiological understanding, better accessibility to high-efficacy disease-modifying therapies, and the formation of specialized workgroups dedicated to enhancing patient management. Despite these advancements, challenges remain. Access to diagnostics techniques, multidisciplinary care, and rehabilitation services still needs major improvements. Efforts to establish dedicated MS centers, expand telemedicine strategies, and bridge gaps between public and private healthcare systems are essential for improving patient outcomes. While obstacles persist, recent developments mark a promising era in Uruguay's MS care, emphasizing the need to develop personalized treatment protocols, and enhance comprehensive care to improve quality of life for people with MS. Copyright © 2025 Elsevier Ltd

Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Bajwa S.S.,Bajwa S.K.,Kaur J.,Sharma V.,Singh A.,Goraya S.P.S.,Parmar S.S.,Singh K.

Database Source: Embase Weekly Updates

Journal Title: Saudi Journal of Anaesthesia

Article Title: Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery

Year: 2011

Issue: 1

Volume: 5

Abstract: Background: Postoperative nausea and vomiting (PONV) is one of the complications which hamper the successful implementation of day care surgical procedure in spite of the availability of so many antiemetic drugs and regimens for its prevention. The aim was to compare the prophylactic effects of intravenously (IV) administered ondansetron and palonosetron on PONV prevention in patients undergoing laparoscopic gynecological surgery under general anesthesia. Method(s): A prospective double-blind study comprised of 60 ASAI/II female patients between the age group of 25 and 40 years was carried out in the Departments of Anesthesiology and Obstetrics and Gynecology of our institute. Patients were randomly divided into two groups of 30 patients each in a double-blind manner. Group I received 8 mg of inj. ondansetron IV while group II received inj. palonosetron 0.075 mg IV 5 minutes before the induction of anesthesia. The need for rescue antiemetics, episodes of PONV and other side effects were observed for 6 hours in the postanesthesia care unit and thereafter complaints were received on phone after the discharge. At the end of study, results were compiled and statistical data was subjected to statistical analysis using Student two-tailed 't' and chi2 test and value of P<0.05 was considered significant. Result(s): The demographical profile of the patients was comparable. Twenty and 13.33% of the patients in group I had nausea and vomiting episodes postoperatively as compared to 6.67% and 3.33%, respectively, in group II which was statistically significant (P<0.05). Twenty percent of the patients in group I experienced significant post-op headache as compared to 6.67% in group II. The mean rescue dose of antiemetic was significantly higher (10.6 mg) in the group I as compared to group II (6.4 mg) (P=0.036). The rest of parameters were comparable and statistically nonsignificant. Conclusion(s): Palonosetron is a comparatively better drug to prevent the PONV in patients undergoing day care surgical procedures as compared to ondansetron as it has got a prolonged duration of action and favorable side-effects profile.

Digital interventions for enhancing communication and collaboration in children with autism spectrum disorder: An integrative review

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Kauts D.S.,Rather M.A.

Database Source: Embase Weekly Updates

Journal Title: Research in Autism

Article Title: Digital interventions for enhancing communication and collaboration in children with autism spectrum disorder: An integrative review

Year: 2025

Issue:

Volume: 125

Abstract: Background: Children with Autism Spectrum Disorder (ASD) often experience significant challenges in communication and collaboration. Traditional interventions, though beneficial, may require substantial resources and may not always accommodate the diverse sensory and cognitive needs of children with ASD. Digital interventions, including mobile applications, virtual reality (VR), and robot-assisted therapy, provide flexible and engaging alternatives by utilizing structured, interactive, and visually enriched environments tailored to the strengths of children with ASD. Method(s): This integrative review, conducted following PRISMA guidelines, analyzed studies published between 2011 and 2022 to explore how various digital interventions support communication and collaboration skills in children with ASD. Eleven studies that met the inclusion criteria were selected from databases such as Google Scholar, ERIC, and PsycINFO. A qualitative synthesis of findings was performed, considering study methodologies, target skills, and reported outcomes. Result(s): Findings suggest that mobile applications, particularly those incorporating speech-generating devices, facilitate verbal communication in younger children. Robot-assisted therapy has shown potential in enhancing nonverbal communication, such as eye contact and gestures, while VR and game-based learning promote collaborative behaviors like turn-taking and joint problem-solving. Although some studies reported effect sizes (e.g., Cohen's d = 0.32 [0.12-0.51]), the heterogeneity in study designs and intervention types limits direct comparisons. Instead, trends across studies indicate promising advancements in digital support for social and communication development in children with ASD. Conclusion(s): Digital interventions offer valuable opportunities for enhancing social and communication skills in children with ASD. While these tools complement traditional therapeutic approaches, variability in intervention designs and sample sizes suggests the need for further research to refine their implementation in educational and clinical settings. Copyright © 2025 Elsevier Ltd

Novel Respiratory Therapy for the Improvement of Post COVID Condition Symptoms: A Case Series

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Golan H.,Courtney R.,Wolfberg J.

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Journal Title: Journal of Voice

Article Title: Novel Respiratory Therapy for the Improvement of Post COVID Condition Symptoms: A Case Series

Year: 2025

Issue: 5

Volume: 39

Abstract: Introduction: Speech-language pathologists are seeing a growing number of patients whose voice and upper airway symptoms are complicated by dyspnea, cognitive difficulties, anxiety, extreme fatigue, and other debilitating post COVID symptoms. These patients are often less responsive to traditional speech-language pathology treatments and there is emerging literature that suggests dysfunctional breathing (DB) might contribute to dyspnea and other symptoms in this patient population. Treatment of DB through breathing retraining has been shown to improve breathing and successfully reduce symptoms similar to those seen in patients with long COVID. There is some preliminary evidence that breathing retraining is helpful for patients with post COVID condition symptoms. However, breathing retraining protocols tend to be heterogeneous and are often not systematic or well described. Method(s): This case series reports on an Integrative Breathing Therapy (IBT) protocol used in patients diagnosed with post COVID condition symptoms attending an otolaryngology clinic who presented with signs and symptoms of DB. A systematic evaluation of the biomechanical, biochemical, and psychophysiological dimensions of DB based on principles of IBT was performed on each patient to enable targeted patient-centered care. Patients were then provided with intensive breathing retraining that aimed to comprehensively improve breathing functionality in all these three dimensions of breathing. Treatment involved 6-12 sessions of weekly 1-hour group telehealth sessions combined with 2-4 individual sessions. Result(s): All participants showed improvements in the parameters of DB measured and also reported a reduction in symptoms and improved daily function. Conclusion(s): These findings suggest that patients with long COVID who present with signs and symptoms of DB might respond positively to comprehensive and intensive breathing retraining that addresses biochemical, biomechanical, and psychophysiological dimensions of breathing. More research is required to further refine this protocol and confirm its effectiveness through a controlled trial. Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Preface

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Calverley P.M.A.

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Journal Title: ERS Monograph

Article Title: Preface

Year: 2025

Issue: 109

Volume: 2025-September

Abstract:

"Voice of concern" for rural veterans with PTSD: Care managers' role engaging rural veterans in evidence-based therapies via telemedicine

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Petrova V.V.,Simons C.,Rajan S.,Reisinger H.S.,Nolan J.P.,Chen J.,Sayre G.,Fortney J.C.

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Journal Title: Psychological trauma : theory, research, practice and policy

Article Title: "Voice of concern" for rural veterans with PTSD: Care managers' role engaging rural veterans in evidence-based therapies via telemedicine

Year: 2025

Issue: 8

Volume: 17

Abstract: OBJECTIVE: In a Department of Veterans Affairs collaborative care implementation trial, care managers (CMs) focused on engaging rural Veterans diagnosed with posttraumatic stress disorder in trauma-focused psychotherapies, specifically cognitive processing therapy and prolonged exposure therapy, delivered over telehealth. As part of a summative evaluation, we interviewed Veterans about their experience, especially their interactions with their CM. Because relatively few Veterans initiated a trauma-focused psychotherapy, we specifically asked them about their conversations with CMs to better understand what worked and what did not work with regard to treatment engagement. METHOD(S): We conducted phone interviews with a purposive sample of 43 unique Veterans between 2017 and 2019. We purposively sampled Veterans who reported changes in satisfaction with Veterans Affairs posttraumatic stress disorder services and had experiences with different care modalities and patients who declined to initiate a trauma-focused psychotherapy. Data were analyzed using deductive-inductive content analysis. RESULT(S): Overall, Veterans perceived CMs as helpful in three ways: (a) for care coordination-especially with therapists; (b) as a "voice of concern"-for Veterans' health and daily life; and (c) as a "side counselor"-helping prepare Veterans for appointments and following up after their trauma-focused psychotherapy sessions. CONCLUSION(S): Veterans appreciated many qualities about their CM unrelated to trauma-focused psychotherapy. For those engaging in trauma-focused psychotherapy, CMs played the role of "side counselor" helping them stay engaged in care. Understanding patient perspectives about CMs' roles can help other types of providers understand how to best engage patients in trauma-focused psychotherapies. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Use of machine learning for predicting stress episodes based on wearable sensor data: A systematic review

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Pataca A.O.,Zdravevski E.,Coelho P.J.,Garcia N.M.,Deryuck M.,Albuquerque C.,Pires I.M.

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Journal Title: Computers in Biology and Medicine

Article Title: Use of machine learning for predicting stress episodes based on wearable sensor data: A systematic review

Year: 2025

Issue:

Volume: 198

Abstract: Objective: This study consists of a systematic literature review that aims to explore the potential of integrating wearable sensor data and machine learning (ML) techniques for predicting stress episodes. It aims to identify prevalent sensors, key physiological features, and the effectiveness of ML methods in real-world stress monitoring and prediction. Method(s): This systematic review follows the PRISMA methodology, analyzing literature from January 2010 to June 2025. Data sources included IEEE Xplore, Elsevier, Springer, Multidisciplinary Digital Publishing Institute (MDPI), and paper repositories such as PubMed Central and the Association of Computing Machinery (ACM). The inclusion criteria encompassed studies that employed wearable devices for ML stress prediction, focusing on physiological data such as heart rate variability (HRV), skin conductance, and sleep patterns. Articles were screened for originality, clinical relevance, and methodological rigor. Result(s): Key findings highlighted the use of diverse wearable sensors, including electrodermal activity (EDA), photoplethysmography (PPG), and accelerometers. Commonly extracted features included HRV metrics, skin conductance levels, and respiratory patterns. ML models, such as Random Forest (RF), Support Vector Machines (SVM), and deep neural networks (DNN), have demonstrated high predictive accuracy (e.g., up to 99%). Despite promising results, challenges such as small sample sizes, variability in data quality, and the need for standardized protocols were noted. Conclusion(s): Wearable sensors combined with ML algorithms provide scalable, real-time stress monitoring solutions, emphasizing proactive healthcare management. However, advancing this field requires addressing limitations through interdisciplinary collaboration and focusing on the accessibility and usability of technologies. Significance: This study highlights the transformative role of wearable technologies in predicting stress, with implications for personalized health interventions, mental health support, and enhanced healthcare efficiency. Copyright © 2025 The Authors

Digital Monitoring of Symptoms and Lung Function During Birch Pollen Season in Pediatric Patients

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Tanninen T.H.,Reitera P.H.,Saarto A.,Burman J.,Pelkonen A.S.,Makela M.J.

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Journal Title: Clinical and Translational Allergy

Article Title: Digital Monitoring of Symptoms and Lung Function During Birch Pollen Season in Pediatric Patients

Year: 2025

Issue: 10

Volume: 15

Abstract: Background: Mobile health (mHealth) applications for asthma and allergic rhinitis (AR) may guide patients in following medication use, symptoms, and lung function supporting self-management. Objective(s): The primary study objective was to investigate the objective effect of birch pollen on asthma and AR symptoms and medicine use in pediatric patients with varying levels of birch-specific immunoglobulin E (IgE) during the 2022 birch pollen season using digital tools. The secondary objectives were to determine the effect of birch pollen on Asthma Control Test scores, and to record the subjective benefits in self-management while using the application. Method(s): Altogether, 48 pediatric participants were categorized into three groups based on their birch-specific IgE levels. Participants continued their existing asthma control therapy. For allergic rhinitis and conjunctivitis, antihistamines, intranasal corticosteroids (INCS) or a combination of INCS and intranasal antihistamines, and cromoglicates or local antihistamines were prescribed. The study involved daily asthma and allergic rhinitis symptom and medication reporting via the mHealth application (KAMU Health, Finland) combined with microspirometry during the birch pollen season in Helsinki, Finland. Result(s): The patients preferred oral AR treatment. However, the low birch pollen levels may have contributed to moderate adherence to AR treatment. A low birch pollen load does not significantly impair lung function in young patients receiving anti-asthmatic treatment regularly. The majority of patients perceived this digital approach as beneficial, irrespective of their level of birch-specific sensitization. Conclusion(s): Digital tools support asthma and AR care by enabling disease monitoring, patient engagement, and provide real-world insights for clinicians. Copyright © 2025 The Author(s). Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

A bibliometric analysis of mindfulness-based interventions for individuals with autism spectrum disorder and their caregivers

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Huang X.,Guan M.,Tomenko T.R.,Tuzankina I.A.,Chereshnev V.A.,Xiao N.

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Journal Title: Research in Autism

Article Title: A bibliometric analysis of mindfulness-based interventions for individuals with autism spectrum disorder and their caregivers

Year: 2025

Issue:

Volume: 126

Abstract: Background: Autism spectrum disorder (ASD) presents significant challenges for both individuals and caregivers, often leading to stress, anxiety, and depression. Although mindfulness-based interventions (MBIs) have emerged as a promising approach to alleviate these burdens, this field lacks a comprehensive bibliometric analysis. Aim(s): We discuss future research hotspots and directions, with the aim of helping researchers quickly identify key areas for collaboration and development in this field, thereby advancing the clinical application of MBIs and improving the physical and mental well-being of autistic individuals and their caregivers. Methodology: We analyzed data from the Web of Science Core Collection (WoSCC), which included 335 articles authored by 1213 researchers and published in 146 journals. We employed bibliometric tools to examine publication trends, citations, key authors, and institutions. We conducted keyword and thematic evolution analyses to identify research hotspots and emerging trends. Finding(s): Since 2013, research on MBIs for ASD has significantly increased, with the USA leading in both output and impact. Family-centered mindfulness interventions focused on caregivers' well-being, particularly for mothers, were a key theme. Researchers widely used psychometric tools like the Beck Anxiety Inventory (BAI) and Parenting Stress Index (PSI). Emerging trends include the integration of MBI with artificial intelligence and remote interventions, which address sensory processing and social communication in ASD. Significance: This is the first bibliometric study on MBIs for ASD, highlighting their growing importance in improving mental health and reducing stress in both autistic individuals and caregivers. Future research should focus on personalized interventions and further explore the underlying mechanisms of MBIs. Copyright © 2025 Elsevier Ltd

INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Song L.,Si L.,Ouyang M.,Arima H.,Bath P.M.,Ford G.A.,Robinson T.G.,Sandset E.C.,Saver J.L.,Sprigg N.,van der Worp H.B.,Anderson C.S.,Sandset E.,Worp B.,Liu Z.,Dawson J.,Wong L.,Peng B.,Billot L.,Li Q.,Ning Y.,Chen X.,Yang Z.,Yu W.,Chen C.,Liu F.,Guo Y.,Lin Y.,Hu R.,Cheng H.,Ma W.,Liao K.,Zhang C.,Jin H.,Yang J.,Xu P.,Wu X.,Wang F.,Wu L.,Wang C.,Peng Y.,Zhao X.,Xu X.,Liu X.,Song X.,Li Z.,Zhang H.,Yu D.,Wang Y.,Tang X.,Cao X.,Liu Y.,Duan Y.,Liu H.,Li C.,Huang J.,Li H.,Fan C.,Tang Y.,Ji Y.,Li G.,Huang Y.,Chen G.,Wang J.

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Journal Title: Trials

Article Title: INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial

Year: 2021

Issue: 1

Volume: 22

Abstract: Background: Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design of the fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4). Method(s): A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed trial of pre-hospital BP lowering in 3116 hypertensive patients with suspected acute stroke at 50+ sites in China. Patients are randomized through a mobile phone digital system to intensive BP lowering to a target systolic BP of < 140 mmHg within 30 min, or guideline-recommended BP management according to local protocols. After the collection of in-hospital clinical and management data and 7-day outcomes, trained blinded assessors conduct telephone or face-to-face assessments of physical function and health-related quality of life in participants at 90 days. The primary outcome is the physical function on the modified Rankin scale at 90 days, analyzed as an ordinal outcome with 7 categories. The sample size was estimated to provide 90% power (alpha = 0.05) to detect a 22% reduction in the odds of a worse functional outcome using ordinal logistic regression. Discussion(s): INTERACT4 is a pragmatic clinical trial to provide reliable evidence on the effectiveness and safety of ambulance-delivered hyperacute BP lowering in patients with suspected acute stroke. Trial registration: ClinicalTrials.gov NCT03790800. Registered on 2 January 2019; Chinese Trial Registry ChiCTR1900020534. Registered on 7 January 2019. All items can be found in this protocol paper. Copyright © 2021, The Author(s).

Exploring the intersection of cochlear implants and artificial intelligence: A mixed-method systematic and scoping review

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Mocelin A.G.,de Paula P.A.B.,Kochinski D.T.,Wiezbicki T.C.,de Azevedo Hamerschmidt R.,Watanabe M.R.,Hamerschmidt R.

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Journal Title: Intelligence-Based Medicine

Article Title: Exploring the intersection of cochlear implants and artificial intelligence: A mixed-method systematic and scoping review

Year: 2025

Issue:

Volume: 12

Abstract: Objective: This study systematically evaluates the role of artificial intelligence (AI) in cochlear implant (CI) technology, focusing on speech enhancement, automated fitting, AI-assisted surgery, predictive modeling, and rehabilitation. The review identifies key advancements, existing limitations, and areas for future development. Method(s): Following PRISMA guidelines, we conducted a systematic search across PubMed, IEEE Xplore, Scopus, ScienceDirect, and Embase. We included peer-reviewed primary data studies on AI applications in CIs. The selected studies were categorized into thematic subdomains, such as noise suppression, adaptive programming, AI-driven surgical planning, and telemedicine applications. Result(s): From an initial pool of 743 records, 129 studies met the eligibility criteria and were included in the final analysis. These studies were categorized into eleven thematic subdomains. The review identified the main application areas and emerging research fronts at the intersection of artificial intelligence and cochlear implant technologies, including speech enhancement, automated fitting, predictive modeling, rehabilitation support, and AI-assisted surgery. Discussion and conclusion: AI is transforming CI technology by improving speech perception, personalization, and surgical precision. However, challenges persist, including computational constraints, data heterogeneity, and the need for large-scale clinical validation. Future research should prioritize energy-efficient AI architectures, regulatory approval pathways, and ethical considerations in automated decision-making. Advancing AI-driven telemedicine solutions can expand CI accessibility, reducing the need for in-person programming. Addressing these challenges will accelerate the development of more adaptive and user-centered CI solutions, ultimately enhancing auditory rehabilitation and quality of life for CI users. Copyright © 2025

Comment on: Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Liu X.,Wang W.

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Journal Title: Hypertension Research

Article Title: Comment on: Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis

Year: 2025

Issue: 10

Volume: 48

Abstract:

From innovation to integration: a global mixed-methods study of VR, metaverse, and 3D simulation in healthcare training and clinical setting

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Tomita D.,Abdelhakim M.,Bartkova J.,Gulsum A.,Sato A.,Alshiblan Alotaibi N.H.,Aboulhassan M.,Dongcai L.,Tomita Y.

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Journal Title: Frontiers in Digital Health

Article Title: From innovation to integration: a global mixed-methods study of VR, metaverse, and 3D simulation in healthcare training and clinical setting

Year: 2025

Issue:

Volume: 7

Abstract: Background: Immersive technologies in healthcare including virtual reality (VR), metaverse platforms, and 3D display technology are transforming global healthcare by improving medical education, advancing surgical training, enhancing patient preparedness, and facilitating remote collaboration. Adoption varies regionally due to infrastructure, cost, and digital literacy gaps. This study examined their impact on healthcare training and delivery outcomes and identified key integration barriers. Method(s): This mixed-methods instructional-integration study spanning four regions, Japan, the Middle East and North Africa, China, and the United States, utilized pre- and post-training surveys. Participant confidence in using immersive technologies was rated on a 5-point Likert scale. Paired t-tests determined significance. Thematic analysis of qualitative data (open-ended responses) identified key benefits and implementation challenges. Result(s): Of 350 healthcare professionals, 300 completed both surveys. Confidence improved significantly across all technologies: VR simulators (2.8-4.2), metaverse platforms (3.1-4.0), and 3D display systems (3.2-4.3), all p < 0.05. Regional trends were consistently positive, with favorable outcomes in surgical precision and spatial understanding (Cairo University, Al Faisal University). Thematic analysis cited expense (62%), limited infrastructure (56%), and need for context-specific training (49%) as key barriers; 88% of participants reported increased willingness towards applying immersive technology in healthcare settings. Discussion(s): Immersive technologies significantly enhance medical education and procedural training, demonstrating cross-regional applicability. Favorable feedback-based gains in user confidence underscore their transformative potential. Equitable adoption requires tackling systemic barriers through strategic investment, localized customization, and international collaboration. These findings offer actionable insights to inform policy and program development for digital healthcare transformation. Copyright 2025 Tomita, Abdelhakim, Bartkova, Gulsum, Sato, Alshiblan Alotaibi, Aboulhassan, Dongcai and Tomita.

From Taboo to Touchscreen: A Qualitative Study of Digital Sexual and Reproductive Health Intervention for Bangladeshi Adolescents

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Hasan K.,Mahmood H.R.,Ether S.T.,Hayder T.,Zannat S.,Sayeed A.,Rumayan Hasan A.M.,Rahman A.E.,Chiu C.,Ahmed A.,Zaman Sajib M.R.U.

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Journal Title: Journal of Medical Internet Research

Article Title: From Taboo to Touchscreen: A Qualitative Study of Digital Sexual and Reproductive Health Intervention for Bangladeshi Adolescents

Year: 2025

Issue: 1

Volume: 27

Abstract: Background: Adolescents in Bangladesh, approximately one-fifth of the total population, face significant challenges accessing relevant sexual and reproductive health (SRH) information, with the added burdens of cultural taboo, limited accessibility, and poor communication channels. Traditional adolescent-friendly approaches have shown limited effectiveness in addressing these challenges. In response, Mukhorito was developed as a peer-led, mobile-based digital platform to facilitate SRH, education, and communication among ninth-grade students. Objective(s): This study explored the feasibility and constraints of piloting the Mukhorito app to enhance adolescent SRH education in Bangladesh. It also sought to determine the self-reported usage, usability, and effect on knowledge and peer communication of the app, as well as to identify implementation and adoption challenges. Method(s): A qualitative design was applied in the context of a broader mixed-methods study. Data were collected through 6 in-depth interviews, 3 key informant interviews, and 1 focus group discussion from 19 participants, including students, peer leaders, teachers, and government representatives, across 3 secondary schools (a boys' school, girls' school, and coeducational school) in the Feni district. Thematic analysis was conducted using NVivo software (QSR International) under Braun and Clarke's guidelines. Result(s): The Mukhorito app was perceived as a valuable tool to meet the SRH needs of adolescents in Bangladesh owing to its well-structured, easily navigable content with relatable stories. Participants described increased awareness of critical SRH issues, including reproductive health, nutrition, early marriage, violence against adolescents, and drug addiction, and reported sharing this knowledge with their families and communities. The app was seen as creating a safe space to discuss previously taboo SRH topics, reducing cultural reluctance to communicate, and promoting peer-to-peer communication. Interactive sessions were noted to strengthen decision-making skills and leadership qualities. Many users reported feeling more comfortable discussing SRH issues without shyness. However, challenges such as limited smartphone access, unreliable internet connection, and economic factors hindered adoption, especially in rural settings. Participants suggested the integration of the Mukhorito app in school curricula, aligning it with the government adolescent health program, adding visually rich and interactive content (eg, short dramas, videos, and animations), and enabling offline access to address connectivity challenges and maximize the effectiveness of the app. Conclusion(s): Mukhorito possesses strong potential as a culturally relevant, digital SRH education tool for Bangladeshi adolescents. The app enabled knowledge and openness in SRH discourse. Alignment with national health programs and enhanced app functionality may promote greater and more sustainable adolescent health. Copyright © Kamrul Hasan, Hassan Rushekh Mahmood, Saraban Tahura Ether, Tanvir Hayder, Soaiba Zannat, Abu Sayeed, A M Rumayan Hasan, Ahmed Ehsanur Rahman, Chungyi Chiu, Anisuddin Ahmed, Md Refat Uz Zaman Sajib.

Effectiveness of remote physiotherapeutic e-Health interventions on pain in patients with musculoskeletal disorders: a systematic review

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Toonders S.A.J.,van der Meer H.A.,van Bruxvoort T.,Veenhof C.,Speksnijder C.M.

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Journal Title: Disability and rehabilitation

Article Title: Effectiveness of remote physiotherapeutic e-Health interventions on pain in patients with musculoskeletal disorders: a systematic review

Year: 2023

Issue: 22

Volume: 45

Abstract: PURPOSE: To systematically review the literature on effectiveness of remote physiotherapeutic e-Health interventions on pain in patients with musculoskeletal disorders. MATERIALS AND METHODS: Using online data sources PubMed, Embase, and Cochrane in adults with musculoskeletal disorders with a pain-related complaint. Remote physiotherapeutic e-Health interventions were analysed. Control interventions were not specified. Outcomes on effect of remote e-Health interventions in terms of pain intensity. RESULT(S): From 11,811 studies identified, 27 studies were included. There is limited evidence for the effectiveness for remote e-Health for patients with back pain based on five articles. Twelve articles studied chronic pain and the effectiveness was dependent on the control group and involvement of healthcare providers. In patients with osteoarthritis (five articles), total knee surgery (two articles), and knee pain (three articles) no significant effects were found for remote e-Health compared to control groups. CONCLUSION(S): There is limited evidence for the effectiveness of remote physiotherapeutic e-Health interventions to decrease pain intensity in patients with back pain. There is some evidence for effectiveness of remote e-Health in patients with chronic pain. For patients with osteoarthritis, after total knee surgery and knee pain, there appears to be no effect of e-Health when solely looking at reduction of pain. Implications for rehabilitationThis review shows that e-Health can be an effective way of reducing pain in some populations.Remote physiotherapeutic e-Health interventions may decrease pain intensity in patients with back pain.Autonomous e-Health is more effective than no treatment in patients with chronic pain.There is no effect of e-Health in reduction of pain for patients with osteoarthritis, after total knee surgery and knee pain.

Innovative Approaches to Head and Neck Cancer Diagnosis

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: George A.,Tikka T.,Conway D.

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Journal Title: Otolaryngologic Clinics of North America

Article Title: Innovative Approaches to Head and Neck Cancer Diagnosis

Year: 2025

Issue:

Volume:

Abstract:

Multidisciplinary ambulatory management of malignant bowel obstruction (MAMBO) program in patients with advanced gynecological cancers: A prospective study

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Garg V.,Armstrong E.,Celeste A.,Wang C.,Shukla A.,Tesfu A.,Odujoko O.,Madariaga A.,Lee Y.C.,Wang L.,Alqaisi H.,Soberanis P.,Grant B.,Braik D.,Chawla T.,Shlomovitz E.,Veneziani A.,Dhani N.,Grant R.,Jivraj N.,Bowering V.,Oza A.M.,Allard J.P.,Coburn B.,Lheureux S.

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Journal Title: Gynecologic Oncology

Article Title: Multidisciplinary ambulatory management of malignant bowel obstruction (MAMBO) program in patients with advanced gynecological cancers: A prospective study

Year: 2025

Issue:

Volume: 202

Abstract: Objectives: This prospective study aimed to assess the feasibility of a risk-stratified, multidisciplinary ambulatory approach for managing malignant bowel obstruction (MBO) in patients with advanced gynecological cancer. Method(s): A clinical risk-based MBO triage system was implemented by incorporating bowel function assessments, management regimes, and educational tools. An interdisciplinary team (IDT) guided treatment decisions. At risk patients received proactive management through nursing phone calls for up to 4 weeks, while patients with MBO continued proactive management for up to 8 weeks based on symptom resolution. The primary endpoint was the ratio of days alive and out of the hospital to days in the hospital within 60 days post-MBO diagnosis. Result(s): 92 patients (median age 62 years [range 31-83]) were enrolled. At enrollment, 49 % (n = 45) had MBO, and 51 % (n = 47) were at risk of MBO development. 7 % (n = 3) at-risk patients progressed to MBO in 4 weeks, while 93 % had symptom resolution with proactive outpatient management. Overall, 62 % (n = 57) of patients developed MBO during study period. Among these, 93 % (n = 53) needed inpatient care, with a median stay of 12.5 days (range 0-57) in the first 60 days. Median OS after MBO was 5.7 months (95 % CI, 3.6-8.4). The median of hospital-to-home ratio was 0.3 (range 0-19) within 60 days. MBO resolved in 42 % (n = 24) of the patients. Microbiome analysis showed lower Shannon diversity and species richness for MBO patients compared to those at risk. Conclusion(s): This study confirms the feasibility of ambulatory management for MBO patients, using a risk-based MBO triage system guided by IDT. Copyright © 2025 Elsevier Inc.

Identifying people with chronic hepatitis B virus who are lost to clinical follow up: A retrospective case finding and re-engagement service improvement exercise

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Jackson R.,Marks A.,Irving W.L.,Jack K.

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Journal Title: Journal of Clinical Virology

Article Title: Identifying people with chronic hepatitis B virus who are lost to clinical follow up: A retrospective case finding and re-engagement service improvement exercise

Year: 2025

Issue:

Volume: 181

Abstract: Background: Hepatitis B virus (HBV) infection is an important cause of liver disease-related mortality and morbidity. The World Health Organisation aims to eliminate this as a public health concern by 2030 and as such the key international guidelines recommend that all patients are reviewed regularly to observe for preventable signs of disease progression. This requires life-long engagement with specialist services, but some patients fall out of the care pathway and become lost to follow-up. Objective(s): This study sought to identify and re-engage patients with HBV who were lost to follow up (LTFU), defined as any HBsAg positive patient who had not been seen in the hepatology outpatient service since 31st December 2021, excluding those with acute infection. Study design: A retrospective case finding and re-engagement healthcare service improvement exercise was conducted to identify and contact individuals with HBV diagnosed between June 2007 and the end of December 2021 who were lost-to-follow-up. Result(s): One third of the HBsAg positive cohort were lost to follow-up (32.9%, n=506/1539). Of this group, 145 people were still living in the hospital's catchment area, yet only 60 people could be contacted by telephone of whom 50 returned to clinic. More than 12% of patients were HBeAg positive at their last clinic visit, and almost one quarter (23.2%) had an abnormally raised ALT. There was extensive ethnic heterogeneity with 65 languages spoken among 474 people. We successfully re-engaged 10.07% (51/506) back into care. Conclusion(s): Patients with potentially progressive HBV-related liver disease are falling out of the care pathway with the attendant long-term problems that failure to control their infection may have. Copyright © 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

The heart team for coronary artery disease: perspectives from centers with heart surgery on site

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Fleckenstein P.,Doenst T.,Franz M.

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Journal Title: Herz

Article Title: The heart team for coronary artery disease: perspectives from centers with heart surgery on site,Das Heart-Team bei koronarer Herzkrankheit: Sicht von Zentren mit institutionalisierter Herzchirurgie

Year: 2025

Issue: 5

Volume: 50

Abstract: The heart team is an important component for guideline-conform treatment of patients with complex coronary artery disease (CAD). Nevertheless, this integrative, multiprofessional approach is not always consistently implemented in clinical practice. This article highlights the role of the heart team, with a particular focus on cardiovascular centers with cardiac surgery on site, presents evidence-based benefits and draws attention to existing structural gaps in daily care, such as the probably widespread use of ad hoc percutaneous coronary intervention (PCI) in multivessel CAD or the lack of interdisciplinary coordination. Numerous studies have shown that consistently implemented heart team decisions and a culture of professional and evidence-based interaction improve patient outcomes. This article appeals to cardiological and cardiac surgery departments to actively shape the heart team process. The presence of both the heart team and cardiac surgery on site paired with modern possibilities of digital communication tools and the wish for individual treatment recommendations should enable faster heart team decisions (practically ad hoc) to improve patient care. Copyright © The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2025.

The Role of Diabetes Distress and Self-Efficacy as Mediators of Barriers to Diabetes Self-Management in Young Adults With Type 1 Diabetes: A Cross-Sectional Study

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Nnoli N.D.,Sideris J.,Lee P.-J.,Fox S.,Raymond J.K.,Pyatak E.A.

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Journal Title: Diabetes Spectrum

Article Title: The Role of Diabetes Distress and Self-Efficacy as Mediators of Barriers to Diabetes Self-Management in Young Adults With Type 1 Diabetes: A Cross-Sectional Study

Year: 2025

Issue: 3

Volume: 38

Abstract: OBJECTIVE This study examined how structural and contextual barriers, including social needs and gender, influence diabetes self-management (DSM) through psychosocial pathways, particularly diabetes distress (DD) and self-efficacy (SE). Although these barriers are well documented, their interactions with psychosocial factors remain underexplored. RESEARCH DESIGN AND METHODS We analyzed cross-sectional baseline data from the REAL-T (Resilient, Empowered, Ac tive Living-Telehealth) study (n = 198). Using hierarchical regression, we assessed factors influencing DSM. Struc tural predictors included unmet social needs and limited insulin access; contextual predictors included gender and ethnicity. Hypothesized mediators were the scores on the Diabetes Distress Scale, the Diabetes Empowerment Scale, and the Audit of Diabetes Dependent Quality of Life. After identifying significant predictors and potential mediators through hierarchical multivariate regression analysis, separate path models were tested for each hypothesized mediator. RESULTS Unmet social needs, as well as female and nonconforming genders, were found likely to increase DSM chal lenges. All selected predictors became nonsignificant when accounting for all psychosocial variables. DD mediated all tested relationships, and SE partially mediated the relationship between unmet social needs and DSM. CONCLUSION The proposed model suggests the need for targeted interventions addressing psychosocial pathways, par ticularly DD and SE, to mitigate the downstream effects of structural barriers to DSM. Inclusive gender-specific care models and systemic reforms to reduce social inequities are crucial for improving DSM outcomes and overall well- being. Copyright © 2025 by the American Diabetes Association.

RE: A step-by-step guide for remote working in the NHS: evaluation of a virtual consultant psychiatrist hiring scheme

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Mann-Wineberg D.,Tomar R.

Database Source: Embase Weekly Updates

Journal Title: BJPsych Bulletin

Article Title: RE: A step-by-step guide for remote working in the NHS: evaluation of a virtual consultant psychiatrist hiring scheme

Year: 2025

Issue: 5

Volume: 49

Abstract:

Effectiveness of the Self-Directed mHealth Exercise Intervention re.flex in Patients With Knee Osteoarthritis: Randomized Controlled Trial

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Dieter V.,Martus P.,Seissler D.,Serna-Higuita L.M.,Janssen P.,Krauss I.

Database Source: Embase Weekly Updates

Journal Title: Journal of Medical Internet Research

Article Title: Effectiveness of the Self-Directed mHealth Exercise Intervention re.flex in Patients With Knee Osteoarthritis: Randomized Controlled Trial

Year: 2025

Issue:

Volume: 27

Abstract: Background: About 1 in 2 patients with knee osteoarthritis (OA) receives a referral or recommendation for exercise. Digital health applications could counteract this undersupply. Objective(s): We aimed to investigate the effectiveness of a 12-week self-directed mobile health exercise intervention (re.flex) when used in addition to usual care compared to a control group receiving usual care only on pain reduction and improvement in physical function in patients with knee OA. Method(s): This monocentric, 2-arm, randomized controlled parallel-group trial included patients from Germany with moderate to severe knee OA. Participants were mainly recruited via newspapers. Randomization was 1:1 into an intervention group (re.flex+usual care) and a control group (usual care) using computer-generated blocks. Participants were unmasked to group assignment. The re.flex group conducted a 12-week self-directed app-based and sensor-assisted exercise program with 3 sessions per week in addition to usual care. Primary outcomes were OA-specific knee pain and physical function (using the subscales pain and activities in daily living of the Knee Osteoarthritis Outcome Score, 0-100) at 3 months. Secondary outcomes included adherence and safety. Multiple imputation was used to account for missing data. Intervention effects were calculated using a baseline-adjusted analyses of covariance (ANCOVA). Bonferroni correction with an alpha level of .025 was applied. Result(s): Between January 25, 2023, and August 11, 2023, a total of 195 participants were enrolled. Of them, 98 participants were allocated to re.flex, and 97 participants to usual care. The primary analysis included 194 participants. The mean age was 61.9 (SD 7.7) years, and the majority were female (132/194, 68%). Pain reduction was significantly larger in re.flex than in usual care, with an adjusted mean difference between study groups of 4.8 (95% CI 0.7-8.9; P=.02; Cohen d=0.35) points. Improvement in physical function was not statistically significant (beta coefficient [beta]=3.9 points, 95% CI 0.0-7.9, P=.049). A total of 12 adverse events were linked to re.flex, none of which were serious. Participants adhered to 77% (2705/3528) of all scheduled exercise sessions. Conclusion(s): The self-directed sensor-based mobile health exercise intervention re.flex demonstrates superiority over usual care for pain reduction and justifies this kind of intervention as an alternative exercise delivery mode for patients with knee OA. Copyright © Valerie Dieter, Peter Martus, David Seisler, Lina Maria Serna-Higuita, Pia Janssen, Inga Krauss.

How to use quality improvement methodology to track missed care opportunities for urodynamics appointments and identify key drivers for future interventions

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Scarpaci K.,Chen C.,Micker M.,Gibbs H.,Harlan P.,Little C.,Allentuck N.,Sprague B.M.,Pohl H.G.,Ho C.P.,Varda B.K.

Database Source: Embase Weekly Updates

Journal Title: Journal of Pediatric Urology

Article Title: How to use quality improvement methodology to track missed care opportunities for urodynamics appointments and identify key drivers for future interventions

Year: 2025

Issue: 5

Volume: 21

Abstract: Missed care opportunities (MCOs) can negatively affect patients, providers and institutions. In 2022, we established a prospective quality improvement (QI) database to track MCOs for urodynamics (UDS). Between 2022 and 2024, 877 appointments were scheduled. The MCO rate was 29 %. Patients with spina bifida (SB) undergoing non-video UDS accounted for 79 % of MCOs. This sub-group was sensitive to reminder type, with MCOs driven down by human phone reminders then rising above the median MCO rate with text reminders (aOR 1.5 [95 % CI 1.09-2.14], p = 0.02). This knowledge, alongside practitioner-assigned reasons for MCOs, has informed targeted QI interventions. Copyright © 2025

Evaluating online chat counselling as a synchronous, digital and text-based mental health support service for autistic individuals and their parents

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Bontinck C.,Baeyens D.,De Schryver M.,Renty J.,Roeyers H.

Database Source: Embase Weekly Updates

Journal Title: Research in Autism

Article Title: Evaluating online chat counselling as a synchronous, digital and text-based mental health support service for autistic individuals and their parents

Year: 2025

Issue:

Volume: 126

Abstract: The value of telehealth for autistic individuals has been well established, yet specific research regarding the implementation of online chat counselling for this population is limited. Addressing this gap, users of an existing chat platform (175 autistic individuals and 66 parents of an autistic individual), the Autism Chat, were asked to participate in a follow-up questionnaire immediately after chatting. The support needs of autistic individuals that led them to consult the Autism Chat were predominantly of an emotionally supportive nature, whereas those of parents were more frequently informative or problem-solving. The majority of autistic individuals and parents were highly satisfied with the support received and chatting was associated with an improvement in well-being right after the chat conversation. Chatting had both communicative (e.g., better self-expression) and practical (e.g., flexibility) advantages, with the benefits of chatting greatly outweighing the drawbacks. The findings offer valuable insights into the implementation as well as advantages and disadvantages of chat counselling as a mental health support service for autistic individuals and their network. Copyright © 2025 Elsevier Ltd

Decomposition analysis of anxiety symptom differences between urban and rural Chinese university students: cross-sectional study

Sat, 18 Oct 2025 08:24:28 +0000

Author Names: Tuersun Y.,Xie Y.,Zhou Q.,Yu Y.,Wang W.,Wang C.,Liu S.,Song Y.,Liang Z.,Qian Y.

Database Source: Embase Weekly Updates

Journal Title: Frontiers in Psychiatry

Article Title: Decomposition analysis of anxiety symptom differences between urban and rural Chinese university students: cross-sectional study

Year: 2025

Issue:

Volume: 16

Abstract: Background: Anxiety is a prevalent psychological disorder characterized by excessive worry and fear, which significantly impacts the mental health of university students. Anxiety symptoms are often misunderstood, leading to delays in seeking help. This issue is particularly notable among college students, who may experience anxiety due to academic pressures, societal expectations, and family issues. This study explores anxiety symptoms among urban and rural Chinese university students, aiming to analyze the differences and contributing factors. The primary goal of this study is to analyze the differences in anxiety symptoms between urban and rural Chinese university students and to decompose these differences into the contributions of various individual and socio-economic factors using the Fairlie decomposition model. Method(s): A cross-sectional survey was conducted between January and February 2023, involving 7,230 valid questionnaires from undergraduate students across ten provinces in China. The Generalized Anxiety Disorder 7 (GAD-7) scale was used to assess anxiety symptoms. Demographic characteristics, academic performance, lifestyle factors, depressive symptoms (Patient Health Questionnaire-9; PHQ-9), and eHealth (SeHealth Literacy Scale) literacy were controlled for as covariates. The Fairlie decomposition model was applied to examine the contributing factors to the observed differences in anxiety symptoms between urban and rural students. Result(s): The study found that 38.91% of students reported experiencing anxiety symptoms. The prevalence was higher among rural students (40.2%) compared to urban students (36.8%). Significant factors contributing to this difference included depressive symptoms (51.07% contribution), exercise habits (7.07% contribution), and family income levels. Rural students were found to be at higher risk for anxiety symptoms, with those from lower-income families and those lacking exercise habits exhibiting greater anxiety. Conclusion(s): The results demonstrate a significant difference in anxiety symptoms between urban and rural college students in China. The disparity is mainly influenced by depressive symptoms, exercise habits, and family income. The findings suggest the need for tailored mental health interventions for rural students, with a focus on improving access to resources, promoting physical activity, and addressing socio-economic factors. The study underscores the importance of considering urban-rural differences in the development of effective mental health strategies for university students. Copyright © 2025 Tuersun, Xie, Zhou, Yu, Wang, Wang, Liu, Song, Liang and Qian.