nutrition_oncologie

Effect of family synchronous empowerment education on postoperative esophageal cancer patients and their primary caregivers

Sat, 13 Sep 2025 04:20:45 -0400

Author Names: Shi Y.-Y.,Shu P.-Y.,Wang M.-X.,Yu R.,Zhang L.-L.,Feng L.-L.,Mao C.-M.,Ding M.

Database Source: Embase Weekly Updates

Journal Title: Precision Medical Sciences

Article Title: Effect of family synchronous empowerment education on postoperative esophageal cancer patients and their primary caregivers

Year: 2025

Issue: 3

Volume: 14

Abstract: The aim of this study was to evaluate the impact of family synchronous empowerment education on the caregiving ability and preparedness of primary caregivers, as well as the nutritional status and quality of life of patients who have undergone esophagectomy. A total of 102 patients who were treated with thoracoscopic radical resection for esophageal cancer and their primary caregivers from August 2023 to March 2024 were selected and evenly divided into a control group and an intervention group, with 51 cases in each group. The control group received standard nursing education, whereas the intervention group received additional family synchronous empowerment education. Both the preparedness and ability of the primary caregivers to provide care, as well as the nutritional status and quality of life of the patients, were assessed at admission and 1 month post-discharge. Post-intervention, the intervention group's primary caregivers demonstrated significantly improved caregiving ability and preparedness compared to the control group (p <.05). Similarly, patients in the intervention group exhibited significantly better nutritional status and quality of life than those in the control group (p <.05). The study concluded that the implementation of family synchronous empowerment education significantly enhances the caregiving ability and preparedness of primary caregivers and improves the nutritional status and quality of life in patients after esophagectomy.<br/>Copyright © 2025 The Author(s). Precision Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital.

Malnutrition and Nutrition Impact Symptoms in Kuwaiti Colorectal Cancer Patients: Validation of PG-SGA Short Form

Fri, 12 Sep 2025 20:00:00 -0400

Nutrients. 2025 Aug 27;17(17):2770. doi: 10.3390/nu17172770.

ABSTRACT

Background/Objectives: Malnutrition is a common but underrecognized complication in colorectal cancer (CRC), contributing to poor treatment outcomes and reduced quality of life. Regional data from the Gulf remains limited. This study assessed the prevalence of malnutrition and nutrition impact symptoms (NISs) among CRC patients in Kuwait. It evaluated the diagnostic performance of the PG-SGA Short Form (PG-SGA SF) in comparison to the full PG-SGA and the Malnutrition Screening Tool (MST). Methods: A cross-sectional study was conducted among 65 CRC outpatients at the Kuwait Cancer Control Center. Nutritional status was assessed using the full PG-SGA, PG-SGA SF, and MST. Dietary intake, anthropometry, biochemical parameters, and NISs were collected. Logistic regression identified independent predictors of malnutrition, and the performance of the tool was evaluated using kappa statistics and diagnostic accuracy metrics. Results: Malnutrition (PG-SGA B/C) was identified in 61.4% of patients. Loss of appetite, dry mouth, and nausea were significantly associated with malnutrition (p < 0.00385); dry mouth independently predicted malnutrition (OR: 17.65, 95% CI: 2.02-154.19, p = 0.009). BMI was not predictive, but reduced mid-arm circumference was significantly associated. PG-SGA SF showed strong agreement with the full PG-SGA (κ = 0.75), with high sensitivity (87.2%) and specificity (88.5%), outperforming MST (κ = 0.38). Only 23.5% of moderately malnourished patients were referred to a dietitian. Conclusions: Malnutrition and NIS are highly prevalent among Kuwaiti CRC patients. PG-SGA SF is a valid and efficient screening tool that should replace MST in oncology settings. Symptom-informed screening and structured referral protocols are crucial for enhancing nutrition care.

PMID:40944163 | PMC:PMC12430223 | DOI:10.3390/nu17172770

Early nutritional and inflammation assessment predicts prognosis in patients with cancer across tumor origin and metastatic status.

Mon, 01 Sep 2025 00:00:00 -0400

Clinical Nutrition; 09/01/2025
(AN 187563639); ISSN: 02615614
CINAHL Complete

Body Subcutaneous Fat Change Predicts Chemoradiotherapy Response and Prognosis of Esophageal Cancer Patients: A Cohort Study.

Mon, 01 Sep 2025 00:00:00 -0400

Nutrition & Cancer; 09/01/2025
(AN 187695845); ISSN: 01635581
CINAHL Complete

老年结直肠癌病人术后化疗期间营养状况与化疗不良反应的相关性.

Mon, 01 Sep 2025 00:00:00 -0400

Chinese Nursing Research; 09/01/2025
(AN 187776236); ISSN: 10096493
CINAHL Complete

Swallowing ability, nutritional status, and functioning in adults with advanced cancer excluding head, neck, and upper gastrointestinal tract: a cross-sectional study in an outpatient palliative care setting

Tue, 26 Aug 2025 20:00:00 -0400

Codas. 2025 Aug 22;37(4):e20240210. doi: 10.1590/2317-1782/e20240210pt. eCollection 2025.

ABSTRACT

PURPOSE: This study sought to analyze the swallowing function of cancer patients undergoing palliative care according to the degree of functionality and nutritional status.

METHODS: observational, cross-sectional study, conducted with advanced cancer patients outside the head and neck and upper gastrointestinal tract, in an outpatient palliative care setting at a Brazilian oncology center, conducted between March 2022 and August 2023. In the first stage, sociodemographic, clinical, functional, and nutritional data were collected. Subsequently, a speech therapy assessment was performed to classify swallowing disorders and feeding route associated with swallowing ability. Descriptive, univariate, and multivariate analyses were conducted using logistic regression.

RESULTS: 39 individuals participated in the study, the majority were female, with functional performance between fair and good, moderately undernourished. Regarding the assessment of swallowing abilities, the sample mostly exhibited fully functional swallowing, followed by functional swallowing with occasional minimal cues, additional time, or avoidance of specific foods. As for the classification of swallowing, most participants had either normal swallowing or functional swallowing, with only one patient presenting mild oropharyngeal dysphagia. Multivariate analysis revealed a significant association between a decline in swallowing ability and poorer functional performance and nutritional status.

CONCLUSION: Poorer swallowing ability in patients with advanced cancer, excluding those with head, neck, and upper gastrointestinal tract cancers, was associated with lower global functionality and nutritional status.

PMID:40862399 | DOI:10.1590/2317-1782/e20240210pt

Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study

Tue, 26 Aug 2025 20:00:00 -0400

PeerJ. 2025 Aug 22;13:e19950. doi: 10.7717/peerj.19950. eCollection 2025.

ABSTRACT

PURPOSE: Inflammation, immune system and nutritional status contribute significantly to tumorigenesis, progression and metastasis. The aim of this study was to evaluate the significance of the inflammation-immune-nutritional score (IINS) on postoperative survival and recurrence in breast cancer patients and to analyze and compare the IINS, platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI) in terms of progression-free survival (PFS) and overall survival (OS) in patients with breast cancer (BC) who underwent surgical treatment prognostic value.

METHODS: We executed a retrospective investigation of the clinical information and related materials of 200 female breast cancer patients who had their first breast cancer operation at the Affiliated Hospital of Jiangnan University between January 2017 and December 2018, and the IINS was built using the sum of preoperative categorical scores for high-sensitivity C-reactive protein (hs-CRP), lymphocytes (LYM), and albumin (ALB). In our survival analysis, we graphed the survival curves employing the Kaplan-Meier method. The effectiveness of pre-operative IINS, PLR, and PNI in PFS and OS of breast cancer patients were evaluated with receiver operating characteristic (ROC) curves and Cox proportional risk regression analyses.

RESULTS: The median age of the patients was 55.5 years (range 34-75 years). In progression-free survival, the areas under the IINS, PLR, and PNI curves were as follows: IINS: 0.735, HR (95% CI) 0.037 [0.662-0.809], PLR: 0.724, HR (95% CI) 0.036 [0.655-0.794], PNI: 0.694, HR (95% CI) 0.038 [0.619-0.769]. In overall survival, the areas under the curves of IINS, PLR, and PNI were as follows: IINS: 0.738, HR (95% CI) 0.049 [0.642-0.834], PLR: 0.700, HR (95% CI) 0.039 [0.623-0.777], and PNI: 0.713 with HR (95% CI) 0.050 [0.615-0.811]. According to the findings, among patients with resectable breast cancer, preoperative IINS may be the most accurate indicator of both overall survival and progression-free survival.

CONCLUSION: IINS may be a dependable marker for predicting postoperative survival in patients with breast cancer, and its prognostic value may be higher than that of traditional markers.

PMID:40860681 | PMC:PMC12377354 | DOI:10.7717/peerj.19950

A model based on preoperative nutrition-inflammation score for predicting mucocutaneous separation after enterostomy in colorectal cancer patients

Sat, 23 Aug 2025 20:00:00 -0400

Sci Rep. 2025 Aug 24;15(1):31095. doi: 10.1038/s41598-025-16430-6.

ABSTRACT

Mucocutaneous separation (MCS) is a common early complication after colorectal cancer (CRC) surgery. The aim of the present study is to investigate the predictive value of preoperative nutrition-inflammation markers for MCS and establish a novel predictive model. The internal cohort composed of CRC patients admitted to Changhai Hospital Affiliated to Naval Medical University was randomly divided into a training cohort and an internal validation cohort at a ratio of 7:3, while patients from the First Affiliated Hospital of Bengbu Medical University and 72nd Group Army Hospital formed an external cohort. The clinical variables were retrospectively analyzed to establish a scoring system for evaluating preoperative nutrition-inflammation status. In the training cohort, the independent factors for MCS were identified through univariate and multivariate Logistics regression analysis. The predictive model was drawn with a nomogram, which was verified in the two validation cohorts by receiver operating characteristic (ROC) curves, calibration curves and decision curve analyses (DCA). 359 and 145 eligible patients were included in the internal and external cohorts, respectively, including 47 and 30 patients suffering MCS in their respective cohorts. Old age, overweight, colostomy, end stoma, and peripheral blood markers were associated with MCS. The ROC curve showed that the nutrition-inflammation score (NIS) composed of GLR, SII and PNI predicted the differentiation of MCS well, and the area under the curve (AUC) was 0.752. Univariate and multivariate analyses showed that old age, end stoma and NIS (= 3) were independent risk factors for MCS. The AUC of the nomogram model based on these factors in the training cohort and validation cohorts were 0.850, 0.909, and 0.906, respectively. The calibration curves showed no significant difference between the predicted value of the model and the actual observed value, and the DCA curves showed that the model had good clinical application value. The risk score of this model was correlated with healing time of MCS, postoperative hospital stays, and chemotherapy intervals of CRC patients. The prediction model of MCS based on preoperative peripheral NIS had good accuracy and demonstrated promising performance of predicting the risk of postoperative MCS in CRC patients.

PMID:40851016 | PMC:PMC12375762 | DOI:10.1038/s41598-025-16430-6

Analysis of nutritional status and its influencing factors in patients with head and neck cancer: An observational study

Mon, 18 Aug 2025 20:00:00 -0400

Medicine (Baltimore). 2025 Aug 15;104(33):e43731. doi: 10.1097/MD.0000000000043731.

ABSTRACT

The objective of this study was to explore the short-term changes in nutritional status from preoperative to 2 months postoperatively in head and neck cancer patients, as well as the influencing factors, to provide guidance for clinical interventions. A total of 148 patients with head and neck cancer admitted to the Department of Head and Neck Oncology, Zhejiang Cancer Hospital, were selected. A general questionnaire (demographic data, tumor-related data, body mass index, laboratory indicators) was used to understand the basic information of the patients. The Nutritional Risk Screening score (NRS 2002) was measured before treatment, 1 and 2 months after finishing treatment. The data was processed by SPSS 25.0 software package for univariate and multivariate analyses. Among the 148 patients, 71 cases (47.9%) had a persistent good nutrition, 38 cases (25.7%) had a worsening nutritional risk, 18 cases (12.2%) alternated between good and poor nutritional risk, 3 cases (2.0%) had an improving nutritional risk, and 38 cases (25.7%) had a persistent nutritional risk. Multiple logistic regression showed that patients with prolonged tube feeding time, low albumin levels, total protein deficiency, low serum creatinine, low blood urea nitrogen, low red blood cells, and hemoglobin were more likely to develop persistent nutritional risk. The nutritional status of patients with head and neck cancer was affected by various factors from preoperative to 2 months postoperatively. Medical workers should pay attention to the high-risk groups of malnutrition and carry out periodic nutritional monitoring, to take a series of targeted nutritional support treatments.

PMID:40826729 | PMC:PMC12366936 | DOI:10.1097/MD.0000000000043731

Effects of Rikkunshito on postgastrectomy weight loss and nutritional status in gastric cancer patients: A retrospective observational study

Mon, 18 Aug 2025 20:00:00 -0400

Medicine (Baltimore). 2025 Aug 15;104(33):e43950. doi: 10.1097/MD.0000000000043950.

ABSTRACT

Postgastrectomy disorders decrease the quality of life of patients because of poor oral intake and nutritional status. Rikkunshito is a Japanese herbal medicine that alleviates anorexia and prevents upper gastrointestinal disorders, particularly in the perioperative period. Herein, we investigated whether Rikkunshito administration in the early perioperative period alleviates weight loss and improves the nutritional status after undergoing minimally invasive distal gastrectomy for gastric cancer. We conducted a retrospective cohort study involving 139 consecutive gastric cancer patients who underwent laparoscopic or robot-assisted distal gastrectomy for potentially curable gastric cancer between January 2018 and May 2023 at our institution. We divided the patients into 2 groups based on Rikkunshito administration time: Rikkunshito administered on postoperative day 4 (RPOD4 group) and on postoperative day 1 (RPOD1 group). We performed one-to-one propensity score matching to balance the baseline characteristics. We examined the postoperative body weight changes and nutritional status at 1 month. One month postoperatively, the RPOD1 group showed a significantly smaller body weight change rate (7.12% [RPOD4] vs 5.35% [RPOD1], P < .05). For nutritional status, the RPOD1 group showed significantly higher prognostic nutritional index score (47.21 ± 16.45 [RPOD4] vs 49.45 ± 5.50 [RPOD1], P < .05) and geriatric nutritional risk index score (97.22 ± 20.49 [RPOD4] vs 100.97 ± 7.96 [RPOD1], P < .05). Initiating rikkunshito in the early perioperative period alleviates weight loss and improves the nutritional status after minimal invasive distal gastrectomy for gastric cancer.

PMID:40826685 | PMC:PMC12366934 | DOI:10.1097/MD.0000000000043950

Early nutritional and inflammation assessment predicts prognosis in patients with cancer across tumor origin and metastatic status

Thu, 14 Aug 2025 20:00:00 -0400

Clin Nutr. 2025 Sep;52:313-322. doi: 10.1016/j.clnu.2025.07.029. Epub 2025 Aug 5.

ABSTRACT

BACKGROUND AND AIMS: Clinical complexity of patients with cancer represents a challenge when aiming to implement individualized clinical management strategies. Despite their impact on patient outcomes, the burden of cancer-associated cachexia and inflammation remains underestimated by cancer physicians. We aimed to evaluate the performances of an early multi-dimensional patient assessment, integrating a comprehensive nutritional and inflammatory evaluation, for patient categorization and prognostication, independently of tumor features.

METHODS: Oncology outpatients evaluated in the setting of a systematic, structured clinical evaluation before anti-cancer treatment [Cochin Hospital, 2017-2023] were included. Retrospective analyses were conducted on routine-practice clinical and biological data, including a comprehensive nutritional and inflammatory assessment. Data were prospectively implemented in structured records, and automatically extracted post-hoc. Unsupervised clustering used principal components identified by factorial analysis of mixed data (N = 53 features). Associations with overall survival (OS) were analyzed using Cox regression.

RESULTS: Among 1370 patients included, 28 % had localized tumors. Main tumor origins were lung (25 %), digestive (18 %), sarcoma (17 %), gynecological/breast (15 %), prostate (9 %), and urinary tract (8 %). Median OS was 28 months [25-31] (N = 833 deaths) (median follow-up = 52 months). Five clusters were identified, described based on contributing features: "fit" (47 %), "older comorbid" (26 %), "dysmetabolic" (10 %), "digestive/liver injured" (2 %), and "critically impaired/inflamed" (15 %) patients. Hazard ratio for OS were 1.84 [1.55-2.19], 1.71 [1.34-2.16], 2.07 [1.28-3.31], and 2.96 [2.43-3.61] for cluster 2-5 respectively (reference: "fit" patients), after adjustment on tumor origin and metastatic status.

CONCLUSIONS: Early, cancer-agnostic, host-centered evaluation of oncology patients identified five main clusters outlining the complexity of patients with cancer, where nutritional and inflammatory features are among key determinants of prognosis independently of tumor origin or metastatic status. Further investigations are warranted to evaluate the benefit of early personalized intervention in each cluster of patients.

PMID:40816211 | DOI:10.1016/j.clnu.2025.07.029

A Cross-Sectional Study: Association Between Nutritional Quality and Cancer Cachexia, Anthropometric Measurements, and Psychological Symptoms

Wed, 13 Aug 2025 20:00:00 -0400

Nutrients. 2025 Aug 4;17(15):2551. doi: 10.3390/nu17152551.

ABSTRACT

Background/Objectives: Cancer is a complex disease that affects patients' nutritional and psychological status. This study aimed to assess the nutritional status of patients diagnosed with lung and gastrointestinal system cancers and evaluate its association with anthropometric measurements, nutrient intake, and psychological symptoms. Methods: This cross-sectional study was conducted with 180 patients with lung and gastrointestinal system cancers. Data were collected face-to-face by a questionnaire that included the Subjective Global Assessment-(SGA), Cachexia Assessment Criteria, 24 h Food Consumption Record, and Symptom Checklist-90-Revised-(SCL-90-R). Some anthropometric measurements were collected. Results: Body Mass Index (BMI) was found to be significantly lower (p < 0.001) in SGA-B (moderately malnourished) and SGA-C (severely malnourished) compared to those in SGA-A (well-nourished). The calf circumference was significantly lower (p = 0.002) in SGA-C compared to those in SGA-A and SGA-B. The mean SGA scores were found to be higher in cachexia-diagnosed participants (p < 0.001). The energy intake of SGA-C was significantly lower than SGA-A and SGA-B (p < 0.001). In addition, the energy intake of SGA-B was lower than SGA-A (p < 0.001). The protein intake of SGA-C was lower than SGA-A and SGA-B (p < 0.001). The protein intake of SGA-B was lower than SGA-A (p < 0.001). Regarding the intake of vitamins A, C, E, B1, and B6 and carotene, folate, potassium, magnesium, phosphorus, iron, and zinc, SGA-B and SGA-C were significantly lower than SGA-A (p < 0.001). Additionally, only phobic anxiety was found to be significantly higher in SGA-B than in SGA-A (p: 0.024). Conclusions: As the level of malnutrition increased, a reduction in some nutrient intake and anthropometric measurements was observed. No significant difference was found in any psychological symptoms except phobic anxiety. With this in mind, it is important that every cancer patient, regardless of the stage of the disease, is referred to a dietitian from the time of diagnosis.

PMID:40806134 | PMC:PMC12348615 | DOI:10.3390/nu17152551

Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial

Fri, 08 Aug 2025 20:00:00 -0400

Support Care Cancer. 2025 Aug 9;33(9):775. doi: 10.1007/s00520-025-09822-x.

ABSTRACT

OBJECTIVES: This study aimed to evaluate the effects of high-protein oral nutritional supplements (ONS) on nutritional status, physical function, and quality of life in older gastric cancer patients undergoing neoadjuvant chemotherapy (NAC).

METHODS: A prospective, randomized controlled trial was conducted between February 2023 and February 2024, including 46 patients aged 65 or older with newly diagnosed, locally advanced gastric cancer. Participants were randomized into two groups: an intervention group receiving high-protein ONS in addition to standard nutrition care, and a control group receiving only standard nutrition care. Nutritional status was assessed using the Mini Nutritional Assessment (MNA), physical function was evaluated through handgrip strength, Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scales, and health-related quality of life was measured using the EORTC QLQ-C30. Bioelectrical impedance was used to analyze body composition.

RESULTS: Among the 46 patients (23 in each group), baseline characteristics were similar between the groups (p > 0.05). The ONS group showed significantly higher energy and protein intake than the control group (p < 0.05). MNA scores improved significantly in the ONS group after 8 weeks (p < 0.001), with a reduction in malnutrition risk to 4.3%, compared to 17.4% in the control group (p = 0.003). ADL and IADL scores remained stable in both groups, and both groups reduced functions and increased symptoms of HRQL over 8 weeks. Emotional functioning scores significantly declined in both groups over the 8-week period (ONS group: from 91.7 [16.67] to 83.3 [8.33], p = 0.001; non-ONS group: from 91.7 [8.33] to 83.3 [16.67], p = 0.011). Fatigue levels also increased markedly in both groups (ONS: from 11.1 [11.11] to 49.3 ± 17.02; non-ONS: from 22.2 [11.11] to 44.4 [22.22], p < 0.001). Additionally, constipation symptoms worsened significantly in the non-ONS group by week 8 (p = 0.008).

CONCLUSIONS: High-protein ONS improved nutritional status and reduced malnutrition risk in older gastric cancer patients undergoing NAC. Further research is needed to assess the long-term effects of ONS on physical function and quality of life.

TRIAL REGISTRATION: Registered under ClinicalTrials.gov Identifier no. NCT06645912.

PMID:40782206 | DOI:10.1007/s00520-025-09822-x

A Prospective Interventional Study on the Beneficial Effect of Fish Oil-Enriched High-Protein Oral Nutritional Supplement (FOHP-ONS) on Malnourished Older Cancer Patients.

Fri, 01 Aug 2025 00:00:00 -0400

Nutrients; 08/01/2025
(AN 187311463); ISSN: 20726643
CINAHL Complete

A Cross-Sectional Study: Association Between Nutritional Quality and Cancer Cachexia, Anthropometric Measurements, and Psychological Symptoms.

Fri, 01 Aug 2025 00:00:00 -0400

Nutrients; 08/01/2025
(AN 187311581); ISSN: 20726643
CINAHL Complete

Editorial Issue 304.

Fri, 01 Aug 2025 00:00:00 -0400

Positive Health; 08/01/2025
(AN 187123116); ISSN: 13563963
CINAHL Complete

A rapid review of nutrition and exercise approaches to managing unintentional weight loss, muscle loss, and malnutrition in cancer.

Fri, 01 Aug 2025 00:00:00 -0400

Oncologist; 08/01/2025
(AN 187729526); ISSN: 10837159
CINAHL Complete

Effects of FSMP on nutrition status and sarcopenia among nutritional risk cancer patients: A randomized, double-blind, placebo-controlled study

Tue, 29 Jul 2025 20:00:00 -0400

Asia Pac J Clin Nutr. 2025 Aug;34(4):566-576. doi: 10.6133/apjcn.202508_34(4).0008.

ABSTRACT

BACKGROUND AND OBJECTIVES: Cancer patients at nutritional risk have a worse prognosis, but this can be improved by nutritional support. Food for special medical purposes (FSMP), as a new form of nutritional support, needs to be further evaluated for its safety and efficacy in these patients. Our study elucidate the impact of FSMP on nutritional status and sarcopenia among nutritional risk cancer outpatients by assessing the NRS2002 score, exercise performance, muscle mass, and inflammatory factors pre- and postintervention.

METHODS AND STUDY DESIGN: We conducted a single-centre, double-blind, randomized controlled interventional study. Patients from the oncology clinic with nutritional risk were randomly allocated to the control group or the FSMP group and received oral intervention for 8 weeks. The primary outcome was improvement in nutritional risk, while the secondary outcomes were improvements in sarcopenia prevalence and physical performance indicators. Other outcomes included alterations in calf circumference, hsCRP, 25(OH)VD3, Alb. etc. A linear mixed-effects model was used to compare the prepost-intervention changes in these results.

RESULTS: Thirty-six cancer patients were included, 25 completed the study. The percentage of patients at nutritional risk after intervention in the FSMP group was significantly lower than the control group (Χ2=4.186, p=0.041). The FSMP group demonstrated significant improvements in the TUG test, gait speed, grip strength, and upper-limb muscle mass. However, there was no significant improvement in the rate of sarcopenia. Moreover, calf circumference, hsCRP, 25(OH)VD3, Alb exhibited no significant changes.

CONCLUSIONS: FSMP can effectively improve the nutritional status, physical performance and upper-limb muscle mass of cancer patients.

PMID:40738724 | PMC:PMC12310436 | DOI:10.6133/apjcn.202508_34(4).0008

Assessment of nutritional status of patients receiving chemotherapy: sample from European Gaza hospital

Mon, 28 Jul 2025 20:00:00 -0400

BMC Cancer. 2025 Jul 28;25(1):1224. doi: 10.1186/s12885-025-14571-5.

ABSTRACT

BACKGROUND: Cancer treatment itself and particularly chemotherapy unavoidably affects host cells, often producing a variety of side effects, e.g., nausea, vomiting, diarrhea, and fever, and further decreases in appetite, physical activity, and body weight. These effects, combined with biochemical and histological injuries to major organ systems, may result in a profound nutritional insufficiency. This study aimed to determine the nutritional status of patients receiving chemotherapy.

METHODS: A prospective study was conducted among 64 adults newly diagnosed cancer patients of various sites, admitted to the Oncology Department at European Gaza Hospital (EGH), and scheduled for the first cycle of chemotherapy. The nutritional status of each patient was assessed using the Subjective Global Assessment (SGA) and anthropometry before commencing the first cycle of the chemotherapy regimen (pre) and after completing the chemotherapy regimen (post). Additionally, biochemical and dietary intake assessments were also performed.

RESULTS: Nutritional status worsened after the completion of a chemotherapy regimen. It has been found that 80.3% of patients suffered from malnutrition (moderate and severe) after the completion of the chemotherapy regimen based on SGA in comparison to 35.9% who were malnourished before commencing the first cycle of chemotherapy. The results reported the presence of a functional vitamin B12 deficiency, such that there is a drastic reduction in serum vitamin B12 levels (355.0(IQR 115.0) to 219.0(IQR 177.0) pg/mL, P < 0.001), accompanied by a significant increase in it is related metabolites methylmalonic acid (MMA) (3.9(IQR 3.0) to 49.7(IQR 32.0) ng/mL, P < 0.001), and homocysteine (Hcy) (3.90(IQR 0.85) to 12.60(IQR 7.05) ng/mL, P < 0.001) after the completion of chemotherapy regimen. Dietary intake in terms of macronutrients and micronutrients changed significantly after the completion of chemotherapy regimen.

CONCLUSIONS: Cancer patients who received chemotherapy were at risk of malnutrition hence it is a wise practice to conduct thoroughly and deep nutritional assessment for each patient at the baseline, during treatment and after the completion of chemotherapy regimen.

PMID:40722067 | PMC:PMC12306121 | DOI:10.1186/s12885-025-14571-5

Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study.

Mon, 28 Jul 2025 00:00:00 -0400

British Journal of Nutrition; 07/28/2025
(AN 187896073); ISSN: 00071145
CINAHL Complete

The Prognostic Value of Nutritional and Immune Indices for Stage IB Non-Small Cell Lung Cancer Patients: Insights From a Retrospective Cohort Study

Sun, 27 Jul 2025 20:00:00 -0400

Cancer Med. 2025 Aug;14(15):e71089. doi: 10.1002/cam4.71089.

ABSTRACT

BACKGROUND: Postoperative recurrence is a critical factor affecting the prognosis of stage IB non-small cell lung cancer (NSCLC). We aimed to evaluate the prognostic value of Nutritional and Immune Indices (NII) for postoperative recurrence among IB NSCLC patients.

METHODS: Clinical data of patients with pathological stage IB NSCLC who underwent surgical resection were collected. Cut-off values for NII were calculated using ROC curves, and patients were grouped accordingly. Univariable and multivariable logistic regression analyses were conducted to identify the association between NII and prognosis. A predictive model and corresponding nomogram were developed based on the identified risk factors. The model's performance was evaluated using the AUC and C-index. Additionally, interactions between NII and tumor marker indices were assessed, and recurrence-free survival (RFS) was analyzed using the Cox proportional hazards model.

RESULTS: A total of 918 patients were included in this study. The results showed that patients with higher preoperative PNI or lower SII, PLR, and MLR had better RFS. For postoperative NII, patients with a higher postoperative PNI or lower PLR demonstrated better RFS. Preoperative PNI (HR = 0.920 [0.910, 0.940], p < 0.0001), postoperative MLR (HR = 1.428 [1.015, 2.010], p = 0.041) and △ (post-pre) PNI (HR = 1.018 [1.002, 1.034], p = 0.031) were identified as independent prognostic factors for postoperative recurrence in stage IB NSCLC. The nomogram model indicated that preoperative PNI was the optimal predictor for postoperative recurrence, achieving the highest C-index (0.658). Additionally, the interaction between preoperative PNI and NSE emerged as an independent prognostic factor for RFS in stage IB NSCLC patients, with a HR of 1.176 (95% CI: 1.159-1.200, p = 0.004).

CONCLUSIONS: This study underscores the value of an NII-based prognostic strategy, with preoperative PNI emerging as a particularly reliable indicator of postoperative recurrence risk in stage IB NSCLC patients.

PMID:40719070 | PMC:PMC12301860 | DOI:10.1002/cam4.71089

Linear inverse association between prognostic nutritional index and colorectal cancer risk based on NHANES data

Mon, 14 Jul 2025 20:00:00 -0400

Sci Rep. 2025 Jul 15;15(1):25647. doi: 10.1038/s41598-025-10574-1.

ABSTRACT

Despite the Prognostic Nutritional Index (PNI) serving as a crucial prognostic marker for predicting survival outcomes in cancer patients, its association with the risk of Colorectal Cancer (CRC) is not well comprehended. We hypothesized that lower PNI levels are associated with a higher risk of CRC. The datasets from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016 were employed in this study, incorporating data on demographics, laboratory tests, and questionnaires. Participants aged ≥ 20 years were included, while those with missing tumor history or incomplete laboratory data for PNI calculation (serum albumin or lymphocyte count) were excluded. A total of 26,229 participants who met the inclusion criteria were evaluated, of which 176 had a history of CRC. The PNI was calculated as 0.005 × absolute lymphocyte count + 10 × serum albumin, and categorized into quartiles. CRC status was determined via self-reported medical history. To investigate the linear relationship between PNI and CRC, multivariable logistic regression models, restricted cubic spline analysis, and subgroup analyses were used. Covariates were adjusted using multiple imputation, and all analyses were conducted using DecisionLinnc v1.0. Statistical significance was set at P < 0.05. The average PNI score was 42.55 ± 3.42. Fully adjusted multivariable logistic regression models identified a significant inverse relationship between higher PNI scores and lower odds of CRC. Specifically, each one-unit increase in PNI was associated with a 6.43% reduction in the odds of CRC [OR: 0.9357; 95% CI: 0.8942, 0.9807; p = 0.005]. Restricted cubic spline analysis further validated a linear association between PNI and CRC risk. Subgroup analyses demonstrated that the association remained consistent across factors including gender, age, marital status, education level, BMI, alcohol consumption, smoking habits, history of hypertension, hyperlipidemia, and diabetes. Males exhibited a more pronounced inverse correlation between PNI and CRC risk. Higher PNI scores are independently associated with reduced odds of CRC. PNI may serve as a valuable risk biomarker for identifying individuals at elevated CRC risk and could enhance large-scale screening strategies.

PMID:40664778 | PMC:PMC12264100 | DOI:10.1038/s41598-025-10574-1

Nutritional impact symptoms and dietary changes among women in a cancer support network: a qualitative analysis

Wed, 09 Jul 2025 20:00:00 -0400

BMC Cancer. 2025 Jul 10;25(1):1158. doi: 10.1186/s12885-025-14219-4.

ABSTRACT

OBJECTIVE: To examine nutritional impact symptoms and dietary changes experienced by cancer patients in Trinidad, as well as the nutritional support and guidance they received during treatment.

METHOD: A qualitative study was conducted of 12 adult cancer patients who were diagnosed within the last five years, undergoing treatment and recruited from a non-profit organisation. Participants' experiences with dietary changes and nutritional needs were examined through face-to-face interviews guided by 21 semi-structured questions. Interviews were recorded, transcribed and analysed thematically using Dedoose© software.

RESULTS: Twelve participants were interviewed, from which three major themes emerged: Nutrition Impact Symptoms (NIS), Dietary Changes, and Lack of Information. Participants experienced a combination of symptoms during treatment: nausea, metallic taste, constipation, fatigue, and loss of appetite, taste and smell. Dietary changes included the introduction of new foods and the decrease or eliminations of others, portion sizes and meal frequency. Intake restrictions were also noted for flour, sugar, processed foods, artificially flavoured foods/beverages, and meats (chicken, beef and pork). Limited information and dietary guidance were received from healthcare professionals; participants relied on personal research, information from other cancer patients and support groups.

CONCLUSION: There is a need for capacity-building initiatives that train healthcare professionals to deliver appropriate nutritional guidance. Efforts are needed to integrate dietary education into public health initiatives which could empower patients and caregivers to make informed decisions about nutrition during treatment.

PMID:40640799 | PMC:PMC12243314 | DOI:10.1186/s12885-025-14219-4

Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study

Wed, 09 Jul 2025 20:00:00 -0400

Br J Nutr. 2025 Jul 28;134(2):97-114. doi: 10.1017/S000711452510384X. Epub 2025 Jul 10.

ABSTRACT

Persistent malnutrition is associated with poor clinical outcomes in cancer. However, assessing its reversibility can be challenging. The present study aimed to utilise machine learning (ML) to predict reversible malnutrition (RM) in patients with cancer. A multicentre cohort study including hospitalised oncology patients. Malnutrition was diagnosed using an international consensus. RM was defined as a positive diagnosis of malnutrition upon patient admission which turned negative one month later. Time-series data on body weight and skeletal muscle were modelled using a long short-term memory architecture to predict RM. The model was named as WAL-net, and its performance, explainability, clinical relevance and generalisability were evaluated. We investigated 4254 patients with cancer-associated malnutrition (discovery set = 2977, test set = 1277). There were 2783 men and 1471 women (median age = 61 years). RM was identified in 754 (17·7 %) patients. RM/non-RM groups showed distinct patterns of weight and muscle dynamics, and RM was negatively correlated to the progressive stages of cancer cachexia (r = -0·340, P < 0·001). WAL-net was the state-of-the-art model among all ML algorithms evaluated, demonstrating favourable performance to predict RM in the test set (AUC = 0·924, 95 % CI = 0·904, 0·944) and an external validation set (n 798, AUC = 0·909, 95 % CI = 0·876, 0·943). Model-predicted RM using baseline information was associated with lower future risks of underweight, sarcopenia, performance status decline and progression of malnutrition (all P < 0·05). This study presents an explainable deep learning model, the WAL-net, for early identification of RM in patients with cancer. These findings might help the management of cancer-associated malnutrition to optimise patient outcomes in multidisciplinary cancer care.

PMID:40637106 | DOI:10.1017/S000711452510384X

Predictive value of preoperative frailty combined with Controlling Nutritional Status score for postoperative lung infection in breast cancer patients

Tue, 08 Jul 2025 20:00:00 -0400

Medicine (Baltimore). 2025 Jul 4;104(27):e43037. doi: 10.1097/MD.0000000000043037.

ABSTRACT

Breast cancer, the most common malignancy in women, often requires modified radical mastectomy, which can lead to complications like postoperative pulmonary infections. These infections, with an incidence of 11.26 to 20.19%, significantly impact prognosis and mortality. Frailty and nutritional status (Controlling Nutritional Status [CONUT] score) are key predictors of these complications, highlighting the need for their early assessment. This study assesses the predictive value of preoperative frailty combined with the CONUT score for postoperative pulmonary infections in breast cancer patients. Patients who underwent elective modified radical mastectomy for breast cancer at Fuyang Cancer Hospital between January 2022 to February 2024 were included. Frailty and nutritional status were evaluated within 24 hours of admission using the frailty scale and CONUT score, respectively. Multivariable logistic regression was employed to identify independent risk factors for postoperative pulmonary infections. The predictive performance of the combined frailty and CONUT score was assessed using receiver operating characteristic curves and decision curve analysis. A total of 416 patients were analyzed, with 84 exhibiting preoperative frailty and 39 experiencing postoperative pulmonary infections. Preoperative frailty, CONUT score, age, and a history of combined chemoradiotherapy were identified as independent risk factors for postoperative pulmonary infections. The combined assessment of preoperative frailty and CONUT score demonstrated strong predictive value, with an area under the curve of 0.777 (95% confidence interval: 0.700-0.854). The combination of preoperative frailty and the CONUT score is an effective tool for predicting postoperative pulmonary infections in breast cancer patients.

PMID:40629623 | PMC:PMC12237331 | DOI:10.1097/MD.0000000000043037

Relationship between preoperative nutritional status with postoperative IL-10 and neopterin in gynecologic oncology patients

Fri, 04 Jul 2025 20:00:00 -0400

Nutrition. 2025 Nov;139:112873. doi: 10.1016/j.nut.2025.112873. Epub 2025 Jun 9.

ABSTRACT

INTRODUCTION: We aimed to investigate the relationship between preoperative nutritional status with postoperative interleukin-10 (IL-10) and neopterin in gynecologic oncology cases.

MATERIALS AND METHODS: This prospective study included cases hospitalized in our clinic. Preoperative cases were divided into two groups as low and high risk according to Nutritional risk score (NSR-2002). Demographic and clinical characteristics and questionnaires including the NSR-2002 form were recorded. IL-10 and neopterin levels were analyzed 1 week postoperatively.

RESULTS: Forty-five low-risk and 43 high-risk cases were evaluated. The mean ages of the cases were 56.7 ± 7.8 and 57.2 ± 14.3 years, respectively, and no significant difference was found between them (P = 0.854). There was a statistically significant difference between the two groups in terms of upper arm circumference (P = 0.043), triceps skinfold thickness (P = 0.010), shorter wound healing time (P = 0.009), neopterin (P = 0.037), IL-10 (P = 0.043), preoperative ferritin (P = 0.001), hemoglobulin (P = 0.026), albumin (P = 0.047), postoperative ferritin (P = 0.015), hemoglobulin (P = 0.044), and albumin (P = 0.042) levels in favor of the low-risk group. Among the significant factors, only wound healing time had positive correlation (P = 0.006, r = +0.290).

CONCLUSIONS: Nutritional status is closely related to case recovery in the postoperative period. Postoperative changes to high interleukin-10 and neopterin levels in cases with low nutritional index show the importance of nutrition in the postoperative period.

PMID:40617128 | DOI:10.1016/j.nut.2025.112873

The relationship between sarcopenia, nutritional status, physical function, and quality of life in elderly cancer patients: a path analysis

Wed, 02 Jul 2025 20:00:00 -0400

BMC Geriatr. 2025 Jul 2;25(1):461. doi: 10.1186/s12877-025-06110-5.

ABSTRACT

OBJECTIVE: This study investigates the associations between sarcopenia and quality of life in elderly cancer patients, with nutritional status and physical function as potential mediators. It also explores the interactions among sarcopenia, nutritional status, and physical function.

METHODS: A cross-sectional study was conducted among 275 elderly cancer patients. Sarcopenia was assessed using the criteria of the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). Nutritional status was evaluated using the Nutritional Risk Screening 2002 (NRS-2002) tool, along with serum albumin, prealbumin levels, and body mass index (BMI). Physical function was assessed using the 6-minute walk distance (6MWD), gait speed, and Timed Up and Go (TUG) test. All functional indicators were standardized into z-scores. Quality of life (QOL) was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Structural equation modeling (SEM) was used to analyze the relationships among sarcopenia, nutritional status, physical function, and QOL.

RESULTS: Multivariate analysis indicated that sarcopenia, nutritional status, and physical function together explained 54% of the variance in quality of life. Path analysis showed significant associations through the following pathways: (1) Sarcopenia → Nutritional status → quality of life (22.0%); (2) Sarcopenia → Physical function → quality of life (17.07%); (3) Sarcopenia → Nutritional status → Physical function → quality of life (6.09%).

CONCLUSION: Sarcopenia, nutritional status, and physical function are significantly associated with quality of life in elderly cancer patients. Physical function mediates the associations between both sarcopenia and nutritional status. Early detection and comprehensive interventions targeting sarcopenia, nutrition, and physical function are essential for improving patient outcomes. Future strategies should be individualized to address the complex needs of this population.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40604519 | PMC:PMC12220749 | DOI:10.1186/s12877-025-06110-5

Nutrition impact symptoms as prognostic indicators in gastric cancer: the role of quality of life and survival outcomes

Tue, 01 Jul 2025 20:00:00 -0400

BMC Cancer. 2025 Jul 1;25(1):1037. doi: 10.1186/s12885-025-14421-4.

ABSTRACT

BACKGROUND: Nutrition impact symptoms (NIS) are common among cancer patients and influence prognosis. This study aimed to investigate the prognostic significance of NIS in gastric cancer patients using data from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) database.

METHODS: We conducted a retrospective cohort study using data from 2,673 adult patients with confirmed gastric cancer enrolled in the INSCOC database between January 2013 to February 2020. NIS, including appetite loss, vomiting, dysphagia, and early satiety, were assessed using the Patient-Generated Subjective Global Assessment (PG-SGA). Overall survival (OS) was the primary outcome, while quality of life (QoL) was the secondary outcome. Statistical analyses included Kaplan-Meier survival analysis, Cox proportional hazards regression, and propensity score matching (PSM) to reduce confounding.

RESULTS: Patients with NIS had significantly worse OS compared to those without (median OS: 74.1 vs. 81.3 months, p < 0.001). In multivariate analysis, NIS was an independent predictor of mortality (HR: 1.28, 95% CI: 1.11-1.48, p = 0.001). Vomiting and dysphagia were particularly associated with increased mortality (HR: 1.22, p = 0.038 and HR: 1.80, p < 0.001, respectively). Interaction analysis revealed that the prognostic impact of NIS was influenced by chemotherapy (P for interaction = 0.002). NIS was also strongly associated with severe malnutrition. Sensitivity analysis confirmed the robustness of these findings, even after excluding short-term mortalities within 180 days.

CONCLUSIONS: NIS are significant independent predictors of poor prognosis in gastric cancer patients, contributing to malnutrition and reduced survival. These findings highlight the importance of early symptom recognition and nutritional intervention to potentially improve outcomes for gastric cancer patients.

TRIAL REGISTRATION: https://www.chictr.org.cn/showproj.html?proj=31813 , identifier ChiCTR1800020329.

PMID:40597891 | PMC:PMC12211481 | DOI:10.1186/s12885-025-14421-4

Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy

Tue, 01 Jul 2025 20:00:00 -0400

BMC Gastroenterol. 2025 Jul 1;25(1):478. doi: 10.1186/s12876-025-03874-3.

ABSTRACT

BACKGROUND: Metabolism plays an important role in the occurrence and development of gastric cancer, including in neoadjuvant immunochemotherapy. However, whether nutrition-related indicators can predict the efficacy of neoadjuvant immunochemotherapy and the prognosis of gastric cancer patients has not been addressed. This study systematically screens various nutritional indicators to explore their efficacy in predicting responses to neoadjuvant immunochemotherapy and patients' prognosis in locally advanced gastric cancer (LAGC).

METHODS: We retrospectively analyzed 134 LAGC patients who underwent radical resection after neoadjuvant immunochemotherapy. According to postoperative tumor regression grade (TRG), these patients were divided into good responder group (TRG1-0) and poor responder group (TRG3-2) (AJCC/CAP guidelines). Inflammatory and/or nutritional markers were compared for their efficacy on predicting patients' pathological tumor regression response. The univariate and multivariate logistic regression were carried out to identify the independent factors for predicting pathological tumor regression response, and a predictive nomogram model was further established.

RESULTS: Among the total 134 LAGC patients, tumor specimens from 71 and 63 patients had TRG1-0 and TRG3-2 tumor responses, respectively. Multivariate analysis showed that controlling nutritional status (CONUT) score and nutrition risk screening 2002 (NRS2002) score were independent predictors of pathological tumor regression response (OR, 0.68; 95% CI, 0.50-0.91; P = 0.010 and OR, 0.66; 95% CI, 0.45-0.96; P = 0.031, respectively). With the use of ROC curve analysis, the optimal critical level of CONUT score and NRS2002 score were both 3. The CONUT-NRS2002 combined score was constructed. Patients with lower CONUT-NRS2002 had a better pathological response than those with higher CONUT-NRS2002 (P = 0.003). Moreover, Patients with higher CONUT-NRS2002 scores had poorer prognosis (P < 0.05). The nomogram based on CONUT score and NRS2002 score demonstrated good predictive ability and clinical application value.

CONCLUSIONS: CONUT score and NRS2002 score are independent factors of pathological tumor regression response in LAGC patients after neoadjuvant immunochemotherapy. The constructed CONUT-NRS2002 combined score has a good potential in predicting pathological tumor regression response and prognosis of LAGC patients after neoadjuvant immunochemotherapy, serving as a new predictive indicator.

PMID:40597721 | PMC:PMC12210651 | DOI:10.1186/s12876-025-03874-3

Nutritional Approach on Management of Diarrhea Induced by EGFR-TKI's in Advanced Non-Small Cell Lung Cancer Patients.

Tue, 01 Jul 2025 00:00:00 -0400

Nutrition & Cancer; 07/01/2025
(AN 185415888); ISSN: 01635581
CINAHL Complete

Prognostic accuracy of preoperative nutritional indicators of survival in head and neck cancer patients

Sun, 29 Jun 2025 20:00:00 -0400

PeerJ. 2025 Jun 26;13:e19496. doi: 10.7717/peerj.19496. eCollection 2025.

ABSTRACT

Head and neck cancer (HNC) patients are known to have high nutritional risk and a high prevalence of malnutrition. The diagnosis of HNC, together with sequelae and other consequences of cancer treatment, directly impacts survival.

AIM: To determine overall 5-year survival in HNC patients submitted to surgery as their initial treatment and to assess the prognostic accuracy of nutritional anthropometric measurements weight loss percentage (%WL), body mass index (BMI), triceps skinfold (TSF), adductor pollicis muscle thickness (APMT), and calf circumference (CC) to predict survival in this population.

METHODS: A prospective cohort study of HNC patients treated at a cancer referral center in Bahia's countryside was conducted.

RESULTS: Seventy-eight patients were included in this study and were followed up for a 5-year period, with an overall survival rate of 52.1%. Most patients were male (83.3%), with a median age of 65.5 years [55-72 years], and most had low education levels, low household income, and a lifestyle marked by alcohol drinking and tobacco smoking. Median values of all nutritional anthropometric variables assessed in this study were significantly lower among patients who died during follow-up, suggesting greater impairment of nutritional status in this group. All nutritional indicators were found to be predictors of survival in the study population, with a prognostic accuracy of 74% for TSF 95% CI [0.63-0.83], 68% for BMI 95% CI [0.56-0.78], 65% for CC 95% CI [0.53-0.75], 63% for APMT 95% CI [0.51-0.63], and 63% for %WL 95% CI [0.51-0.73].

CONCLUSION: The overall 5-year survival rate was found to be 52.1%, and all nutritional anthropometric variables, namely BMI, %WL, TSF, APMT, and CC, were found to be good predictors of survival in HNC patients initially treated with surgery.

PMID:40585334 | PMC:PMC12206401 | DOI:10.7717/peerj.19496

Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy

Thu, 26 Jun 2025 20:00:00 -0400

In Vivo. 2025 Jul-Aug;39(4):2277-2285. doi: 10.21873/invivo.14023.

ABSTRACT

BACKGROUND/AIM: The clinical evaluation of the GNRI in nutritional status management has been reported in several malignancies. This study aimed to investigate the relationship between the GNRI and clinical outcomes in postoperative patients who underwent radical gastrectomy.

PATIENTS AND METHODS: Clinical data of 940 gastric cancer patients who underwent radical gastrectomy at Kanagawa Cancer Center from 2013 to 2020 were retrospectively collected and divided into a high-GNRI group (≥98) and a low-GNRI group (<98) according to the GNRI. The association between the GNRI and overall survival (OS) and recurrence-free survival (RFS) was investigated.

RESULTS: The respective 3- and 5-year OS rates were 92.0% and 86.3% in the high-GNRI group and 82.4% and 73.2% in the low-GNRI group (p<0.001). A multivariate analysis showed that the GNRI was an independent predictor of the OS and RFS.

CONCLUSION: GNRI is an objective, noninvasive, and easily accessible prognostic biomarker for gastric cancer patients. Patient stratification using the GNRI and preoperative nutritional interventions may improve prognosis.

PMID:40579004 | PMC:PMC12223658 | DOI:10.21873/invivo.14023

Nutritional risk investigation and related factors of 197 patients with early-stage non-small cell lung cancer

Sun, 22 Jun 2025 20:00:00 -0400

Wei Sheng Yan Jiu. 2025 May;54(3):444-448. doi: 10.19813/j.cnki.weishengyanjiu.2025.03.014.

ABSTRACT

OBJECTIVE: To investigate the nutritional risk status of patients with non-small cell lung cancer(NSCLC), and to analyze the factors that may cause the nutritional risk of NSCLC patients.

METHODS: A total of 197 patients with non-small cell lung cancer(NSCLC) who were admitted to the Department of Oncology of Beijing Friendship Hospital, Capital Medical University from January 2023 to January 2024 were selected as the study subjects, and the nutritional status of 197 non-small cell patients was measured and evaluated by the Nutritional Risk Screening Scale(NRS 2002), and Analysis of the related factors of nutritional risk in patients with non-small cell lung cancer.

RESULTS: Among 197 patients with early-stage non-small cell lung cancer, 13(6.60%) had a nutritional risk score of ≥3 points. Univariate analysis result showed that age, lesion size, body mass index(BMI), hemoglobin level, and smoking and hypertension history were related factors for nutritional risk in non-small cell lung cancer patients(P<0.05). Multivariate analysis result indicated that BMI level was a protective factor for nutritional risk in non-small cell lung cancer surgery patients(OR=0.51, 95%CI 0.38-0.70, P<0.01).

CONCLUSION: The incidence of nutritional risk exists among patients with early-stage non-small cell lung cancer. The patient's age, lesion size, hemoglobin level, BMI, and whether they have a history of smoking or hypertension are related factors for the patient's nutritional risk. BMI is a protective factor for the nutritional risk of non-small cell lung cancer patients.

PMID:40550611 | DOI:10.19813/j.cnki.weishengyanjiu.2025.03.014

Nutritional outcomes and impact of malnutrition in a randomised comparison between standard and prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer

Sun, 22 Jun 2025 20:00:00 -0400

Eur J Surg Oncol. 2025 Sep;51(9):110228. doi: 10.1016/j.ejso.2025.110228. Epub 2025 Jun 11.

ABSTRACT

BACKGROUND: Prolonged time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) may enable malnourished oesophageal cancer patients' nutritional status to recover better, possibly improving outcomes with fewer complications and better overall survival (OS) after oesophagectomy.

METHODS: This is a substudy within a multicentre randomised controlled trial comparing outcomes in patients with oesophageal cancer after standard TTS of 4-6 weeks to prolonged TTS of 10-12 weeks after nCRT. Patients were categorised as malnourished or non-malnourished at baseline and compared regarding weight, dysphagia, postoperative complications, and OS.

RESULTS: The mean weight from baseline to time of surgery decreased significantly in patients allocated to standard TTS (p < 0.001) while patients with prolonged TTS recovered during the extended time to similar weight as at baseline (p = 0.131). The mean dysphagia score at the time of surgery improved significantly in both groups (p < 0.001). There were no significant differences between patients allocated to standard versus prolonged TTS regarding postoperative complications, regardless of malnourishment status at baseline. No significant differences in OS after prolonged TTS compared to standard TTS, was observed in neither malnourished patients (hazard ratio, HR 1.72 (95 %, CI: 0.82-3.59, p = 0.147) nor non-malnourished patients (HR 1.26 (95 % CI:0.82-1.94, p = 0.291).

CONCLUSIONS: Prolonged TTS was associated with better weight recovery at the time of surgery compared to standard TTS. Patients malnourished at baseline did not benefit in terms of less postoperative complications after prolonged TTS.

PMID:40550184 | DOI:10.1016/j.ejso.2025.110228

Scored Patient-Generated Subjective Global Assessment (PG-SGA) in Brazilian Cancer Patients and Association with Anthropometric Parameters

Fri, 20 Jun 2025 20:00:00 -0400

Asian Pac J Cancer Prev. 2025 Jun 1;26(6):2009-2014. doi: 10.31557/APJCP.2025.26.6.2009.

ABSTRACT

INTRODUCTION: The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is a multidimensional tool used to assess malnutrition and associated risk factors.

OBJECTIVE: To evaluate the nutritional status of Brazilian cancer patients hospitalized using the Scored PG-SGA and to examine the correlations with selected nutritional parameters.

METHODS: This observational study included 2.027 cancer patients aged over 18 years at a hospital of cancer, Brazil. All patients were assessed for nutritional status using the Brazilian PG-SGA and anthropometric measurements were evaluated.

RESULTS: According to the PG-SGA global assessment categories, 56.2% (1.138) cancer patients were well-nourished, 29.3% (594) were moderately malnourished, and 14.4% (292) were severely malnourished. The average body mass index (BMI) was 23.7±5.49 kg/m², and the current weight was 66.34±58.07 kg. The PG-SGA, nutritional status and clinical variable assessed by PG-SGA, were all significantly correlated with body mass index (p < 0.005) and weigh < 0.005).

CONCLUSIONS: The Brazilian PG-SGA showed a 43.7% of malnourished cancer patients. The classification of severely malnourished by PG-SGA demonstrated strong positive correlations with BMI. Anthropometric parameters correlates with PG-SGA variable, weigh with sex, nausea, diarrhea, dysgeusia, diagnostics of cancer, fever and death and BMI with sex, food intake, nausea, diarrhea , dysgeusia.

PMID:40542762 | PMC:PMC12374500 | DOI:10.31557/APJCP.2025.26.6.2009

Effect of taste perception on nutritional status in patients with breast cancer: a systematic review

Wed, 11 Jun 2025 20:00:00 -0400

Nutr Hosp. 2025 Sep 4;42(4):807-819. doi: 10.20960/nh.05722.

ABSTRACT

Introduction: breast cancer is one of the leading causes of death among women over 30 years of age. Treatments such as chemotherapy and radiotherapy can alter taste and smell, reducing appetite and potentially leading to weight loss, malnutrition, and decreased quality of life. These sensory changes may also affect treatment response. Objective: to explain how chemotherapy-induced taste changes impact the diet and nutritional status of women with breast cancer. Methodology: a review of reliable scientific articles was conducted using databases such as SciELO, PubMed, Scopus, and Web of Science. Evidence-based studies in medicine and nutrition were included. Results: out of 19 articles analyzed, 58 % reported the prevalence of taste alterations in breast cancer patients undergoing chemotherapy, with rates ranging from 44 % to 93 %. Dysgeusia was reported in 68 % of patients treated with trastuzumab, 53 % with epirubicin and cyclophosphamide, and up to 80 % with taxanes. Most studies used validated questionnaires to assess taste changes, although no standard method exists. Some studies also reported changes in food preferences, appetite, and weight and evaluated interventions such as self-monitoring, educational sessions, and photobiomodulation, which showed positive effects in reducing symptoms and improving quality of life. Conclusions: chemotherapy can alter taste perception in breast cancer patients, negatively affecting their nutrition and quality of life. Identifying and addressing these issues can help improve patients' food intake and treatment outcomes.

PMID:40504002 | DOI:10.20960/nh.05722

Frailty, Nutritional Status and Prehabilitation in Head and Neck Oncology

Sun, 01 Jun 2025 20:00:00 -0400

Laryngorhinootologie. 2025 Jun;104(6):384-397. doi: 10.1055/a-2473-3880. Epub 2025 Jun 2.

ABSTRACT

Since treatment of patients with head and neck cancer is often challenging due to adverse events and especially severe adverse events, continuous efforts are required optimize patients' health status before therapy in order to achieve as little toxicity as possible, while providing the same therapeutic standards especially for elderly individuals, who statistically represent the largest group of patients with head and neck cancer. Modern prehabilitation concepts, that primarily aim at optimizing the nutritional status of patients before beginning of treatment and during treatment, appear to be of particular interest in order to adequately meet this challenge. In this context, both poor nutritional status and frailty have been established as well known risk factors and predictors of poor outcome in patients with head and neck cancer. Assessment of the nutritional status, pretherapeutic evaluation of frailty and the associated potential optimization of the patient's general health status is barely implemented in German head and neck cancer centers, but should be included in the multidisciplinary treatment of head and neck cancer patients in order to reduce the rate of severe adverse events in particular. This article is therefore intended to contribute to a better understanding of the importance of pretherapeutic assessment of frailty, nutritional status and its optimization, as well as further explain the concept of prehabilitation in head and neck oncology.

PMID:40456225 | DOI:10.1055/a-2473-3880

Normalcy of Swallowing in Head and Neck Cancer Patients Undergoing Particle Therapy Supported by Combined Swallowing Training and Feeding Management: A Randomised Controlled Trial.

Sun, 01 Jun 2025 00:00:00 -0400

Journal of Oral Rehabilitation; 06/01/2025
(AN 185398647); ISSN: 0305182X
CINAHL Complete

Validity of a nutrition screening tool for childhood cancer.

Sun, 01 Jun 2025 00:00:00 -0400

Nutrition in Clinical Practice; 06/01/2025
(AN 184927370); ISSN: 08845336
CINAHL Complete

Prognostic Nutrition Index as a Biomarker for Treatment Sensitivity to Chemotherapy and Nivolumab as the First-Line Treatment in Patients with Unresectable Advanced or Recurrent Gastric Cancer: A Multicenter Study.

Sun, 01 Jun 2025 00:00:00 -0400

Oncology; 06/01/2025
(AN 185905898); ISSN: 00302414
CINAHL Complete

Malnutrition in Colorectal Cancer Patients: Association with the Lack of Eating Motivation and Inappropriate Diet

Wed, 28 May 2025 20:00:00 -0400

Asian Pac J Cancer Prev. 2025 May 1;26(5):1661-1670. doi: 10.31557/APJCP.2025.26.5.1661.

ABSTRACT

OBJECTIVE: Colorectal cancer (CRC) significantly contributes to cancer-related mortality in Vietnam. Notably, malnutrition, rather than cancer itself, accounts for one-fifth of the deaths among cancer patients. Therefore, understanding the nutritional status and related factors among CRC patients is essential. We aimed to investigate the nutritional status and related factors in CRC in Vietnam.

METHODS: This cross-sectional study, conducted from October 2022 to April 2023, included CRCs of both sexes aged ≥18 years. Data collection involved face-to-face interviews, anthropometric assessments, and medical record reviews. Nutritional status was evaluated using the Patient-Generated Subjective Global Assessment (PG-SGA). Multivariable logistic regression was used to identify malnutrition-related factors.

RESULTS: In total, 388 patients were included (median age, 60.0 years, [IQR: 51.0-66.0 years]; men, 57.7%). The prevalence of malnutrition was 87.9% (95%CI: 84.6-91.1), and urgent nutritional intervention was needed in 64.7% of participants. Malnutrition-associated factors included lack of eating motivation (OR=8.76, 95%CI: 1.81-42.38), dieting for fear of cancer cell growth (OR=3.82, 95%CI: 1.27-11.52), gastrointestinal symptoms (OR=5.38, 95%CI: 1.76-16.45), daily energy intake <25kcal/kg (OR=7.02, 95%CI: 1.70-28.99), protein ≤ 1g/kg (OR=5.21, 95%CI: 1.32-20.60), fat <18% of total energy intake (OR=3.13, 95%CI: 1.02-9.57), mean corpuscular volume <85fL (OR=4.74, 95%CI: 1.11-20.22), and total lymphocyte count ≤1700 lymphocytes/mm3 (OR=4.06, 95%CI: 1.22-13.50). Additionally, a 1-kg increase in dominant hand strength reduced the risk of malnutrition by 4% (OR=0.96, 95%CI: 0.93-0.99).

CONCLUSION: The high prevalence of malnutrition among CRCs in Vietnam necessitates nutritional intervention. The main contributors include loss of eating motivation and inadequate dietary intake.

PMID:40439378 | PMC:PMC12290175 | DOI:10.31557/APJCP.2025.26.5.1661

Impact of prognostic nutritional index on oncological outcomes and mortality among advanced gastric cancer patients: European GASTRODATA registry analysis

Tue, 27 May 2025 20:00:00 -0400

Int J Cancer. 2025 Oct 15;157(8):1734-1745. doi: 10.1002/ijc.35489. Epub 2025 May 28.

ABSTRACT

While Prognostic Nutritional Index (PNI) is an established predictor of outcomes in Asian gastric cancer (GC) patients, data among Western populations are limited. This study assessed the predictive value of PNI in European GC patients undergoing multimodal treatment. Data from GASTRODATA, the largest European repository of GC patients undergoing gastrectomy, were collected between 2017 and 2022. The primary outcome was textbook outcome (TO) achievement, and the secondary was 90-day mortality. PNI was calculated one day before surgery, with a cut-off of 45.5 based on ROC analysis. Among 721 patients included 60.7% were men. Most patients had advanced tumors (cT3-4 = 75.2%) and metastatic lymph nodes (57.7%). Neoadjuvant chemotherapy (NAC) was administered to 46.7% of patients, and 32.9% received adjuvant chemotherapy. Median PNI was 49.5 (IQR 45.0-56.4). Low PNI was present among 30% of patients and was associated with decreased odds of TO achievement (OR = 0.57, 95% CI 0.37-0.89), higher 90-day mortality (OR = 4.99, 95% CI 2.32-10.73). NAC administration was associated with lower morbidity risk (OR = 0.56, p = 0.0408), and low PNI was a predictor of receiving AC (p = 0.0005). PNI was a valuable predictor for oncological outcomes and morbidity among European GC patients undergoing multimodal. While low PNI was associated with decreased odds of TO achievement and increased risk of 90-day mortality, further prospective and nutritional intervention studies are warranted to standardize the PNI threshold and improve its clinical applicability.

PMID:40432576 | DOI:10.1002/ijc.35489

Association of Systemic Inflammatory Response Index and Prognostic Nutritional Index Scores with Sarcopenia in Patients with Metastatic Gastric Cancer

Tue, 27 May 2025 20:00:00 -0400

Medicina (Kaunas). 2025 Apr 23;61(5):785. doi: 10.3390/medicina61050785.

ABSTRACT

Background and Objectives: Sarcopenia is frequently observed in cancer patients and is associated with short survival. In this study, the aim was to research the sarcopenia risk factors, the correlation of sarcopenia with inflammatory biomarkers, and the prognostic significance of sarcopenia and inflammation markers in patients with metastatic gastric cancer. Material and Method: The study included 177 patients diagnosed with metastatic gastric cancer attending Dokuz Eylül University Faculty of Medicine (DEUFM) Medical Oncology clinic from 2016 to 2022. The skeletal muscle area at L3 vertebral level was identified on abdominal computed tomography (CT) images, and the skeletal muscle index (SMI, cm²/m²) was calculated. Additionally, PLR, MLR, NLR, dNLR, SIRI, SII, PIV, PNI, CAR, and LAR were assessed among systemic inflammatory biomarkers. Cut-off values were determined with ROC curve analysis. Survival analyses were performed with the Kaplan-Meier method, and risk factors were investigated with Cox regression analysis. For all statistical analyses, p < 0.05 was accepted as significant. Results: Among patients, 71.8% were identified to have sarcopenia. Significant levels of difference were identified for median SIRI, NLR, MLR, PLR, SII, PNI, and dNLR values between patients with and without sarcopenia (p < 0.05). The sarcopenia risk was assessed between groups created according to the cut-off values for inflammation markers. Univariate regression analysis found that SIRI, PIV, NLR, MLR, PLR, SII, PNI, and dNLR were statistically significant (p < 0.05). Multivariate analysis identified SIRI and PNI as independent risk factors. For all patients, median overall survival was identified to be 12.4 ± 0.8 months (CI 95%, 10.8-13.9). For patients with sarcopenia, overall survival duration was 11.5 ± 0.8 months, while survival duration for patients without sarcopenia was 17.5 ± 4.6 months (p = 0.010). Elevation in the inflammatory biomarkers of SIRI, NLR, SII, LAR, and CAR and low PNI values appear to be associated with short survival (p < 0.05). Conclusions: In this study, sarcopenia was frequently observed in patients with metastatic gastric cancer and sarcopenia was associated with shorter survival. A significant correlation was observed between sarcopenia and inflammatory biomarkers, with SIRI and PNI identified to be independent risk factors for sarcopenia. Our study emphasizes the prognostic importance of sarcopenia and inflammatory markers for the management of patients with metastatic gastric cancer.

PMID:40428743 | PMC:PMC12113276 | DOI:10.3390/medicina61050785

Efficacy prediction of systemic immune-inflammation index and prognostic nutritional index in breast cancer patients and their variations after neoadjuvant chemotherapy

Sun, 25 May 2025 20:00:00 -0400

Front Immunol. 2025 May 9;16:1514736. doi: 10.3389/fimmu.2025.1514736. eCollection 2025.

ABSTRACT

OBJECTIVE: The purpose of this study was to evaluate the predictive values of systemic immune-inflammatory index (SII), prognostic nutrition index (PNI), change of SII (ΔSII), change of PNI (ΔPNI) and ΔPNI-ΔSII score in patients with neoadjuvant chemotherapy for breast cancer.

METHODS: We enrolled in a retrospective study involving 72 patients with breast cancer between February 2020 and January 2022. All patients had clinical features of axillary lymph node metastasis and received neoadjuvant therapy. PNI and SII were detected by hematology before and after treatment. Chi-square test was used to compare the clinicopathological and experimental parameters among all groups. Logistic regression analysis was used to evaluate the prognostic value of each factor.

RESULTS: The prognosis was evaluated and 18 patients (25%) achieved pathological complete response (pCR) after neoadjuvant therapy. The pCR rate of breast cancer patients was significantly correlated with ER, PR, HER-2, molecular subsets, tumor size, vascular invasion, nerve invasion, N stage, clinical stage and chemotherapy regimen. Low ΔPNI, high ΔSII and higher ΔPNI-ΔSII score values had better prediction of therapeutic effect, especially the ΔPNI-ΔSII score.

CONCLUSION: In breast cancer patients receiving neoadjuvant chemotherapy, ΔPNI-ΔSII score is an effective predictor of efficacy, which helps to identify high-risk groups and evaluate efficacy.

PMID:40416969 | PMC:PMC12098438 | DOI:10.3389/fimmu.2025.1514736

Nutrition Assessment and Counseling in Integrative Cancer Care: Effects on Patient Self-Reported Symptoms

Sat, 24 May 2025 20:00:00 -0400

Integr Cancer Ther. 2025 Jan-Dec;24:15347354251342756. doi: 10.1177/15347354251342756. Epub 2025 May 24.

ABSTRACT

BACKGROUND: Nutrition guidance can affect treatment and survival outcomes for patients with cancer. The effect of a single nutrition consult on patient-reported outcomes is not well known. This study describes characteristics of patients referred for a single outpatient nutrition consult in an integrative oncology center at a cancer hospital, examining effects on self-reported symptoms.

METHODS: We completed a retrospective chart review of 1517 adult oncology patients who completed a single nutrition consult. Demographics, clinical characteristics, and reasons for referral were extracted. Modified Edmonton Symptom Assessment System (mESAS) and Patient-Reported Outcomes Measurement Information System (PROMIS10) scores were collected. Standard descriptive statistics and the Wilcoxon signed-rank test were used.

RESULTS: Most patients were white, women, overweight/obese with breast cancer and non-advanced disease, mean age 55.3 years. Primary reasons for referral were "lifestyle change," "overweight weight-related," and "nutrition knowledge deficit." PROMIS10 results were average. Other than sleep and hot flashes, mESAS symptom scores at baseline were in the mild range. All change scores after nutrition consult were statistically but not clinically significant.

CONCLUSION: Patients presenting for nutrition counseling had a mild symptom burden at baseline and experienced statistically, not clinically, significant improvement in self-reported symptoms following a single visit. Additional research is needed to explore strategies to enhance the intervention and understand the effects of multiple follow-up sessions.

PMID:40413565 | PMC:PMC12103658 | DOI:10.1177/15347354251342756

Rapid identification of tumor patients with PG-SGA ≥ 4 based on machine learning: a prospective study

Mon, 19 May 2025 20:00:00 -0400

BMC Cancer. 2025 May 20;25(1):902. doi: 10.1186/s12885-025-14222-9.

ABSTRACT

BACKGROUND: Malnutrition is common in cancer patients and worsens treatment and prognosis. The Patient-Generated Subjective Global Assessment (PG-SGA) is the best tool to evaluate malnutrition, but it is complicated has limited its routine clinical use.

METHODS: We reviewed 798 records from 416 cancer patients treated at our hospital from July 2022 to March 2024. We used machine learning methods like XGBoost and Random Forest to find important factors linked to PG-SGA scores of 4 or higher. We confirmed the most important factors with logistic regression analysis.

RESULTS: Among all models, XGBoost and Random Forest models perform the best, with the area under the curve (AUC) reaching of 0.75 and 0.77. Multivariate logistic regression analysis identified body mass index (BMI) (OR = 0.82, 95%CI 0.66-0.99; P = 0.045), handgrip strength (HGS) (OR = 0.89, 95%CI 0.82-0.96; P = 0.004), fat-free mass index (FFMI) (OR = 1.36, 95%CI 1.01-1.88; P = 0.045), and bedridden status (OR = 3.16, 95%CI 1.17-9.14; P = 0.026) as key predictors for PG-SGA scores of ≥ 4.

CONCLUSION: BMI, HGS, FFMI, and bedridden status were identified as practical indicators to efficiently screen patients likely to have PG-SGA scores ≥ 4.

PMID:40394504 | PMC:PMC12093709 | DOI:10.1186/s12885-025-14222-9

Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta-analysis

Sun, 18 May 2025 20:00:00 -0400

Colorectal Dis. 2025 May;27(5):e70120. doi: 10.1111/codi.70120.

ABSTRACT

AIM: The Controlling Nutritional Status (CONUT) scoring system integrates components of inflammation and nutrition, both of which significantly influence cancer progression. However, its utility in colorectal cancer remains ambiguous and contradictory. The aim of this study is to evaluate the efficacy of the CONUT score in forecasting the prognosis of colorectal cancer patients.

METHOD: A thorough search was performed on the Scopus, Medline, Europe PMC and Cochrane Library databases up to 18 November 2024. This review includes evidence that investigates the correlation between the CONUT score and outcomes in colorectal cancer patients. We utilized random-effects models to evaluate the hazard ratio (HR) for the occurrence of the outcomes.

RESULTS: A total of 22 papers were included in the systematic review, with 20 of them included in the meta-analysis. The pooled analysis from multivariable data revealed that a high CONUT score was an independent predictor of poor overall survival (HR 2.02, 95% CI 1.74-2.34, p < 0.00001), disease-free survival (HR 2.96, 95% CI 1.28-6.85, p = 0.01), cancer-specific survival (HR 3.93, 95% CI 2.16-7.15, p < 0.00001) and recurrence-free survival (HR 1.76, 95% CI 1.42-2.19, p < 0.00001) among colorectal cancer patients. A high CONUT score was also correlated with a greater likelihood of postoperative complications than a low CONUT score in colorectal cancer patients (HR 2.04, 95% CI 1.44-2.89, p < 0.0001).

CONCLUSIONS: This study suggests the prognostic capability of the CONUT score in forecasting the short- and long-term outcomes of colorectal cancer patients; it therefore can be routinely calculated to stratify the risk of patients.

PMID:40387055 | DOI:10.1111/codi.70120

Retrospective Analysis of the Impact of a Dietitian and the Canadian Nutrition Screening Tool in a Geriatric Oncology Clinic

Tue, 13 May 2025 20:00:00 -0400

Nutrients. 2025 May 6;17(9):1591. doi: 10.3390/nu17091591.

ABSTRACT

INTRODUCTION: Canada's aging population is leading to an increased number of older adults being diagnosed with cancer. This population faces unique challenges, including frailty, comorbidities, polypharmacy, and malnutrition, which can negatively affect treatment outcomes. The role of registered dietitians (RDs) in managing nutrition-related issues in this population is well-documented, but there is limited research on their integration into geriatric oncology clinics. We evaluated the impact of integrating a registered dietitian (RD) into the Older Adult with Cancer Clinic (OACC) at the Princess Margaret Cancer Centre, Toronto, Canada.

MATERIALS AND METHODS: A retrospective chart review was conducted of older adult cancer patients seen at the OACC, comparing outcomes before and after the RD's integration. The focus was on weight characteristics and change, malnutrition screening/identification, and management. The two-item Canadian Nutrition Screening Tool (CNST) was introduced during the RD's integration and was also examined to see its usefulness in identifying malnutrition risk. Chi-squared tests and t-tests were used for data analysis.

RESULTS: The pre-cohort (n = 140) had a mean age of 80.2 years, 48.6% female, and 77.9% vulnerable (Vulnerable Elders Survey (VES-13) ≥ 3). The post-cohort (n = 117) had a mean age of 81.4 years, 59.8% female, and 80.3% vulnerable (VES-13 ≥ 3). Weight change within 3 ± 1 months after the initial OACC consult was similar between pre and post groups with -1.4 kg and -1.2 kg, respectively (p = 0.77). Patients at nutritional risk, as determined by the OACC team, generated significantly more referrals to the RD in the post group (100% vs. 36.4%, p < 0.001). Among patients who had CNST screening and saw the RD, there was a higher rate of high nutrition risk among CNST-positive compared to CNST-negative patients (67.2% versus 44.4%, respectively). After the integration of the RD, a greater number of patients at nutritional risk received nutritional education and referrals to other healthcare professionals (43 versus 1).

CONCLUSIONS: The integration of an RD into the OACC led to improved referral rates, nutritional education, and referrals to other healthcare professionals. Moreover, patients who were CNST positive were more likely to have high nutritional risk.

PMID:40362900 | PMC:PMC12073638 | DOI:10.3390/nu17091591

Impact of 'Internet + dietary diary management' on serum TP, ALB, PA levels and nutritional risk for elderly patients with esophageal cancer

Tue, 06 May 2025 20:00:00 -0400

Exp Gerontol. 2025 Jul;206:112780. doi: 10.1016/j.exger.2025.112780. Epub 2025 May 5.

ABSTRACT

OBJECTIVE: This study examines the impact of "Internet + diet diary management" on serum total protein (TP), albumin (ALB), and prealbumin (PA) levels, as well as nutritional risk during the postoperative home care period for elderly esophageal cancer patients.

METHODS: From May 2022 to May 2023, 74 elderly patients who underwent surgical treatment and were discharged as planned were included. Patients were assigned into a control group and a research group, with 37 in each, using a digital randomization table. Both groups received continuous nursing care, with the research group receiving additional "Internet + diet diary management" during their ongoing care. Serum levels of TP, ALB, and PA, along with other nutritional indicators and scores from the Patient-Generated Subjective Global Assessment (PG-SGA), were compared preoperatively and one month post-discharge.

RESULTS: Preoperatively, there was no significant difference in serum indicators and PG-SGA scores between the two groups (P > 0.05). One month postoperatively, the research group showed higher levels of serum ALB, TP, PA, IgA, and IgG, and lower PG-SGA scores than the control group (P < 0.05); no significant differences were found in serum levels of IgM, CA19-9, CA72-4, cyfra21-1, NSE, SCC, and CEA between the groups (P > 0.05).

CONCLUSION: The application of "Internet + diet diary management" can improve the nutritional status and reduce nutritional risk during the postoperative home care period for elderly patients with esophageal cancer.

PMID:40334756 | DOI:10.1016/j.exger.2025.112780

Postoperative Geriatric Nutritional Risk Index as a Determinant of Tolerance to S-1 Adjuvant Chemotherapy After Curative Surgery for Pancreatic Ductal Adenocarcinoma: A Cohort Study with External Validation.

Thu, 01 May 2025 00:00:00 -0400

Cancers; 05/01/2025
(AN 185133286); ISSN: 20726694
CINAHL Complete

nutrition_oncologie

Effect of family synchronous empowerment education on postoperative esophageal cancer patients and their primary caregivers

Malnutrition and Nutrition Impact Symptoms in Kuwaiti Colorectal Cancer Patients: Validation of PG-SGA Short Form

Early nutritional and inflammation assessment predicts prognosis in patients with cancer across tumor origin and metastatic status.

Body Subcutaneous Fat Change Predicts Chemoradiotherapy Response and Prognosis of Esophageal Cancer Patients: A Cohort Study.

老年结直肠癌病人术后化疗期间营养状况 与化疗不良反应的相关性.

Swallowing ability, nutritional status, and functioning in adults with advanced cancer excluding head, neck, and upper gastrointestinal tract: a cross-sectional study in an outpatient palliative care setting

Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study

A model based on preoperative nutrition-inflammation score for predicting mucocutaneous separation after enterostomy in colorectal cancer patients

Analysis of nutritional status and its influencing factors in patients with head and neck cancer: An observational study

Effects of Rikkunshito on postgastrectomy weight loss and nutritional status in gastric cancer patients: A retrospective observational study

Early nutritional and inflammation assessment predicts prognosis in patients with cancer across tumor origin and metastatic status

A Cross-Sectional Study: Association Between Nutritional Quality and Cancer Cachexia, Anthropometric Measurements, and Psychological Symptoms

Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial

A Prospective Interventional Study on the Beneficial Effect of Fish Oil-Enriched High-Protein Oral Nutritional Supplement (FOHP-ONS) on Malnourished Older Cancer Patients.

A Cross-Sectional Study: Association Between Nutritional Quality and Cancer Cachexia, Anthropometric Measurements, and Psychological Symptoms.

Editorial Issue 304.

A rapid review of nutrition and exercise approaches to managing unintentional weight loss, muscle loss, and malnutrition in cancer.

Effects of FSMP on nutrition status and sarcopenia among nutritional risk cancer patients: A randomized, double-blind, placebo-controlled study

Assessment of nutritional status of patients receiving chemotherapy: sample from European Gaza hospital

Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study.

The Prognostic Value of Nutritional and Immune Indices for Stage IB Non-Small Cell Lung Cancer Patients: Insights From a Retrospective Cohort Study

Linear inverse association between prognostic nutritional index and colorectal cancer risk based on NHANES data

Nutritional impact symptoms and dietary changes among women in a cancer support network: a qualitative analysis

Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study

Predictive value of preoperative frailty combined with Controlling Nutritional Status score for postoperative lung infection in breast cancer patients

Relationship between preoperative nutritional status with postoperative IL-10 and neopterin in gynecologic oncology patients

The relationship between sarcopenia, nutritional status, physical function, and quality of life in elderly cancer patients: a path analysis

Nutrition impact symptoms as prognostic indicators in gastric cancer: the role of quality of life and survival outcomes

Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy

Nutritional Approach on Management of Diarrhea Induced by EGFR-TKI's in Advanced Non-Small Cell Lung Cancer Patients.

Prognostic accuracy of preoperative nutritional indicators of survival in head and neck cancer patients

Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy

Nutritional risk investigation and related factors of 197 patients with early-stage non-small cell lung cancer

Nutritional outcomes and impact of malnutrition in a randomised comparison between standard and prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer

Scored Patient-Generated Subjective Global Assessment (PG-SGA) in Brazilian Cancer Patients and Association with Anthropometric Parameters

Effect of taste perception on nutritional status in patients with breast cancer: a systematic review

Frailty, Nutritional Status and Prehabilitation in Head and Neck Oncology

Normalcy of Swallowing in Head and Neck Cancer Patients Undergoing Particle Therapy Supported by Combined Swallowing Training and Feeding Management: A Randomised Controlled Trial.

Validity of a nutrition screening tool for childhood cancer.

Prognostic Nutrition Index as a Biomarker for Treatment Sensitivity to Chemotherapy and Nivolumab as the First-Line Treatment in Patients with Unresectable Advanced or Recurrent Gastric Cancer: A Multicenter Study.

Malnutrition in Colorectal Cancer Patients: Association with the Lack of Eating Motivation and Inappropriate Diet

Impact of prognostic nutritional index on oncological outcomes and mortality among advanced gastric cancer patients: European GASTRODATA registry analysis

Association of Systemic Inflammatory Response Index and Prognostic Nutritional Index Scores with Sarcopenia in Patients with Metastatic Gastric Cancer

Efficacy prediction of systemic immune-inflammation index and prognostic nutritional index in breast cancer patients and their variations after neoadjuvant chemotherapy

Nutrition Assessment and Counseling in Integrative Cancer Care: Effects on Patient Self-Reported Symptoms

Rapid identification of tumor patients with PG-SGA ≥ 4 based on machine learning: a prospective study

Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta-analysis

Retrospective Analysis of the Impact of a Dietitian and the Canadian Nutrition Screening Tool in a Geriatric Oncology Clinic

Impact of 'Internet + dietary diary management' on serum TP, ALB, PA levels and nutritional risk for elderly patients with esophageal cancer

Postoperative Geriatric Nutritional Risk Index as a Determinant of Tolerance to S-1 Adjuvant Chemotherapy After Curative Surgery for Pancreatic Ductal Adenocarcinoma: A Cohort Study with External Validation.

老年结直肠癌病人术后化疗期间营养状况与化疗不良反应的相关性.