nutrition_parenterale

Psychological impact of vascular access devices in young patients receiving parenteral nutrition: A meta-analysis.

Tue, 01 Jul 2025 04:00:00 +0000

Clinical Nutrition; 07/01/2025
(AN 185935823); ISSN: 02615614
CINAHL Complete

A rare case of steroid-resistant nephrotic syndrome complicated by Wernicke's encephalopathy.

Tue, 01 Jul 2025 04:00:00 +0000

Pediatric Nephrology; 07/01/2025
(AN 185446716); ISSN: 0931041X
CINAHL Complete

Improvement of lactic acidosis in pyruvate dehydrogenase complex deficiency using custom-made amino acid–based dialysate for peritoneal dialysis.

Tue, 01 Jul 2025 04:00:00 +0000

Pediatric Nephrology; 07/01/2025
(AN 185446719); ISSN: 0931041X
CINAHL Complete

Parenteral nutrition for preterm infants: benefits and risks in 2025.

Tue, 01 Jul 2025 04:00:00 +0000

Seminars in Fetal & Neonatal Medicine; 07/01/2025
(AN 185836471); ISSN: 1744165X
CINAHL Complete

Effect of Individualized Versus Standardized Parenteral Nutrition on Nutrient Intake and Postnatal Growth in Premature Infants: A Retrospective Clinical Study: Erratum.

Tue, 01 Jul 2025 04:00:00 +0000

Topics in Clinical Nutrition; 07/01/2025
(AN 186206207); ISSN: 08835691
CINAHL Complete

Incidence of catheter-related bloodstream infections with sodium citrate lock therapy in adult patients receiving home parenteral nutrition: A descriptive cohort study

Sat, 28 Jun 2025 08:23:41 +0000

Author Names: Leong R.,Dave N.J.,Griffith D.P.,Guo A.,Easley K.A.,Galloway J.R.,Ziegler T.R.,Zhao V.M.

Database Source: Embase Daily Updates

Journal Title: Journal of Parenteral and Enteral Nutrition

Article Title: Incidence of catheter-related bloodstream infections with sodium citrate lock therapy in adult patients receiving home parenteral nutrition: A descriptive cohort study

Year: 2025

Issue:

Volume:

Abstract: Background: We determined the incidence of catheter-related bloodstream infections in adult patients requiring home parenteral nutrition (HPN) while receiving sodium citrate locks. Method(s): We conducted a single-center descriptive cohort study involving 38 adults who required HPN from January 1, 2020, to August 31, 2022. The exact method, assuming a Poisson distribution, was used to estimate the incidence rate of catheter-related bloodstream infections per 1000 catheter days among patients receiving sodium citrate locks. Univariate and multivariate analyses using Poisson regression and frailty models were employed to evaluate predictive factors. Result(s): Thirty-eight patients received sodium citrate locks, with 65.8% women (mean age, 50.2 +/- 14.5 years). The average length of HPN was 3.6 years. Forty-six catheter-related bloodstream infections occurred during 20,085 catheter days, demonstrating an incidence rate of 2.3 (95% confidence interval, 1.7-3.1) per 1000 catheter days. Peripheral-inserted central catheters had a higher incidence rate (3.9 per 1000 catheter days) than Hickman catheters (2.2 per 1000 catheter days), with a hazard ratio of 1.27, indicating a 27% increased risk of catheter-related bloodstream infections. Univariate and multivariate Poisson regression analyses revealed that for every 1-h increase in HPN infusion duration (h/day), the incidence rate of catheter-related bloodstream infections is expected to increase by 10%. Conclusion(s): Catheter-related bloodstream infections are common in adult patients requiring HPN. Sodium citrate locks may help prevent these infections. Recognizing predictive factors, such as the duration of parenteral infusion, can help healthcare providers develop more effective prevention strategies. Copyright © 2025 American Society for Parenteral and Enteral Nutrition.

Are South African registered dietitians ready to take responsibility for prescription of parenteral nutrition and intravenous nutrients?

Sat, 28 Jun 2025 08:23:41 +0000

Author Names: Kroukam B.J.,Du Toit A.L.,Nel D.G.,Visser J.

Database Source: Embase Weekly Updates

Journal Title: South African Journal of Clinical Nutrition

Article Title: Are South African registered dietitians ready to take responsibility for prescription of parenteral nutrition and intravenous nutrients?

Year: 2025

Issue: 2

Volume: 38

Abstract: Objective: To assess registered dietitians' (RDs') knowledge of their right to prescribe parenteral nutrition (PN) and intravenous nutrients (IVN) to adults, while exploring associated attitudes and practices. Design(s): A mixed-methods approach included a descriptive study design and semi-structured interviews. Setting(s): Dietitians registered with the Health Professions Council of South Africa, working in government and private sectors. Subjects: Registered dietitians (n = 145), mostly female (95%), participated in an online self-administered questionnaire and semi-structured interviews (n = 6). Result(s): Most participants (64%, n = 93/145) actively recommend PN/IV nutrients and felt RDs should have the authority to prescribe (77%, n = 108/140). Only 11% (n = 11/104) had a good knowledge score > 65%. Those practising for >= 7 years or with additional training demonstrated significantly better knowledge scores (p < 0.001 and p = 0.002), emphasising the need for additional training (PN: p = 0.019; IV nutrients: p = 0.018). Qualitative and quantitative findings underscored RDs' pivotal role in PN/IV nutrients prescription. It also revealed knowledge gaps pertaining to pharmaceutical aspects, IV nutrients, and prescribing rights. Participants agreed that prescription of IV nutrients remains the doctor's responsibility but emphasised the importance of multidisciplinary nutrition support teams. Conclusion and implication: There was a disparity between RDs' perceived competence and their actual knowledge of PN and IV nutrients. Registered dietitians need more education and training to ensure their competency and confidence in the discussion, recommendation, and management of PN and IV nutrients for adults. The research suggests a need for clarity on legal responsibilities in prescribing rights to ensure consistency in prescription practices between healthcare professionals and health sectors in South Africa. Copyright © 2025 The Author(s). Co-published by NISC Pty (Ltd) and Informa UK Limited, trading as Taylor & Francis Group.

CONECT study: A prospective observational study on comparative nutritional efficacy in critically ill patients receiving ready-to-use vs. compounded parenteral nutrition

Sat, 28 Jun 2025 08:23:41 +0000

Author Names: Toledo D.O.,Yacoub G.B.,Gallafassi E.D.A.,Ribeiro F.A.,Moraes J.R.,Nogueira P.B.D.P.,Malheiro D.T.,Silva J.M.

Database Source: Embase Weekly Updates

Journal Title: Clinical Nutrition Open Science

Article Title: CONECT study: A prospective observational study on comparative nutritional efficacy in critically ill patients receiving ready-to-use vs. compounded parenteral nutrition

Year: 2025

Issue:

Volume: 62

Abstract: Introduction: Critically ill patients often require parenteral nutrition (PN), however the clinical and economic impact of ready-to-use diets compared to compounded diets is not well understood. This study aimed to analyze the safety and cost-effectiveness of these nutritional strategies. Methodology: A prospective observational study was conducted with patients requiring parenteral nutritional therapy. Data on nutritional composition, costs, and complications were collected, and propensity score adjustment was applied to the total sample to ensure an appropriate balance between the ready-to-use diet and the compounded diet groups. Cost calculations were adjusted for diet duration. Outcomes included total complications, mortality, cost per avoided complication, and cost per life saved. Result(s): A total of 398 patients were screened, and 329 were included. Following propensity score adjustment, the study included 50 patients, with 25 in each group. The compounded diet showed a higher supply of proteins and lipids, resulting in significantly higher levels of triglycerides (451.11 mg/dL vs. 120.22 mg/dL), pre-albumin (27.24 mg/dL vs. 14.24 mg/dL), glucose (144.32 mg/dL vs. 123.93 mg/dL), and urea (75.6 mg/dL vs. 56.3 mg/dL) in the first week, with persistently elevated levels over four weeks. Although the compounded diet exhibited a lower daily complication rate (0.96 vs. 2.14), the daily mortality rate was higher (0.32 deaths/day vs. 0.14 deaths/day), with no statistically significant difference (P = 0.34). The total cost during the administration of the diet was USD 129,919.00 for the ready-to-use diet and USD 331,525.00 for the compounded diet, resulting in a total incremental cost of USD 201,606.00 over 25 days. The cost per avoided complication was USD 11,121.07 for the ready-to-use diet and USD 12,730.54 for the compounded diet, while the cost per life saved was USD 727.55 for the ready-to-use diet and USD 4,243.51 for the compounded diet. Conclusion(s): Compounded PN resulted in higher costs without a statistically significant difference in complications or mortality when compared to the ready-to-use diet. These findings highlight the need for further studies to evaluate the clinical and economic impact of different parenteral nutrition strategies before large-scale implementation. Copyright © 2025 The Author(s)

Evaluation of the efficacy of laparoscopic hepatolobectomy for primary liver cancer with early combined enteral and parenteral nutritional support

Sat, 28 Jun 2025 08:23:41 +0000

Author Names: Wei Z.,Li Y.,Jiang S.

Database Source: Embase Weekly Updates

Journal Title: Discover Oncology

Article Title: Evaluation of the efficacy of laparoscopic hepatolobectomy for primary liver cancer with early combined enteral and parenteral nutritional support

Year: 2025

Issue: 1

Volume: 16

Abstract: The recovery of patients with liver cancer (LC) after laparoscopic hepatolobectomy is often affected by malnutrition, low immune function, and inflammatory responses, which may lead to an increase in postoperative complications and delayed recovery. Therefore, choosing a reasonable nutritional support plan is crucial for improving the postoperative recovery of patients. Material(s) and Method(s): One hundred and fifty patients with primary LC who underwent laparoscopic hepatolobectomy were grouped: nutritional group (NG) and control group (CG). The NG implemented early enteral nutrition (EN) combined with parenteral nutrition (PN) support within 24 h postoperatively, while the CG only received early EN support. The liver function, nutritional indicators, plasma endotoxin levels, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) score, and postoperative recovery of the subjects were assessed. Result(s): Compared with the CG, the NG suggested visible improvement in postoperative aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and a marked increase in albumin (ALB), prealbumin (PA), and total protein (TP). In addition, the plasma endotoxin levels were visibly lower, and the postoperative time to first bowel movement was visibly shortened in the NG as against the CG. There was no statistically meaningful distinction in hospital stay, time to ambulation, and time to first flatus in the subjects. The total score of the EORTC QLQ-C30 scale in the NG was significantly higher than that in the CG after intervention (P = 0.012). The overall incidence of complications in the NG was 6.7% (5/75), which was significantly lower than the 17.3% (13/75) in the CG (P = 0.042). Conclusion(s): Early EN combined with PN support can visibly improve the liver function and nutritional status of patients with primary LC after laparoscopic hepatolobectomy, promote postoperative immune recovery, and shorten recovery time. Copyright © The Author(s) 2025.

Post-operative nutritional practice in emergency laparotomy

Wed, 25 Jun 2025 00:00:00 +0000

Dan Med J. 2025 May 21;72(6):A11240841. doi: 10.61409/A11240841.

ABSTRACT

INTRODUCTION: Post-operative nutrition in emergency abdominal surgery can be challenging, and evidence on nutritional management in this population needs to be included in guidelines. This study aimed to describe the nutritional practice after emergency laparotomy at a university hospital and compare the routine practice to current guidelines.

METHODS: This was a single-centre retrospective cohort study of consecutive patients undergoing emergency laparotomy from August 2021 to August 2022. Patients transferred to other hospitals or non-surgical wards were excluded. Nutritional data during admission were assessed daily from post-operative day (POD) 1 up to POD 30.

RESULTS: A total of 231 patients were included; 118 (51.1%) were male, and the median age was 71 years (IQR: 58-79 years). Bowel obstruction was found in 144 (62.3%) of patients. The median length of stay was eight days (IQR: 5-14 days). Any oral intake on POD 1 was achieved by 113 (48.9%), increasing to 203 (87.9%) on POD 5. Nasogastric tubes and dietary restrictions were standard in patients not achieving oral intake on POD 1. Parenteral nutrition was used in 66 (28.6%) patients; the median time from surgery to initiation of parenteral nutrition was four days (IQR: 3-6.75 days), and the median duration of parenteral nutrition was seven days (IQR: 5-15 days).

CONCLUSIONS: Early oral intake after major emergency abdominal surgery was only achieved in half of the patients, and current practice deviates from current guidelines. Special considerations should be made in patients undergoing emergency laparotomy as their post-operative condition differs from that of elective cases.

FUNDING: This study was supported by the Novo Nordisk Foundation (grant number NNF22OC0079459). The Novo Nordisk Foundation was not involved in study design, data collection, analysis, interpretation or writing.

TRIAL REGISTRATION: Not relevant.

PMID:40557861 | DOI:10.61409/A11240841

Incidence of catheter-related infection in cancer patients receiving parenteral nutrition: A retrospective cohort study of French administrative claims data

Mon, 09 Jun 2025 00:00:00 +0000

Medicine (Baltimore). 2025 Jun 6;104(23):e42704. doi: 10.1097/MD.0000000000042704.

ABSTRACT

Data confirming parenteral nutrition (PN) as an independent risk factor for catheter-related infection (CRI) are scarce and not recent. This study aims to estimate the effect of PN on CRI in cancer patients after catheter placement. A retrospective cohort analysis of the French National Health Data System was conducted. A total of 5300 gastric, 5975 pancreatic, and 15,102 lung cancer patients with central venous catheter insertion between 2012 and 2016 were included. Potential confounders for CRI were evaluated using Poisson regression. Incidence rates (IRs) of CRI were calculated. Incidence rate ratio (IRR) was estimated to assess the effect of exposure to PN on infection occurrence in all patients and among patients receiving chemotherapy (CT). The independent risk factors found to be associated with CRI were age, sex, Charlson Comorbidity Index, PN, CT, metastasis, and history of infection. After adjustment, there was an increased risk of CRI in patients with versus without PN in gastric (IRR: 1.1165; 95% confidence interval [95% CI]: 1.0119-1.2319), pancreatic (IRR: 1.2071; 95% CI: 1.0985-1.3265), and lung cancer (IRR: 1.1850; 95% CI: 1.0832-1.2962). In patients who received PN, IRs of CRI were higher than in those who did not, for gastric (34.84% vs 29.69%, respectively; P = .0001), pancreatic (38.89% vs 28.58%, respectively; P < .0001), and lung (23.64% vs 22.13%, respectively; P = .0967) cancer cohorts. The results of this National administrative claims database analysis suggested that PN might be one of the independent risk factors for CRI. However, the risk was smaller than previously reported, regardless of whether the patient was receiving CT or not.

PMID:40489839 | PMC:PMC12150976 | DOI:10.1097/MD.0000000000042704

Incidence of catheter-related infection in cancer patients receiving parenteral nutrition: A retrospective cohort study of French administrative claims data.

Fri, 06 Jun 2025 04:00:00 +0000

Medicine; 06/06/2025
(AN 185812073); ISSN: 00257974
CINAHL Complete

Psychological impact of vascular access devices in young patients receiving parenteral nutrition: A meta-analysis

Fri, 06 Jun 2025 00:00:00 +0000

Clin Nutr. 2025 Jul;50:240-252. doi: 10.1016/j.clnu.2025.05.002. Epub 2025 May 21.

ABSTRACT

BACKGROUND: Vascular access devices (VADs) are crucial for administering parenteral nutrition to young patients with various medical conditions. However, the psychological impact of these devices on this vulnerable population is not well understood.

OBJECTIVE: To synthesize and quantify the existing literature on the psychological effects of VADs in young patients (0-25 years) receiving parenteral nutrition.

METHODS: A systematic review and meta-analysis were conducted using PubMed, EMBASE, PsycINFO, and CINAHL databases. Studies published between January 2000 and December 2023 were included if they reported quantitative psychological outcomes in young patients with VADs for parenteral nutrition. Random-effects models were used to pool effect sizes for anxiety, depression, body image, and quality of life outcomes.

RESULTS: Twenty-eight studies met the inclusion criteria, encompassing 2437 patients. The pooled prevalence of clinically significant anxiety was 31.7 % (95 % CI: 26.4-37.5 %), and depression was 23.9 % (95 % CI: 19.2-29.3 %). VADs were associated with moderate negative effects on body image (Hedges' g = -0.62, 95 % CI: -0.78 to -0.46) and small but significant reductions in overall quality of life (Hedges' g = -0.34, 95 % CI: -0.47 to -0.21). Subgroup analyses revealed that centrally inserted catheters had a greater psychological impact compared to peripherally inserted devices.

CONCLUSION: VADs for parenteral nutrition are associated with significant psychological burden in young patients. These findings highlight the need for routine psychological screening and targeted interventions to support this population.

PMID:40479906 | DOI:10.1016/j.clnu.2025.05.002

Prescribing errors in hospitalized patients on the ketogenic diet.

Mon, 02 Jun 2025 04:00:00 +0000

American Journal of Health-System Pharmacy; 06/02/2025
(AN 185489044); ISSN: 10792082
CINAHL Complete

Nutrition issues in adult hematopoietic cell transplantation: A narrative review of latest advances.